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List of works by Patrick A. Baeuerle

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

scientific article published in November 1989

A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration

scientific article

A human cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM overexpressing tumor cells.

scientific article published on 17 February 2006

A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF.

scientific article published on 11 May 2006

A humanized monoclonal antibody against interleukin-2 that can inactivate the cytokine/receptor complex

scientific article published on 26 September 2006

A hydrophobic region within the adenovirus E1B 19 kDa protein is necessary for the transient inhibition of NF-kappaB activated by different stimuli.

scientific article

A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene ⬇️

scientific article published on January 1, 1992

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

scientific article

A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients

scientific article

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

scientific article

A revival of bispecific antibodies

scientific article

Activate NF-kappa B or die?

scientific article published on February 1997

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor

scientific journal article

Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers

scientific article published on 01 August 1996

Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.

scientific article

Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue

scientific article published on 01 April 1996

Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention

scientific article published on February 1996

Anti-psoriatic drug anthralin activates transcription factor NF-kappa B in murine keratinocytes

scientific article published on June 1996

Antioxidants as well as oxidants activate c-fos via Ras-dependent activation of extracellular-signal-regulated kinase 2 and Elk-1

scientific article published on 01 February 1997

Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein ⬇️

scientific article published on November 1, 1992

Antitumor activity of a dual cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM expressing tumor cells

scientific article published on September 2006

Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release

scientific article

Antiviral Activity of HIV gp120 Targeting Bispecific T Cell Engager (BiTE®) Antibody Constructs.

scientific article

Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-kappa B.

scientific article published on January 1994

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis

scientific article published on July 1996

BiTE: Teaching antibodies to engage T-cells for cancer therapy

scientific article

BiTEs: bispecific antibody constructs with unique anti-tumor activity

scientific article

Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection

scientific article published on 28 February 2017

Bispecific T-Cell Engager (BiTE) Antibody Construct Blinatumomab for the Treatment of Patients With Relapsed/Refractory Non-Hodgkin Lymphoma: Final Results From a Phase I Study.

scientific article published on 16 February 2016

Bispecific T-cell engaging antibodies for cancer therapy

scientific article (publication date: 15 June 2009)

Bispecific antibodies for polyclonal T-cell engagement

scientific article published on August 1, 2003

Blinatumomab: a historical perspective

scientific article published on 24 August 2012

Brain synapses contain inducible forms of the transcription factor NF-kappa B.

scientific article

CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis

scientific article

CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330.

scientific article published on 3 December 2013

CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas

scientific article

Changes in clinical laboratory parameters and pharmacodynamic markers in response to blinatumomab treatment of patients with relapsed/refractory ALL

scientific article published on 18 May 2017

Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element

scientific article published on November 1992

Cloning of the murine relA (p65 NF-kappa B) gene and comparison to the human gene reveals a distinct first intron

scientific article published on October 1996

Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells

scientific article published on 02 October 2008

Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor -independent mouse model

article

Combined transcriptome and genome analysis of single micrometastatic cells

scientific article

Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110.

scientific article

Constitutive NF-kappa B activity in neurons

scientific journal article

Constitutive nuclear NF-kappa B in cells of the monocyte lineage

scientific article

Control of gene expression by proteolysis

scientific article

Cytotoxic activity of novel human monoclonal antibody MT201 against primary ovarian tumor cells

scientific article published on 18 June 2003

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition

scientific article

Distinct Domains of the RelA NF-κB Subunit Are Required for Negative Cross-talk and Direct Interaction with the Glucocorticoid Receptor ⬇️

scientific article published on August 29, 1997

Efficient tumor cell lysis by autologous, tumor-resident T lymphocytes in primary ovarian cancer samples by an EP-CAM-/CD3-bispecific antibody

scientific article published on June 2003

EpCAM (CD326) finding its role in cancer

scientific article

EpCAM (CD326) finding its role in cancer.

scientific article published in May 2007

Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy.

scientific article published on 16 October 2004

Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen

scientific article published on 23 March 2010

Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct

scientific article

Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

scientific article published on 26 August 2006

Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

scientific article published on 07 June 2020

Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma

scientific article published on 20 December 2005

Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B.

scientific article published on March 1995

Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF rece

scientific article published on December 1990

Expression, tyrosine sulfation, and secretion of yolk protein 2 of Drosophila melanogaster in mouse fibroblasts.

