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List of works by Richard M. Kream

A Novel Vaccine Employing Non-Replicating Rabies Virus Expressing Chimeric SARS-CoV-2 Spike Protein Domains: Functional Inhibition of Viral/Nicotinic Acetylcholine Receptor Complexes

scientific article published on 28 May 2020

A functionally coupled mu3-like opiate receptor/nitric oxide regulatory pathway in human multi-lineage progenitor cells.

scientific article

ADHD and growth: questions still unanswered

scientific article published on January 2014

Aging Reversal and Healthy Longevity is in Reach: Dependence on Mitochondrial DNA Heteroplasmy as a Key Molecular Target.

scientific article published on 5 June 2017

Alcohol-, nicotine-, and cocaine-evoked release of morphine from human white blood cells: substances of abuse actions converge on endogenous morphine release.

scientific article published in November 2006

Alcohol-, nicotine-, and cocaine-evoked release of morphine from invertebrate ganglia: model system for screening drugs of abuse.

scientific article published in May 2006

Alkaloids, Nitric Oxide, and Nitrite Reductases: Evolutionary Coupling as Key Regulators of Cellular Bioenergetics with Special Relevance to the Human Microbiome.

scientific article published on 14 May 2018

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

scientific article published on 05 May 2020

Anti-Diabetogenic Properties of Mineralocorticoid Receptor Antagonists: Implications for Enhanced Safety and Efficacy of Post-Transplantation Pharmacotherapies

Antibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric Disorders

scientific article (publication date: 7 January 2017)

Artificial Intelligence, DNA Mimicry, and Human Health

scientific article published on 14 August 2017

Association Between Red Blood Cell Distribution Width and Prognosis of Renal Transplant Recipients with Early-Onset Pneumonia

scientific article published on 04 September 2019

Augmentation of Whole-Body Metabolic Status by Mind-Body Training: Synchronous Integration of Tissue- and Organ-Specific Mitochondrial Function

scientific article published on 11 January 2019

Behaviorally-Mediated Entrainment of Whole-Body Metabolic Processes: Conservation and Evolutionary Development of Mitochondrial Respiratory Complexes

scientific article published on 06 December 2019

Biological indications of a novel "short" µ opiate receptor in domestic chicken

scientific article published on August 2010

Burnout syndrome in medical professionals: a manifestation of chronic stress with counterintuitive passive characteristics

scientific article published on January 2013

Cancer: Mitochondrial Origins

scientific article

Catechol-O-methyltransferase: potential relationship to idiopathic hypertension

scientific article

Cholinergic regulation of endogenous morphine release from lobster nerve cord.

scientific article published in September 2006

Chromosomal Processes in Mind-Body Medicine: Chronic Stress, Cell Aging, and Telomere Length

scientific article published on 17 September 2018

Chronic alcohol exposure increases ganglia endogenous morphine levels.

scientific article

Co-morbidity and self medication in schizophrenia: involvement of endogenous morphine signaling mechanisms.

scientific article published on October 2012

Comparing bioinformatic gene expression profiling methods: microarray and RNA-Seq

scientific article

Convalescent Memory T Cell Immunity in Individuals with Mild or Asymptomatic SARS-CoV-2 Infection May Result from an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'

scientific article published on 26 November 2020

Convergent dysregulation of frontal cortical cognitive and reward systems in eating disorders.

scientific article published on 10 May 2013

Converging cellular processes for substances of abuse: endogenous morphine.

scientific article

DNA MemoChip: Long-Term and High Capacity Information Storage and Select Retrieval.

scientific article published on 26 February 2018

De novo biosynthesis of morphine in animal cells: an evidence-based model.

scientific article

Disruptive patterns of eating behaviors and associated lifestyles in males with ADHD.

scientific article published on 14 April 2014

Dopamine Coupling to Mitochondrial Signaling: Implications for Transplantation

scientific article

Dopamine, morphine, and nitric oxide: an evolutionary signaling triad.

scientific article

Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review)

scientific article

Dysregulation of Nitric Oxide Signaling in Microglia: Multiple Points of Functional Convergence in the Complex Pathophysiology of Alzheimer Disease

scientific article published on 25 September 2020

Emerging Roles of Blood-Borne Intact and Respiring Mitochondria as Bidirectional Mediators of Pro- and Anti-Inflammatory Processes

scientific article published on 30 March 2020

Emerging regulatory roles of opioid peptides, endogenous morphine, and opioid receptor subtypes in immunomodulatory processes: Metabolic, behavioral, and evolutionary perspectives

scientific article published on 19 August 2020

Endogenous morphine and nitric oxide coupled regulation of mitochondrial processes

scientific article published on December 2009

Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition

scientific article published on 16 June 2007

Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review).

