List of works - Vincent W. Yang

A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α).

scientific article published on 07 January 2014

A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4.

scientific article

All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5

scientific article

Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene ⬇️

scientific article published on November 9, 2010

An Update on the Biology of RAS/RAF Mutations in Colorectal Cancer

scientific article

CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage.

scientific article

Chemoprevention of familial adenomatous polyposis by bromo‐noscapine (EM011) in the ApcMin/+ mouse model ⬇️

scientific article published on February 9, 2012

Correction to: The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury.

scientific article published on 19 February 2018

Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus

scientific article

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease

scientific article

Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis

scientific article published on 16 November 2016

Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer ⬇️

scientific article

Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblasts

scientific article

Genetic and Chemical Models of Colorectal Cancer in Mice

scientific article

Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response

scientific article

Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis

scientific article published on October 2005

Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis

scientific article published in December 2004

Genetics of colorectal cancer

scientific article published on 13 August 2004

Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine

scientific article published on 12 May 2009

High-Throughput Screening Strategies for Targeted Identification of Therapeutic Compounds in Colorectal Cancer ⬇️

scientific article published on March 1, 2012

Human cancer cells commonly acquire DNA damage during mitotic arrest

scientific article

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice

scientific article published on 5 June 2015

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer

scientific article

Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-like Factor 5 Expression by Ultrahigh-Throughput Screening ⬇️

scientific article published on September 1, 2011

Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening

scientific article

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

scientific article published on 13 July 2016

Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium-specific Deletion of Klf4

scientific article published on 14 August 2018

Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon

scientific article published on 15 January 2014

Intestinal stem cell resurgence by enterocyte precursors

scientific article published on 23 September 2016

KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis

scientific article

KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-RasG12D expression.

scientific article published in April 2018

Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells

scientific article

Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers

scientific article published on 10 June 2016

Krüppel-Like Factor 5 Is Important for Maintenance of Crypt Architecture and Barrier Function in Mouse Intestine ⬇️

scientific article published on July 18, 2011

Krüppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice

scientific article

Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells

scientific article published on 25 November 2019

Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar to Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice

scientific article published on 14 December 2017

Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation

scientific article published on 21 June 2018

Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.

scientific article

Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage

scientific article

Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts

scientific article

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations

scientific article

Krüppel-like factor 5 is essential for maintenance of barrier function in mouse colon

scientific article published on September 2017

Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells

scientific article

Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis

scientific article

Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras

scientific article

Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection

scientific article published on 11 January 2008

Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation

scientific article

Krüppel-like factor 5 protects against dextran sulfate sodium-induced colonic injury in mice by promoting epithelial repair

scientific article

Krüppel-like factor 6 regulates mitochondrial function in the kidney

scientific article

Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

scientific article

Krüppel-like factors in mammalian stem cells and development

scientific article published on March 2017

Loss of the Krüppel-like factor 4 tumor suppressor is associated with epithelial-mesenchymal transition in colorectal cancer

scientific article published on 26 November 2019

Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.

scientific article

Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad.

scientific article published on 3 May 2007

ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer

scientific article

Mitotic Origins of Chromosomal Instability in Colorectal Cancer

scientific article published on April 2007

Molecular Genetics of Colorectal Cancer: An Overview

scientific article published on April 2006

Murine Model for Colitis-Associated Cancer of the Colon

scientific article published on January 2016

Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium

scientific article published on December 2008

Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice.

scientific article

Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS

Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet

scientific article published on 25 July 2019

Oral contraceptives and polyp regression in familial adenomatous polyposis.

scientific article

Podocyte-Specific Induction of Krüppel-Like Factor 15 Restores Differentiation Markers and Attenuates Kidney Injury in Proteinuric Kidney Disease

Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease

scientific article published on 16 August 2018

Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney

scientific article published on 03 September 2021

Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells

scientific article published on 16 April 2008

Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5.

