List of works - Bernard L. Trumpower

A comparison of stigmatellin conformations, free and bound to the photosynthetic reaction center and the cytochrome bc1 complex

scientific article

A concerted, alternating sites mechanism of ubiquinol oxidation by the dimeric cytochrome bc(1) complex

scientific article

Anti-cooperative oxidation of ubiquinol by the yeast cytochrome bc1 complex.

scientific article published on 3 February 2004

Asymmetric and redox-specific binding of quinone and quinol at center N of the dimeric yeast cytochrome bc1 complex. Consequences for semiquinone stabilization

scientific article published on 21 June 2007

Asymmetric binding of stigmatellin to the dimeric Paracoccus denitrificans bc1 complex: evidence for anti-cooperative ubiquinol oxidation and communication between center P ubiquinol oxidation sites

scientific article published on 08 June 2007

Bcs1p can rescue a large and productive cytochrome bc1 complex assembly intermediate in the inner membrane of yeast mitochondria

scientific article published on 18 August 2010

Biogenesis of the yeast cytochrome bc1 complex.

scientific article published on 03 May 2008

Chapter 27 An improved method for introducing point mutations into the mitochondrial cytochrome B gene to facilitate studying the role of cytochrome B in the formation of reactive oxygen species.

scientific article

Combining Inhibitor Resistance-conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomyces cerevisiae

scientific article published on 29 January 2009

Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae

scientific article

DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae

scientific article published on October 2004

Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex

scientific article

Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance

scientific article published on 18 January 2011

Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin

scientific article published on November 2007

Direct demonstration of half-of-the-sites reactivity in the dimeric cytochrome bc1 complex: enzyme with one inactive monomer is fully active but unable to activate the second ubiquinol oxidation site in response to ligand binding at the ubiquinone r

scientific article

Disulfide bond formation involves a quinhydrone-type charge–transfer complex ⬇️

scientific article published on November 11, 2003

Elimination of the Disulfide Bridge in the Rieske Iron−Sulfur Protein Allows Assembly of the [2Fe-2S] Cluster into the Rieske Protein but Damages the Ubiquinol Oxidation Site in the Cytochrome bc1 Complex ⬇️

scientific article published on November 25, 2003

Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane

scientific article published on 19 February 2009

Failure to insert the iron-sulfur cluster into the Rieske iron-sulfur protein impairs both center N and center P of the cytochrome bc1 complex.

scientific article published on 10 October 2002

Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b.

scientific article published in March 2004

Identification and characterization of cytochrome bc1 subcomplexes in mitochondria from yeast with single and double deletions of genes encoding cytochrome bc1 subunits

article

Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc1 Complex Reveal Electron Transfer and Regulatory Interactions between Monomers

scientific article published on 27 January 2009

Inhibition of the yeast cytochrome bc1 complex by ilicicolin H, a novel inhibitor that acts at the Qn site of the bc1 complex.

scientific article published on 10 December 2003

Inhibitory analogs of ubiquinol act anti-cooperatively on the Yeast cytochrome bc1 complex. Evidence for an alternating, half-of-the-sites mechanism of ubiquinol oxidation.

scientific article published on 7 November 2001

Introduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins

scientific article published on 27 April 2008

Investigating the Qn site of the cytochrome bc1 complex in Saccharomyces cerevisiae with mutants resistant to ilicicolin H, a novel Qn site inhibitor

scientific article published on 20 September 2006

Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles

scientific article published on 28 May 2009

Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi

scientific article published on 07 September 2007

Molecular basis for atovaquone binding to the cytochrome bc1 complex

scientific article

Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae

scientific article published on 23 October 2003

Molecular basis of Toxoplasma gondii atovaquone resistance modeled in Saccharomyces cerevisiae

scientific article published on 27 December 2005

Multiple cytochrome B mutations may cause atovaquone resistance

scientific article published in March 2005

Mutational Analysis of Cytochrome b at the Ubiquinol Oxidation Site of Yeast Complex III

scientific article published in Journal of Biological Chemistry

Mutations in cytochrome b that affect kinetics of the electron transfer reactions at center N in the yeast cytochrome bc1 complex

scientific article published on 6 September 2007

Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex

scientific article

Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones

scientific article published on 4 August 2009

Protonmotive pathways and mechanisms in the cytochrome bc1 complex

scientific article

RPL29 codes for a non-essential protein of the 60S ribosomal subunit in Saccharomyces cerevisiae and exhibits synthetic lethality with mutations in genes for proteins required for subunit coupling

scientific article published on 01 April 2002

Rapid electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center N.

scientific article published on 15 April 2005

Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci

scientific article published on September 2003

Regulatory interactions between ubiquinol oxidation and ubiquinone reduction sites in the dimeric cytochrome bc1 complex

scientific article published on 14 August 2006

Regulatory interactions in the dimeric cytochrome bc(1) complex: the advantages of being a twin

scientific article published on 22 April 2008

Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex

scientific article published on 28 September 2006

Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo site inhibitor bound

scientific article (publication date: 15 August 2003)

