List of works - Nicolas Sluis-Cremer

624. Microbiota and Associations with Treatment Outcome in Fecal Microbiota Transplantation

scholarly article by Tatiana Bogdanovich et al published November 2018 in Open Forum Infectious Diseases

Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides

scientific article published on 13 July 2009

Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

scientific article

Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT.

scientific article published on May 2007

Competitive fitness assays indicate that the E138A substitution in HIV-1 reverse transcriptase decreases in vitro susceptibility to emtricitabine

scientific article

Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation

scientific article published on 27 August 2019

Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding

scientific article

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors

scientific article

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1.

scientific article published on 29 January 2014

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog ⬇️

scientific article published on January 14, 2013

E138A in HIV-1 reverse transcriptase is more common in subtype C than B: implications for rilpivirine use in resource-limited settings

scientific article

Efavirenz accelerates HIV-1 reverse transcriptase ribonuclease H cleavage, leading to diminished zidovudine excision

scientific article published on 16 November 2007

Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation

scientific article published in January 2005

Effect of Reverse Transcriptase Inhibitors and Mutations on the Low-Cost Cavidi Reverse Transcriptase Viral Load Assay

scientific article published on 01 December 2009

Efficient HIV-1 Trans Infection of CD4+ T Cells Occurs in the Presence of Antiretroviral Therapy

scientific article published on 24 May 2019

Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.

scientific article published on 29 June 2016

Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay

scientific article published on 09 July 2013

Failure of Initial Therapy With Two Nucleosides and Efavirenz Is Not Associated With Early Emergence of Mutations in the C-Terminus of HIV-1 Reverse Transcriptase ⬇️

scientific article published on April 1, 2011

Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors

scientific article

Future of nonnucleoside reverse transcriptase inhibitors

scientific article published on 11 January 2018

Glutathione-S-transferase FosA6 of Klebsiella pneumoniae origin conferring fosfomycin resistance in ESBL-producing Escherichia coli.

scientific article published on 3 June 2016

High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.

scientific article

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.

scientific article published on 18 May 2015

Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability

scientific article

In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine, and MIV-150, Nonnucleoside Reverse Transcriptase Inhibitor Microbicides in Clinical Development for the Prevention of HIV-1 Infection

scientific article published on 15 May 2017

In vitro characterization of a sustained-release formulation for enfuvirtide.

scientific article

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase.

scientific article published on 24 September 2016

Inhibition of fosfomycin resistance protein FosA by phosphonoformate (foscarnet) in multidrug-resistant Gram-negative pathogens.

scientific article published on 9 October 2017

Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency

scientific article published on 29 January 2019

Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells

scientific article published on 29 April 2011

Large Multidomain Protein NMR: HIV-1 Reverse Transcriptase Precursor in Solution

scientific article published on 15 December 2020

Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance

scientific article published on December 2008

Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence

scientific article

Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine

scientific article published on 29 October 2007

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

scientific article

Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules

scientific article

Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors

scientific article published on 6 November 2006

Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine

scientific article

Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase

scientific article published in July 2007

Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones

scientific article published on 29 October 2001

N348I in HIV-1 reverse transcriptase counteracts the synergy between zidovudine and nevirapine

scientific article

N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

scientific article

N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations

scientific article

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

scientific article

Naive CD4+ T Cells Harbor a Large Inducible Reservoir of Latent, Replication-competent Human Immunodeficiency Virus Type 1

scientific article published on 01 November 2019

Nonnucleoside Reverse Transcriptase Inhibitor Hypersusceptibility and Resistance by Mutation of Residue 181 in HIV-1 Reverse Transcriptase

scientific article published on 25 July 2019

Nonnucleoside Reverse Transcriptase Inhibitors Reduce HIV-1 Production from Latently Infected Resting CD4+ T Cells following Latency Reversal.

scientific article published on 19 December 2016

Novel N-3 substituted TSAO-T derivatives: synthesis and anti-HIV-evaluation.

scientific article

Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4+ T cells.

scientific article published on 29 May 2017

Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action

scientific article

Origin of the plasmid-mediated fosfomycin resistance gene fosA3.

scientific article published on 2 November 2017

Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors

scientific article published on 24 January 2020

Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol

scientific article

Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses

scientific article

Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation

scientific article

Radiation target analyses of DNA template/primer complexes

scientific article

Replication fitness of multiple nonnucleoside reverse transcriptase-resistant HIV-1 variants in the presence of etravirine measured by 454 deep sequencing

scientific article published on 29 May 2013

Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection

scientific article published on 30 October 2015

Role of RNase H Activity in NRTI/NNRTI Drug Resistance

Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

scientific article

Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency.

scientific article published on November 2008

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations

scientific article

Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens

scientific article published on 26 February 2019

Stereo-selectivity of HIV-1 reverse transcriptase toward isomers of thymidine-5'-O-1-thiotriphosphate

scientific article published on 3 June 2005

Structural basis of reduced susceptibility to ceftazidime-avibactam and cefiderocol in Enterobacter cloacae due to AmpC R2 loop deletion

scientific article published on 13 April 2020

Structure and dynamics of FosA-mediated fosfomycin resistance in Klebsiella pneumoniae and Escherichia coli.

