List of works - Benjamin P Fauber

A reversed sulfonamide series of selective RORc inverse agonists

scientific article

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

scientific article published on 26 August 2016

Concise syntheses of (-)-galanthamine and (+/-)-codeine via intramolecular alkylation of a phenol derivative

scientific article

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

scientific journal article

Discovery and Optimization of a Novel Series of Potent Mutant B-RafV600E Selective Kinase Inhibitors ⬇️

scientific article published on February 27, 2013

Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists

scientific article published in April 2004

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) i

scientific article published on 23 June 2015

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

scientific article published on 28 May 2015

Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO

scientific article published on 30 April 2012

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties

scientific article published on 3 August 2016

Experimental and Computational Studies of the Diastereoselective Alkylations of 3-Substituted γ-Sultams

scientific article

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

scientific article

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

scientific article

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists

scientific article published on 14 August 2015

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

scientific article

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

scientific article

Identification of tertiary sulfonamides as RORc inverse agonists

scientific article published on 21 March 2014

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.

scientific article published on 4 December 2014

Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc)

scientific article

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

scientific article

Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes

scientific article published on 17 September 2015

Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides

scientific article published on 17 June 2014

Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists

scientific article published on 01 November 2004

Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists

scientific article

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

scientific article

Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc

scientific article

List of works by Benjamin P Fauber

A reversed sulfonamide series of selective RORc inverse agonists

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

Concise syntheses of (-)-galanthamine and (+/-)-codeine via intramolecular alkylation of a phenol derivative

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

Discovery and Optimization of a Novel Series of Potent Mutant B-RafV600E Selective Kinase Inhibitors ⬇️

Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) i

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties

Experimental and Computational Studies of the Diastereoselective Alkylations of 3-Substituted γ-Sultams

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Identification of tertiary sulfonamides as RORc inverse agonists

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.

Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc)

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes

Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides

Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists

Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc