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List of works by Loek van Alphen

16th International Pathogenic Neisseria Conference: recent progress towards effective meningococcal disease vaccines.

scientific article published in February 2009

31P nuclear magnetic resonance and freeze-fracture electron microscopy studies on Escherichia coli. I. Cytoplasmic membrane and total phospholipids

scientific article published on 01 April 1980

31P nuclear magnetic resonance and freeze-fracture electron microscopy studies on Escherichia coli. II. Lipopolysaccharide and lipopolysaccharide-phospholipid complexes

scientific article published on April 1980

31P nuclear magnetic resonance and freeze-fracture electron microscopy studies on Escherichia coli. III. The outer membrane

scholarly article by E Burnell et al published 24 April 1980 in Biochimica et Biophysica Acta

A Neisserial autotransporter NalP modulating the processing of other autotransporters ⬇️

scientific article published on November 1, 2003

A family showing inheritance of the Anton blood group antigen An Wj and independence of An Wj from Lutheran ⬇️

scientific article published on December 1, 1991

A nosocomial outbreak of amoxycillin-resistant non-typable Haemophilus influenzae in a respiratory ward.

scientific article

A novel phase-variable autotransporter serine protease, AusI, of Neisseria meningitidis

scientific article published on 08 June 2006

A prospective, population-based study of Haemophilus influenzae type b meningitis in The Gambia and the possible consequences

scientific article

Absence of meningitis caused by Haemophilus influenzae type b in The Netherlands following twofold vaccination

scientific article

Airway inflammation in nonobstructive and obstructive chronic bronchitis with chronic haemophilus influenzae airway infection. Comparison with noninfected patients with chronic obstructive pulmonary disease

scientific article published on September 2000

An efficient procedure for the generation of human monoclonal antibodies based on activation of human B lymphocytes by a murine thymoma cell line

scientific article published on March 1993

Antibiotic susceptibility of invasive and non-invasive isolates of Haemophilus influenzae from the Gambia, west Africa.

scientific article

Antibodies to Haemophilus influenzae type b polysaccharide affect bacterial adherence and multiplication

scientific article

Antibody avidity and immunoglobulin G isotype distribution following immunization with a monovalent meningococcal B outer membrane vesicle vaccine

scientific article

Antibody responses to the capsular polysaccharide of Neisseria meningitidis serogroup B in patients with meningococcal disease

scientific article

Antigenic drift of Haemophilus influenzae in patients with chronic obstructive pulmonary disease.

scientific article published on October 1989

Antigenic drift of non-encapsulated Haemophilus influenzae major outer membrane protein P2 in patients with chronic bronchitis is caused by point mutations

scientific article published in March 1994

Antigenic sites on porin of Haemophilus influenzae type b: mapping with synthetic peptides and evaluation of structure predictions ⬇️

scientific article published on June 1, 1992

Antigenic variation of immunoglobulin A1 proteases among sequential isolates of Haemophilus influenzae from healthy children and patients with chronic obstructive pulmonary disease

scientific article published on November 1993

Antimicrobial Susceptibility of Haemophilus influenzae in the Respiratory Tracts of Patients with Cystic Fibrosis ⬇️

scientific article published on February 1, 1998

Architecture of the Outer Membrane of Escherichia coli III. Protein-Lipopolysaccharide Complexes in Intramembraneous Particles ⬇️

scientific article published on June 1, 1978

Architecture of the Outer Membrane of Escherichia coli K12. Phase Transitions of the Bacteriophage K3 Receptor Complex ⬇️

scientific article published on November 1, 1979

Architecture of the outer membrane of Escherichia coli K12 IV. Relationship between outer membrane particles and aqueous pores ⬇️

scientific article published on September 21, 1979

Architecture of the outer membrane of Escherichia coli K12. I. Action of phospholipases A2 and C on wild type strains and outer membrane mutants ⬇️

scientific article published on April 18, 1977

Architecture of the outer membrane of Escherichia coli K12. II. Freeze fractur morphology of wild type and mutant strains ⬇️