scientific article published on 5 September 2017

Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis

scientific article published on September 2003

Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

scientific article

Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs ⬇️

scientific article published on September 13, 2011

Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase ⬇️

scientific article published on August 22, 2011

Synthesis and Anti-HIV Evaluation of 3′-Triazolo Nucleosides ⬇️

scientific article published on April 1, 2011

Synthesis and Anti-HIV-1 Activity of a Novel Series of Aminoimidazole Analogs

scientific article

Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

scientific article

Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides ⬇️

scientific article published on May 30, 2011

Temporal transcriptional response to latency reversing agents identifies specific factors regulating HIV-1 viral transcriptional switch

scientific article

The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.

scientific article

The Base Component of 3′-Azido-2′,3′-Dideoxynucleosides Influences Resistance Mutations Selected in HIV-1 Reverse Transcriptase ⬇️

scientific article published on June 6, 2011

The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro

scientific article

The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization

scientific article

The emerging profile of cross-resistance among the nonnucleoside HIV-1 reverse transcriptase inhibitors

scientific article

The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs

scientific article published on 04 February 2009

Therapeutic Approaches to Eradicate Latent HIV-1 in Resting CD4+ T Cells

scientific article published on September 2015

Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue

scientific article published on October 2013

Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1.

scientific article published on 2 April 2019

Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene

scientific article

Zidovudine (AZT) Monotherapy Selects for the A360V Mutation in the Connection Domain of HIV-1 Reverse Transcriptase ⬇️

scientific article published on February 21, 2012

List of works by Nicolas Sluis-Cremer

624. Microbiota and Associations with Treatment Outcome in Fecal Microbiota Transplantation

Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides

Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT.

Competitive fitness assays indicate that the E138A substitution in HIV-1 reverse transcriptase decreases in vitro susceptibility to emtricitabine

Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation

Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1.

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog ⬇️

E138A in HIV-1 reverse transcriptase is more common in subtype C than B: implications for rilpivirine use in resource-limited settings

Efavirenz accelerates HIV-1 reverse transcriptase ribonuclease H cleavage, leading to diminished zidovudine excision

Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation

Effect of Reverse Transcriptase Inhibitors and Mutations on the Low-Cost Cavidi Reverse Transcriptase Viral Load Assay

Efficient HIV-1 Trans Infection of CD4+ T Cells Occurs in the Presence of Antiretroviral Therapy

Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.

Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay

Failure of Initial Therapy With Two Nucleosides and Efavirenz Is Not Associated With Early Emergence of Mutations in the C-Terminus of HIV-1 Reverse Transcriptase ⬇️

Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors

Future of nonnucleoside reverse transcriptase inhibitors

Glutathione-S-transferase FosA6 of Klebsiella pneumoniae origin conferring fosfomycin resistance in ESBL-producing Escherichia coli.

High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.

Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability

In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine, and MIV-150, Nonnucleoside Reverse Transcriptase Inhibitor Microbicides in Clinical Development for the Prevention of HIV-1 Infection

In vitro characterization of a sustained-release formulation for enfuvirtide.

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase.

Inhibition of fosfomycin resistance protein FosA by phosphonoformate (foscarnet) in multidrug-resistant Gram-negative pathogens.

Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency

Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells

Large Multidomain Protein NMR: HIV-1 Reverse Transcriptase Precursor in Solution

Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance

Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence

Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules

Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors

Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine

Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase

Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones

N348I in HIV-1 reverse transcriptase counteracts the synergy between zidovudine and nevirapine

N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

Naive CD4+ T Cells Harbor a Large Inducible Reservoir of Latent, Replication-competent Human Immunodeficiency Virus Type 1

Nonnucleoside Reverse Transcriptase Inhibitor Hypersusceptibility and Resistance by Mutation of Residue 181 in HIV-1 Reverse Transcriptase

Nonnucleoside Reverse Transcriptase Inhibitors Reduce HIV-1 Production from Latently Infected Resting CD4+ T Cells following Latency Reversal.

Novel N-3 substituted TSAO-T derivatives: synthesis and anti-HIV-evaluation.

Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4+ T cells.

Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action

Origin of the plasmid-mediated fosfomycin resistance gene fosA3.

Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors

Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol

Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses

Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation

Radiation target analyses of DNA template/primer complexes

Replication fitness of multiple nonnucleoside reverse transcriptase-resistant HIV-1 variants in the presence of etravirine measured by 454 deep sequencing

Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection

Role of RNase H Activity in NRTI/NNRTI Drug Resistance

Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency.

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations

Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens

Stereo-selectivity of HIV-1 reverse transcriptase toward isomers of thymidine-5'-O-1-thiotriphosphate

Structural basis of reduced susceptibility to ceftazidime-avibactam and cefiderocol in Enterobacter cloacae due to AmpC R2 loop deletion

Structure and dynamics of FosA-mediated fosfomycin resistance in Klebsiella pneumoniae and Escherichia coli.

Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis

Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs ⬇️

Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase ⬇️

Synthesis and Anti-HIV Evaluation of 3′-Triazolo Nucleosides ⬇️

Synthesis and Anti-HIV-1 Activity of a Novel Series of Aminoimidazole Analogs

Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides ⬇️

Temporal transcriptional response to latency reversing agents identifies specific factors regulating HIV-1 viral transcriptional switch

The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.

The Base Component of 3′-Azido-2′,3′-Dideoxynucleosides Influences Resistance Mutations Selected in HIV-1 Reverse Transcriptase ⬇️

The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro

The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization