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List of works by Eric P. Krenning

"To serve and protect": enzyme inhibitors as radiopeptide escorts promote tumor targeting

scientific article published on 28 November 2013

(68)Ga-labeled DOTA-peptides and (68)Ga-labeled radiopharmaceuticals for positron emission tomography: current status of research, clinical applications, and future perspectives

scientific article

(99m)Tc-labeled gastrins of varying peptide chain length: Distinct impact of NEP/ACE-inhibition on stability and tumor uptake in mice

scientific article published on 19 March 2016

111In-labelled somatostatin analogues in a rat tumour model: somatostatin receptor status and effects of peptide receptor radionuclide therapy

scientific article published on 15 July 2005

99mTc radiotracers based on human GRP(18-27): synthesis and comparative evaluation

scientific article published on 5 September 2013

99mTc-tetrofosmin or 99mTc-sestamibi for double-phase parathyroid scintigraphy?

scientific article

A Delphic consensus assessment: imaging and biomarkers in gastroenteropancreatic neuroendocrine tumor disease management

scientific article published on 31 August 2016

A standardised study to compare prostate cancer targeting efficacy of five radiolabelled bombesin analogues

scientific article

A stylized computational model of the rat for organ dosimetry in support of preclinical evaluations of peptide receptor radionuclide therapy with (90)Y, (111)In, or (177)Lu.

scientific article published in July 2004

Amifostine protects rat kidneys during peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]octreotate.

scientific article published on 5 December 2006

Anaphylactoid reaction from amifostine

scientific article published on 20 December 2006

Androgen-dependent expression of the gastrin-releasing peptide receptor in human prostate tumor xenografts

scientific article published on January 2007

Androgen-regulated gastrin-releasing peptide receptor expression in androgen-dependent human prostate tumor xenografts

scientific article published in June 2010

Anti-tumor effect and increased survival after treatment with [177Lu-DOTA0,Tyr3]octreotate in a rat liver micrometastases model

scientific article

Anticancer activity of targeted proapoptotic peptides.

scientific article published in January 2006

Bone marrow dosimetry in peptide receptor radionuclide therapy with [177Lu-DOTA(0),Tyr(3)]octreotate

scientific article published on 27 February 2009

Characteristics of SnO2-based 68Ge/68Ga generator and aspects of radiolabelling DOTA-peptides ⬇️

scientific article published on November 23, 2010

Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs.

scientific article

Comparison of [(177)Lu-DOTA(0),Tyr(3)]octreotate and [(177)Lu-DOTA(0),Tyr(3)]octreotide: which peptide is preferable for PRRT?

scientific article published on 18 July 2006

Comparison of response evaluation in patients with gastroenteropancreatic and thoracic neuroendocrine tumors after treatment with [177Lu-DOTA0,Tyr3]octreotate

scientific article published in October 2013

Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma

scientific article published on 06 March 2009

Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumors – Well-Differentiated Jejunal-Ileal Tumor/Carcinoma

scientific article published on 12 December 2007

Crucial role for somatostatin receptor subtype 2 in determining the uptake of [111In-DTPA-D-Phe1]octreotide in somatostatin receptor-positive organs.

scientific article published in August 2003

Cubilin and megalin in radiation-induced renal injury with labelled somatostatin analogues: are we just dealing with the kidney?

scientific article published on 01 June 2006

DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals

scientific article published on 21 August 2003

Diagnostic imaging of dopamine receptors in pituitary adenomas

scientific article published on April 2007

Diagnostic versus therapeutic doses of [(177)Lu-DOTA-Tyr(3)]-octreotate: uptake and dosimetry in somatostatin receptor-positive tumors and normal organs

scientific article published on 01 February 2007

Dopamine agonist therapy of clinically non-functioning pituitary macroadenomas. Is there a role for 123I-epidepride dopamine D2 receptor imaging?

scientific article published in November 2006

Dosimetry of yttrium-labelled radiopharmaceuticals for internal therapy: 86Y or 90Y imaging?

