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List of works by Michael P. Waalkes

14. Metal Ions in Human Cancer Development

article

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

scientific article published in February 2006

A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response

scientific article

A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis

scientific article

A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits

scientific article

Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic

scientific article published on 31 March 2007

Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis

scientific article published on 12 June 2009

Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic

scientific article published on 15 January 2014

Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake

scientific article published on 10 November 2005

Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation

scientific article

Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression.

scientific article

Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity

scientific article published on 18 July 2003

Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice

scientific article published in March 2002

Altered apoptotic gene expression and acquired apoptotic resistance in cadmium-transformed human prostate epithelial cells

scientific article published on August 2002

Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice

scientific article

Arsenic and Environmental Health: State of the Science and Future Research Opportunities

scientific article

Arsenic exposure in utero and nonepidermal proliferative response in adulthood in Tg.AC mice

scientific article published in May 2010

Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype

scientific article

Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required

scientific article published on 25 May 2004

Arsenic, Stem Cells, and the Developmental Basis of Adult Cancer ⬇️

scientific article published on November 11, 2010

Arsenic-induced cancer cell phenotype in human breast epithelia is estrogen receptor-independent but involves aromatase activation

scientific article published on 26 September 2013

Arsenic-specific stem cell selection during malignant transformation

scientific article

Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype

scientific article

Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite

scientific article

Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice

scientific article

Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China

scientific article published in July 2007

Cadmium and cancer of prostate and testis

scientific article

Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways

scientific article

Cadmium at a non-toxic dose alters gene expression in mouse testes

scientific article published in December 2004

Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studies

scientific article published on 08 May 2008

Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype

scientific article

Cadmium-stimulated invasion of rat liver cells during malignant transformation: Evidence of the involvement of oxidative stress/TET1-sensitive machinery

scientific article published on 11 November 2020

Cancer in experimental animals exposed to arsenic and arsenic compounds ⬇️

scientific article published on November 1, 2010

Carcinogenic Effects of “Whole-Life” Exposure to Inorganic Arsenic in CD1 Mice ⬇️

scientific article published on October 11, 2010

Cellular glutathione prevents cytolethality of monomethylarsonic acid

scientific article published on March 2004

Changes in hepatic gene expression in response to hepatoprotective levels of zinc

scientific article

Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice

scientific article published on 31 March 2004

Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver

scientific article

Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China

scientific article

Chronic arsenic-exposed human prostate epithelial cells exhibit stable arsenic tolerance: mechanistic implications of altered cellular glutathione and glutathione S-transferase

scientific article

Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells.

scientific article

Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells.

scientific article published on 26 June 2013

Chronic exposure of renal stem cells to inorganic arsenic induces a cancer phenotype

scientific article

Chronic inorganic arsenic exposure in vitro induces a cancer cell phenotype in human peripheral lung epithelial cells

scientific article

Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis

scientific article published on 8 April 2004

Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice.

scientific article published on 2 December 2004

Current status and prevention strategy for coal-arsenic poisoning in Guizhou, China.

scientific article

Differential effects between maotai and ethanol on hepatic gene expression in mice: Possible role of metallothionein and heme oxygenase-1 induction by maotai.

scientific article

Early life inorganic lead exposure induces testicular teratoma and renal and urinary bladder preneoplasia in adult metallothionein-knockout mice but not in wild type mice

scientific article published on 23 June 2010

Early-life arsenic exposure: methylation capacity and beyond

scientific article

Effect of mercury vapor exposure on metallothionein and glutathione s-transferase gene expression in the kidney of nonpregnant, pregnant, and neonatal rats

scientific article published in September 2002

Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation ⬇️

scientific article published on June 10, 2003

Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen.

scientific article

Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells

scientific article published on February 2007

Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero

scientific article published in March 2004

Fetal arsenic exposure appears to facilitate endocrine disruption by postnatal diethylstilbestrol in neonatal mouse adrenal

scientific article published on 7 August 2009

Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure

scientific article

Focal adhesion kinase as a potential target in arsenic toxicity

scientific article

Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells

scientific journal article

Gene array analysis of the hepatic response to endotoxin in glutathione peroxidase-deficient mice

scientific article published in October 2003

Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells

scientific article

Genomic Analysis of the Rat Lung following Elemental Mercury Vapor Exposure ⬇️

scientific article published on May 2, 2003

High dietary fat exacerbates arsenic-induced liver fibrosis in mice

scientific article

Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses.