scientific article published in October 1988

Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody

scientific article

Failure of the splicing variant p65 delta of the NF-kappa B subunit p65 to transform fibroblasts

scientific article published on August 1994

Function and activation of NF-kappa B in the immune system

scientific article (publication date: 1994)

Functional analysis of mutated cDNA clones by direct use of PCR products in in vitro transcription/translation reactions

scientific article published on October 1993

GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice

scientific article published on 4 October 2006

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

scientific article

Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization

scientific article

High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G.

scientific article published on 15 August 2005

Highly Efficient Elimination of Colorectal Tumor-Initiating Cells by an EpCAM/CD3-Bispecific Antibody Engaging Human T Cells ⬇️

scientific article published on October 18, 2010

Highly efficient antigen targeting to M-DC8+ dendritic cells via FcgammaRIII/CD16-specific antibody conjugates

scientific article published on 18 March 2005

Human IgG1 antibodies antagonizing activating receptor NKG2D on natural killer cells

scientific article

Hypoxia Induces c-fos Transcription via a Mitogen-activated Protein Kinase-dependent Pathway ⬇️

scientific article published on September 12, 1997

I kappa B: a specific inhibitor of the NF-kappa B transcription factor

scientific article

IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase ⬇️

scientific article published on August 1, 1995

Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-kappaB.

scientific article

Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab

scientific article

Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab

scientific article published on 16 May 2012

Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab

scientific article

Immunotherapy using bispecific T cell engager (BiTE®) antibodies: preclinical and clinical experience in acute leukemia.

scientific article published on 6 November 2014

Impact of Diverse Immune Evasion Mechanisms of Cancer Cells on T Cells Engaged by EpCAM/CD3-Bispecific Antibody Construct AMG 110

scientific article published on 28 October 2015

Implications of T cell receptor biology on the development of new T cell therapies for cancer

scientific article published on 06 January 2020

In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment

scientific article published on 01 July 2002

Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB ⬇️

scientific article published on November 10, 1995

Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells

scientific article

Inhibition of N-glycosylation induces tyrosine sulphation of hybridoma immunoglobulin G.

scientific article published on October 1984

Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators

scientific article

Interleukin-1 beta uses common and distinct signaling pathways for induction of the interleukin-6 and tumor necrosis factor alpha genes in the human astrocytoma cell line U373.

scientific article

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit

scientific article published on March 20, 1992

Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B

scientific article published on 01 October 1991

Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.

scientific article

KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells

scientific article

Lysis of cancer cells by autologous T cells in breast cancer pleural effusates treated with anti-EpCAM BiTE antibody MT110

scientific article published on 26 September 2008

MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

scientific article published on September 2005

Mode of cytotoxic action of T cell-engaging BiTE antibody MT110.

scientific article

Multi-step activation of NF-kappa B/Rel transcription factors.

scientific article published on July 1995

Myocardial gene expression of matched hibernating and control tissue from patients with ischemic left ventricular dysfunction

scientific article published on 23 July 2008

NF-kappa B activation in human knee-joint synovial tissue during the early stage of joint inflammation

scientific article published on 01 August 1997

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules

scientific article published on January 1, 1997

NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene

scientific article

NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit

scientific article

NF-kappa B: ten years after

scientific article (publication date: 4 October 1996)

Novel anti-denatured collagen humanized antibody D93 inhibits angiogenesis and tumor growth: An extracellular matrix-based therapeutic approach

scientific article published on 01 December 2006

Nuclear signalling by tumour-associated antigen EpCAM

scientific article

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus ⬇️

scientific article published on January 1, 1993

On the abundance of EpCAM on cancer stem cells

scientific article published on 09 January 2009

Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer.

scientific article

Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients with Non-Hodgkin Lymphoma.

scientific article published in January 2018

Phase II study of the human anti-epithelial cell adhesion molecule antibody adecatumumab in prostate cancer patients with increasing serum levels of prostate-specific antigen after radical prostatectomy

scientific article published on 02 July 2010

Phorbol-ester-induced activation of the NF-kappa B transcription factor involves dissociation of an apparently cytoplasmic NF-kappa B/inhibitor complex

scientific article published on 01 January 1988

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

scientific article

Potent control of tumor growth by CEA/CD3-bispecific single-chain antibody constructs that are not competitively inhibited by soluble CEA.

scientific article

Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3.