scientific article published on 11 March 2011

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Peptide Receptor Radionuclide Therapy with Radiolabelled Somatostatin Analogues

article

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological, Nuclear Medicine and Hybrid Imaging

scientific article published on 30 March 2017

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: peptide receptor radionuclide therapy with radiolabeled somatostatin analogs

scientific article published on 28 August 2009

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: somatostatin receptor imaging with (111)In-pentetreotide

scientific article published on 28 August 2009

ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary

scientific article

Effect of diabetes mellitus on myocardial 18F-FDG SPECT using acipimox for the assessment of myocardial viability

scientific article

Effects of therapy with [177Lu-DOTA 0,Tyr 3]octreotate on endocrine function

scientific article published on 27 May 2009

Effects of therapy with [177Lu-DOTA0, Tyr3]octreotate in patients with paraganglioma, meningioma, small cell lung carcinoma, and melanoma

scientific article published on 01 October 2006

Endocrine tumours of the gastrointestinal tract. Peptide receptor radionuclide therapy

scientific article

Feasibility and image quality of dual-isotope SPECT using 18F-FDG and (99m)Tc-tetrofosmin after acipimox administration.

scientific article

Five Stabilized 111In-labeled neurotensin analogs in nude mice bearing HT29 tumors

scientific article published on 01 June 2007

From outside to inside? Dose-dependent renal tubular damage after high-dose peptide receptor radionuclide therapy in rats measured with in vivo (99m)Tc-DMSA-SPECT and molecular imaging

scientific article published on 01 February 2007

Gastrin releasing peptide receptor-directed radioligands based on a bombesin antagonist: synthesis, (111)in-labeling, and preclinical profile

scientific article published on 8 March 2013

Gastroenteropancreatic neuroendocrine tumours

scientific article

Health-Related Quality of Life in Patients With Progressive Midgut Neuroendocrine Tumors Treated With 177Lu-Dotatate in the Phase III NETTER-1 Trial.

scientific article published on 7 June 2018

Hormonal crises following receptor radionuclide therapy with the radiolabeled somatostatin analogue [177Lu-DOTA0,Tyr3]octreotate.

scientific article published on 16 January 2008

Hypocalcaemia after treatment with [177Lu-DOTA 0,Tyr3]octreotate

scientific article published on 23 July 2013

Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [(111)In-DOTA]MG11-first estimates for clinical translation

scientific article published on 16 February 2016

Impact of diabetes mellitus on prediction of clinical outcome after coronary revascularization by 18F-FDG SPECT in patients with ischemic left ventricular dysfunction.

scientific article published in January 2006

Impact of liver tumour burden, alkaline phosphatase elevation, and target lesion size on treatment outcomes with 177Lu-Dotatate: an analysis of the NETTER-1 study

scientific article published on 02 March 2020

Improved Control of Severe Hypoglycemia in Patients with Malignant Insulinomas by Peptide Receptor Radionuclide Therapy ⬇️

scientific article published on September 14, 2011

Improving the In Vivo Profile of Minigastrin Radiotracers: A Comparative Study Involving the Neutral Endopeptidase Inhibitor Phosphoramidon

scientific article published on 01 February 2016

In vivo and in vitro detection of dopamine d2 receptors in uveal melanomas

scientific article published on December 2003

In vivo enzyme inhibition improves the targeting of [177Lu]DOTA-GRP(13-27) in GRPR-positive tumors in mice

scientific article published on 6 October 2014

In vivo inhibition of neutral endopeptidase enhances the diagnostic potential of truncated gastrin (111)In-radioligands

scientific article published on 29 July 2015

Increased cell death after therapy with an Arg-Gly-Asp-linked somatostatin analog.

scientific article

Induction of apoptosis with hybrids of Arg-Gly-Asp molecules and peptides and antimitotic effects of hybrids of cytostatic drugs and peptides.

scientific article

Inhibition of kidney uptake of radiolabeled somatostatin analogs: amino acids or gelofusine?

