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List of works by Youngchul Sung

(p40)2-Fc reduces immune-inflammatory response through the activation of T cells in collagen induced arthritis mice

scientific article published on 23 May 2016

A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3

scientific article published on 14 November 2019

A Therapeutic Strategy for Metastatic Malignant Fibrous Histiocytoma Through Mesenchymal Stromal Cell-Mediated TRAIL Production ⬇️

scientific article published on May 1, 2013

A glycosylated Fc-fused GLP-1 exhibits equivalent glucose lowering effect but lesser gastrointestinal side effect than Dulaglutide

scientific article published on 20 April 2020

AIDS vaccine development: the past, the present, and the future

scientific article

Action mechanism in immunopathogenesis and clearance of HBV

scientific article published in June 2006

Biochemical characterization of a new recombinant TNF receptor-hyFc fusion protein expressed in CHO cells ⬇️

scientific article published on September 23, 2012

Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice

scientific article published on 01 October 2019

COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway

scientific article

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

scientific article

Co-immunization of plasmid DNA encoding IL-12 and IL-18 with Bacillus Calmette-Guérin vaccine against progressive tuberculosis

scientific article published on November 2011

Codelivery of IL-7 Augments Multigenic HCV DNA Vaccine-induced Antibody as well as Broad T Cell Responses in Cynomolgus Monkeys

scientific article

Codelivery of PEG-IFN-alpha inhibits HCV DNA vaccine-induced T cell responses but not humoral responses in African green monkeys.

scientific article published on 2 June 2008

Complete Regression of Metastatic Renal Cell Carcinoma by Multiple Injections of Engineered Mesenchymal Stem Cells Expressing Dodecameric TRAIL and HSV-TK ⬇️

scientific article published on November 30, 2012

Complete protection against a H5N2 avian influenza virus by a DNA vaccine expressing a fusion protein of H1N1 HA and M2e ⬇️

scientific article published on June 12, 2011

Controlled release of human growth hormone fused with a human hybrid Fc fragment through a nanoporous polymer membrane

scientific article published on May 2013

Crucial roles of interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity

scientific article

Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3'-OH kinase pathway.

scientific article published in January 2002

Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa.

scientific article published on 13 July 2012

Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor CD8 T-cell responses

scientific article

Differential regulation of antigen-specific CD8+ T cell responses by IL-12p40 in a dose-dependent manner

scientific article

Discovery of a novel natural killer cell line with distinct immunostimulatory and proliferative potential as an alternative platform for cancer immunotherapy

scientific article published on 24 May 2019

Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53.

scientific article published on November 2002

Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability

scientific article

Ectopic vascularized bone formation by human umbilical cord-derived mesenchymal stromal cells expressing bone morphogenetic factor-2 and endothelial cells

scientific article published on 04 September 2018

Effect of mesenchymal stem cells associated to matrixen on the erectile function in the rat model with bilateral cavernous nerve crushing injury.

scientific article published in November 2012

Efficient induction of T helper 1 CD4+ T-cell responses to hepatitis C virus core and E2 by a DNA prime-adenovirus boost.

scientific article published on November 2003

Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

scientific article

Enhancement of DNA Vaccine-induced Immune Responses by Influenza Virus NP Gene

scientific article

Enhancement of Vaccine-induced Primary and Memory CD8+ T-cell Responses by Soluble PD-1 ⬇️

scientific article published on April 1, 2011

Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11.

scientific article published on 5 August 2013

Enhancement of interleukin-12 gene-based tumor immunotherapy by the reduced secretion of p40 subunit and the combination with farnesyltransferase inhibitor

scientific article

Erratum to: PD-1 deficiency protects experimental colitis via alteration of gut microbiota

scientific article published in June 2018

Erratum: Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection

scientific article published on 29 November 2017

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

scientific article published on 24 August 2015

Gene Therapy of Intracranial Glioma Using Interleukin 12–Secreting Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells ⬇️

scientific article published on March 23, 2011

Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma

scientific article

Genetically engineered mesenchymal stem cell therapy using self-assembling supramolecular hydrogels

scientific article

HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1.

scientific article

HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice

scientific article published on 30 July 2018

HIV-1 protease has a genetic T-cell adjuvant effect which is negatively regulated by proteolytic activity

scientific article

Hepatitis C virus core inhibits the Fas-mediated p38 mitogen activated kinase signaling pathway in hepatocytes

scientific article published in June 2002

IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells

scientific article published in March 2004

IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway

scientific article published on 01 October 2002

IL-12p40 Homodimer Ameliorates Experimental Autoimmune Arthritis

scientific article published on 31 August 2015

IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model

scientific article published on July 2008

IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization

scientific journal article

IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R

scientific article published on 22 April 2013

Immunogenicity of a DNA prime and recombinant adenovirus boost regime significantly varies between rhesus macaques of Chinese and Indian origins.

scientific article published in August 2007

Improved effector activity and memory CD8 T cell development by IL-2 expression during experimental respiratory syncytial virus infection

scientific article published in January 2004

In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis

scientific article published on 04 October 2013

In vivo kinetics and biodistribution of HB-110, a novel HBV DNA vaccine, after administration in mice

scientific article published on 01 March 2007

In vivo kinetics and biodistribution of a HIV-1 DNA vaccine after administration in mice.