scientific article

Impact of life stage and duration of exposure on arsenic-induced proliferative lesions and neoplasia in C3H mice

scientific article

Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers ⬇️

scientific article published on September 26, 2003

Inorganic arsenic and human prostate cancer

scientific article

Inorganic arsenite-induced malignant transformation of human prostate epithelial cells

scientific article published on December 2002

Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells

scientific article published on 16 May 2008

KRAS-retroviral fusion transcripts and gene amplification in arsenic-transformed, human prostate CAsE-PE cancer cells

scientific article published on 25 April 2020

Liver is a target of arsenic carcinogenesis

scientific article

Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses

scientific article

Macrophage solubilization and cytotoxicity of indium-containing particles as in vitro correlates to pulmonary toxicity in vivo

scientific article

Macrophage solubilization and cytotoxicity of indium-containing particles in vitro

scientific article

Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells

scientific article published on 20 November 2006

Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation

scientific article

Metal ions in human cancer development

scientific article published on January 1, 2011

Metallothionein Is a Potential Negative Regulator of Apoptosis ⬇️

scientific article published on April 15, 2003

Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure

scientific article

Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation

scientific article published in November 2004

Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice

scientific article published on 01 July 2005

Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic

scientific article

Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite

scientific article published on 07 May 2008

Minimal influence of metallothionein over-expression on nickel carcinogenesis in mice

scientific article published in November 2004

Mitigation of arsenic-induced acquired cancer phenotype in prostate cancer stem cells by miR-143 restoration

scientific article published on 22 December 2015

Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation

scientific article

Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure

scientific article published on 20 March 2006

Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues

scientific article published in January 2002

NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation: Research Report 3

scientific article published on 18 July 2018

Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO.

scientific article

Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: requirement for Cyp1a1

scientific article

Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation.

scientific article published on June 2004

O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays

scientific article

Overabundance of Putative Cancer Stem Cells in Human Skin Keratinocyte Cells Malignantly Transformed by Arsenic ⬇️

scientific article published on October 19, 2011

Oxidative DNA damage after acute exposure to arsenite and monomethylarsonous acid in biomethylation-deficient human cells

scientific article published on 6 February 2013

Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.

scientific article

Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation

scientific article published on 19 June 2009

Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity

scientific article published on 22 February 2013

Purine nucleoside phosphorylase: a fortuitous cytosolic arsenate reductase?

scientific article

Recruitment of normal stem cells to an oncogenic phenotype by noncontiguous carcinogen-transformed epithelia depends on the transforming carcinogen.

scientific article published on 17 May 2013

Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas

scientific article published on January 2004

Renal, hepatic, pulmonary and adrenal tumors induced by prenatal inorganic arsenic followed by dimethylarsinic acid in adulthood in CD1 mice

scientific article

Requirement of arsenic biomethylation for oxidative DNA damage

scientific article published on December 2009

Response to letter to the editor by Cohen et al. (2014) "Re: Waalkes et al.: Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses, Arch Toxicol, 2014".

scientific article published on 25 September 2014

Role of glutathione in dimethylarsinic acid-induced apoptosis

scientific article published in August 2004

Silencing KRAS Overexpression in Cadmium-Transformed Prostate Epithelial Cells Mitigates Malignant Phenotype

scientific article published on 11 August 2016

Silencing KRAS overexpression in arsenic-transformed prostate epithelial and stem cells partially mitigates malignant phenotype

scientific article

The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats

scientific article

The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies

scientific article published on March 2002

The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice

scientific article published on 9 March 2004

The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice

scientific article published in February 2003

The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice

scientific article published in August 2003

The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis

scientific article

The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level.

scientific article published on March 2005

Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic

scientific article published on 22 December 2003

Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.

scientific article

Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice

scientific article published on January 2004

Transcriptional changes associated with reduced spontaneous liver tumor incidence in mice chronically exposed to high dose arsenic

scientific article published on 12 October 2009

Transplacental arsenic carcinogenesis in mice

scientific article

Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver

scientific article

Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice

scientific article published in January 2003

Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase

scientific article

Tumors and proliferative lesions in adult offspring after maternal exposure to methylarsonous acid during gestation in CD1 mice ⬇️

scientific article published on March 8, 2012

Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment

scientific article published in February 2006

V-PROLI/NO, a nitric oxide donor prodrug, protects liver cells from arsenic-induced toxicity

scientific article published on 15 December 2008

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