List of works - Theodor W Schulte

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin ⬇️

scientific article published on June 1, 1998

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

scientific article

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association ⬇️

scientific article published on October 13, 1995

Expression of PAX3 in Ewing's sarcoma family of tumors

scientific article published on April 1997

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

scientific article

Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome ⬇️

scientific article published on October 29, 1997

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

scientific article published on June 1997

Hsp90 as an anti-cancer target

scientific article published on 01 June 1999

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones

scientific article published on September 1999

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

scientific article published on June 1999

Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint

scientific article

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

scientific article published on 01 September 2000

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

scientific article published on 01 February 2000

Stereospecific antitumor activity of radicicol oxime derivatives

scientific article published in December 2001

Taxol induction of p21WAF1 and p53 requires c-raf-1.

scientific article published on October 1995

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

scientific article published on April 1996

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation ⬇️

scientific article published on September 19, 1997

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin ⬇️

scientific article published on January 1, 1998

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase

scientific article published on January 1999

The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome

scientific article published on July 2000

List of works by Theodor W Schulte

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin ⬇️

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association ⬇️

Expression of PAX3 in Ewing's sarcoma family of tumors

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome ⬇️

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

Hsp90 as an anti-cancer target

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

Stereospecific antitumor activity of radicicol oxime derivatives

Taxol induction of p21WAF1 and p53 requires c-raf-1.

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation ⬇️

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin ⬇️

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase

The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome