List of works by Jane B Trepel

1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment

scientific article published on 8 March 2017

A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001.

scientific article

A Phase II Clinical Trial of TRC105 (Anti-Endoglin Antibody) in Adults With Advanced/Metastatic Urothelial Carcinoma.

scientific article published on 27 May 2016

A Phase II Single Arm Pilot Study of the CHK1 Inhibitor Prexasertib (LY2606368) in BRCA Wild-Type, Advanced Triple-Negative Breast Cancer

scientific article published on 08 June 2020

A brief review of the management of platinum-resistant-platinum-refractory ovarian cancer

scientific article

A correlation of bombesin-responsiveness with myc-family gene expression in small cell lung carcinoma cell lines

scientific article published on 01 January 1988

A link between histone deacetylase inhibitors and NF- kappaB signaling

scientific article

A multi-histology trial of fostamatinib in patients with advanced colorectal, non-small cell lung, head and neck, thyroid, and renal cell carcinomas, and pheochromocytomas

scientific article published on 13 February 2013

A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line

scientific article published on 01 November 1988

A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas

scientific article

A phase I study of TRC105 anti-endoglin (CD105) antibody in metastatic castration-resistant prostate cancer

scientific article published on 19 November 2014

A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1-3 inhibitor, cediranib, in recurrent women's cancers with biomarker analyses

scientific article published on 25 July 2019

A phase I/II trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide in thymic epithelial tumors: a clinical and translational study.

scientific article

A phase II study of TRC105 in patients with hepatocellular carcinoma who have progressed on sorafenib

scientific article

A phase II study of perifosine in androgen independent prostate cancer

scientific article published in October 2005

A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma

scientific article published on 21 March 2014

A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

scientific article

A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion

scientific article published on 29 October 2007

Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells

scientific article published on March 2004

Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations

scholarly article by Fatima Karzai et al published 4 December 2018 in Journal for Immunotherapy of Cancer

Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiation

scientific article published on 09 May 2013

Alterations of immune cell subsets in relapsed, thymoma-associated minimal change disease: A case report

scientific article published on 5 June 2015

Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma

scientific article

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

scientific article

Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin

scientific article

Antisense oligonucleotides targeted to the human alpha folate receptor inhibit breast cancer cell growth and sensitize the cells to doxorubicin treatment.

scientific article published in December 2004

Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells.

scientific article published on June 2004

Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole

scientific article published in January 2002

Assays for pharmacodynamic analysis of histone deacetylase inhibitors

scientific article published on April 2006

Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors

scientific article published on January 2014

Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer

scientific article

Autocrine growth factors and lung cancer

scientific article published on January 1989

Bombesin-related peptides induce calcium mobilization in a subset of human small cell lung cancer cell lines.

scientific article

CBMT-42. LOSS OF PROMOTER METHYLATION IN GLYCOLYTIC GENES IS ASSOCIATED WITH AGGRESSIVENESS IN IDH1-MUTANT LOWER GRADE GLIOMAS

scientific article published on 5 November 2018

CECs and IL-8 Have Prognostic and Predictive Utility in Patients with Recurrent Platinum-Sensitive Ovarian Cancer: Biomarker Correlates from the Randomized Phase-2 Trial of Olaparib and Cediranib Compared with Olaparib in Recurrent Platinum-Sensitiv

scientific article published on June 2015

CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential

scientific article

Cabozantinib in patients with platinum-refractory metastatic urothelial carcinoma: an open-label, single-centre, phase 2 trial

scientific article published on 06 July 2020

Cabozantinib plus Docetaxel and Prednisone in Metastatic Castrate Resistant Prostate Cancer

scientific article published on 24 September 2020

Cancer vaccine strategies: translation from mice to human clinical trials.

scientific article

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

scientific article published on May 2011

Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli

scientific article published in December 2001

Cell microarray platform for anticancer drug development

article

Chromosomal protein HMGN1 modulates the expression of N-cadherin

scientific article

Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Metastatic Genitourinary Cancer Patients

scientific article published on 01 December 2020

Cixutumumab for patients with recurrent or refractory advanced thymic epithelial tumours: a multicentre, open-label, phase 2 trial

scientific article published on 15 January 2014

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

scientific article

Clinical Evaluation and Biomarker Profiling of Hsp90 Inhibitors

scientific article published in January 2018

Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug ⬇️

scientific article published on March 12, 2003

Clinical outcomes of prexasertib monotherapy in recurrent BRCA wild-type high-grade serous ovarian cancer involve innate and adaptive immune responses

scientific article published on 01 July 2020

Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells

scientific article

Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models

scientific article published in March 2003

Complete metabolic response of metastatic castration-resistant neuroendocrine carcinoma of the prostate after treatment with RRx-001 and reintroduced platinum doublets.

scientific article published on 5 November 2018

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity

scientific article published on June 2013

Curcumin is an inhibitor of p300 histone acetylatransferase

scientific article published on 01 March 2006

Cyclic AMP induces inhibition of cyclin A expression and growth arrest in human hepatoma cells

scientific article published on April 1999

Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3 ⬇️

scientific article published on April 15, 1992

Cytotoxicity and metabolism of 4-methoxy-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine in HCT 116 colon cancer cells

scientific article published on November 1994

DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

scientific article published on February 2003

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

scientific article

Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study

scientific article published on 22 January 2020

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

scientific article

Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer

scientific article published on 22 July 2015

Diltiazem inhibits transferrin receptor expression and causes G1 arrest in normal and neoplastic T cells

scientific article published on December 1986

Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.

scientific article published on May 1995

Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study

scientific article published on 04 May 2019

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

scientific article published on 01 February 2020

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

scientific article

Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair-deficient tumors

scientific article published on 07 October 2020

E2F sites in the Op18 promoter are required for high level of expression in the human prostate carcinoma cell line PC-3-M.

scientific article

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models

scientific article published on 02 August 2016

Effect of guanine and adenine nucleotides on bombesin-stimulated phospholipase C activity in membranes from Swiss 3T3 and small cell lung carcinoma cells.

scientific article published on September 1990

Effect of the mutation of tyrosine 713 in p93c-fes on its catalytic activity and ability to promote myeloid differentiation in K562 cells

scientific article published on July 1993

Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies

scientific article published on 2 February 2016

Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer.

scientific article

Emerging immunotherapies for bladder cancer

scientific article published on May 2015

Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma ⬇️

scientific article published on September 2, 2010

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality

scientific article

Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

scientific article

Entinostat plus pembrolizumab in patients with metastatic NSCLC previously treated with anti-PD-(L)1 therapy

scientific article published on 17 November 2020

Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection

scientific article

Expression of interleukin-2 receptor beta subunit in hematopoietic malignancies

scientific article published on 01 May 1989

Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects

scientific article

Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells

scientific article published on 01 March 1994

FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells

scientific article published on 13 September 2007

Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling

scientific article published in October 2001

Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions.

scientific article published on 9 July 2001

Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.

scientific article published on January 1991

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

scientific article published on 26 May 2009

Ganetespib, an HSP90 inhibitor, kills Epstein-Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood.

scientific article published on 11 August 2016

Gastrin-releasing peptide and other autocrine growth factors in lung cancer: pathogenetic and treatment implications

scientific article published on January 1988

Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription

scientific article (publication date: 15 February 2001)

Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability

scientific article published on 08 January 2009

Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1-integrin

scientific article published on September 1996

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

scientific article (publication date: August 2005)

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.

scientific article

Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer.

scientific article published on 16 January 2018

Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

scientific article

High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer.

scientific article published on 19 June 2019

High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma

scientific article

Histone deacetylase inhibitor pharmacodynamic analysis by multiparameter flow cytometry.

scientific article published in January 2005

Histone deacetylase inhibitors in cancer therapy

scientific article published on 01 November 2008

Histone deacetylase inhibitors induce apoptosis with minimal viral reactivation in cells infected with Kaposi's sarcoma-associated herpesvirus

scientific article published on 29 June 2006

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

scientific article published on 18 October 2009

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1.

scientific article published on 12 June 2019

Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2

scientific article published on January 2002

Human T lymphotropic virus I infection deregulates surface expression of the transferrin receptor

scientific article

Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I.

scientific article published on April 1986

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation

scientific article published on March 2003

Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.

scientific article

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

scientific article

Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity

scientific article published on 02 January 2017

Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines ⬇️

scientific article published on August 15, 1992

Immunotherapies for bladder cancer: a new hope.

scientific article published on 12 September 2015

Immunotherapy: a new treatment paradigm in bladder cancer

scientific article published on 16 March 2017

In vitro enhancement of immunoglobulin gene expression in chronic lymphocytic leukemia

scientific article

In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome

scientific article published on 01 March 1998

Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

scientific article published on 22 June 2018

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

scholarly article

Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells

scientific article published on April 1998

Inhibition of tumor cell motility by the interferon-inducible GTPase MxA

scientific article

Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.

scientific article

Inhibitors of bombesin-stimulated intracellular signals: interruption of an autocrine pathway as a therapeutic strategy in small cell lung carcinoma

scientific article published on 01 January 1990

Ion channels as molecular targets in prostate cancer.