scientific article published on April 18, 1977

Bacteriologic epidemiology of Hemophilus influenzae type b strains causing invasive infections in Finland

scientific article published on 01 August 1989

Binding of Haemophilus influenzae to purified mucins from the human respiratory tract

scientific article

Biochemical characterization and worldwide distribution of serologically distinct lipopolysaccharides of Haemophilus influenzae type b

scientific article published on 01 September 1990

Blocking of fimbria-mediated adherence of Haemophilus influenzae by sialyl gangliosides ⬇️

scientific article published on December 1, 1991

Carriage of Haemophilus influenzae in healthy Gambian children

scientific article

Changes in outer membrane proteins of nontypable Haemophilus influenzae in patients with chronic obstructive pulmonary disease

scientific article published in August 1988

Changes in the distribution of Haemophilus influenzae type b clones associated with widespread infant vaccination in Finland

scientific article published on 01 December 1992

Characteristics of major outer membrane proteins of Haemophilus influenzae

scientific article

Characterization of adherence of nontypeable Haemophilus influenzae to human epithelial cells

scientific article

Characterization of genetic and phenotypic diversity of invasive nontypeable Haemophilus influenzae

scientific article

Cloning and expression in Escherichia coli of Haemophilus influenzae fimbrial genes establishes adherence to oropharyngeal epithelial cells

scientific article

Cloning of genes of nontypeable Haemophilus influenzae involved in penetration between human lung epithelial cells

scientific article

Combination vaccine against invasive meningococcal B and pneumococcal infections: potential epidemiological and economic impact in the Netherlands

scientific article published in January 2006

Combined inheritance of epithelial and erythrocyte receptors for Haemophilus influenzae.

scientific article

Comparability of antibody response to a booster dose of 7-valent pneumococcal conjugate vaccine in infants primed with either 2 or 3 doses

scientific article published on 18 November 2009

Comparison of antibiotic resistant and sensitive strains of Haemophilus influenzae type b in The Netherlands by outer-membrane protein subtyping

scientific article published in April 1988

Comparison of two nonculture techniques for detection of Hemophilus influenzae in sputum. In situ hybridization and immunoperoxidase staining with monoclonal antibodies

scientific article published on August 1988

Complete two-dimensional gel electrophoresis pattern of de novo synthesized acute phase reactants.

scientific article published in November 1986

Conformational analysis of opacity proteins from Neisseria meningitidis

scientific article published in November 2002

Construction of porA Mutants

scientific article

Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2

scientific article

Contribution of the major and minor subunits to fimbria-mediated adherence of Haemophilus influenzae to human epithelial cells and erythrocytes ⬇️

scientific article published on December 1, 1995

Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response

scientific article published on 01 August 2001

Correlates of protection: the crosstalk between immunology and medical microbiology

scientific article published on 01 January 1999

Cross-reactions between Neisseria meningitidis group H and Escherichia coli K2 and K62 polysaccharides

scientific article published on February 1988

Cross-reactivity of antibodies against PorA after vaccination with a meningococcal B outer membrane vesicle vaccine

scientific article

Crystal structure of an Anti-meningococcal subtype P1.4 PorA antibody provides basis for peptide-vaccine design

scientific article published in September 2005

Detection of Haemophilus influenzae in cerebrospinal fluids by polymerase chain reaction DNA amplification

scientific article published on 01 December 1990

Detection of Haemophilus influenzae with monoclonal antibody

scientific article published on 01 February 1987

Diagnosis of infection

scientific article

Differences in genetic diversity of nonecapsulated Haemophilus influenzae from various diseases

scientific article published on 01 April 1997

Differences in subtype distribution of Haemophilus influenzae type b from carriers in the general population and patients with meningitis

scientific article published on June 1991

Differential binding of Haemophilus influenzae to human tissues by fimbriae

scientific article published on September 1, 1991

Distinct geographic distribution of subtypes of Haemophilus influenzae type b in Western Europe

scientific article published on 01 July 1987

Distribution of environmentally regulated genes of Streptococcus suis serotype 2 among S. suis serotypes and other organisms

scientific article

Economic evaluation of meningococcal serogroup C conjugate vaccination programmes in The Netherlands and its impact on decision-making.