scientific article published in June 2003

Increase of Plasma IL-12/p40 Ratio Induced by the Combined Therapy of DNA Vaccine and Lamivudine Correlates with Sustained Viremia Control in CHB Carriers

scientific article

Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation

scientific article published on December 2008

Inhibition of TCR-induced CD8 T cell death by IL-12: regulation of Fas ligand and cellular FLIP expression and caspase activation by IL-12.

scientific article published in March 2003

Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation

scientific article

Interleukin‐27 suppresses osteoclastogenesis via induction of interferon‐γ ⬇️

scientific article published on 01 December 2012

Intranasal Introduction of Fc-Fused Interleukin-7 Provides Long-Lasting Prophylaxis against Lethal Influenza Virus Infection

scientific article published on 9 December 2015

Intravaginal Administration of Fc-Fused IL7 Suppresses the Cervicovaginal Tumor by Recruiting HPV DNA Vaccine-Induced CD8 T Cells

scientific article published on 12 July 2016

Irradiation-induced localization of IL-12-expressing mesenchymal stem cells to enhance the curative effect in murine metastatic hepatoma.

scientific article

KIAA1114, a full-length protein encoded by the trophinin gene, is a novel surface marker for isolating tumor-initiating cells of multiple hepatocellular carcinoma subtypes

scientific article

Marked enhancement of antigen-specific T-cell responses by IL-7-fused nonlytic, but not lytic, Fc as a genetic adjuvant

scientific article

Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge.

scientific article

Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4(+)CD8(-)CD25(-) naïve cells in a dendritic cell-independent manner

scientific article published on 06 November 2007

Natural Form of Noncytolytic Flexible Human Fc as a Long-Acting Carrier of Agonistic Ligand, Erythropoietin ⬇️

scientific article published on September 16, 2011

Negative role of inducible PD-1 on survival of activated dendritic cells

scientific article published on 6 December 2013

Nonlytic Fc-fused IL-7 synergizes with Mtb32 DNA vaccine to enhance antigen-specific T cell responses in a therapeutic model of tuberculosis

scientific article published on 23 April 2013

Optimal Induction of T-Cell Responses against Hepatitis C Virus E2 by Antigen Engineering in DNA Immunization

scientific article (publication date: November 2003)

Optimal induction of HPV DNA vaccine-induced CD8+ T cell responses and therapeutic antitumor effect by antigen engineering and electroporation

scientific article published on 3 August 2009

Oral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum with adjuvant saponin protects mice against highly pathogenic avian influenza A virus infection.

scientific article

Overexpression of hepatitis C virus NS5A protein induces chromosome instability via mitotic cell cycle dysregulation

scientific article published on 29 March 2006

PD-1 deficiency protects experimental colitis via alteration of gut microbiota

scientific article published on 25 October 2017

Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial

scientific article published on 01 December 2020

Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection

scientific article published on 24 October 2017

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells.

scientific article published on 26 January 2016

Protective effects of Fc-fused PD-L1 on two different animal models of colitis.

scientific article published on 5 June 2014

STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice

scientific article (publication date: May 2006)

Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice

scientific article published on 29 March 2014

Serum IP-10 Levels Correlate with the Severity of Liver Histopathology in Patients Infected with Genotype-1 HCV.

scientific article published on 21 November 2011

Supramolecular hydrogels for long-term bioengineered stem cell therapy

scientific article

Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee

scientific article

Synergistic Effect of Mesenchymal Stem Cells Infected with Recombinant Adenovirus Expressing Human BDNF on Erectile Function in a Rat Model of Cavernous Nerve Injury ⬇️

scientific article published on October 19, 2012

T cell expression of CIITA represses Th1 immunity

scientific article published on 6 September 2004

The MHC class I homolog of human cytomegalovirus is resistant to down-regulation mediated by the unique short region protein (US)2, US3, US6, and US11 gene products.

scientific article published in April 2002

The cyanase operon and cyanate metabolism

scientific article published in 1990

The past, present, and future of adoptive T cell therapy ⬇️

scientific article published on August 31, 2012

The pharmacology study of a new recombinant TNF receptor-hyFc fusion protein ⬇️

scientific article published on November 26, 2012

The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met as a novel adjuvant for DNA vaccine.

scientific article

Therapeutic strategies for locally recurrent and metastatic de-differentiated liposarcoma with herpes simplex virus-thymidine kinase-expressing mesenchymal stromal cells

scientific article

Transplantation of Muscle-Derived Stem Cells into the Corpus Cavernosum Restores Erectile Function in a Rat Model of Cavernous Nerve Injury ⬇️

scientific article published on May 24, 2011

Unified immune modulation by 4-1BB triggering leads to diverse effects on disease progression in vivo ⬇️

scientific article published on June 22, 2011

Use of Pre-S Protein-Containing Hepatitis B Virus Surface Antigens and a Powerful Adjuvant To Develop an Immune Therapy for Chronic Hepatitis B Virus Infection ⬇️

scientific article published on December 7, 2011

[The role of hepatitis C virus core protein on liver fibrogenesis: a study using an in vitro co-culture system]

scientific article published on 01 November 2003

hIL-7-hyFc, a long-acting IL-7, increased absolute lymphocyte count in healthy subjects

scientific article published on 27 April 2020

p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest

scientific article published in June 2003

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