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Authors whose works are in public domain in at least one jurisdiction

List of works by Shigeru Sassa

5-Aminolevulinate synthase expression and hemoglobin synthesis in a human myelogenous leukemia cell line

scientific article published on March 1997

A Microassay for Uroporphyrinogen I Synthase, One of Three Abnormal Enzyme Activities in Acute Intermittent Porphyria, and its Application to the Study of the Genetics of this Disease ⬇️

scientific article published on March 1, 1974

A comparative study of heme degradation by NADPH-cytochrome c reductase alone and by the complete heme oxygenase system. Distinctive aspects of heme degradation by NADPH-cytochrome c reductase

scientific article published on 01 July 1982

A comparison of the utility of Dowex resin and polybenzimidazole Aurorez resin in the determination of urinary porphobilinogen concentrations

scientific article published on 01 April 1987

A heat-inducible nuclear factor that binds to the heat-shock element of the human haem oxygenase gene

scientific article

A novel mutation of the erythroid-specific delta-aminolaevulinate synthase gene in a patient with X-linked sideroblastic anaemia

scientific article published on 01 July 1999

A novel mutation of the erythroid-specific gamma-Aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia

scientific article

A protective role of interleukin 11 on hepatic injury in acute endotoxemia

scientific article published in February 2004

Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts

scientific article published on 3 October 2002

Abnormal serum porphyrin levels in patients with the acquired immunodeficiency syndrome with or without hepatitis C virus infection

scientific article

Absence of C282Y and H63D mutations of the hemochromatosis gene in Japanese patients with sideroblastic anemia

scientific article published on 01 August 1999

Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells

scientific article published on February 1990

Acute intermittent porphyria

scientific article published on 01 December 1981

Adrenalectomy enhances the induction of heme oxygenase and the degradation of cytochrome P-450 in liver.

scientific article published on December 1980

An acquired acute hepatic porphyria: a novel type of delta-aminolevulinate dehydratase inhibition

scientific article published on November 16, 1992

Arg452 substitution of the erythroid-specific 5-aminolaevulinate synthase, a hot spot mutation in X-linked sideroblastic anaemia, does not itself affect enzyme activity

scientific article

Assays for Porphyrins, δ-Aminolevulinic-Acid Dehydratase, and Porphyrinogen Synthetase in Microliter Samples of Whole Blood: Applications to Metabolic Defects Involving the Heme Pathway ⬇️

scientific article published on September 1, 1972

CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1.

scientific article published on January 2003

Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria

scientific article

Chloro-substituent sites and probability of co-planarity in polychlorinated biphenyls in determining uroporphyrin formation in cultured liver cells

scientific article published on December 1986

Cloning and expression of the defective genes from a patient with delta-aminolevulinate dehydratase porphyria ⬇️

scientific article published on May 1, 1992

Cloning and expression of the defective genes in delta-aminolevulinate dehydratase porphyria: compound heterozygosity in this hereditary liver disease

scientific article published on 01 January 1992

Cytochrome P-450C-M/F, a new constitutive form of microsomal cytochrome P-450 in male and female rat liver with estrogen 2- and 16 alpha-hydroxylase activity

scientific article published on 01 January 1988

Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b

scientific article

Deficient induction of uroporphyrinogen-I synthase activity in mitogen-stimulated lymphocytes from patients with acute intermittent porphyria

scientific article published on January 1, 1977

Delta-Aminolevulinate-Induced Host-Parasite Porphyric Disparity for Selective Photolysis of Transgenic Leishmania in the Phagolysosomes of Mononuclear Phagocytes: a Potential Novel Platform for Vaccine Delivery ⬇️

scientific article published on February 3, 2012

Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes.

scientific article published on 7 December 2005

Differential induction responses of delta-aminolevulinate synthase mRNAs during erythroid differentiation: use of nonradioactive in situ hybridization

scientific article published on January 1, 1992

Differential responses to inducers of delta-aminolaevulinate synthase and haem oxygenase during pregnancy

scientific article

Dimethyl sulphoxide and haemin induce ferrochelatase mRNA by different mechanisms in murine erythroleukaemia cells

scientific article published on 01 March 1993

Drug metabolism by the human hepatoma cell, Hep G2

scientific article published on 01 February 1987

Drug metabolism in normal children, lead-poisoned children, and normal adults

scientific article published on 01 February 1975

Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient

scientific article published in January 2006

Early-stage HIV infection and hepatitis C virus infection are associated with elevated serum porphyrin levels

scientific article published in December 1998

Effect of UVA and blue light on porphyrin biosynthesis in epidermal cells

scientific article published in May 1993

Effect of interleukin-11 on the levels of mRNAs encoding heme oxygenase and haptoglobin in human HepG2 hepatoma cells

scientific article published on 01 May 1993

Effect of lead and genetic factors on heme biosynthesis in the human red cell

scientific article published on April 15, 1975

Effect of soluble complement receptor type 1 on porphyrin-induced phototoxicity in guinea pigs ⬇️

scientific article published on 01 January 1998

Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition ⬇️

scientific article published on December 25, 1975

Effects of dimethyl sulphoxide on the synthesis of plasma proteins in the human hepatoma HepG2. Induction of an acute-phase-like reaction

scientific article published on August 1988

Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria

scientific article

Endocrine-gene interaction in the pathogenesis of acute intermittent porphyria.

scientific article

Enzymatic defect in a child with hereditary hepatic porphyria due to homozygous delta-aminolevulinic acid dehydratase deficiency: immunochemical studies

scientific article published on 01 December 1987

Erythrocyte uroporphyrinogen decarboxylase activity in porphyria cutanea tarda: a study of 40 consecutive patients

scientific article published on 01 September 1989

Erythroleukemia differentiation. Distinctive responses of the erythroid-specific and the nonspecific delta-aminolevulinate synthase mRNA.

scientific article published on September 1991

Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7.

scientific article published on July 1993

Expression of cytochrome P450 mRNAs in the colon and the rectum in normal human subjects

scientific article published on 01 May 1995

Extremely rare association of HFE mutations with porphyria cutanea tarda in Japanese patients

scientific article published on 01 December 1999

Fluorometric measurement of tin-protoporphyrin in biological samples

scientific article published on 01 August 1984

Genetic rescue of Leishmania deficiency in porphyrin biosynthesis creates mutants suitable for analysis of cellular events in uroporphyria and for photodynamic therapy

scientific article published on 8 February 2002

Genetic, metabolic, and biochemical aspects of the porphyrias.

scientific article published on January 1981

Growth-promoting effects of iron- and cobalt- protoporphyrins on cultured embryonic cells

scientific article published on 01 August 1983

Haem is necessary for a continued increase in ferrochelatase mRNA in murine erythroleukaemia cells during erythroid differentiation

scientific article

Heat shock induction of heme oxygenase mRNA in human Hep 3B hepatoma cells

scientific article published on 01 November 1989

Heme binding to murine erythroleukemia cells. Evidence for a heme receptor

scientific article published on 01 October 1985

Heme biosynthesis and drug metabolism in mice with hereditary hemolytic anemia. Heme oxygenase induction as an adaptive response for maintaining cytochrome P-450 in chronic hemolysis ⬇️

scientific article published on February 10, 1979

Heme biosynthesis and iron metabolism

scientific article published on March 1, 2003

Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload

scientific article

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

scientific article published on June 2001

Heme oxygenase is a positive acute-phase reactant in human Hep3B hepatoma cells.

scientific article published on March 1992

Hemin control of heme biosynthesis in mouse Friend virus-transformed erythroleukemia cells in culture ⬇️

scientific article published on August 10, 1978

Hepatoerythropoietic porphyria: clinical, biochemical, and enzymatic studies in a three-generation family lineage

scientific article published on 01 March 1987

Hereditary hepatic porphyria due to homozygous delta-aminolevulinic acid dehydratase deficiency: studies in lymphocytes and erythrocytes

scientific article published on 01 April 1991

Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone

scientific article

Hereditary tyrosinemia. Formation of succinylacetone-amino acid adducts

scientific article published on September 1985

Highly heterogeneous nature of delta-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria

scientific article

Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity

scientific article published on 01 October 2006

Hormonal regulation of heme oxygenase induction in avian hepatocyte culture

scientific article

How Genetic Defects Are Identified ⬇️

scientific article published on March 1, 1998

Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway

scientific article

Immunochemical detection of cytochrome P450C-M/F and NADPH-cytochrome P450 reductase in rat liver and kidney

scientific article published on 01 February 1988

Immunochemical study of uroporphyrinogen decarboxylase in a patient with mild hepatoerythropoietic porphyria

scientific article

Increased erythrocyte uroporphyrinogen-l-synthetase, delta-aminolevulinic acid dehydratase and protoporphyrin in hemolytic anemias

scientific article published on 01 September 1977

Induction of -aminolevulinic acid synthetase in chick embryo liver cells in cluture

scientific article

Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process ⬇️

scientific article published on April 10, 1977

Induction of haem synthesis in Hep G2 human hepatoma cells by dimethyl sulphoxide. A transcriptionally activated event ⬇️

scientific article published on July 1986

Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia

scientific article

Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells

scientific article published on April 30, 1992

Lack of effect of pregnancy or hematin therapy on erythrocyte porphobilinogen deaminase activity in acute intermittent porphyria

scientific article published on 01 July 1989

Late-onset X-linked sideroblastic anemia following hemodialysis

scientific article published on 16 January 2003

Late-onset porphyrias: what are they?

scientific article

Lead hazard among ironworkers. Dismantling lead-painted elevated subway line in New York City

scientific article published on July 1, 1978

Lead intoxication among demolition workers: the effect of lead on the hepatic cytochrome P-450 system in humans

scientific article published on October 1, 1977

Lead intoxication: effects on cytochrome P-450-mediated hepatic oxidations

scientific article published on February 1, 1976

Lead poisoning from art restoration and pottery work: unusual exposure source and household risk

scientific article published on January 1, 1992

Lead poisoning in an art conservator

scientific article published on 01 April 1982

Leishmania spp.: delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway

scientific article published on 3 December 2007

Long-term administration of massive doses of Sn-protoporphyrin in anemic mutant mice (sphha/sphha)

scientific article

Message amplification phenotyping of an inherited delta-aminolevulinate dehydratase deficiency in a family with acute hepatic porphyria

scientific article published on October 1990

Metabolism of estradiol in liver cell culture. Differential responses of C-2 and C-16 oxidations to drugs and other chemicals that induce selective species of cytochrome P-450

scientific article

Metal ion-mediated regulation of heme oxygenase induction in cultured avian liver cells

scientific article published on 01 May 1982

Molecular analysis of delta-aminolevulinate dehydratase deficiency in a patient with an unusual late-onset porphyria

scientific article published on 01 November 2000

Molecular aspects of the inherited porphyrias

scientific article (publication date: February 2000)

Molecular basis of variegate porphyria: a de novo insertion mutation in the protoporphyrinogen oxidase gene

scientific article

Molecular defects of the coproporphyrinogen oxidase gene in hereditary coproporphyria

scientific article published on February 1997

Multiple mechanisms for hereditary sideroblastic anemia

scientific article

Novel molecular defects of the delta-aminolevulinate dehydratase gene in a patient with inherited acute hepatic porphyria

scientific article

Partial purification of cytochrome P450 from rat brain and demonstration of estradiol hydroxylation

scientific article published in September 1987

Phenotypic variation in human HepG2 hepatoma cells: alterations in cell growth, plasma protein synthesis and heme pathway enzymes

scientific article published on 01 January 1990

Plumbism from airborne lead in a firing range. An unusual exposure to a toxic heavy metal

scientific article published in August 1977

Porphyria cutanea tarda associated with the acquired immune deficiency syndrome

scientific article published on 01 May 1987

Porphyrin synthesis by murine epidermal cells

scientific article published on 01 January 1993

Porphyrin-heme biosynthesis in organotypic cultures of mouse dorsal root ganglia. Effects of heme and lead on porphyrin synthesis and peripheral myelin

scientific article published on August 1984

Porphyrogenic effects and induction of heme oxygenase in vivo by delta-aminolevulinic acid

scientific article published on 01 September 1981

Prenatal diagnosis of acute intermittent porphyria ⬇️

scientific article published on 01 December 1976

Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes

scientific article published on 01 May 1971

Prevention of cyclical attacks of acute intermittent porphyria with a long-acting agonist of luteinizing hormone-releasing hormone

scientific article published on 01 September 1984

Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources

scientific article published on April 1987

Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis

scientific article published in March 2003

Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation

scientific article published on 01 July 1982

Purification and properties of human erythrocyte uroporphyrinogen decarboxylase: immunological demonstration of the enzyme defect in porphyria cutanea tarda

scientific article published on 01 January 1983

Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III

scientific journal article

R411C mutation of the ALAS2 gene encodes a pyridoxine-responsive enzyme with low activity

scientific article published on 01 December 1998

Regulation of NF-E2 activity in erythroleukemia cell differentiation

scientific article published in February 1998

Regulation of beta-globin mRNA accumulation by heme in dimethyl sulfoxide (DMSO)-sensitive and DMSO-resistant murine erythroleukemia cells

scientific article published on 01 March 1994

Regulation of heme synthesis in HepG2 human hepatoma cells by dimethyl sulfoxide

scientific article published in June 1988

Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells

scientific article

Sequential induction of enzymes in the heme biosynthetic pathway during erythroid differentiation

scientific article published on 01 December 1975

Some Biochemical and Clinical Aspects of Lead Intoxication

scientific article published on January 1, 1978

Steroid induction of delta-aminolevulinic acid synthase and porphyrins in liver. Structure-activity studies and the permissive effects of hormones on the induction process ⬇️

scientific article (publication date: 25 October 1979)