scientific article

Effect of nationwide vaccination of 3-month-old infants in The Netherlands with conjugate Haemophilus influenzae type b vaccine: High efficacy and lack of herd immunity ⬇️

scientific article published on 01 December 1997

Effect of reduced-dose schedules with 7-valent pneumococcal conjugate vaccine on nasopharyngeal pneumococcal carriage in children: a randomized controlled trial

scientific article published on July 2009

Effect of seven-valent pneumococcal conjugate vaccine on Staphylococcus aureus colonisation in a randomised controlled trial

scientific article (publication date: 2011)

Electrophoretic resolution of the "major outer membrane protein" of Escherichia coli K12 into four bands

scientific article published on 01 October 1975

Endogenous and exogenous reinfections by Haemophilus influenzae in patients with chronic obstructive pulmonary disease: the effect of antibiotic treatment on persistence

scientific article published in March 1990

Enhanced decision support for policy makers using a web interface to health-economic models--illustrated with a cost-effectiveness analysis of nation-wide infant vaccination with the 7-valent pneumococcal conjugate vaccine in the Netherlands

scientific article published on 5 February 2007

Entrance and survival of Salmonella typhimurium and Yersinia enterocolitica within human B- and T-cell lines

scientific article published on June 1994

Environmental chemoprevention of Haemophilus influenzae type B meningitis. Consequences of 2 indirectly related case pairs

scientific article published on 01 June 1992

Epidemiology and prevention of respiratory tract infections due to nonencapsulated Haemophilus influenzae

scientific article published on June 1, 1992

Epidemiology of Haemophilus influenzae meningitis in patients more than 6 years of age.

scientific article published on July 1987

Epidemiology of meningitis and bacteraemia due to Streptococcus pneumoniae in The Netherlands.

scientific article

Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity

scientific article published in September 2002

Fimbria-mediated adherence and hemagglutination of Haemophilus influenzae

scientific article published on June 1, 1992

Fine mapping of outer membrane protein P2 antigenic sites which vary during persistent infection by Haemophilus influenzae

scientific article

Functional activity of antibodies against the recombinant OpaJ protein from Neisseria meningitidis.

scientific article

Genes of non-typeable Haemophilus influenzae expressed during interaction with human epithelial cell lines

scientific article

Genetic analysis of the diversity in outer membrane protein P2 of non-encapsulated Haemophilus influenzae

scientific article published on 01 June 1993

Genomic DNA fingerprinting of clinical Haemophilus influenzae isolates by polymerase chain reaction amplification: comparison with major outer-membrane protein and restriction fragment length polymorphism analysis

scientific article published in July 1994

HLA-B27 as a relative risk factor in ankylosing enthesopathy in transgenic mice

scientific article published on 01 February 1995

Haemophilus Influenzae in Lung Explants of Patients with End-stage Pulmonary Disease ⬇️

scientific article published on March 1, 1998

Haemophilus influenzae infections in patients with chronic obstructive pulmonary disease despite specific antibodies in serum and sputum

scientific article published on 01 May 1990

Haemophilus influenzae is frequently detected with monoclonal antibody 8BD9 in sputum samples from patients with cystic fibrosis

scientific article published on September 1992

Haemophilus influenzae localized in epithelial cell layers is shielded from antibiotics and antibody-mediated bactericidal activity.

scientific article published on May 1999

Haemophilus influenzae receptor and the AnWj antigen

scientific article published on 01 May 1988

Haemophilus influenzae type b strains of outer membrane subtypes 1 and 1c cause different types of invasive disease.

