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List of works by Lisa L. von Moltke

143 A Combination of Olanzapine and Samidorphan Has No Clinically Relevant Effect on QT Prolongation up to Supratherapeutic Doses

scientific article published on 01 April 2020

A Phase I Open-Label Study to Evaluate the Effects of Rifampin on the Pharmacokinetics of Olanzapine and Samidorphan Administered in Combination in Healthy Human Subjects

scientific article published on 01 May 2019

A quantitative framework and strategies for management and evaluation of metabolic drug-drug interactions in oncology drug development: new molecular entities as object drugs

scientific article published on 01 November 2010

A randomized, placebo-controlled study of the pharmacokinetics, pharmacodynamics, and tolerability of the oral JAK2 inhibitor fedratinib (SAR302503) in healthy volunteers.

scientific article

Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate

scientific article published in November 2004

Age-related differences in CYP3A expression and activity in the rat liver, intestine, and kidney

scientific article published on 23 January 2004

Alprazolam hydroxylation by mouse liver microsomes in vitro: the effect of age and phenobarbital induction

Alprazolam is another substrate for human cytochrome P450-3A isoforms.

scientific article published in June 1998

Alprazolam metabolism in vitro: studies of human, monkey, mouse, and rat liver microsomes

scientific article published on 01 October 1993

Alprazolam pharmacokinetics, metabolism, and plasma levels: clinical implications.

scientific article

Alprazolam-ritonavir interaction: implications for product labeling

scientific article published on 01 April 2000

Analysis of generic antiretroviral formulations manufactured in India

scientific article published on 01 July 2004

Analysis of ritonavir in plasma/serum and tissues by high-performance liquid chromatography

scientific article published in November 1998

Antipyrine kinetics in patients with primary biliary cirrhosis

scientific article published on 01 January 1993

Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers

scientific article published on July 2006

Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine

scientific article published in March 2003

Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir ⬇️

scientific article published on March 1, 2003

Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine

scientific article published on 01 August 1998

Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.

scientific article published in April 2001

Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro.

scientific article

Bioequivalence of Olanzapine Given in Combination With Samidorphan as a Bilayer Tablet (ALKS 3831) Compared With Olanzapine-Alone Tablets: Results From a Randomized, Crossover Relative Bioavailability Study

scientific article published on 30 July 2018

Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species

scientific article published on 01 April 1997

Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors

scientific article published on 01 March 1997

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

scientific article

CYP2C9 is a principal low-affinity phenacetin O-deethylase: fluvoxamine is not a specific CYP1A2 inhibitor

scientific article published on 01 December 1999

CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

scientific article

Characterization of six in vitro reactions mediated by human cytochrome P450: application to the testing of cytochrome P450-directed antibodies

scientific article published on 01 February 1996

Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age

scientific article published on 01 September 2019

Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects.

scientific article published on September 1999

Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications

scientific article

Clinically Important Drug Interactions with Zopiclone, Zolpidem and Zaleplon

scientific article published on January 1, 2003

Cognitive toxicity of drugs used in the elderly ⬇️

scientific article published on September 1, 2001

Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate

scientific article published on 01 January 2020

Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: Results from a phase 1 QT/QTc study

scientific article published on 28 January 2020

Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo

scientific article published in November 1998

Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences

scientific article published in May 2000

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

scientific article published in December 2000

Cytochromes in psychopharmacology

scientific article published on 01 February 1994

Differential impairment of triazolam and zolpidem clearance by ritonavir

scientific article published in June 2000

Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression

scientific article published in April 2003

Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture

scientific article published in July 2002

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole

scientific article published in November 1999

Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration

scientific article published in April 1990

Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study ⬇️

scientific article published on April 9, 2011

Drug Metabolism and Drug Interactions: Application and Clinical Value of In Vitro Models ⬇️

scientific article published on October 1, 2003

Drug interactions with grapefruit juice: an update

scientific article (publication date: August 2001)

Drug interactions with newer antidepressants: role of human cytochromes P450

scientific article published on 01 January 1998

Drug transporters in psychopharmacology--are they important?

scientific article published on 01 June 2000

Drug transporters revisited

scientific article

Drugs in cardiac transplantation

scientific article published in February 1996

Effect of Food on the Pharmacokinetics of a Combination of Olanzapine and Samidorphan

scientific article published on 28 March 2019

Effect of age on in vitro triazolam biotransformation in male human liver microsomes

scientific article published on 21 November 2003

Effect of bupropion on CYP2B6 and CYP3A4 catalytic activity, immunoreactive protein and mRNA levels in primary human hepatocytes: comparison with rifampicin

scientific article published in September 2003

Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir

scientific article published on 7 February 2006

Effect of food on the bioavailability and tolerability of the JAK2-selective inhibitor fedratinib (SAR302503): Results from two phase I studies in healthy volunteers

scientific article published on 27 October 2014

Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet

scientific article published on 22 August 2019

Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study

scientific article published on January 2009

Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein

scientific article published on December 2002

Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes.

