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List of works by Dennis E. Hruby

A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis

scientific article

A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis

scientific article

A novel inhibitor of dengue virus replication that targets the capsid protein

scientific article published on 15 October 2012

A trans-Golgi Network Resident Protein, golgin-97, Accumulates in Viral Factories and Incorporates into Virions during Poxvirus Infection.

scientific article

A trans-Golgi network resident protein, golgin-97, accumulates in viral factories and incorporates into virions during poxvirus infection

scientific article

Activity of the Anti-Orthopoxvirus Compound ST-246 against Vaccinia, Cowpox and Camelpox Viruses in Cell Monolayers and Organotypic Raft Cultures

scientific article published on 14 April 2022

Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures

scientific article published in January 2007

An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge

scientific article

An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications

scientific article published on 03 September 2020

Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors

scientific article published on May 2002

Analysis of vaccinia virus temperature-sensitive I7L mutants reveals two potential functional domains

scientific article

Antiviral Potency of ST-246 on the Production of Enveloped Orthopoxviruses and Characterization of ST-246 Resistant Vaccinia, Cowpox and Camelpox Viruses

article

Antiviral options for biodefense

scientific article published on 15 June 2013

BiZyme: a novel fusion protein-mediating selection of vaccinia virus recombinants by fluorescence and antibiotic resistance

scientific article published in May 2002

Biological consequences of antigen and cytokine co-expression by recombinant Streptococcus gordonii vaccine vectors

scientific article

Chlamydial development is blocked in host cells transfected with Chlamydophila caviae incA

scientific article

Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine

scientific article

Clinical features and management of human monkeypox: a retrospective observational study in the UK

scientific article published on 24 May 2022

Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge

scientific article published on 31 October 2019

Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism

scientific article

Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys ⬇️

scientific article published on August 15, 2011

Comparison of transformation protocols in Streptococcus gordonii and evaluation of native promoter strength using a multiple-copy plasmid.

scientific article published in March 2007

Conditional expression of vaccinia virus genes in mammalian cell lines expressing the tetracycline repressor

scientific article published on September 2004

Construction of recombinant vaccinia virus: cloning into the thymidine kinase locus

scientific article published on January 2004

Deletion of the vaccinia virus F13L gene results in a highly attenuated virus that mounts a protective immune response against subsequent vaccinia virus challenge ⬇️

scientific article published on November 25, 2011

Development of PLEX, a plasmid-based expression system for production of heterologous gene products by the gram-positive bacteria Streptococcus gordonii

scientific article published on 01 April 2005

Development of ST-246® for Treatment of Poxvirus Infections ⬇️

scientific article published on November 3, 2010

Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity

scientific article

Development of the Small-Molecule Antiviral ST-246 ® as a Smallpox Therapeutic ⬇️

scientific article published on May 1, 2011

Discovery and development of antiviral drugs for biodefense: experience of a small biotechnology company

scientific article

Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole ⬇️

scientific article published on February 1, 2013

Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles ⬇️

scientific article published on February 1, 2013

Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches

scientific article

Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus ⬇️

scientific article published on June 22, 2011

Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques

scholarly article by Andrew T Russo et al published 22 September 2018 in Journal of Infectious Diseases

Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice

scientific article

Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice

scientific article published on 20 November 2006

Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).

scientific article published on 07 October 2013

Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.

scientific article

Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin

scientific article

Evaluation of Lassa antiviral compound ST-193 in a guinea pig model

scientific article published in March 2011

Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox – An animal model of smallpox ⬇️

scientific article published on February 18, 2012

Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model

scientific article published on 23 April 2008

Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses

scientific article

Identification of a broad-spectrum arenavirus entry inhibitor

scientific article published on 20 August 2008

Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination

scientific article published on 26 December 2007

Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice ⬇️

scientific article published on October 29, 2010

Importance of disulphide bonds for vaccinia virus L1R protein function

scientific article published on 9 December 2005

In vitro efficacy of ST246 against smallpox and monkeypox

scientific article published on 15 December 2008

Increased susceptibility of Cantagalo virus to the antiviral effect of ST-246® ⬇️

scientific article published on December 17, 2012

Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus

scientific article

Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence

scientific article

Mass spectrometry analysis of synthetically myristoylated peptides

scientific article published in January 2004

Molecular Dissection of the Vaccinia Virus I7L Core Protein Proteinase ⬇️

scientific article published on October 1, 2003

Mutational analysis of the potential catalytic residues of the VV G1L metalloproteinase

scientific article published on 27 February 2006

N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors

scientific article

New class of orthopoxvirus antiviral drugs that block viral maturation

scientific article published in November 2004

Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.

scientific article published on 06 April 2009

Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase ⬇️

scientific article published on February 12, 2013

Oral Tecovirimat for the Treatment of Smallpox

article by Douglas W. Grosenbach et al published 5 July 2018 in The New England Journal of Medicine

Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers ⬇️

scientific article published on April 23, 2012

Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans ⬇️

scientific article published on December 17, 2012

Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection

scientific article

Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins.

scientific article

Preliminary Screening and In Vitro Confirmation of Orthopoxvirus Antivirals

scientific article published on 01 January 2019

Preparation of a large hydrophobic protein for mass spectrometry analysis: vaccina virus ATI protein ⬇️

scientific article published on April 15, 2003

Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001.

scientific article

Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.

scientific article

SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity ⬇️

scientific article published on May 17, 2012

ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification

scientific article published on 17 February 2009

ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation

scientific article published on 14 September 2009

ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping

scientific article published on 27 January 2015

Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers

scientific article

Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects

scientific article

Screening for vaccinia virus egress inhibitors: separation of IMV, IEV, and EEV.

scientific article

Sequence-independent acylation of the vaccinia virus A-type inclusion protein

scientific article published on July 2004

Severe eczema vaccinatum in a household contact of a smallpox vaccinee

scientific article published in May 2008

Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor

scientific article

Smallpox antiviral drug development: satisfying the animal efficacy rule

scientific article

Specific Targeting of the F13L Protein by St-246 Affects Orthopoxvirus Production Differently

scientific article published on 14 April 2022

Specific targeting of the F13L protein by ST-246 affects orthopoxvirus production differently

scientific article

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses

scientific article

The broad-spectrum antiviral compound ST-669 restricts chlamydial inclusion development and bacterial growth and localizes to host cell lipid droplets within treated cells

scientific article

The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus

scientific article published on 2 May 2007

The vaccinia virus G1L putative metalloproteinase is essential for viral replication in vivo.

scientific article published on September 2004

The vaccinia virus I7L gene product is the core protein proteinase

scientific article published on September 2002

Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection

scientific article published on 20 April 2015

Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge

scientific article

Vaccinia virus A12L protein and its AG/A proteolysis play an important role in viral morphogenic transition

scientific article published on 11 July 2007

Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis

scientific article published on 28 April 2009

Vaccinia virus proteolysis--a review

scientific article

Viral proteinases: targets of opportunity

publication published on 01 June 2006

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