scientific article published in December 2003

KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia

scientific article published on 18 October 2007

Lack of Impact of Robotic Assisted Laparoscopic Radical Prostatectomy on Intraoperative Levels of Prostate Cancer Circulating Tumor Cells

scientific article published on 12 November 2015

Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint

scientific article

MGMT Status as a Clinical Biomarker in Glioblastoma

scientific article published on 27 March 2020

MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells.

scientific article

Megakaryocyte differentiation: studies at the molecular level using the K-562 cell line

scientific article published on 01 January 1986

Melanoma cell lines contain a proteasome-sensitive, nuclear cytoskeleton-associated pool of beta-catenin

scientific article

Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas

scientific article published on 30 October 2019

Metabolism and RNA incorporation of cyclopentenyl cytosine in human colorectal cancer cells

scientific article published on 01 April 1992

Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy.

scientific article

Metastasis-associated differences in gene expression in a murine model of osteosarcoma.

scientific article

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

scientific article published in February 2018

Methoxychalcone inhibitors of androgen receptor translocation and function

scientific article published on 21 January 2012

Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein

scientific article

Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line

scientific article

Modulation of prion protein structural integrity by geldanamycin

scientific article published on 28 May 2003

Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer.

scientific article published on 19 May 2016

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

scientific article

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

scientific article published on 19 January 2016

Myeloperoxidase: an enzyme involved in intrinsic vincristine resistance in human myeloblastic leukemia.

scientific article

NAD glycohydrolase: enzyme characterization using intact mammalian erythrocytes ⬇️

scientific article published on 01 January 1982

Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

scientific article published on 23 June 2021

Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells

scientific article published on 01 February 2000

Overcoming resistance to DNA targeted agents by epigenetic activation of Schlafen 11 (SLFN11) expression with class I histone deacetylase inhibitors

scientific article

P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells ⬇️

scientific article published on January 1, 1992

PC12 cells regulate inducible cyclic AMP (cAMP) element repressor expression to differentially control cAMP response element-dependent transcription in response to nerve growth factor and cAMP.

scientific article published on 24 October 2006

Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild-type disease during the early disease course

scientific article published on 07 August 2019

Peptide-induced mRNAs in whole blood ex vivo as a unique assay for peptide-specific T cell immunity

scientific article published on 7 November 2013

Pharmacodynamic assessment of histone deacetylase inhibitors: infrared vibrational spectroscopic imaging of protein acetylation

scientific article published on 24 July 2008

Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function

scientific article published on 05 February 2020

Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

scientific article published on April 2007

Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors

scientific article published on 23 October 2020

Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors

scientific article published on 18 December 2017

Phase I Study of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced or Metastatic Urothelial Carcinoma and Other Genitourinary Tumors

scientific article published on 11 September 2020

Phase I and Preliminary Phase II Study of TRC105 in Combination with Sorafenib in Hepatocellular Carcinoma.

scientific article published on 2 May 2017

Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma

scientific article published on 25 April 2005

Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.

scientific article

Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors

scientific article published on 18 June 2015

Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies

scientific article published on 01 September 2007

Phase I trial of belinostat with cisplatin and etoposide in advanced solid tumors, with a focus on neuroendocrine and small cell cancers of the lung.

scientific article published on 7 February 2018

Phase I trial of vandetanib and bevacizumab evaluating the VEGF and EGF signal transduction pathways in adults with solid tumours and lymphomas

scientific article

Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma

scientific article published on 02 December 2019

Phase II study of belinostat in patients with recurrent or refractory advanced thymic epithelial tumors

scientific article

Phase II trial of bevacizumab, thalidomide, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer

scientific article

Phase II trial of docetaxel, bevacizumab, lenalidomide and prednisone in patients with metastatic castration-resistant prostate cancer.

scientific article

Phorbol ester enhances deoxynucleoside incorporation while inhibiting proliferation of K-562 cells

scientific article published on 01 November 1985

Phorbol ester induces c-sis gene transcription in stem cell line K-562.

scientific article published on May 1986

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors

scientific article

Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease

scientific article published on 01 March 1999

Preliminary association of circulating tumor cells (CTCs) pre- and post-AdHER2 dendritic cell vaccination with overall survival in patients with metastatic HER2+ solid tumors

scientific article published on 4 November 2015

Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors

scientific article published on 01 November 2000

Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study

scientific article published on 17 January 2018

Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21(waf1/cip1)

scientific article published on 01 September 1998

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

scientific article published on July 2000

Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

scientific article published on 05 December 2019

Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics

scientific article

RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB

scientific article published on 21 May 2019

RRx-001 Priming of PD-1 Inhibition in the Treatment of Small Cell Carcinoma of the Vagina: A Rare Gynecological Tumor.