Stimulation of hepatic porphyrin synthesis in tissue culture by sera of patients with acute porphyria

scientific article published on 01 January 1969

Stimulators and Inhibitors of Hepatic Porphyrin Formation in Human Sera ⬇️

scientific article published on April 1, 1974

Studies in lead poisoning. I. Microanalysis of erythrocyte protoporphyrin levels by spectrophotometry in the detection of chronic lead intoxication in the subclinical range

scientific article published on 01 August 1973

Studies in lead poisoning. II. Correlation between the ratio of activated to inactivated delta-aminolevulinic acid dehydratase of whole blood and the blood lead level

scientific article published on 01 August 1973

Studies in porphyria IX: Detection of the gene defect of erythropoietic protoporphyria in mitogen-stimulated human lymphocytes

scientific article published on 01 January 1979

Studies in porphyria. IV. Expression of the gene defect of acute intermittent porphyria in cultured human skin fibroblasts and amniotic cells: prenatal diagnosis of the porphyric trait ⬇️

scientific article (publication date: September 1975)

Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.

scientific article published in January 1976

Studies in porphyria. VII. Induction of uroporphyrinogen-I synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes ⬇️

scientific article published on February 1, 1978

Studies in porphyria. VIII. Relationship of the 5 alpha-reductive metabolism of steroid hormones to clinical expression of the genetic defect in acute intermittent porphyria

scientific article published on April 1979

Studies in porphyria: functional evidence for a partial deficiency of ferrochelatase activity in mitogen-stimulated lymphocytes from patients with erythropoietic protoporphyria

scientific article published on April 1982

Studies of the influence of chloro-substituent sites and conformational energy in polychlorinated biphenyls on uroporphyrin formation in chick-embryo liver cell cultures

scientific article

Studies on porphyrin-heme biosynthesis in organotypic cultures of chick dorsal root ganglia. II. The effect of lead

scientific article published on August 1979

Studies on porphyrin-heme biosynthesis in organotypic cultures of chick dorsal root ganglion. I. Observations on neuronal and non-neuronal elements ⬇️

scientific article published on 01 September 1978

Studies on the inheritance of human erythrocyte delta-aminolevulinate dehydratase and uroporphyrinogen synthetase

scientific article published on 01 January 1973

Succinylacetone and delta-aminolevulinic acid dehydratase in hereditary tyrosinemia: immunochemical study of the enzyme

scientific article published on 01 July 1990

Succinylacetone inhibits delta-aminolevulinate dehydratase and potentiates the drug and steroid induction of delta-aminolevulinate synthase in liver

scientific article published on 01 January 1982

Suppression of cytochrome P450IA1 by interleukin-6 in human HepG2 hepatoma cells

scientific article published on 01 March 1994

The effect of porphyrin and radiation on ferrochelatase and 5‐aminolevulinic acid synthase in epidermal cells ⬇️

scientific article published on February 1, 1995

The effects of acute-phase inducers and dimethyl sulphoxide on delta-aminolaevulinate synthase activity in human HepG2 hepatoma cells

scientific article published on April 1989

The influence of steroid hormone metabolites on the in vitro development of erythroid colonies derived from human bone marrow ⬇️

scientific article published on June 1, 1979

The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin

scientific article published on February 1985

The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury

scientific article published in February 2005

The molecular defect of ferrochelatase in a patient with erythropoietic protoporphyria

scientific article

The occurrence of molecular interactions among NADPH-cytochrome c reductase, heme oxygenase, and biliverdin reductase in heme degradation

scientific article published on 01 July 1982

The occurrence of substances in human plasma capable of inducing the enzyme delta-aminolevulinate synthetase in liver cells

scientific article

The oxidative degradation of heme c by the microsomal heme oxygenase system

scientific article published on 01 July 1982

The potent heme oxygenase inducing action of arsenic and parasiticidal arsenicals

scientific article published on 01 January 1981

The role of inorganic metals and metalloporphyrins in the induction of haem oxygenase and heat-shock protein 70 in human hepatoma cells

scientific article published on March 1993

Tin-protoporphyrin inhibits heme oxygenase and prevents the decline in hepatic heme and cytochrome P-450 contents produced in nude mice by tumor transplantation

scientific article published on 01 January 1988

Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia

scientific article published on 01 May 1983

Transgenic Leishmania model for delta-aminolevulinate-inducible monospecific uroporphyria: cytolytic phototoxicity initiated by singlet oxygen-mediated inactivation of proteins and its ablation by endosomal mobilization of cytosolic uroporphyrin

scientific article published on 16 May 2008

delta-Aminolaevulinate synthase in human HepG2 hepatoma cells. Repression by haemin and induction by chemicals

scientific article published on September 1989

delta-Aminolevulinate dehydratase (ALAD) porphyria: the first case in North America with two novel ALAD mutations

scientific article published on 15 December 2005

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