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List of works by Kohzoh Imai

2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation

scientific article published on November 2006

A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers.

scientific article published on December 2010

A case of Mikulicz's disease complicated by autoimmune pancreatitis, in which impaired glucose tolerance was improved by glucocorticoid treatment

scientific article published in October 2005

A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer

scientific article published on 24 May 2016

A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease

scientific article published on 20 December 2006

A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointestinal stromal tumors

scientific article published on 26 October 2010

A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

scientific article published on 23 June 2009

A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma

scientific article published on 10 January 2012

A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells

scientific article

A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.

scientific article

Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer

scientific article published on May 2004

Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer

scientific article published in January 2002

Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.

scientific article published on February 2005

Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer.

scientific article

Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.

scientific article

Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.

scientific article

Adult-onset Still’s disease in pregnancy ⬇️

scientific article published on July 14, 2011

Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer

scientific article

Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer

scientific article published on 19 August 2014

Analysis of serum IgG subclasses in Churg-Strauss syndrome--the meaning of elevated serum levels of IgG4.

scientific article published on 15 July 2010

Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy

scientific article

Antisense therapy of MAdCAM-1 for trinitrobenzenesulfonic acid-induced murine colitis

scientific article published on August 2006

Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization.

scientific article

Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway

scientific article published on 13 March 2015

Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer

scientific article

Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis.

scientific article published on March 2015

Association of MicroRNA-31-5p with Clinical Efficacy of Anti-EGFR Therapy in Patients with Metastatic Colorectal Cancer

scientific article

Association of SLC22A4/5 polymorphisms with steroid responsiveness of inflammatory bowel disease in Japan

scientific article published on 15 February 2008

Association of glypican-3 expression with growth signaling molecules in hepatocellular carcinoma.

scientific article published on July 2010

Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation

scientific article

Bortezomib plus dexamethasone treatment followed by reduced-intensity allogeneic stem cell transplantation for multiple myeloma refractory to high-dose chemotherapy with autologous transplantation

scientific article published on 01 March 2011

Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.

scientific article published on March 2013

Cancer epigenomics: implications of DNA methylation in personalized cancer therapy

scientific article published on 19 February 2009

Characteristics of Japanese inflammatory bowel disease susceptibility loci

scientific article published on 13 August 2013

Clinicopathologic similarities between Mikulicz disease and Küttner tumor

scientific article published on 31 October 2009

Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients.

scientific article

Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer ⬇️

scientific article published on May 20, 2011

Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.

scientific article published on May 2006

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer

scientific article

Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors

scientific article published on 12 November 2013

Contextual niche signals towards colorectal tumor progression by mesenchymal stem cell in the mouse xenograft model.

scientific article

Correction: Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma

scientific article

Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma

scientific article published on 4 March 2008

Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer

scientific article published on 29 February 2008

DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer

scientific article

DNA methylation and cancer pathways in gastrointestinal tumors

scientific article published on December 2008

DNA methylation changes in gastrointestinal disease.

scientific article

DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae

scientific article

Detection of fecal interferon-induced transmembrane protein messenger RNA for colorectal cancer screening

scientific article

Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability.

scientific article published on 19 March 2007

Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer ⬇️

scientific article published on 05 January 2012

Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity.

scientific article published in July 2009

Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.

scientific article published in May 2011

Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer

scientific article (publication date: 15 December 2003)

Epigenetic inactivation of CHFR in human tumors

scientific article

Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.

scientific article

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

scientific article

Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis

scientific article published on 11 February 2011

Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells.

scientific article

Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies

scientific article published on 27 October 2009

Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.

scientific article published on 17 August 2015

Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

scientific article

Epigenetics in gastroenterological cancer and prospects for translational research.

scientific article published on September 2007

Establishment of a refined culture method for rat colon organoids

scientific article published on 27 May 2017

Evaluation and Clinical Validity of a New Questionnaire for Mikulicz's Disease ⬇️

scientific article published on May 8, 2012

Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: results from the SMART database

scientific article published on 27 August 2014

Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas.

scientific article

Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.

scientific article published on 3 August 2007

Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma

scientific article

Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.

scientific article

Gene amplification and overexpression of PRDM14 in breast cancers.

scientific article

Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen

scientific article

Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers.

scientific article published on 20 December 2006

Genetic variants in surfactant, pulmonary-associated protein D (SFTPD) and Japanese susceptibility to ulcerative colitis

scientific article published in June 2009

Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus

scientific article published in April 2006

Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma.

scientific article

Genome-wide profiling of chromatin signatures reveals epigenetic regulation of MicroRNA genes in colorectal cancer.

scientific article

Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma.

scientific article

Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma.

scientific article

Haploinsufficiency in multiploid colorectal cancer

scientific article published on 01 July 2005

Heat stress activates ER stress signals which suppress the heat shock response, an effect occurring preferentially in the cortex in rats

scientific journal article

Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models

scientific article

Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation

scientific article published on July 2006

IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.

scientific article

IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype

scientific article

Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer

scientific article published on January 2007

Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.

scientific article

Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members

scientific article

Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment.

scientific article

Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

scientific article (publication date: 18 April 2002)

Increased expression of T-fimbrin gene after DNA damage in CHO cells and inactivation of T-fimbrin by CpG methylation in human colorectal cancer cells

scientific article

Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma

scientific article published on 20 December 2006

Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas

scientific article

Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin.

scientific article published on 3 June 2009

Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45.