scientific article published in March 2000

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

scientific article

Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram

scientific article published in August 2001

Ethanol inhibits in-vitro metabolism of nifedipine, triazolam and testosterone in human liver microsomes

scientific article

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

scientific article published in September 2003

Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6.

scientific article published in August 2004

Evaluation of Supermix as an in vitro model of human liver microsomal drug metabolism

scientific article

Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction

scientific article published in August 1999

Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine.

scientific article

Factors influencing midazolam hydroxylation activity in human liver microsomes

scientific article published on 25 April 2006

Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir

scientific article published in November 2002

Five Distinct Human Cytochromes Mediate Amitriptyline N‐Demethylation In Vitro: Dominance of CYP 2C19 and 3A4 ⬇️

scientific article published on 01 February 1998

Fluoxetine inhibition of phenytoin metabolism

scientific article published on 01 December 1994

Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics

scientific article published in November 2005

Gender has a small but statistically significant effect on clearance of CYP3A substrate drugs

scientific article published on 29 August 2008

Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo

scientific article published in May 2005

Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects

scientific article published on 01 December 1998

Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate

scientific article published in February 2006

Human cytochromes P450 mediating phenacetin O-deethylation in vitro: validation of the high affinity component as an index of CYP1A2 activity

scientific article published on 01 December 1998

Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions.

scientific article

Human cytochromes mediating N-demethylation of fluoxetine in vitro

scientific article published on 01 August 1997

Human cytochromes mediating gepirone biotransformation at low substrate concentrations

scientific article published in March 2003

Human cytochromes mediating sertraline biotransformation: seeking attribution

scientific article published on 01 December 1999

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

scientific article

Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity

scientific article

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

scientific article

Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism

scientific article published on February 2010

In vitro approaches to predicting drug interactions in vivo.

scientific article published on January 1998

In vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11.

scientific article

In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions

scientific article

In vitro interactions of water-soluble garlic components with human cytochromes p450

scientific article published on 01 March 2006

In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.

scientific article

In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors.

scientific article

In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction

scientific article published in December 1994

In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat.

scientific article published in September 2002

Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells

scientific article published in July 2007

Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture

scientific article published in June 2000

Influence of polyethylene glycol and acetone on the in vitro biotransformation of tamoxifen and alprazolam by human liver microsomes

scientific article published on 01 November 1996

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p‐hydroxylation ⬇️

scientific article published on November 1, 1997

Inhibition of acetaminophen and lorazepam glucuronidation in vitro by probenecid

scientific article published on 01 March 1993

Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants

scientific article published on 01 April 1995

Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation

scientific article published on April 1996

Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo

scientific article published on 01 October 1998

Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo

scientific article published on 01 March 1994

Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors

scientific article

Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast

scientific article published on 01 November 1999

Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies

scientific article published on September 1996

Inhibition of human cytochromes P450 by components of Ginkgo biloba ⬇️

scientific article

Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo

scientific article published on 01 April 1996

Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences

scientific article published on 01 September 1998

Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine

scientific article

Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies

scientific article published on January 2006

Interaction of triazolam and ketoconazole

scientific article published on 01 January 1995

Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice

scientific article

Interaction of warfarin with drugs, natural substances, and foods

scientific article

Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A.

scientific article

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

scientific article published in December 2001

Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences

scientific article published on 01 September 1998

Kinetic Characterization and Identification of the Enzymes Responsible for the Hepatic Biotransformation of Adinazolam and N-Desmethyladinazolam in Man ⬇️

scientific article published on March 1, 1998

Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole

scientific article published on 01 December 1998

Kinetics and dynamics of lorazepam during and after continuous intravenous infusion

scientific article

Lack of clinical pharmacodynamic and pharmacokinetic drug-drug interactions between warfarin and the antisense oligonucleotide mipomersen.

scientific article

Levothyroxine up-regulates P-glycoprotein independent of the pregnane X receptor

scientific article published on August 2004

Long-acting formulations delivering aripiprazole: beyond single-value characterizations of steady-state pharmacokinetics

scientific article published on 12 July 2017

MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

scientific article published on 01 December 2009

Mechanism of cytochrome P450-3A inhibition by ketoconazole ⬇️

scientific article published on February 1, 2011

Medication dependence and anxiety ⬇️

scientific article published on September 1, 2003

Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

scientific article

Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.

scientific article published on January 1995

Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4

scientific article published on 01 October 2000

Methadone inhibits rhodamine123 transport in Caco-2 cells

scientific article published in July 2001

Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level

scientific article published in January 2000

Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro

scientific article published in May 2000

Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors

scientific article published in December 2002

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

scientific article published in February 2000

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents

scientific article published in September 1996

Molecular and pharmacokinetic evaluation of rat hepatic and gastrointestinal cytochrome p450 induction by tamoxifen

scientific article published in January 2001

Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A

scientific article published on 01 September 1998

N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors

scientific article published on 01 November 1995

Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

scientific article

Neurotoxicity and tretinoin

scientific article published on 01 November 1996

Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs

scientific article published on 01 June 1999

O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants

scientific article

P-glycoprotein interactions of nefazodone and trazodone in cell culture

scientific article published in July 2001

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes

scientific article

Pharmacokinetic Evaluation of a 1-Day Treatment Initiation Option for Starting Long-Acting Aripiprazole Lauroxil for Schizophrenia.