scientific article published on December 2007

Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: implications for cancer biology.

scientific article published on 08 December 2007

Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors

scientific article published on 05 December 2007

Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part I).

scientific article

Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part II)

scientific article

Glycolytic Coupling to Mitochondrial Energy Production Ensures Survival in an Oxygen Rich Environment

scientific article

Homeopathic ethanol

scientific article published in September 2008

Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders

scientific article

Hypoxia defined as a common culprit/initiation factor in mitochondrial-mediated proinflammatory processes

scientific article published on 22 May 2015

Identification of a µ opiate receptor signaling mechanism in human placenta.

scientific article published on November 2010

Interactive effects of endogenous morphine, nitric oxide, and ethanol on mitochondrial processes.

scientific article published on 26 October 2010

Long-Term Respiratory and Neurological Sequelae of COVID-19

scientific article published on 01 November 2020

Low dose morphine adjuvant therapy for enhanced efficacy of antipsychotic drug action: potential involvement of endogenous morphine in the pathophysiology of schizophrenia

scientific article

Microbiome and Health: Ramifications of Intelligent Deception.

scientific article published on 7 April 2018

Microbiome: A Potential Component in the Origin of Mental Disorders.

scientific article

Mitochondria, Chloroplasts in Animal and Plant Cells: Significance of Conformational Matching

scientific article (publication date: 2015)

Mitochondrial DNA heteroplasmy in human health and disease.

scientific article published on 4 February 2016

Mitochondrial Heteroplasmy.

scientific article

Morphine stimulates nitric oxide release in human mitochondria.

scientific article published on 9 September 2015

Morphine synthesis in animals

scientific article published on 25 September 2006

Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis.

scientific article published on June 2007

Nitric Oxide Regulation of Mitochondrial Processes: Commonality in Medical Disorders

scientific article

Opioid peptides and opiate alkaloids in immunoregulatory processes

scientific article

Parkinson's disease, L-DOPA, and endogenous morphine: a revisit

scientific article

Persistence of evolutionary memory: primordial six-transmembrane helical domain mu opiate receptors selectively linked to endogenous morphine signaling.

scientific article published in December 2007

Personalized- and one- medicine: bioinformatics foundation in health and its economic feasibility

scientific article

Potential Immunoregulatory and Antiviral/SARS-CoV-2 Activities of Nitric Oxide

scientific article published on 26 May 2020

Prebiotic Formation of Protoalkaloids within Alkaline Oceanic Hydrothermal Vents in the Hadean Seafloor as a Prerequisite for Evolutionary Biodiversity

scientific article published on 22 September 2020

Profiles of B-cell subsets in immunologically stable renal allograft recipients and end-stage renal disease patients

scientific article published on 15 October 2019

Proinflammation and preconditioning protection are part of a common nitric oxide mediated process.

scientific article published on June 2010

Reciprocal Evolution of Opiate Science from Medical and Cultural Perspectives

scientific article published on 13 June 2017

Reciprocal regulation of cellular nitric oxide formation by nitric oxide synthase and nitrite reductases.

scientific article published on October 2011

Revisiting tolerance from the endogenous morphine perspective

scientific article published on September 2009

Synthesis and pharmacological analysis of a morphine/substance P chimeric molecule with full analgesic potency in morphine-tolerant rats.

scientific article

TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues

scientific article

Targeted D4 dopamine receptors: implications for drug discovery and therapeutic development

scientific article

Targeting mitochondrial biogenesis for promoting health

scientific article

The Micro-Hospital: 5G Telemedicine-Based Care

scientific article published on 14 July 2018

The presence of endogenous morphine signaling in animals

scientific article published on 06 September 2008

Variations in critical morphine biosynthesis genes and their potential to influence human health.

scientific article published on January 2010

Vascular dysfunction associated with type 2 diabetes and Alzheimer's disease: a potential etiological linkage

scientific article

Xenobiotic perturbation of endogenous morphine signaling: paradoxical opiate hyperalgesia

scientific article published on May 2009

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