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List of works by Gerard C Blobe

3292 Duke Integrated Physician-Scientist Development

A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma

scientific article published on 29 December 2006

A Phase II Study of Capecitabine, Oxaliplatin, and Bevacizumab in the Treatment of Metastatic Esophagogastric Adenocarcinomas ⬇️

scientific article published on March 13, 2013

A Phase II Study of Oxaliplatin, Dose-intense Capecitabine, and High-dose Bevacizumab in the Treatment of Metastatic Colorectal Cancer ⬇️

scientific article published on April 24, 2011

A phase I dose-escalation study of imatinib mesylate (Gleevec/STI571) plus capecitabine (Xeloda) in advanced solid tumors

scientific article

A phase I study of ABT‐510 plus bevacizumab in advanced solid tumors ⬇️

scientific article published on March 21, 2013

A phase I study of bevacizumab (B) in combination with everolimus (E) and erlotinib (E) in advanced cancer (BEE).

scientific article

A phase I study of bevacizumab, everolimus and panitumumab in advanced solid tumors ⬇️

scientific article published on May 26, 2012

A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer ⬇️

scientific article published on January 1, 2011

A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer

scientific article published on 27 July 2011

A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial)

scientific article published on 23 August 2019

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration

scientific article

An Automated High-throughput Array Microscope for Cancer Cell Mechanics

scientific article

Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction

scientific article

BMP-2 and TGFβ2 Shared Pathways Regulate Endocardial Cell Transformation ⬇️

scientific article published on January 7, 2011

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

scientific article

Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results

scientific article published on 01 June 2007

Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2.

scientific article published on 04 December 2008

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

scientific article

Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling

scientific article

Cell-surface co-receptors: emerging roles in signaling and human disease

scientific article (publication date: November 2005)

Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades

scientific article

Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs

scientific article

Development of human protein reference database as an initial platform for approaching systems biology in humans

scientific article (publication date: October 2003)

Dichotomous roles of TGF-β in human cancer

scientific article published on October 2016

Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion

scientific article

Effects of the combination of TRC105 and bevacizumab on endothelial cell biology

scientific article published on 5 July 2014

Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC.

scientific article

Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation

scientific article published on 8 October 2008

Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading.

scientific article

Endoglin interacts with VEGFR2 to promote angiogenesis.

scientific article published on 11 January 2018

Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells

scientific article

Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.

scientific article published on 5 September 2008

Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis

scientific article

Erratum to: angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction

scientific article published on 01 March 2015

Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta

scientific article

Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage

scientific article published on 2 February 2010

Heparan sulfate signaling in cancer

scientific article (publication date: June 2014)

Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation

scientific article

Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results

scientific article published in February 2006

Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition

scientific article published on 14 January 2019

Inhibiting the TGF-beta signalling pathway as a means of cancer immunotherapy

scientific article

Loss of betaglycan expression in ovarian cancer: role in motility and invasion

scientific article published on 23 May 2007

Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression

scientific article

Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.

scientific article published on 3 June 2011

Molecular characterization of the tumor-suppressive function of nischarin in breast cancer

scientific article

Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development

scientific article published on 05 December 2013

Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer

scientific article

Phase I study of pazopanib plus TH-302 in advanced solid tumors

scientific article

Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.

scientific article published on 08 May 2009

Regulation of ALK-1 signaling by the nuclear receptor LXRbeta

scientific article

Regulation of TGF-β receptor hetero-oligomerization and signaling by endoglin.

scientific article

Role of TGF-β receptor III localization in polarity and breast cancer progression

scientific article

Role of transforming growth factor Beta in human cancer

scientific article

Role of transforming growth factor-beta in hematologic malignancies

scientific article

Role of transforming growth factor-beta superfamily signaling pathways in human disease

scientific article published on 11 February 2008

Roles for the type III TGF-beta receptor in human cancer

scientific article

Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer

scientific article published on 30 October 2013

Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGF-β Inhibitor Sequencing in Melanoma

scientific article published on 12 September 2018

Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth

scientific article

TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.

scientific article

TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3.

scientific article published on 7 September 2016

TbetaRIII suppresses non-small cell lung cancer invasiveness and tumorigenicity

scientific article published on 3 January 2008

The balance of cell surface and soluble type III TGF-β receptor regulates BMP signaling in normal and cancerous mammary epithelial cells

scientific article

The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells

scientific article published on 31 May 2007

The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors

scientific article published on 02 September 2009

The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.

scientific article

The type III TGF-beta receptor signals through both Smad3 and the p38 MAP kinase pathways to contribute to inhibition of cell proliferation

scientific article

The type III TGF-beta receptor suppresses breast cancer progression

scientific article

The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling

scientific article

The type III TGFbeta receptor regulates directional migration: new tricks for an old dog

scientific article published on 08 October 2009

The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer

scientific article published on February 2007

The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.

scientific article published on 26 March 2009

The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells

scientific article

The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells

scientific article

Type III TGF-β Receptor Enhances Colon Cancer Cell Migration and Anchorage-Independent Growth ⬇️

scientific article published on August 1, 2011

Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.

scientific article published on 08 August 2013

Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

scientific article

TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling.

scientific article

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