List of works - Ikuo Saiki

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

scientific article published on 18 December 2013

A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine

scientific article

A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.

scientific article

A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells

scientific article published on January 2010

Anti-inflammatory effect of cinnamaldehyde in Helicobacter pylori induced gastric inflammation

scientific article

Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice

scientific article

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

scientific article

Antitumor immune activity by chemokine CX3CL1 in an orthotopic implantation of lung cancer model in vivo

scientific article

Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer.

scientific article published on July 2013

Bioimaging of fluorescence-labeled mitochondria in subcutaneously grafted murine melanoma cells by the "in vivo cryotechnique".

scientific article published on 06 January 2014

Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways

scientific article

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

scientific article

Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response

scientific article published on November 2007

Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells

scientific article published on 17 February 2017

Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

scientific article

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

scientific journal article

Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper

scientific article published on January 2013

Efficient Use of a Crude Drug/Herb Library Reveals Ephedra Herb As a Specific Antagonist for TH2-Specific Chemokine Receptors CCR3, CCR4, and CCR8

scientific article

Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.

scientific article

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner

scientific article

Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel

scientific article published on 02 October 2013

Highly oxygenated antiausterity agents from the leaves of Uvaria dac.

scientific article

Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways

scientific article published on 02 December 2009

IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression

scientific article published on 6 July 2016

Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-κB activation

scientific article published on 27 August 2014

Imaging of thrombosis and microcirculation in mouse lungs of initial melanoma metastasis with in vivo cryotechnique

scientific article published on 5 December 2013

Lupinacidin C, an inhibitor of tumor cell invasion from Micromonospora lupini.

scientific article

Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation

scientific article published on 29 May 2015

Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.

scientific article published on 30 December 2008

Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B.

scientific article published on 29 January 2014

Multi-pathway cellular analysis on crude natural drugs/herbs from Japanese Kampo formulations

scientific article published on 2 June 2015

Nonthmicin, a Polyether Polyketide Bearing a Halogen-Modified Tetronate with Neuroprotective and Antiinvasive Activity from Actinomadura sp.

scientific article

P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer

scientific article published on 12 July 2016

Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells

scientific article published on April 2014

Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line.

scientific article published on 16 October 2013

Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats

scientific article

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

scientific article

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.

scientific article published on 28 April 2015

Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells

scientific article

Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage

scientific article

Severe pulmonary metastasis in obese and diabetic mice

scientific article published on December 2006

Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis

scientific article

TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo

scientific article

Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells

scientific article

The long-term effects of a kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination

scientific article

Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer

scientific article published on January 2012

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

scientific article

List of works by Ikuo Saiki

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine

A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.

A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells

Anti-inflammatory effect of cinnamaldehyde in Helicobacter pylori induced gastric inflammation

Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

Antitumor immune activity by chemokine CX3CL1 in an orthotopic implantation of lung cancer model in vivo

Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer.

Bioimaging of fluorescence-labeled mitochondria in subcutaneously grafted murine melanoma cells by the "in vivo cryotechnique".

Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response

Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells

Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper

Efficient Use of a Crude Drug/Herb Library Reveals Ephedra Herb As a Specific Antagonist for TH2-Specific Chemokine Receptors CCR3, CCR4, and CCR8

Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner

Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel

Highly oxygenated antiausterity agents from the leaves of Uvaria dac.

Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways

IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression

Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-κB activation

Imaging of thrombosis and microcirculation in mouse lungs of initial melanoma metastasis with in vivo cryotechnique

Lupinacidin C, an inhibitor of tumor cell invasion from Micromonospora lupini.

Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation

Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.

Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B.

Multi-pathway cellular analysis on crude natural drugs/herbs from Japanese Kampo formulations

Nonthmicin, a Polyether Polyketide Bearing a Halogen-Modified Tetronate with Neuroprotective and Antiinvasive Activity from Actinomadura sp.

P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer

Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells

Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line.

Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.

Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells

Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage

Severe pulmonary metastasis in obese and diabetic mice

Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis

TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo

Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells

The long-term effects of a kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination

Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway