List of works - Pavel Majer

ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles

scientific article published on 12 January 2017

Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding.

scientific article

An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study

scientific article (publication date: 24 April 2003)

Biochemical characterization of human glutamate carboxypeptidase III

scientific article

Co-option of the sphingolipid metabolism for the production of nitroalkene defensive chemicals in termite soldiers

scientific article published on 23 January 2017

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

scientific article published on 13 March 2019

Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA).

scientific article published in March 2016

Enantiospecificity of glutamate carboxypeptidase II inhibition

scientific article published in April 2005

Facile synthesis of alpha-substituted acrylate esters

scientific article published on 01 October 2002

Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models

scientific journal article

High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen

scientific article

Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors.

scientific article published in April 2005

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

scientific article

Metabolomic and transcriptomic data on major metabolic/biosynthetic pathways in workers and soldiers of the termite Prorhinotermes simplex (Isoptera: Rhinotermitidae) and chemical synthesis of intermediates of defensive (E)-nitropentadec-1-ene biosy

scientific article published on 2 May 2018

Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate

scientific article (publication date: 30 January 2003)

Potency comparison of peptidomimetic inhibitors against HIV-1 and HIV-2 proteinases: design of equipotent lead compounds

scientific article

Reduced-bond tight-binding inhibitors of HIV-1 protease. Fine tuning of the enzyme subsite specificity

scientific article published on February 1992

Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases

scientific article

Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus

scientific article

Specificity mapping of HIV-1 protease by reduced bond inhibitors.

scientific article published on July 1993

Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs

scientific article

Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II

scientific article

Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain

scientific article published on 01 May 2006

Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer

scientific article

Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling

scientific article published on 01 September 2006

Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.

scientific article published in February 2002

Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor ⬇️

scientific article published on May 8, 2003

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

scientific article

δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors

scientific article published on 27 December 2013

List of works by Pavel Majer

ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles

Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding.

An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study

Biochemical characterization of human glutamate carboxypeptidase III

Co-option of the sphingolipid metabolism for the production of nitroalkene defensive chemicals in termite soldiers

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA).

Enantiospecificity of glutamate carboxypeptidase II inhibition

Facile synthesis of alpha-substituted acrylate esters

Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models

High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen

Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors.

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

Metabolomic and transcriptomic data on major metabolic/biosynthetic pathways in workers and soldiers of the termite Prorhinotermes simplex (Isoptera: Rhinotermitidae) and chemical synthesis of intermediates of defensive (E)-nitropentadec-1-ene biosy

Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate

Potency comparison of peptidomimetic inhibitors against HIV-1 and HIV-2 proteinases: design of equipotent lead compounds

Reduced-bond tight-binding inhibitors of HIV-1 protease. Fine tuning of the enzyme subsite specificity

Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases

Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus

Specificity mapping of HIV-1 protease by reduced bond inhibitors.

Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs

Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II

Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain

Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer

Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling

Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.

Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor ⬇️

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors