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List of works by George S. Drummond

A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns

scientific article

Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity

An experimental model of postnatal jaundice in the suckling rat. Suppression of induced hyperbilirubinemia by Sn-protoporphyrin

scientific article

Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats

scientific article published on 28 September 2007

CD163-Mediated hemoglobin-heme uptake activates macrophage HO-1, providing an antiinflammatory function

scientific article published on 01 October 2006

Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model

scientific article published on 01 September 1982

Chemoprevention of severe neonatal hyperbilirubinemia

scientific article

Cobalt-protoporphyrin suppresses thyroid and testicular hormone concentrations in rat serum: a novel action of this synthetic heme analogue

scientific article published on 01 January 1987

Comparative pharmacology of zinc mesoporphyrin and tin mesoporphyrin: toxic actions of zinc mesoporphyrin on hematopoiesis and progenitor cell mobilization

scientific article published on 01 January 1999

Control of Hyperbilirubinemia in Glucose-6-Phosphate Dehydrogenase-deficient Newborns Using an Inhibitor of Bilirubin Production, Sn-Mesoporphyrin ⬇️

scientific article published on May 1, 1998

Control of bilirubin production by synthetic heme analogs: pharmacologic and toxicologic considerations.

scientific article published on May 1996

Control of heme and cytochrome P-450 metabolism by inorganic metals, organometals and synthetic metalloporphyrins

scientific article

Control of heme metabolism with synthetic metalloporphyrins

scientific article

Control of heme oxygenase and plasma levels of bilirubin by a synthetic heme analogue, tin-protoporphyrin

scientific article published on 01 March 1984

Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin.

scientific article published in January 1994

Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin

scientific article published in January 1999

Depletion of cytochrome P-450 by thyroid hormone and cobalt-protoporphyrin IX in rat liver: evidence that susceptibility varies among forms of the heme protein

scientific article published on 01 October 1995

Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage, reversed by increases in pAMPK, heme oxygenase-1, and adiponectin

scientific article published on February 2009

Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns

scientific article published on 01 April 1995

Direct in vitro effects of bis(tri-n-butyltin)oxide on hepatic cytochrome P-450

scientific article published on 01 December 1983

Disposition of tin-protoporphyrin and suppression of hyperbilirubinemia in humans

scientific article published on 01 May 1986

Downregulation of the human heme oxygenase gene by glucocorticoids and identification of 56b regulatory elements

scientific article published in January 1996

Dual role of heme oxygenase in epithelial cell injury: contrasting effects of short-term and long-term exposure to oxidant stress

scientific article published on September 1996

Effect of hemin and carbon monoxide releasing molecule (CORM-3) on cGMP in rat penile tissue

scientific article

Effects of a series of metalloporphyrins on adrenal, testicular and thyroid function in rats

scientific article published on 01 March 1996

Effects of tin-porphyrins on developmental changes in hepatic cytochrome P450 content, selected P450-dependent drug-metabolizing enzyme activities and brain glutathione levels in the newborn rat.

scientific article published in January 1989

Fluorometric measurement of tin-protoporphyrin in biological samples

scientific article published on 01 August 1984

Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway

scientific article published on 29 August 2006

HO-1 overexpression and underexpression: Clinical implications

scientific article published on 16 August 2019

Heme oxygenase -1 gene therapy: recent advances and therapeutic applications

scientific article published on April 2007

Heme oxygenase inhibitors transiently increase serum ferritin concentrations without altering other acute-phase reactants in man

scientific article published on 01 July 1999

Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats

scientific article published on 26 January 2009

Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes

scientific article

Heme oxygenase: a target gene for anti-diabetic and obesity

scientific article published on January 2008

Heme oxygenase: the key to renal function regulation

scientific article published on July 2009

Impact of silencing HO-2 on EC-SOD and the mitochondrial signaling pathway

scientific article

Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling.

scientific article published on April 2010

Induction of heme oxygenase mRNA by cobalt protoporphyrin in rat liver

scientific article published on 01 January 1991

Intestinal heme oxygenase inhibition and increased biliary iron excretion by metalloporphyrins.

scientific article

Investigations on the role of hemopexin and albumin in plasma clearance and tissue distribution of Sn-protoporphyrin

scientific article published on 01 August 1993

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

scientific article published on 19 April 2008

Long-term administration of massive doses of Sn-protoporphyrin in anemic mutant mice (sphha/sphha)

scientific article

Manganese and zinc blockade of enzyme induction: Studies with microsomal heme oxygenase ⬇️

scientific article published on October 1, 1979

Metal induction of haem oxygenase without concurrent degradation of cytochrome P-450. Protective effects of compound SKF 525A on the haem protein

scientific article published on January 1982

Metal ion interactions in the control of haem oxygenase induction in liver and kidney

scientific article published on November 1980

Pharmacologic effects of the red blood cell substitutes cross-linked and non-cross-linked hemoglobins on hematopoiesis in rabbits

scientific article published on 01 June 1999

Photodynamic properties of Sn-protoporphyrin: clinical investigations and phototesting in human subjects