scientific article published in September 1987

Homogeneity of cell envelope protein subtypes, lipopolysaccharide serotypes, and biotypes among Haemophilus influenzae type b from patients with meningitis in The Netherlands

scientific article published on 01 July 1983

Human lactoferrin receptor activity in non-encapsulated Haemophilus influenzae

scientific article published in November 1997

Human serum antibody response to the presence of Aeromonas spp. in the intestinal tract

scientific article published on March 1990

Immunochemical characterization of variable epitopes of outer membrane protein P2 of nontypeable Haemophilus influenzae ⬇️

scientific article published on January 1, 1991

Immunogenicity and safety of a hexavalent meningococcal outer-membrane-vesicle vaccine in children of 2-3 and 7-8 years of age

scientific article published on 01 February 2000

Immunogenicity and safety of monovalent p1.7(h),4 meningococcal outer membrane vesicle vaccine in toddlers: comparison of two vaccination schedules and two vaccine formulations

scientific article published on 01 December 2000

Immunogenicity of Peptide-vaccine Candidates Predicted by Molecular Dynamics Simulations

article

Immunogenicity of a combination vaccine containing pneumococcal conjugates and meningococcal PorA OMVs

scientific article published on 20 September 2006

Immunogenicity of outer membrane proteins in a lipopolysaccharide-deficient mutant of Neisseria meningitidis: influence of adjuvants on the immune response

scientific article

Immunological Detection of Heterogeneous O-antigen Containing Lipopolysaccharides in Escherichia coli ⬇️

scientific article published on 01 January 1983

In vivo and in vitro expression of outer membrane components of Haemophilus influenzae

scientific article published on April 1990

In vivo antibody response and in vitro CTL activation induced by selected measles vaccine candidates, prepared with purified Quil A components

scientific article published on 01 May 2000

In vivo expression of Neisseria meningitidis proteins homologous to the Haemophilus influenzae Hap and Hia autotransporters

scientific article

Incorporation of LpxL1, a detoxified lipopolysaccharide adjuvant, in influenza H5N1 virosomes increases vaccine immunogenicity.

scientific article

Influence of infection of cells with bacteria associated with reactive arthritis on the peptide repertoire presented by HLA-B27.

scientific article published in April 2001

Interaction of Haemophilus influenzae with human erythrocytes and oropharyngeal epithelial cells is mediated by a common fimbrial epitope

scientific article published on July 1988

Interaction of Haemophilus influenzae with the mammalian extracellular matrix

scientific article published on May 1996

Interaction of bacteria and airway epithelial cells

scientific article published on 01 July 1996

Interaction of clinical isolates of nonencapsulated Haemophilus influenzae with mammalian extracellular matrix proteins

scientific article published on 01 June 2000

Interaction of fimbriae of Haemophilus influenzae type B with heparin-binding extracellular matrix proteins

scientific article published on October 2000

Intranasal immunisation of mice with liposomes containing recombinant meningococcal OpaB and OpaJ proteins.

scientific article

Invasive pneumococcal disease among adults: associations among serotypes, disease characteristics, and outcome

scientific article published on 01 July 2009

Involvement of lipooligosaccharides of Haemophilus influenzae and Neisseria meningitidis in defensin-enhanced bacterial adherence to epithelial cells

scientific article published on March 2003

Iron-binding proteins in sputum of chronic bronchitis patients with Haemophilus influenzae infections ⬇️

scientific article published on 01 October 1997

Lipoprotein signal peptidase of Streptococcus suis serotype 2.

scientific article published in June 2003

Major outer membrane protein d of Escherichia coli K12. Purification and in vitro activity of bacteriophages k3 and f-pilus mediated conjugation

scientific article

Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors ⬇️

scientific article published on November 1, 2003

Mechanism of antibody-mediated reduction of nasopharyngeal colonization by Haemophilus influenzae type b studied in an infant rat model

scientific article published on 01 December 1996

Meningococcal B vaccine development and evaluation of efficacy.