scientific article published on 01 October 2006

Inhomogeneous localization of radioactivity in the human kidney after injection of [(111)In-DTPA]octreotide.

scientific article published in July 2004

Localisation and mechanism of renal retention of radiolabelled somatostatin analogues

scientific article published on 24 May 2005

Long-Term Efficacy, Survival, and Safety of [177Lu-DOTA0,Tyr3]octreotate in Patients with Gastroenteropancreatic and Bronchial Neuroendocrine Tumors.

scientific article

Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0),Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate

scientific article published in January 2005

Long-term prognostic value of dobutamine stress echocardiography compared with myocardial perfusion scanning in patients unable to perform exercise tests

scientific article

Long-term tolerability of PRRT in 807 patients with neuroendocrine tumours: the value and limitations of clinical factors

scientific article published on 2 October 2014

Long-term toxicity of [(177)Lu-DOTA (0),Tyr (3)]octreotate in rats

scientific article published on 22 September 2006

Low-dose-rate irradiation by 131I versus high-dose-rate external-beam irradiation in the rat pancreatic tumor cell line CA20948.

scientific article published on June 2004

Lutetium-labelled peptides for therapy of neuroendocrine tumours ⬇️

scientific article published on February 1, 2012

Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotide.

scientific article

Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene

scientific article published on February 2004

Molecular imaging as in vivo molecular pathology for gastroenteropancreatic neuroendocrine tumors: implications for follow-up after therapy

scientific article published on 01 January 2005

Molecular radiotherapy with somatostatin analogs for (neuro-)endocrine tumors.

scientific article

NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the thorax (includes lung and thymus).

scientific article published on August 2010

Neoadjuvant Treatment of Nonfunctioning Pancreatic Neuroendocrine Tumors with [177Lu-DOTA0,Tyr3]Octreotate

scientific article published on 13 August 2015

Nephrotoxicity after PRRT with (177)Lu-DOTA-octreotate

scientific article published on 10 May 2016

Neuroendocrine Tumors

Neuroendocrine tumors. Peptide receptor radionuclide therapy

scientific article published on March 2007

Neuroendocrine tumours: the role of imaging for diagnosis and therapy

scientific article published on 10 December 2013

New advances in peptide receptor radionuclide therapy.

scientific article

Nuclear medicine techniques for the imaging and treatment of neuroendocrine tumours

scientific article published on 17 October 2011

Octreoscan Radioreceptor Imaging ⬇️

scientific article published on April 1, 2003

Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities

scientific article published on 4 April 2003

Oral versus intravenous administration of lysine: equal effectiveness in reduction of renal uptake of [111In-DTPA]octreotide.

scientific article

Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs.

scientific article

PRRT genomic signature in blood for prediction of 177Lu-octreotate efficacy.

scientific article published on 26 February 2018

PRRT neuroendocrine tumor response monitored using circulating transcript analysis: the NETest

scientific article published on 14 December 2019

Patient-specific dosimetry in predicting renal toxicity with (90)Y-DOTATOC: relevance of kidney volume and dose rate in finding a dose-effect relationship

scientific article published in January 2005

Peptide Receptor Radionuclide Therapy with radiolabelled somatostatin analogues in patients with somatostatin receptor positive tumours

scientific article published on January 2007

Peptide receptor imaging and therapy

scientific article

Peptide receptor radionuclide therapy

scientific article

Peptide receptor radionuclide therapy (PRRT) for GEP-NETs

scientific article published in December 2012

Peptide receptor radionuclide therapy for non-radioiodine-avid differentiated thyroid carcinoma

scientific article published in January 2005

Peptide receptor radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors

scientific article

Peptide receptor radionuclide therapy in vitro using [111In-DTPA0]octreotide.

scientific article published on January 2003

Peptide receptor radionuclide therapy with 177Lu-DOTATATE for patients with somatostatin receptor-expressing neuroendocrine tumors: the first US phase 2 experience

scientific article published in May 2014

Peptide receptor radionuclide therapy with 177Lu-octreotate in patients with foregut carcinoid tumours of bronchial, gastric and thymic origin

scientific article published on 27 January 2007

Peptide-receptor radionuclide therapy for endocrine tumors

scientific article published on 02 June 2009

Peptides and Monoclonal Antibodies in Oncology: An Introduction ⬇️

scientific article published on 01 August 2003

Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors.