scientific article

RRx-001 followed by platinum plus etoposide in patients with previously treated small-cell lung cancer

scientific article published on 24 June 2019

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials

scientific article published on 9 December 2016

Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal a

scientific article published on 06 May 2013

Ras, ROS and proteotoxic stress: a delicate balance

scientific article

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

scientific article published on 18 June 2019

Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1

scientific article published on 01 December 1998

Regulation of BRCA1 by protein degradation

scientific article published on November 1999

Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1.

scientific article published on May 1999

Regulation of cyclin D1 by calpain protease

scientific article published on November 1997

Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin.

scientific article published in August 2002

Results from a biomarker study to accompany a phase II trial of RRx-001 with reintroduced platinum-based chemotherapy in relapsed small cell carcinoma

scientific article published on 11 December 2020

Role of protein kinase C in the modulation of multidrug resistance: expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin ⬇️

scientific article published on December 1, 1992

SIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stress

scientific article (publication date: September 2014)

STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma

scientific article published on 06 September 2016

STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer.

scientific article published on December 2010

Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis

scholarly article by Clint T Allen et al published 3 May 2019 in Journal for Immunotherapy of Cancer

Selumetinib with and without erlotinib in KRAS mutant and KRAS wild-type advanced nonsmall-cell lung cancer.

scientific article published on 22 January 2016

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition

scientific article published on 21 August 2007

Sequential 5-Aza 2'-deoxycytidine/depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2 (TFPI-2) expression in cancer cells.

scientific article published on March 2005

Serotonin concentrations in brain and blood of scrapie-infected and normal hamsters and mice

scientific article published on 01 September 1981

Significant non-S-phase DNA synthesis visualized by flow cytometry in activated and in malignant human lymphoid cells

scientific article published on 01 February 1985

Stressing the development of small molecules targeting HSP90

scientific article

Sunitinib in patients with chemotherapy-refractory thymoma and thymic carcinoma: an open-label phase 2 trial.

scientific article

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

scientific article

Synthesis and structure-activity relationship studies of novel dihydropyridones as androgen receptor modulators

scientific article published on 30 October 2013

TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer

scientific article published on July 2016

Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma

scientific article

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

scientific article published on 15 May 2018

Targeting the dynamic HSP90 complex in cancer

scientific article

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

scientific article

Taxol induction of p21WAF1 and p53 requires c-raf-1.

scientific article published on October 1995

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

scientific article published on April 1996

Temozolomide in the Era of Precision Medicine

scientific article published on 3 February 2017

Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP

scientific article

The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models

scientific article published on 11 October 2013

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

scientific article

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase

scientific article published on January 1999

The beta subunit of the interleukin-2 receptor mediates interleukin-2 induction of anti-CD3 redirected cytotoxic capability in large granular lymphocytes

scientific article published on 01 March 1988

The detergent Triton X-100 induces a death pattern in human carcinoma cell lines that resembles cytotoxic lymphocyte-induced apoptosis

scientific article published on 01 October 1994

The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

scientific article

The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.

scientific article published on November 2003

The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties

scientific article

The interplay of epigenetic therapy and immunity in locally recurrent or metastatic estrogen receptor-positive breast cancer: Correlative analysis of ENCORE 301, a randomized, placebo-controlled phase II trial of exemestane with or without entinosta

scientific article published on 31 August 2016

The macrophage stimulating anti-cancer agent, RRx-001, protects against ischemia-reperfusion injury

scientific article published on 27 April 2017

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

scientific article published on 01 April 2021

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

scientific article

Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor

scientific article published on 01 March 2001

Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells

scientific article published on July 1987

Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells

scientific article published on 13 December 2001

Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein

scientific article published on June 1991

Transferrin receptor expression and the control of cell growth

scientific article published on 01 January 1986

Transferrin receptor induction is required for human B-lymphocyte activation but not for immunoglobulin secretion

scientific article published on 01 January 1985

Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy

scientific article

UGT1A1 genotype-dependent dose adjustment of belinostat in patients with advanced cancers using population pharmacokinetic modeling and simulation.

scientific article published on 4 December 2015

Update on Hsp90 inhibitors in clinical trial.

scientific article

Various methods of analysis of mdr-1/P-glycoprotein in human colon cancer cell lines

scientific article published on May 6, 1992

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

scientific article published on 28 July 2015

c-Met ectodomain shedding rate correlates with malignant potential

scientific article published on July 2006

c-myc Down-regulation in suramin-treated HL60 cells precedes growth inhibition but does not trigger differentiation

scientific article published on 01 July 1994

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

scientific article

p53 inhibits hypoxia-inducible factor-stimulated transcription

scientific article published on 01 May 1998

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