scientific article published on 27 September 2005

Potential involvement of the transcription factor NF-kappa B in neurological disorders

scientific article

Preclinical Characterization of HPN536, a Trispecific, T Cell-activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors

scientific article published on 01 December 2020

Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia

scientific article published on 27 March 2014

Pro-inflammatory signaling: last pieces in the NF-kappaB puzzle?

scientific article

Productivity and quality of recombinant proteins produced by stable CHO cell clones can be predicted by transient expression in HEK cells

scientific article published in June 2013

Proteins controlling the nuclear uptake of NF-kappa B, Rel and dorsal

scientific article published on November 1991

Purification of yolk protein 2 of Drosophila melanogaster and identification of its site of tyrosine sulfation.

scientific article published in October 1988

Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription

scientific article

Purified human I kappa B can rapidly dissociate the complex of the NF-kappa B transcription factor with its cognate DNA.

scientific article

Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty

scientific article published on 16 November 2004

Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties

scientific article published in April 2004

Rapid characterization of lambda cDNA clones after amplification and radioactive labeling with the PCR technique

scientific article published on 01 June 1993

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

scientific article (publication date: 9 September 1993)

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

scientific article

Redirected lysis of human melanoma cells by a MCSP/CD3-bispecific BiTE antibody that engages patient-derived T cells

scientific article

Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes.

scientific article

Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens.

scientific article published on 5 October 2012

Regulation of the transcription factors NF-kappa B and AP-1 by redox changes

scientific article published on 01 June 1994

Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

scientific article

Selective recognition of the activated form of transcription factor NF-kappa B by a monoclonal antibody

scientific article published on January 1995

Selective targeting and potent control of tumor growth using an EphA2/CD3-Bispecific single-chain antibody construct

scientific article published on April 2007

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct.

scientific article published on May 2005

Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies ⬇️

scientific article published on November 2, 2010

Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system

scientific article published on May 1994

Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons

scientific article

Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class

scientific article

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation

scientific article published on 01 October 1994

Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates

scientific article published on March 1997

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

scientific article published on 07 May 2019

T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3- bispecific single-chain antibody construct

scientific article published on 01 April 2003

T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells

scientific article

T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct

scientific article published on 20 July 2005

Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.

scientific article published on 16 May 2011

Targeting of humanized antibody D93 to sites of angiogenesis and tumor growth by binding to multiple epitopes on denatured collagens

scientific article published on 15 May 2007

The 65-kD subunit of NF-kappa B is a receptor for I kappa B and a modulator of DNA-binding specificity

scientific article

The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product

scientific article (publication date: 7 September 1990)

The ER-overload response: activation of NF-kappa B.

scientific article published on February 1997

The NF-kappa B transcription factor induces DNA bending which is modulated by its 65-kD subunit

scientific article published on November 1990

The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K.

scientific article

The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct

scientific article published on 20 February 2007

The emerging role of EpCAM in cancer and stem cell signaling

scientific article

The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B

scientific article published on 01 December 1995

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

scientific article published in April 1996

The inducible transcription activator NF-kappa B: regulation by distinct protein subunits

scientific article

The inducible transcription factor NF-kappa B: structure-function relationship of its protein subunits

scientific article

The interleukin-2 antagonizing antibody MT204 delays allogeneic skin graft rejection in non-human primates and is well tolerated

scientific article published on 25 June 2011

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B

scientific article

The primary structure of bovine chromogranin A: a representative of a class of acidic secretory proteins common to a variety of peptidergic cells

scientific article

The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region

scientific article

The proto-oncogene bcl-3 encodes an I kappa B protein

scientific article published on December 1992

The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation

scientific article

The role of NF-kappa B1 (p50/p105) gene expression in activation of human blood T-lymphocytes via CD2 and CD28 adhesion molecules

scientific article

The role of the p50 and p65 subunits of NF-kappa B in the recognition of cognate sequences

scientific article

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B

scientific article published on 01 January 1995

Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3.

scientific article published in January 2008

Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans

scientific article

Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells

scientific article published on 01 June 1995

Transcription factor NF-kappa B is activated in microglia during experimental autoimmune encephalomyelitis

scientific article published on 01 November 1994

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

scientific article

TriTACs, a novel class of T cell-engaging protein constructs designed for the treatment of solid tumors

scientific article published on 17 November 2020

Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B transcription factor to a high-affinity kappa B element in the TNF-beta promoter

scientific article published on November 1990

Tumor regression in cancer patients by very low doses of a T cell-engaging antibody

scientific article

Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

scientific article published on 01 September 1996

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