scientific article

Phase I study of peptide receptor radionuclide therapy with [In-DTPA]octreotide: the Rotterdam experience

scientific article published in April 2002

Pitfalls in the response evaluation after peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]octreotate

scientific article published on 20 March 2017

Practical dosimetry of peptide receptor radionuclide therapy with (90)Y-labeled somatostatin analogs.

scientific article

Preclinical and clinical studies of peptide receptor radionuclide therapy

scientific article published on May 2010

Preclinical and first clinical experience with the gastrin-releasing peptide receptor-antagonist [⁶⁸Ga]SB3 and PET/CT.

scientific article published on 2 December 2015

Preclinical comparison of (111)In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy.

scientific article published in December 2002

Preoperative comparison of different noninvasive strategies for predicting improvement in left ventricular function after coronary artery bypass grafting

scientific article published on July 2003

Prognostic implications of a normal stress technetium-99m-tetrofosmin myocardial perfusion study in patients with a healed myocardial infarct and/or previous coronary revascularization

scientific article published on 4 November 2005

Quality of Life in 265 Patients with Gastroenteropancreatic or Bronchial Neuroendocrine Tumors Treated with [177Lu-DOTA0,Tyr3]Octreotate ⬇️

scientific article published on July 27, 2011

Quality of life in patients with gastroenteropancreatic tumors treated with [177Lu-DOTA0,Tyr3]octreotate

scientific article

Radiation dose distribution in human kidneys by octreotides in peptide receptor radionuclide therapy

scientific article published on 01 January 2007

Radiolabeled RGD-DTPA-Tyr3-octreotate for receptor-targeted radionuclide therapy

scientific article published on April 2004

Radiolabeled Somatostatin Analogue Therapy Of Gastroenteropancreatic Cancer

scientific article published on May 2016

Radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3]octreotate in patients with endocrine gastroenteropancreatic tumors

scientific article

Radiolabelled peptides for tumour therapy: current status and future directions. Plenary lecture at the EANM 2002.

scientific article

Radiolabelling DOTA-peptides with 68Ga

scientific article published on 18 January 2005

Rare functioning pancreatic endocrine tumors

scientific article published on January 2006

Receptor imaging in the diagnosis and treatment of pituitary tumors

scientific article

Reduction of Renal Uptake of Radiolabeled Octreotate by Amifostine Coadministration ⬇️

scientific article published on April 10, 2012

Reduction of skeletal accumulation of radioactivity by co-injection of DTPA in [90Y-DOTA0,Tyr3]octreotide solutions containing free 90Y3+.

scientific article published in August 2004

Refractory immune-mediated and haematological diseases: candidates for peptide receptor radiotherapy?

scientific article

Renal uptake and retention of radiolabeled somatostatin, bombesin, neurotensin, minigastrin and CCK analogues: species and gender differences

scientific article published in August 2007

Report on short-term side effects of treatments with 177Lu-octreotate in combination with capecitabine in seven patients with gastroenteropancreatic neuroendocrine tumours

scientific article

Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy

scientific article published on 13 July 2010

Safe and effective inhibition of renal uptake of radiolabelled octreotide by a combination of lysine and arginine

scientific article

Salvage peptide receptor radionuclide therapy with [177Lu-DOTA,Tyr3]octreotate in patients with bronchial and gastroenteropancreatic neuroendocrine tumours

scientific article published on 28 September 2018

Salvage therapy with (177)Lu-octreotate in patients with bronchial and gastroenteropancreatic neuroendocrine tumors

scientific article

Somatostatin analogs for the treatment of neuroendocrine tumors.