scientific article

Meningococcal disease in The Netherlands, 1958-1990: a steady increase in the incidence since 1982 partially caused by new serotypes and subtypes of Neisseria meningitidis

scientific article published on 01 February 1993

Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity

scientific article

Molecular architecture and functioning of the outer membrane of Escherichia coli and other gram-negative bacteria ⬇️

scientific article published on March 21, 1983

Molecular epidemiology of Haemophilus influenzae type b in the Gambia ⬇️

scientific article published on February 1, 1992

Molecular epidemiology of Haemophilus influenzae type b.

scientific article published on April 1990

Molecular variation in the major outer membrane protein P5 gene of nonencapsulated Haemophilus influenzae during chronic infections

scientific article

Mucin in middle ear effusions inhibits attachment of Haemophilus influenzae to mucosal epithelial cells

scientific article published on 3 October 2002

Multidisciplinary investigation of a multicountry outbreak of Salmonella Stanley infections associated with turkey meat in the European Union, August 2011 to January 2013.

scientific article published on 15 May 2014

Multiple Haemophilus influenzae Strains and Strain Variants Coexist in the Respiratory Tract of Patients with Cystic Fibrosis ⬇️

scientific article published on 01 November 1995

N-acetyl-D-glucosamine medium improves recovery of Haemophilus influenzae from sputa of patients with cystic fibrosis ⬇️

scientific article published on July 1, 1993

Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005.

scientific article published in June 2006

Neonatal meningitis caused by Escherichia coli in The Netherlands

scientific article published in December 1984

Non-typable Haemophilus influenzae invasive disease

scientific article published on 01 June 1993

Nonculture detection of Haemophilus influenzae in sputum with monoclonal antibodies specific for outer membrane lipoprotein P6.

scientific article published on October 1989

Opsonic antibodies to outer membrane protein P2 of nonencapsulated Haemophilus influenza are strain specific

scientific article published on March 1994

Opsono-phagocytosis of non-encapsulated Haemophilus influenzae

scientific article published in January 1995

Outbreak of multiresistant non-encapsulated Haemophilus influenzae infections in a pulmonary rehabilitation centre.

scientific article published in January 1990

Outer membrane protein vesicle vaccines for meningococcal disease

scientific article

Paracytosis of Haemophilus influenzae through cell layers of NCI-H292 lung epithelial cells ⬇️

scientific article published on December 1, 1995

Persisting Haemophilus influenzae strains induce lower levels of interleukin-6 and interleukin-8 in H292 lung epithelial cells than nonpersisting strains ⬇️

scientific article published on October 1, 1997

Phagocytosis of Staphylococcus aureus and Haemophilus influenzae type B opsonized with polyclonal human IgG1 and IgG2 antibodies. Functional hFc gamma RIIa polymorphism to IgG2

scientific article published on 01 August 1993

Phase variation of H. influenzae fimbriae: transcriptional control of two divergent genes through a variable combined promoter region.

scientific article

Pneumococcal conjugate vaccination and nasopharyngeal acquisition of pneumococcal serotype 19A strains

scientific article published on September 2010

PorA-specific differences in antibody avidity after vaccination with a hexavalent Men B outer membrane vesicle vaccine in toddlers and school children

scientific article published on 01 August 2004

Portrait of a leading vaccinologist: dedicated to meningitis and respiratory tract infections.

scientific article

Predicted disappearance of Haemophilus influenzae type b meningitis in Netherlands

scientific article published on 01 July 1994

Predisposing conditions to bacterial infections in chronic obstructive pulmonary disease

scientific article published on June 1995

Preparation of cell envelopes of large numbers of individual bacterial strains with the use of an automatic cell disruptor

scientific article published on 01 October 1987

Prevention of meningococcal serogroup B infections in children: a protein-based vaccine induces immunologic memory

scientific article

Quantitative flow cytometric analysis of opsonophagocytosis and killing of nonencapsulated Haemophilus influenzae by human polymorphonuclear leukocytes

scientific article published on July 1994

Relationship between secretion of the Anton blood group antigen in saliva and adherence of Haemophilus influenzae to oropharynx epithelial cells

scientific article

Relative Immunogenicity of PorA Subtypes in a Multivalent Neisseria meningitidis Vaccine Is Not Dependent on Presentation Form ⬇️

scientific article published on November 1, 2003

Response regulator important in pathogenesis of Streptococcus suis serotype 2.

