List of works - Rita Derua

De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation

scientific article published on 28 September 2010

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

scientific article published on 9 June 2016

Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype

scientific article published on 2005

Substrate specificity and activity regulation of protein kinase MELK

scientific article

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

scientific article

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling.

scientific article

An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

scientific article published on May 2004

Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles

scientific article published on 7 April 2015

A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties

scientific article published on April 6, 2011

Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome

scientific article

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

scientific article published in Nature

Maize plasma membrane aquaporins belonging to the PIP1 and PIP2 subgroups are in vivo phosphorylated

scientific article

Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

scientific article published on September 2006

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination

scientific article

Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons

scientific journal article

Activation of plant plasma membrane H+-ATPase by 14-3-3 proteins is negatively controlled by two phosphorylation sites within the H+-ATPase C-terminal region

scientific article

Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.

scientific article published on 2 August 2016

NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes

scientific article

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

scientific article published on 03 February 2016

Protein kinase D regulates RhoA activity via rhotekin phosphorylation

scientific article

PREPL: a putative novel oligopeptidase propelled into the limelight

scientific article published in July 2006

Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction

scientific article

Characterization of cortactin as an in vivo protein kinase D substrate: interdependence of sites and potentiation by Src.

scientific article

Split-BioID: a proximity biotinylation assay for dimerization-dependent protein interactions.

scientific article

p53 attenuates AKT signaling by modulating membrane phospholipid composition

scientific article

Lipid degradation promotes prostate cancer cell survival

scientific article

Tissue specific analysis reveals a differential organization and regulation of both ethylene biosynthesis and E8 during climacteric ripening of tomato.

scientific article published on 8 January 2014

A phosphorylation in the c-terminal auto-inhibitory domain of the plant plasma membrane H+-ATPase activates the enzyme with no requirement for regulatory 14-3-3 proteins

scientific article

In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants

scientific article published on January 15, 2014

A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes

scientific article published on 25 October 2011

Lipidomics in drug development.

scientific article published on 07 May 2015

SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells

scientific article published on January 29, 2016

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

scientific article published on 27 June 2018

Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability

scientific article

Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin

scientific article published on 27 March 2009

Seroreactivity against glycolytic enzymes in inflammatory bowel disease

scientific article

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

scientific article

Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.

scientific article published on 22 April 2015

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons

scientific article published on 24 November 2018

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.

scientific article published on 8 June 2018

Specific regulation of protein phosphatase 2A PR72/B'' subunits by calpain

scientific article

Immune reactivity to -tubulin isotype 5 and vesicular integral-membrane protein 36 in patients with autoimmune gastrointestinal disorders

scientific article published on 15 December 2010

A substrate-trapping strategy for protein phosphatase PP1 holoenzymes using hypoactive subunit fusions

scientific article published on 16 August 2018

Heterogeneous nuclear RNPs as targets of autoantibodies in systemic rheumatic diseases

scientific article published on 01 January 2012

Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs.

scientific article

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

article

Heterogeneous nuclear ribonucleoprotein h1, a novel nuclear autoantigen

scientific article

Betaine homocysteine methyl transferase 1, a novel auto-antigen associated with anti-Golgi immune reactivity

scientific article published on September 22, 2011

Fulfilling the Krebs and Beavo criteria for studying protein phosphorylation in the era of mass spectrometry-driven kinome research

scientific article published on December 2009

Structural analysis of bacteriophage-encoded peptidoglycan hydrolase domain KMV36C: crystallization and preliminary X-ray diffraction

scientific article

List of works by Rita Derua

De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype

Substrate specificity and activity regulation of protein kinase MELK

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling.

An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles

A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties

Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Maize plasma membrane aquaporins belonging to the PIP1 and PIP2 subgroups are in vivo phosphorylated

Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination

Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons

Activation of plant plasma membrane H+-ATPase by 14-3-3 proteins is negatively controlled by two phosphorylation sites within the H+-ATPase C-terminal region

Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.

NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

Protein kinase D regulates RhoA activity via rhotekin phosphorylation

PREPL: a putative novel oligopeptidase propelled into the limelight

Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction

Characterization of cortactin as an in vivo protein kinase D substrate: interdependence of sites and potentiation by Src.

Split-BioID: a proximity biotinylation assay for dimerization-dependent protein interactions.

p53 attenuates AKT signaling by modulating membrane phospholipid composition

Lipid degradation promotes prostate cancer cell survival

Tissue specific analysis reveals a differential organization and regulation of both ethylene biosynthesis and E8 during climacteric ripening of tomato.

A phosphorylation in the c-terminal auto-inhibitory domain of the plant plasma membrane H+-ATPase activates the enzyme with no requirement for regulatory 14-3-3 proteins

In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants

A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes

Lipidomics in drug development.

SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability

Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin

Seroreactivity against glycolytic enzymes in inflammatory bowel disease

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.

Specific regulation of protein phosphatase 2A PR72/B'' subunits by calpain

Immune reactivity to -tubulin isotype 5 and vesicular integral-membrane protein 36 in patients with autoimmune gastrointestinal disorders

A substrate-trapping strategy for protein phosphatase PP1 holoenzymes using hypoactive subunit fusions

Heterogeneous nuclear RNPs as targets of autoantibodies in systemic rheumatic diseases

Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs.

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Heterogeneous nuclear ribonucleoprotein h1, a novel nuclear autoantigen

Betaine homocysteine methyl transferase 1, a novel auto-antigen associated with anti-Golgi immune reactivity

Fulfilling the Krebs and Beavo criteria for studying protein phosphorylation in the era of mass spectrometry-driven kinome research

Structural analysis of bacteriophage-encoded peptidoglycan hydrolase domain KMV36C: crystallization and preliminary X-ray diffraction