scientific article published on 01 February 1993

Photophysical properties of Sn-porphyrins: potential clinical implications ⬇️

scientific article published on 01 April 1988

Physiological significance of heme oxygenase in hypertension

scientific article

Porphyrogenic effects and induction of heme oxygenase in vivo by delta-aminolevulinic acid

scientific article published on 01 September 1981

Potent heme-degrading action of antimony and antimony-containing parasiticidal agents

scientific article published on February 1981

Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation

scientific article

Prolonged clinical use of a heme oxygenase inhibitor: hematological evidence for an inducible but reversible iron-deficiency state

scientific article published on 01 March 1993

Prolonged induction of hepatic haem oxygenase and decreases in cytochrome P-450 content by organotin compounds

scientific article published on August 1980

Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources

scientific article published on April 1987

Protective effect of Sn-protoporphyrin against doxorubicin-induced perturbations of heme metabolism

scientific article published on 01 January 1990

Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism

scientific article published on 01 May 1987

Relationship of suppression of the androgenic axis by cobalt-protoporphyrin to its effects on weight loss and hepatic heme oxygenase induction

scientific article published in January 1987

Retinoic acid can enhance the stimulation by thyroid hormone of heme oxygenase activity in the liver of thyroidectomized rats

scientific article published on 01 October 1991

Sn-Mesoporphyrin interdiction of severe hyperbilirubinemia in Jehovah's Witness newborns as an alternative to exchange transfusion

scientific article published in December 2001

Sn-mesoporphyrin Suppression of Hyperbilirubinemia in EHBR/Eis Rats, an Animal Model of Dubin-Johnson Syndrome ⬇️

scientific article published on March 1, 1998

Sn-protoporphyrin blocks the increase in serum bilirubin levels that develops postnatally in homozygous Gunn rats

scientific article published on March 1988

Sn-protoporphyrin inhibition of fetal and neonatal brain heme oxygenase. Transplacental passage of the metalloporphyrin and prenatal suppression of hyperbilirubinemia in the newborn animal

scientific article

Sn-protoporphyrin lowers serum bilirubin levels, decreases biliary bilirubin output, enhances biliary heme excretion and potently inhibits hepatic heme oxygenase activity in normal human subjects

scientific article published in May 1988

Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver

scientific article

Sn-protoporphyrin suppresses chemically induced experimental hepatic porphyria. Potential clinical implications

scientific article

Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility

scientific article published on 01 April 1988

Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production

scientific article

Studies with the haeme oxygenase inhibitor Sn-protoporphyrin in patients with primary biliary cirrhosis and idiopathic haemochromatosis

scientific article

Suppression of bilirubin production in the Crigler-Najjar type I syndrome: studies with the heme oxygenase inhibitor tin-mesoporphyrin ⬇️

scientific article published on February 1, 1992

Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen

scientific article

Synthetic metalloporphyrins: a class of compounds of pharmacological interest

scientific article published on 01 December 1985

Targeted delivery of a heme oxygenase inhibitor with a lyophilized liposomal tin mesoporphyrin formulation

scientific article published on 01 May 1993

Targeting of heme oxygenase inhibitors to the spleen markedly increases their ability to diminish bilirubin production

scientific article published on 01 December 1989

The Biological Significance and Physiological Role of Heme Oxygenase

scientific article published in 1996

The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology

scientific article

The in vitro and in vivo inhibition of intestinal heme oxygenase by tin-protoporphyrin

scientific article published on 01 January 1989

The influence of organometals on heme metabolism. In vivo and in vitro studies with organotins

scientific article published on 01 January 1982

The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin

scientific article published on February 1985

The potent heme oxygenase inducing action of arsenic and parasiticidal arsenicals

scientific article published on 01 January 1981

Thyroid Hormone Regulation of Heme Synthesis in Rat Liver* ⬇️

scientific article published on May 1, 1988

Thyroid hormone regulation of heme oxidation in the liver

scientific article

Tin(Sn+4)-diiododeuteroporphyrin; an in vitro and in vivo inhibitor of heme oxygenase with substantially reduced photoactive properties

scientific article

Tin-mesoporphyrin inhibits heme oxygenase activity and heme-iron absorption in the intestine.

scientific article published in November 1993

Tin-protoporphyrin and long wave length ultraviolet light in treatment of psoriasis

scientific article published on June 1989

Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia

scientific article published on 01 May 1983

Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase

scientific article published on 01 February 1984

Tissue distribution of synthetic heme analogues: studies with tin, chromium, and zinc mesoporphyrins

scientific article published in March 1996

Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome

scientific article

Treatment of hyperbilirubinemia pharmacologic approach SnMP(tin-mesoporphyrin).

scientific article published in December 2001

Tryptophan pyrrolase in heme metabolism. Comparative actions of inorganic tin and cobalt and their protoporphyrin chelates on tryptophan pyrrolase in liver

scientific article published on 01 February 1986

Upregulation of heme oxygenase-1 combined with increased adiponectin lowers blood pressure in diabetic spontaneously hypertensive rats through a reduction in endothelial cell dysfunction, apoptosis and oxidative stress

scientific article published on December 2008

Zinc porphyrins: potent inhibitors of hematopoieses in animal and human bone marrow

scientific article

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