List of works - Giorgos Kollias

The transcriptional landscape of the mammalian genome

scientific article

Onset and progression in inherited ALS determined by motor neurons and microglia

scientific article (publication date: 2 June 2006)

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

scientific journal article

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

scientific journal article

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

scientific article published on 01 March 1999

CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity

scientific article

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

scientific journal article

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

scientific article

Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.

scientific article

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

scientific article published on 01 July 1997

Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination

scientific article

Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.

scientific article published on September 1998

Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis

scientific article

The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans

scientific article published on 08 September 2009

Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns

scientific article published in July 1986

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

scientific article

HuR as a negative posttranscriptional modulator in inflammation

scientific journal article

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

scientific article

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

scientific article published on 4 February 2008

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

scientific article

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

article

Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.

scientific article published on May 2003

Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.

scientific article

The European dimension for the mouse genome mutagenesis program

scientific article

Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

scientific article

Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin

scientific article published in March 2002

Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction

scientific article published on 01 January 2004

Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

scientific article

Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases

scientific article published on August 2004

Role of TL1A and its receptor DR3 in two models of chronic murine ileitis

scientific article

Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.

scientific article published on 27 April 2009

Regulatory T cells protect from local and systemic bone destruction in arthritis

scientific article published on 17 May 2010

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

scientific article published on 10 December 2015

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

article

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells

scientific article published on 6 August 2013

Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis

scientific article published on 01 November 2005

Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments

scientific article

The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells

scientific article

Soluble TNF mediates the transition from pulmonary inflammation to fibrosis

scientific article

Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie

scientific article published on April 2000

Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis

scientific article

Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis

scientific article published on May 2000

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

scientific journal article

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

scientific article published on 9 April 2012

TNF-alpha transgenic and knockout models of CNS inflammation and degeneration

scientific article published on February 1997

The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice

scientific article published on 01 June 1995

FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses

scientific article published in January 2006

Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice

scientific article published in July 2003

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

scientific article

Cellular mechanisms of TNF function in models of inflammation and autoimmunity

scientific article published on 18 February 2010

List of works by Giorgos Kollias

The transcriptional landscape of the mammalian genome

Onset and progression in inherited ALS determined by motor neurons and microglia

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination

Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.

Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis

The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans

Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

HuR as a negative posttranscriptional modulator in inflammation

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.

Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.

The European dimension for the mouse genome mutagenesis program

Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin

Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction

Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases

Role of TL1A and its receptor DR3 in two models of chronic murine ileitis

Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.

Regulatory T cells protect from local and systemic bone destruction in arthritis

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells

Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis

Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments

The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells

Soluble TNF mediates the transition from pulmonary inflammation to fibrosis

Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie

Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis

Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

TNF-alpha transgenic and knockout models of CNS inflammation and degeneration

The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice

FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses

Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

Cellular mechanisms of TNF function in models of inflammation and autoimmunity