scientific article published on 24 January 2011

Insulin‐like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers ⬇️

scientific article published on December 13, 2011

Integrated analysis of genetic and epigenetic alterations in cancer

scientific article published on December 2009

Interferon gamma assay for detecting latent tuberculosis infection in rheumatoid arthritis patients during infliximab administration

scientific article published on 15 May 2007

Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo

scientific article (publication date: 9 May 2011)

Intractable colitis associated with chronic granulomatous disease.

scientific article

Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling

scientific article

LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.

scientific article

Leukoencephalopathy during administration of etanercept for refractory rheumatoid arthritis

scientific article published on 20 February 2007

Loss of interleukin-21 leads to atrophic germinal centers in multicentric Castleman's disease

scientific article published on 17 September 2015

Low-Frequency IL23R Coding Variant Associated with Crohn's Disease Susceptibility in Japanese Subjects Identified by Personal Genomics Analysis

scientific article published on 16 September 2015

Mesenchymal stem cells cancel azoxymethane-induced tumor initiation.

scientific article published in April 2014

Methylation of a Panel of MicroRNA Genes Is a Novel Biomarker for Detection of Bladder Cancer ⬇️

scientific article published on November 23, 2012

Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect

scientific article published on 5 October 2010

MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.

scientific article published on 30 April 2014

Mikulicz's disease and systemic IgG4-related plasmacytic syndrome (SIPS).

scientific article published on February 2008

Model of translational cancer research in multiple myeloma ⬇️

scientific article published on August 17, 2012

Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype.

scientific article published on 17 September 2012

Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours.

scientific article

Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat.

scientific article

Necessity of early intervention for IgG4-related disease--delayed treatment induces fibrosis progression ⬇️

scientific article published on December 19, 2012

Nonspecific cross-reacting antigen (NCA)--carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)

scientific article published on 01 July 2010

Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer

scientific article published on March 2007

Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth

scientific article

Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.

scientific article published on August 2009

Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis

scientific article published on 30 June 2006

Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.

scientific article published on October 2008

Oxidative stress impairs the heat stress response and delays unfolded protein recovery

scientific article

PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.

scientific article published on August 2007

Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity

scientific article published on 01 December 2006

Phenotypic alteration of interstitial cells of Cajal in idiopathic sigmoid megacolon

scientific article published on 17 August 2008

Plasma analysis of rheumatoid arthritis by SELDI

scientific article

Rapidly growing early gastric cancer with microsatellite instability

scientific article published on 01 January 2003

Relapse patterns in IgG4-related disease: Table 1 ⬇️

scientific article published on May 15, 2012

Risk of malignancies in IgG4-related disease

scientific article published on 06 September 2011

Role of interleukin-32 in the mechanism of chronic inflammation in IgG4-related disease and as a predictive biomarker for drug-free remission

scientific article published on 16 September 2015

Seasonal allergies and serial changes of serum levels of IgG4 in cases treated with maintenance therapy for IgG4-related disease

scientific article published on 13 January 2015

Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors.

scientific article published on 6 July 2005

Sulindac enhances the proteasome inhibitor bortezomib-mediated oxidative stress and anticancer activity

scientific article published in July 2005

Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers

scientific article

The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer

scientific article

The birthday of a new syndrome: IgG4-related diseases constitute a clinical entity

scientific article published on 10 May 2010

The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma.

scientific article published on 13 September 2013

The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.

scientific article published on 17 June 2016

The efficacy of IGF-I receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation status.

scientific article published on 3 June 2011

The immunobiology and clinical characteristics of IgG4 related diseases ⬇️

scientific article published on February 15, 2012

The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway

scientific article published on 08 February 2016

The role of T-fimbrin in the response to DNA damage: silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents

scientific article

The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease

Tophaceous gout in the cervical spine

scientific article published on February 2012

Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.

scientific article published on May 2005

Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

scientific article published on 18 January 2012

Usefulness of measuring serum IgG4 level as diagnostic and treatment marker in IgG4-related disease ⬇️

scientific article published on 01 January 2012

Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases ⬇️

scientific article published on September 28, 2011

[A case in which the subject was affected by Listeia meningoencephalitis during administration of infliximab for steroid-dependent adult onset Still's disease].

scientific article

[A case of AFP and PIVKA-II producing gastric carcinoma]

scientific article published on 01 April 2006

[A case of alveolar hydatid disease of the liver for which progression was seen on CT images].

scientific article

[A case of lupus erythematosus profundus followed by systemic lupus erythematosus presenting with severe intestinal involvement].

scientific article published on February 2007

[Epigenetic alterations in cancer].

scientific article

[Evidence of cartilaginous benefit of treatment with infliximab in rheumatoid arthritis using measurement of serum COMP]

scientific article published on 01 February 2007

[Hemorrhage from varices of an interposed jejunum after choledochojejunostomy successfully treated by transileocolic vein obliteration]

scientific article published on 01 November 2008

[Long-term survival after autologous peripheral blood stem cell transplantation in a patient with primary AL amyloidosis complicating congestive heart failure]

scientific article published on 01 November 2007

[SFRP, a family of new colorectal tumor suppressor candidate genes]

scientific article published on 01 April 2005

[The significance of disease-independence in Mikulicz's disease--revival interests in Mikulicz's disease]

scientific article published on 01 February 2006

p53 family members regulate the expression of the apolipoprotein D gene.

scientific article

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