scientific article published in October 2018

Pharmacokinetic Profile of a 2-Month Dose Regimen of Aripiprazole Lauroxil: A Phase I Study and a Population Pharmacokinetic Model

scientific article published on 08 June 2017

Pharmacokinetic and pharmacodynamic interactions between zolpidem and caffeine

scientific article published on 18 April 2007

Pharmacokinetic and pharmacodynamic study of two doses of bortezomib in patients with relapsed multiple myeloma

scientific article published on 20 March 2010

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.

scientific article published in September 2003

Pharmacokinetics and Short-term Safety of ALKS 3831, a Fixed-dose Combination of Olanzapine and Samidorphan, in Adult Subjects with Schizophrenia

scientific article published on 20 October 2018

Pharmacokinetics and safety of deltoid or gluteal injection of aripiprazole lauroxil NanoCrystal® Dispersion used for initiation of the long-acting antipsychotic aripiprazole lauroxil

scientific article published on 02 July 2019

Pharmacokinetics, Safety, and Tolerability of a 2-Month Dose Interval Regimen of the Long-Acting Injectable Antipsychotic Aripiprazole Lauroxil: Results From a 44-Week Phase I Study

scientific article published on 03 July 2020

Pharmacokinetics, safety and tolerability of mipomersen in healthy Japanese volunteers and comparison with Western subjects

scientific article

Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

scientific article published on 01 December 1996

Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats

scientific article

Physiologically-Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan

scientific article published on 31 January 2020

Population Pharmacokinetic Analysis and Model-Based Simulations of Aripiprazole for a 1-Day Initiation Regimen for the Long-Acting Antipsychotic Aripiprazole Lauroxil

scientific article published on 01 August 2018

Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole

scientific article published on 01 June 2000

Predicting interactions between conventional medications and botanical products on the basis of in vitro investigations

scientific article published on July 2008

Protease Inhibitors as Inhibitors of Human Cytochromes P450: High Risk Associated with Ritonavir ⬇️

scientific article published on 01 February 1998

Quantitative prediction and clinical observation of a CYP3A inhibitor-based drug-drug interactions with MLN3897, a potent C-C chemokine receptor-1 antagonist

scientific article published on 4 November 2009

Rapid assessment of P-glycoprotein inhibition and induction in vitro

scientific article published on August 2003

Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: implications for diazepam disposition in humans

scientific article published in August 1996

Relative Quantities of Catalytically Active CYP 2C9 and 2C19 in Human Liver Microsomes: Application of the Relative Activity Factor Approach ⬇️

scientific article published on July 1, 1998

Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies

scientific article

Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine

scientific article published in April 2001

Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats

scientific article published in February 2004

Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis

scientific article published in December 2008

Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers

scientific article published on 01 May 2006

Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line

scientific article

Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion

scientific article

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice

scientific article published on 28 March 2007

Role of CYP3A enzymes in the biotransformation of triazolam in rat liver

scientific article published in May 2004

Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes

scientific article published on 06 October 2008

Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity

scientific article

Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure

scientific article

Scaling drug biotransformation data from cDNA-expressed cytochrome P-450 to human liver: a comparison of relative activity factors and human liver abundance in studies of mirtazapine metabolism

scientific article

Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences

scientific article published in February 2003

Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem

scientific article published on 25 February 2009

Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone.

scientific article published in April 2003

Size matters: the importance of particle size in a newly developed injectable formulation for the treatment of schizophrenia

scientific article published on 21 May 2019

Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro

scientific article published on October 2010

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

scientific article (publication date: November 2002)

THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER

scientific article published on 04 April 2006

The Impact of Formulation, Delivery, and Dosing Regimen on the Risk of Drug-Drug Interactions

scientific article published on 21 March 2019

The clinician and drug interactions--an update

scientific article published on 01 June 1996

The effect of age on P-glycoprotein expression and function in the Fischer-344 rat.

scientific article published on 2 February 2004

The effect of age on sildenafil biotransformation in rat and mouse liver microsomes.

scientific article published in November 2003

The importance of presystemic extraction in clinical psychopharmacology

scientific article published on 01 December 1996

The influence of age and sex on the clearance of cytochrome P450 3A substrates

scientific article

Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice

scientific article (publication date: August 2003)

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole

scientific article published on 01 February 1996

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

scientific article

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).

scientific article

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

scientific article

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver

scientific article published in August 2005

Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes

scientific article published in June 1999

Unusually low clearance of two CYP3A substrates, alprazolam and trazodone, in a volunteer subject with wild-type CYP3A4 promoter region

scientific article published on 01 February 2000

Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.

scientific article

Validity of self-reports of caffeine use

scientific article published on 01 July 1991

Venlafaxine and metabolites are very weak inhibitors of human cytochrome P450-3A isoforms

scientific article published on 01 February 1997

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

scientific article

Zolpidem pharmacokinetic properties in young females: influence of smoking and oral contraceptive use.

scientific article published in October 2002

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