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List of works by Edward G Mimnaugh

17AAG: low target binding affinity and potent cell activity--finding an explanation

scientific article published in February 2003

A comprehensive study of in vitro drug metabolism in several laboratory species ⬇️

scientific article published on May 1, 1976

A possible role for membrane lipid peroxidation in anthracycline nephrotoxicity

scientific article published in December 1986

A role for the interleukin 1 receptor in the synergistic antitumor effects of human interleukin 1 alpha and etoposide against human melanoma cells ⬇️

scientific article published on February 1, 1991

Activation of pharmacologic agents to radical intermediates. Implications for the role of free radicals in drug action and toxicity

scientific article published on November 1982

Acute toxicity of substrates of the mixed function oxidase system in normal and phenobarbital-pretreated mice

scientific article published on September 1, 1975

Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance.

scientific article

Adriamycin-enhanced membrane lipid peroxidation in isolated rat nuclei

scientific article published on 01 July 1985

Biochemical and pharmacological characterization of MCF-7 drug-sensitive and AdrR multidrug-resistant human breast tumor xenografts in athymic nude mice ⬇️

scientific article published on July 5, 1991

Bleomycin-metal interaction: Ferrous iron-initiated chemiluminescence ⬇️

scientific article published on April 29, 1983

Bronchiolar epithelial damage and impairment of pulmonary microsomal monooxygenase activity in mice by naphthalene

scientific article published on 01 December 1982

Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli

scientific article published in December 2001

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

scientific article

Clara cell damage and inhibition of pulmonary mixed-function oxidase activity by naphthalene

scientific article published on 01 June 1981

Comparative alterations in extrahepatic drug metabolism by factors known to affect hepatic activity ⬇️

scientific article published on April 15, 1977

Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species ⬇️

scientific article published on July 1, 1975

Differential effects of anthracycline drugs on rat heart and liver microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation

scientific article published on 01 September 1982

Differential oxygen radical susceptibility of adriamycin-sensitive and -resistant MCF-7 human breast tumor cells

scientific article published on January 1989

Distribution and biochemical effects of pentylenetetrazol in brains of swine treated with a polychlorinated biphenyl

scientific article published in April 1974

Distribution of 14C-lomustine (14C-CCNU)-derived radioactivity following intravenous administration of three potential clinical formulations to rabbits

scientific article published on 01 November 1974

Doxorubicin-Induced Cross-Resistance to Tumor Necrosis Factor (TNF) Related to Differential TNF Processing ⬇️

scientific article published on June 1, 1991

Drug metabolism by microsomes from extrahepatic organs of rat and rabbit prepared by calcium aggregation

scientific article published in September 1975

Effect of Strain Differences and Tumor Presence on Microsomal Drug Metabolism in the Guinea Pig: Brief Communication ⬇️

scientific article published on December 1, 1977

Effect of storage on microsomal mixed function oxidase activity in mouse liver

scientific article published on 01 September 1974

Effect of the proteasome inhibitor ALLnL on cisplatin sensitivity in human ovarian tumor cells.

scientific article published in October 2001

Effect of whole-body hyperthermia on the disposition and metabolism of adriamycin in rabbits ⬇️

scientific article published on 01 May 1978

Effects of activators in vitro on rabbit lung and liver microsomal UDP-glucuronyltransferase activity

scientific article published on 01 September 1975

Effects of dietary ascorbic acid supplementation on hepatic drug-metabolizing enzymes in the guinea pig ⬇️

scientific article published on November 1, 1977

Effects of glutathione and ethylxanthate on mitomycin C activation by isolated rat hepatic or EMT6 mouse mammary tumor nuclei.

scientific article

Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade

scientific article published on 01 September 2006

Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo

scientific article published on 01 July 1983

Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin

scientific article published on 01 March 1985

Enzymatic activation and binding of adriamycin to nuclear DNA ⬇️

scientific article published on 01 July 1984

Enzymatic conjugation of foreign chemical compounds by rabbit lung and liver

scientific article published on 01 May 1974

Free radicals and anticancer drug resistance: oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors

scientific article published on January 1990

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

scientific article

Hepatic cytochrome P-450-dependent metabolism and enzymatic conjugation of foreign compounds in vitamin A-deficient rats

scientific article published on 01 January 1980

Hsp90 as an anti-cancer target

scientific article published on 01 June 1999

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

scientific article

Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2

scientific article published on January 2002

Immunoblotting methods for the study of protein ubiquitination

scientific article published on 01 January 2002

Improved therapeutic index of bleomycin when administered by continuous infusion in mice

scientific article published on December 1, 1978

In vitro drug metabolism in male and female athymic, nude mice

scientific article published in May 1978

In vitro stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes ⬇️

scientific article published on September 15, 1981

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

scientific article

Lack of correlation between cortisol-induced precocious maturation of the fetal rabbit lung and drug metabolism ⬇️

scientific article published on March 1, 1979

Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression.