scientific article published in October 2002

Roles of interleukin-6 and macrophage inflammatory protein-2 in pneumolysin-induced lung inflammation in mice

scientific article published on 30 November 2001

Selection of recombinant antibodies specific for pathogenic Streptococcus suis by subtractive phage display

scientific article

Sequence variation in the hpd gene of nonencapsulated Haemophilus influenzae isolated from patients with chronic bronchitis ⬇️

scientific article published on May 20, 1997

Serological Characterization

scientific article published on January 1, 2001

Seronegative ("reactive") arthritis; bacterial cell envelope antigens with cross reactions against HLA-B27

scientific article published in May 1985

Serum bactericidal activity and isotype distribution of antibodies in toddlers and schoolchildren after vaccination with RIVM hexavalent PorA vesicle vaccine ⬇️

scientific article published on November 12, 2001

Short-Sequence DNA Repeats in Prokaryotic Genomes ⬇️

scientific article published on June 1, 1998

Social integration of people with intellectual disability: insights from a social psychological research programme ⬇️

scientific article published on July 5, 2011

Spectrum of invasive Haemophilus influenzae type b disease in adults

scientific article published in December 1990

Stimulation of bacterial adherence by neutrophil defensins varies among bacterial species but not among host cell types

scientific article

Stimulation of the Adherence ofHaemophilus influenzaeto Human Lung Epithelial Cells by Antimicrobial Neutrophil Defensins ⬇️

scientific article published on 01 October 1998

The Fimbria Gene Cluster of Nonencapsulated Haemophilus influenzae ⬇️

scientific article published on February 1, 1998

The epidemiology of Haemophilus influenzae meningitis in children under five years of age in The Gambia, West Africa

scientific article published on 01 June 1990

The erythrocyte and epithelial cell receptors for Haemophilus influenzae are expressed independently

scientific article

The fimbrial gene cluster of Haemophilus influenzae type b.

scientific article published on August 1994

The use of modeling in the economic evaluation of vaccines

scientific article published on October 2002

The variable P5 proteins of typeable and non-typeable Haemophilus influenzae target human CEACAM1

scientific article published on 01 February 2001

Types and subtypes of 73 strains of Haemophilus influenzae isolated from patients more than 6 years of age with meningitis in The Netherlands

scientific article published on 01 July 1987

Typing of Aeromonas strains by DNA restriction endonuclease analysis and polyacrylamide gel electrophoresis of cell envelopes

scientific article published on June 1989

Variable number of tandem repeats in clinical strains of Haemophilus influenzae ⬇️

scientific article published on December 1, 1997

Variable numbers of tandem repeat loci in genetically homogeneous Haemophilus influenzae strains alter during persistent colonisation of cystic fibrosis patients

scientific article published on 01 April 1999

Variation in metabolic enzyme activity of persistent Haemophilus influenzae in respiratory tracts of patients with cystic fibrosis.

scientific article published on August 1996

Variation in the composition and pore function of major outer membrane pore protein P2 of Haemophilus influenzae from cystic fibrosis patients

scientific article

Virulence factors in the colonization and persistence of bacteria in the airways

scientific article published on June 1995

[Compulsory reporting of diseases caused by Haemophilus influenzae type b?]

scientific article published on 01 June 1987

[Pathogenesis and diagnosis of bacterial airway infections in patients with cystic fibrosis]

scientific article published on 01 November 1995

[Prevention and therapy of airway infections in patients with cystic fibrosis]

scientific article published on 01 November 1995

meoA is the structural gene for outer membrane protein c of Escherichia coli K12 ⬇️

scientific article published on January 31, 1979

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