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List of works by Edward Doerffler

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

scientific article published on 26 January 2017

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity ⬇️

scientific article published on December 13, 2011

Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease ⬇️

scientific article published on February 2012

Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection

scientific article published on 6 November 2013

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

scientific article published on 20 February 2017

Discovery of novel phosphonate derivatives as hepatitis C virus NS3 protease inhibitors

scientific article

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

scientific article

Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

scientific article published on 29 April 2015

Novel, potent and orally bioavailable indolizidinone-derived inhibitors of the hepatitis C virus NS3 protease ⬇️

scientific article published on December 6, 2011

Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease ⬇️

scientific article published on May 3, 2011

Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors

scientific article published on 8 August 2011

Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase

scientific article published on 26 November 2012

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

scientific article

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