scientific article

Lung-selective impairment of cytochrome P-450-dependent monooxygenases and cellular injury by 1,1-dichloroethylene in mice

scientific article published on 01 January 1983

Measuring ubiquitin conjugation in cells

scientific article

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

scientific article published on September 1996

Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase

scientific article published on December 1995

Potentiation by reduced glutathione of adriamycin-stimulated lipid peroxidation in kidney microsomes

scientific article published on 01 December 1986

Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.

scientific article published on February 1989

Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors

scientific article published on 01 November 2000

Protection by methylprednisolone against butylated hydroxytoluene-induced pulmonary damage and impairment of microsomal monooxygenase activities in the mouse: lack of effect on fibrosis

scientific article published on 01 January 1986

Quantification of bleomycin pulmonary toxicity in mice by changes in lung hydroxyproline content and morphometric histopathology

scientific article published on March 1978

Rapid Deubiquitination of Nucleosomal Histones in Human Tumor Cells Caused by Proteasome Inhibitors and Stress Response Inducers: Effects on Replication, Transcription, Translation, and the Cellular Stress Response ⬇️

scientific article published on November 25, 1997

Selective damage to nonciliated bronchiolar epithelial cells in relation to impairment of pulmonary monooxygenase activities by 1,1-dichloroethylene in mice

scientific article published on 01 June 1984

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

scientific article (publication date: 2 February 2001)

Sex-dependent differences in the effects of portacaval anastomosis on hepatic monooxygenases in rats

scientific article published on 01 February 1982

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

scientific article published on May 2004

Species and dose differences in the accumulation of imipramine by mammalian lungs ⬇️

scientific article published on July 1, 1981

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

scientific article published on 01 October 1981

Stimulation of mouse heart and liver microsomal lipid peroxidation by anthracycline anticancer drugs: characterization and effects of reactive oxygen scavengers

scientific article published on 01 September 1983

Studies on the in vitro interaction of mitomycin C, nitrofurantoin and paraquat with pulmonary microsomes. Stimulation of reactive oxygen-dependent lipid peroxidation

scientific article published on 01 March 1982

Studies on the interaction of bleomycin A2 with rat lung microsomes. I. Characterization of factors which influence bleomycin-mediated DNA chain breakage ⬇️

scientific article published on 01 April 1982

Studies on the interaction of bleomycin A2 with rat lung microsomes. II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage.

scientific article published in April 1982

Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.

scientific article

Synergistic antiproliferative effects of interleukin-1 alpha and doxorubicin against the human ovarian carcinoma cell line (NIH:OVCAR-3).

scientific article published on May 1993

Synergistic antiproliferative effects of the combination of interleukin-1 alpha and doxorubicin against human melanoma cells

scientific article published on January 1, 1992

Synergistic antitumor activity of etoposide and human interleukin-1 alpha against human melanoma cells.

scientific article

Synergistic interactions of etoposide and interleukin-1 alpha are not due to DNA damage in human melanoma cells

scientific article published on 01 January 1993

Taxol induction of p21WAF1 and p53 requires c-raf-1.

scientific article published on October 1995

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation ⬇️

scientific article published on September 19, 1997

The distribution of 14C-imipramine in mice bearing lewis lung carcinoma ⬇️

scientific article published on November 19, 1979

The effect of unilateral pneumonectomy on in vitro drug metabolism by the contralateral lung of rabbits ⬇️

scientific article published on July 1, 1979

The effect of vitamin A deficiency on hepatic, renal and pulmonary glutathione S-transferase activities in the rat.

scientific article published on June 1980

The effects of adriamycin in vitro and in vivo on hepatic microsomal drug-metabolizing enzymes: Role of microsomal lipid peroxidation ⬇️

scientific article published on 01 December 1981

The effects of ascorbic acid deficiency and repletion on pulmonary, renal, and hepatic drug metabolism in the guinea pig ⬇️

scientific article published on March 1, 1977

The effects of α-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice ⬇️

scientific article published on June 15, 1979

The measurement of ubiquitin and ubiquitinated proteins

scientific article

Toxicologic implications of the iron-dependent activation of bleomycin A2 by mouse lung microsomes

scientific article published on 01 January 1986

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

scientific article

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