List of works - David E. Briles

A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly

scientific article

Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins

scientific article

Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae

scientific article

CCL5-independent helper T lymphocyte responses to immuno-dominant pneumococcal surface protein A epitopes

scientific article published on 14 December 2011

Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence

scientific article

Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model.

scientific article published on 29 January 2007

Decrease in penicillin susceptibility due to heat shock protein ClpL in Streptococcus pneumoniae.

scientific article

Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae.

scientific article published on 6 November 2006

Development of antibodies to PspA families 1 and 2 in children after exposure to Streptococcus pneumoniae

scientific article published on 27 August 2008

Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage

scientific article

Distribution of pneumococcal surface protein A families 1 and 2 among Streptococcus pneumoniae isolates from children in finland who had acute otitis media or were nasopharyngeal carriers

scientific article published on 27 August 2008

Effect of apolactoferrin on experimental pneumococcal otitis media

scientific article

Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.

scientific article

Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface

scientific article

Effects of zinc deficiency and pneumococcal surface protein a immunization on zinc status and the risk of severe infection in mice

scientific article

Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae ⬇️

scientific article

Ethanol-induced alcohol dehydrogenase E (AdhE) potentiates pneumolysin in Streptococcus pneumoniae.

scientific article

Evaluation of a vaccine formulation against Streptococcus pneumoniae based on choline-binding proteins

scientific article

Evolution and virulence of serogroup 6 pneumococci on a global scale

scientific article

Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae infection is dependent on pneumococcal neuraminidase A.

scientific article

Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A.

scientific article

Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection

scientific article

Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12.

scientific article

Mapping of epitopes recognized by antibodies induced by immunization of mice with PspA and PspC.

scientific article

Maternal immunization with pneumococcal surface protein A protects against pneumococcal infections among derived offspring

scientific article (publication date: 2011)

Mn2+-dependent regulation of multiple genes in Streptococcus pneumoniae through PsaR and the resultant impact on virulence

scientific article

Mouse, but not human, ApoB-100 lipoprotein cholesterol is a potent innate inhibitor of Streptococcus pneumoniae pneumolysin

scientific article

Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection

scientific article

Nontypeable pneumococci can be divided into multiple cps types, including one type expressing the novel gene pspK

scientific article published on 24 April 2012

Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection ⬇️

scientific article published on November 10, 2003

Protection of the elderly from pneumococcal pneumonia with a protein-based vaccine?

scientific article published on February 2004

PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation

scientific article

PspA family distribution, antimicrobial resistance and serotype of Streptococcus pneumoniae isolated from upper respiratory tract infections in Japan

scientific article

PspA family distribution, unlike capsular serotype, remains unaltered following introduction of the heptavalent pneumococcal conjugate vaccine

scientific article

Regions of PspA/EF3296 best able to elicit protection against Streptococcus pneumoniae in a murine infection model

scientific article

Relative fitness of fluoroquinolone-resistant Streptococcus pneumoniae

scientific article

Relative roles of genetic background and variation in PspA in the ability of antibodies to PspA to protect against capsular type 3 and 4 strains of Streptococcus pneumoniae

scientific article

Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae

scientific article

Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin

scientific article

Serum antibodies to pneumococcal neuraminidase NanA in relation to pneumococcal carriage and acute otitis media

scientific article

Specific immunization strategies against oxidized low-density lipoprotein: a novel way to reduce nonalcoholic steatohepatitis in mice

scientific article

Streptococcus pneumoniae isolates from middle ear fluid and nasopharynx of children with acute otitis media exhibit phase variation

scientific article

Structure of a complex of human lactoferrin N-lobe with pneumococcal surface protein a provides insight into microbial defense mechanism

scientific article

The Effects of CFTR and Mucoid Phenotype on Susceptibility and Innate Immune Responses in a Mouse Model of Pneumococcal Lung Disease.

scientific article published on 15 October 2015

The nasal dendritic cell-targeting Flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcal pneumonia

scientific article

List of works by David E. Briles

A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly

Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins

Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae

CCL5-independent helper T lymphocyte responses to immuno-dominant pneumococcal surface protein A epitopes

Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence

Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model.

Decrease in penicillin susceptibility due to heat shock protein ClpL in Streptococcus pneumoniae.

Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae.

Development of antibodies to PspA families 1 and 2 in children after exposure to Streptococcus pneumoniae

Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage

Distribution of pneumococcal surface protein A families 1 and 2 among Streptococcus pneumoniae isolates from children in finland who had acute otitis media or were nasopharyngeal carriers

Effect of apolactoferrin on experimental pneumococcal otitis media

Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.

Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface

Effects of zinc deficiency and pneumococcal surface protein a immunization on zinc status and the risk of severe infection in mice

Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae ⬇️

Ethanol-induced alcohol dehydrogenase E (AdhE) potentiates pneumolysin in Streptococcus pneumoniae.

Evaluation of a vaccine formulation against Streptococcus pneumoniae based on choline-binding proteins

Evolution and virulence of serogroup 6 pneumococci on a global scale

Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae infection is dependent on pneumococcal neuraminidase A.

Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A.

Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection

Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12.

Mapping of epitopes recognized by antibodies induced by immunization of mice with PspA and PspC.

Maternal immunization with pneumococcal surface protein A protects against pneumococcal infections among derived offspring

Mn2+-dependent regulation of multiple genes in Streptococcus pneumoniae through PsaR and the resultant impact on virulence

Mouse, but not human, ApoB-100 lipoprotein cholesterol is a potent innate inhibitor of Streptococcus pneumoniae pneumolysin

Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection

Nontypeable pneumococci can be divided into multiple cps types, including one type expressing the novel gene pspK

Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection ⬇️

Protection of the elderly from pneumococcal pneumonia with a protein-based vaccine?

PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation

PspA family distribution, antimicrobial resistance and serotype of Streptococcus pneumoniae isolated from upper respiratory tract infections in Japan

PspA family distribution, unlike capsular serotype, remains unaltered following introduction of the heptavalent pneumococcal conjugate vaccine

Regions of PspA/EF3296 best able to elicit protection against Streptococcus pneumoniae in a murine infection model

Relative fitness of fluoroquinolone-resistant Streptococcus pneumoniae

Relative roles of genetic background and variation in PspA in the ability of antibodies to PspA to protect against capsular type 3 and 4 strains of Streptococcus pneumoniae

Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae

Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin

Serum antibodies to pneumococcal neuraminidase NanA in relation to pneumococcal carriage and acute otitis media

Specific immunization strategies against oxidized low-density lipoprotein: a novel way to reduce nonalcoholic steatohepatitis in mice

Streptococcus pneumoniae isolates from middle ear fluid and nasopharynx of children with acute otitis media exhibit phase variation

Structure of a complex of human lactoferrin N-lobe with pneumococcal surface protein a provides insight into microbial defense mechanism

The Effects of CFTR and Mucoid Phenotype on Susceptibility and Innate Immune Responses in a Mouse Model of Pneumococcal Lung Disease.

The nasal dendritic cell-targeting Flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcal pneumonia