scientific article published on March 2011

Somatostatin receptor gene therapy combined with targeted therapy with radiolabeled octreotide: a new treatment for liver metastases

scientific article published in December 2002

Somatostatin receptor imaging

scientific article

Somatostatin receptor imaging for neuroendocrine tumors

scientific article published on January 2006

Somatostatin receptor subtype 2-mediated uptake of radiolabelled somatostatin analogues in the human kidney

scientific article published on 02 June 2007

Somatostatin receptor-targeted radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors

scientific article published on March 2011

Somatostatin receptor-targeted radionuclide therapy of tumors: preclinical and clinical findings

scientific article

Somatostatin-receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors

scientific article published on 29 January 2010

Staging and treatment of differentiated thyroid carcinoma with radiolabeled somatostatin analogs

scientific article

Subacute haematotoxicity after PRRT with (177)Lu-DOTA-octreotate: prognostic factors, incidence and course

scientific article published on 30 September 2015

The addition of DTPA to [177Lu-DOTA0,Tyr3]octreotate prior to administration reduces rat skeleton uptake of radioactivity

scientific article

The inhibitory effect of (111)In-DTPA(0)-octreotide on intrahepatic tumor growth after partial hepatectomy

scientific article published in December 2002

Theranostic Perspectives in Prostate Cancer with the Gastrin-Releasing Peptide Receptor Antagonist NeoBOMB1: Preclinical and First Clinical Results

scientific article published on 4 August 2016

Therapy using labelled somatostatin analogues: comparison of the absorbed doses with 111In-DTPA-D-Phe1-octreotide and yttrium-labelled DOTA-D-Phe1-Tyr3-octreotide

scientific article

Therapy-related hematological malignancies after peptide receptor radionuclide therapy with (177)Lu-DOTA-Octreotate: Incidence, course & predicting factors in patients with GEP-NETs

scientific article published on 03 August 2017

Treatment of Gastroenteropancreatic Neuroendocrine Tumors with Peptide Receptor Radionuclide Therapy ⬇️

scientific article published on January 10, 2012

Treatment of patients who have endocrine gastroenteropancreatic tumors with radiolabeled somatostatin analogues

scientific article published on June 2007

Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [177Lu-DOTA(0),Tyr3]octreotate

scientific article

Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survival

scientific article published in May 2008

Tumor Response Assessment to Treatment with [177Lu-DOTA0,Tyr3]Octreotate in Patients with Gastroenteropancreatic and Bronchial Neuroendocrine Tumors: Differential Response of Bone Versus Soft-Tissue Lesions ⬇️

scientific article published on July 10, 2012

Tumor diagnosis with new 111In-radioligands based on truncated human gastrin releasing peptide sequences: synthesis and preclinical comparison

scientific article published on 23 October 2013

Tumor imaging and therapy using radiolabeled somatostatin analogues.

scientific article published in July 2009

Tyr3-octreotide and Tyr3-octreotate radiolabeled with 177Lu or 90Y: peptide receptor radionuclide therapy results in vitro

scientific article published on October 2003

Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms

scientific article published on 28 August 2018

Uptake of [111In-DTPA0]octreotide in the rat kidney is inhibited by colchicine and not by fructose

scientific article published in April 2004

[(111)In-DTPA]octreotide tumor uptake in GEPNET liver metastases after intra-arterial administration: an overview of preclinical and clinical observations and implications for tumor radiation dose after peptide radionuclide therapy

scientific article published on 01 May 2014

[(123)I]metaiodobenzylguanidine and [(111)In]octreotide uptake in begnign and malignant pheochromocytomas

scientific article

[(99m)Tc]Demotate 2 in the detection of sst(2)-positive tumours: a preclinical comparison with [(111)In]DOTA-tate

scientific article published on 28 March 2006

[DOTA]Somatostatin-14 analogs and their (111)In-radioligands: effects of decreasing ring-size on sst1-5 profile, stability and tumor targeting

scientific article

mTOR Inhibitor RAD001 Promotes Metastasis in a Rat Model of Pancreatic Neuroendocrine Cancer ⬇️

scientific article published on November 13, 2012

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