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List of works by Melanie Welham

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.

scientific article published on 24 May 2011

A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells.

scientific article published on 18 November 2011

A single point mutation has pleiotropic effects on pp60v-src function

scientific article published on June 1988

Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo

scientific article

Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs

scientific article

Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells: identification of novel regulators of pluripotency

scientific article published on April 2009

Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling ⬇️

scientific article published on April 1, 2011

Correction: Formation of a Polarised Primitive Endoderm Layer in Embryoid Bodies Requires Fgfr/Erk Signalling

scientific article published on 30 October 2015

Correction: IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59

correction of a scholarly article

Cytokine-induced protein kinase B activation and Bad phosphorylation do not correlate with cell survival of hemopoietic cells.

scientific article published on June 1999

Differential coupling of self-renewal signaling pathways in murine induced pluripotent stem cells

scientific article

Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing

scientific article

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

scientific article published on 01 April 1999

Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells

scientific article published on 9 June 2009

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

scientific article

Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling

scientific article

Genetic basis of hypo-responsiveness of A/J mice to interleukin-3

scientific article published on 01 April 1996

Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal

scientific article

High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells

scientific article

IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59

scientific article published on 01 December 1993

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells

scientific article published on January 1997

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase ⬇️

scientific article published on September 23, 1994

Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin

scientific article published on May 1995

Interleukin-3 Induces Association of the Protein-tyrosine Phosphatase SHP2 and Phosphatidylinositol 3-Kinase with a 100-kDa Tyrosine-phosphorylated Protein in Hemopoietic Cells ⬇️

scientific article published in Journal of Biological Chemistry

Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth

scientific article published on 01 February 1994

Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides

scientific article published in January 2009

Isolation of C15: a novel antibody generated by phage display against mesenchymal stem cell-enriched fractions of adult human marrow

scientific article published on 19 December 2005

Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the g

scientific article published in January 2006

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.

scientific article

Mitogenesis induced by pp60v-src is not accompanied by increased expression of immediate early response genes

scientific article

Modulation of c-kit mRNA and protein by hemopoietic growth factors ⬇️

scientific article published on May 1, 1991

Molecular interactions of SHP1 and SHP2 in IL-3-signalling

scientific article (publication date: March 2002)

Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members ⬇️

scientific article published on September 1, 1992

Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation

scientific article published on 01 August 1994

Novel octavalent cross-linker displays efficient trapping of protein-protein interactions.

scientific article published on 20 March 2007

PI3K comes of age

scientific article published on 01 January 2003

Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis

scientific article published on 24 April 2007

Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.

scientific article published on 2 May 2001

Phosphoinositide 3-kinases and regulation of embryonic stem cell fate

scientific article published on April 2007

Phosphoinositide 3-kinases can act independently of p27Kip1 to regulate optimal IL-3-dependent cell cycle progression and proliferation

scientific article published in April 2005

Regulation of Nanog Expression by Phosphoinositide 3-Kinase-dependent Signaling in Murine Embryonic Stem Cells

scientific article published in Journal of Biological Chemistry

Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling.

scientific article published on 24 August 2004

Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).

scientific article published on November 2003

Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling

scientific article published on December 2002

SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates

scientific journal article

Shc associates with the IL-3 receptor β subunit, SHIP and Gab2 following IL-3 stimulation

scientific article (publication date: March 2000)

Spray-dried insulin particles retain biological activity in rapid in-vitro assay ⬇️

scientific article published on October 1, 2001

Steel factor-induced tyrosine phosphorylation in murine mast cells. Common elements with IL-3-induced signal transduction pathways ⬇️

scientific article published on October 15, 1992

Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells

scientific article published on 19 March 2008

The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation

scientific article

The PI3K inhibitor arsenal: choose your weapon!

scientific article published in October 2007

The coupling of TEL/PDGFbetaR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases.

scientific article published on 24 April 2003

The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses

scientific article published on 4 November 2005

Three-dimensional culture systems for the expansion of pluripotent embryonic stem cells

scientific article published in November 2010

Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoiesis

scientific article published on 8 February 2005

Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells

scientific article

p110δ, a novel phosphoinositide 3-kinase in leukocytes

scientific article

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein

scientific article

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