Superoxide anion generation by the cytochrome bc1 complex ⬇️

scientific article published on November 15, 2003

The dimeric structure of the cytochrome bc(1) complex prevents center P inhibition by reverse reactions at center N.

scientific article

The rate-limiting step in the cytochrome bc1 complex (Ubiquinol-Cytochrome c Oxidoreductase) is not changed by inhibition of cytochrome b-dependent deprotonation: implications for the mechanism of ubiquinol oxidation at center P of the bc1 complex

scientific article published on 26 March 2009

List of works by Bernard L. Trumpower

A comparison of stigmatellin conformations, free and bound to the photosynthetic reaction center and the cytochrome bc1 complex

A concerted, alternating sites mechanism of ubiquinol oxidation by the dimeric cytochrome bc(1) complex

Anti-cooperative oxidation of ubiquinol by the yeast cytochrome bc1 complex.

Asymmetric and redox-specific binding of quinone and quinol at center N of the dimeric yeast cytochrome bc1 complex. Consequences for semiquinone stabilization

Asymmetric binding of stigmatellin to the dimeric Paracoccus denitrificans bc1 complex: evidence for anti-cooperative ubiquinol oxidation and communication between center P ubiquinol oxidation sites

Bcs1p can rescue a large and productive cytochrome bc1 complex assembly intermediate in the inner membrane of yeast mitochondria

Biogenesis of the yeast cytochrome bc1 complex.

Chapter 27 An improved method for introducing point mutations into the mitochondrial cytochrome B gene to facilitate studying the role of cytochrome B in the formation of reactive oxygen species.

Combining Inhibitor Resistance-conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomyces cerevisiae

Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae

DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae

Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex

Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance

Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin

Direct demonstration of half-of-the-sites reactivity in the dimeric cytochrome bc1 complex: enzyme with one inactive monomer is fully active but unable to activate the second ubiquinol oxidation site in response to ligand binding at the ubiquinone r

Disulfide bond formation involves a quinhydrone-type charge–transfer complex ⬇️

Elimination of the Disulfide Bridge in the Rieske Iron−Sulfur Protein Allows Assembly of the [2Fe-2S] Cluster into the Rieske Protein but Damages the Ubiquinol Oxidation Site in the Cytochrome bc1 Complex ⬇️

Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane

Failure to insert the iron-sulfur cluster into the Rieske iron-sulfur protein impairs both center N and center P of the cytochrome bc1 complex.

Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b.

Identification and characterization of cytochrome bc1 subcomplexes in mitochondria from yeast with single and double deletions of genes encoding cytochrome bc1 subunits

Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc1 Complex Reveal Electron Transfer and Regulatory Interactions between Monomers

Inhibition of the yeast cytochrome bc1 complex by ilicicolin H, a novel inhibitor that acts at the Qn site of the bc1 complex.

Inhibitory analogs of ubiquinol act anti-cooperatively on the Yeast cytochrome bc1 complex. Evidence for an alternating, half-of-the-sites mechanism of ubiquinol oxidation.

Introduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins

Investigating the Qn site of the cytochrome bc1 complex in Saccharomyces cerevisiae with mutants resistant to ilicicolin H, a novel Qn site inhibitor

Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles

Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi

Molecular basis for atovaquone binding to the cytochrome bc1 complex

Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae

Molecular basis of Toxoplasma gondii atovaquone resistance modeled in Saccharomyces cerevisiae

Multiple cytochrome B mutations may cause atovaquone resistance

Mutational Analysis of Cytochrome b at the Ubiquinol Oxidation Site of Yeast Complex III

Mutations in cytochrome b that affect kinetics of the electron transfer reactions at center N in the yeast cytochrome bc1 complex

Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex

Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones

Protonmotive pathways and mechanisms in the cytochrome bc1 complex

RPL29 codes for a non-essential protein of the 60S ribosomal subunit in Saccharomyces cerevisiae and exhibits synthetic lethality with mutations in genes for proteins required for subunit coupling

Rapid electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center N.

Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci

Regulatory interactions between ubiquinol oxidation and ubiquinone reduction sites in the dimeric cytochrome bc1 complex

Regulatory interactions in the dimeric cytochrome bc(1) complex: the advantages of being a twin

Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex

Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo site inhibitor bound

Superoxide anion generation by the cytochrome bc1 complex ⬇️

The dimeric structure of the cytochrome bc(1) complex prevents center P inhibition by reverse reactions at center N.

The rate-limiting step in the cytochrome bc1 complex (Ubiquinol-Cytochrome c Oxidoreductase) is not changed by inhibition of cytochrome b-dependent deprotonation: implications for the mechanism of ubiquinol oxidation at center P of the bc1 complex