scientific article published on 18 December 2006

Recent changes in relationships between medical school physicians and industry

scientific article published on 25 September 2010

Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5.

scientific article published on 23 July 2013

Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt

scientific article published on January 2015

Role of neutral ceramidase in colon cancer

scientific article published on 8 September 2016

Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer

scientific article

SP and KLF Transcription Factors in Digestive Physiology and Diseases

scientific article

SUMOylation regulates nuclear localization of Krüppel-like factor 5.

scientific article published on 9 September 2008

Shanthi V. Sitaraman, MD, PhD: physician, scientist, educator, and humanitarian

scientific article published on July 2011

The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein ⬇️

scientific article published on September 27, 2011

The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo

scientific article published on 29 July 2019

The Pathobiology of Krüppel-like Factors in Colorectal Cancer

scientific article published on April 2008

The Role of Inflammation in the Pathogenesis of Colorectal Cancer

scientific article published on April 2009

The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury.

scientific article

The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer

scientific article published on 09 January 2009

The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology

scientific article

The loss of Krüppel-like factor 15 in Foxd1+ stromal cells exacerbates kidney fibrosis

scientific article published on 24 June 2017

p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells

scientific article published on April 2007

List of works by Vincent W. Yang

A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α).

A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4.

All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5

Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene ⬇️

An Update on the Biology of RAS/RAF Mutations in Colorectal Cancer

CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage.

Chemoprevention of familial adenomatous polyposis by bromo‐noscapine (EM011) in the ApcMin/+ mouse model ⬇️

Correction to: The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury.

Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease

Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis

Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer ⬇️

Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblasts

Genetic and Chemical Models of Colorectal Cancer in Mice

Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response

Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis

Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis

Genetics of colorectal cancer

Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine

High-Throughput Screening Strategies for Targeted Identification of Therapeutic Compounds in Colorectal Cancer ⬇️

Human cancer cells commonly acquire DNA damage during mitotic arrest

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer

Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-like Factor 5 Expression by Ultrahigh-Throughput Screening ⬇️

Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium-specific Deletion of Klf4

Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon

Intestinal stem cell resurgence by enterocyte precursors

KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis

KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-RasG12D expression.

Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells

Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers

Krüppel-Like Factor 5 Is Important for Maintenance of Crypt Architecture and Barrier Function in Mouse Intestine ⬇️

Krüppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice

Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells

Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar to Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice

Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation

Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.

Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage

Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations

Krüppel-like factor 5 is essential for maintenance of barrier function in mouse colon

Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells

Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis

Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras

Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection

Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation

Krüppel-like factor 5 protects against dextran sulfate sodium-induced colonic injury in mice by promoting epithelial repair

Krüppel-like factor 6 regulates mitochondrial function in the kidney

Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

Krüppel-like factors in mammalian stem cells and development

Loss of the Krüppel-like factor 4 tumor suppressor is associated with epithelial-mesenchymal transition in colorectal cancer

Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.

Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad.

ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer

Mitotic Origins of Chromosomal Instability in Colorectal Cancer

Molecular Genetics of Colorectal Cancer: An Overview

Murine Model for Colitis-Associated Cancer of the Colon

Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium

Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice.

Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS

Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet

Oral contraceptives and polyp regression in familial adenomatous polyposis.

Podocyte-Specific Induction of Krüppel-Like Factor 15 Restores Differentiation Markers and Attenuates Kidney Injury in Proteinuric Kidney Disease

Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease

Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney

Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells

Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5.

Recent changes in relationships between medical school physicians and industry

Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5.

Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt

Role of neutral ceramidase in colon cancer

Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer

SP and KLF Transcription Factors in Digestive Physiology and Diseases

SUMOylation regulates nuclear localization of Krüppel-like factor 5.

Shanthi V. Sitaraman, MD, PhD: physician, scientist, educator, and humanitarian

The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein ⬇️

The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo