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List of works by Anthea Hardcastle

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation

scientific article published on 01 March 2007

A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors

scientific article

Application of meso scale technology for the measurement of phosphoproteins in human tumor xenografts

scientific article

Assays for HSP90 and inhibitors.

scientific article

Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor ⬇️

scientific article published on November 16, 2010

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells

scientific article published in September 2003

Identification of Autophosphorylation Inhibitors of the Inositol-Requiring Enzyme 1 Alpha (IRE1α) by High-Throughput Screening Using a DELFIA Assay ⬇️

scientific article published on November 8, 2012

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

scientific article

Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.

scientific article published in June 2005

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response ⬇️

scientific article published on February 11, 2011

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