Search filters

List of works by Lewis T. Williams

A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF.

scientific article published in September 1988

A common PDGF receptor is activated by homodimeric A and B forms of PDGF

scientific article

A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy ⬇️

scientific article published on March 1, 1978

A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine ⬇️

scientific article published on February 1, 1991

A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo

scientific article

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

scientific article published on January 1997

Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

scientific article published on January 1988

Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes

scientific article

Activation of Na+/H+ exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma

scientific article published in December 1994

Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation ⬇️

scientific article published on October 1, 1998

Activation of Raf-1 by 14-3-3 proteins

scientific article

Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding

scientific article published in May 1976

Agents that increase cAMP accumulation block endothelial c-sis induction by thrombin and transforming growth factor-beta

scientific article

Alpha-Adrenergic Receptor Identification by [ 3 H]Dihydroergocryptine Binding ⬇️

scientific article published on May 21, 1976

Beta-adrenergic receptors: Regulatory role of agonists ⬇️

scientific article published on January 1, 1978

Biosynthetic and glycosylation studies of cell surface platelet-derived growth factor receptors.

scientific article

Blockade of autocrine stimulation in simian sarcoma virus-transformed cells reverses down-regulation of platelet-derived growth factor receptors ⬇️

scientific article published on December 1, 1984

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression

scientific article

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis ⬇️

scientific article (publication date: 10 October 1997)

Catecholamine binding to the beta-adrenergic receptor ⬇️

scientific article published on February 1, 1977

Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

scientific journal article

Characterization of a new member of the TNF family expressed on antigen presenting cells

scientific article (publication date: December 1999)

Chromosomal localization of the gene for AA-type platelet-derived growth factor receptor (PDGFRA) in humans and mice ⬇️

scientific article published on January 1, 1991

Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities ⬇️

scientific article published on January 1, 1992

Direct activation of phospholipase C-gamma by fibroblast growth factor receptor is not required for mesoderm induction in Xenopus animal caps

scientific article published on May 1994

Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor

scientific article published on August 1989

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

scientific article (publication date: May 1992)

Dominant-negative mutations of platelet-derived growth factor (PDGF) receptors. Inhibition of receptor function by ligand-dependent formation of heterodimers between PDGF alpha- and beta-receptors.

scientific article published on October 1993

Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase ⬇️

scientific article published on February 1, 1977

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors ⬇️

scientific article published on December 18, 2001

Evidence for both tyrosine kinase and G-protein-coupled pathways leading to starfish egg activation

scientific article

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

scientific article

Fibroblast growth factor receptor 1-IIIb is dispensable for skin morphogenesis and wound healing

scientific article published in February 2004

Identification of alpha-adrenergic receptors in human platelets by [3H]dihydroergocryptine binding ⬇️

scientific article published on February 1, 1978

Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding

scientific article

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding ⬇️

scientific article published on January 1, 1976

Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding

scientific article

Identification of phosphotyrosine residues during protein sequence analysis

scientific article published in January 1991

Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor ⬇️

scientific article published on May 10, 1991

Inhibition of mSOS-activity by binding of phosphatidylinositol 4,5-P2 to the mSOS pleckstrin homology domain ⬇️

scientific article published on May 7, 1998

Interactions of Growth Factor Receptors with Cytoplasmic Signaling Molecules ⬇️

scientific article published on January 1, 1991

Interactions of PDGF and FGF receptors with cytoplasmic signaling molecules

scientific article published on January 1, 1992

Large induction of keratinocyte growth factor expression in the dermis during wound healing ⬇️

scientific article published on August 1, 1992

Ligand activation causes a phosphorylation-dependent change in platelet-derived growth factor receptor conformation

scientific article published on September 1988

Ligand activation causes a phosphorylation-dependent change in platelet-derived growth factor receptor conformation

scientific article published on January 1988

Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin ⬇️

scientific article published on December 9, 1997

Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors ⬇️

scientific article published on May 10, 1978

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

scientific article

Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells ⬇️

scientific article published on August 1, 1992

Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors

scientific article published on January 1, 1978

Molecular mechanisms of platelet-derived growth factor action

scientific article

Molecular pharmacology of alpha adrenergic receptors: utilization of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations ⬇️

scientific article published on March 1, 1977

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

scientific article

Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis

scientific article published on October 1989

Oncogene-related growth factors and growth factor receptors in human malignant glioma-derived cell lines

scientific article published in May 1989

Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes

scientific article

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

scientific article (publication date: July 2001)

Phosphatidylinositol 3-kinase activity is important for progesterone-induced Xenopus oocyte maturation

scientific article

Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown

scientific article published on November 1996

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

scientific article

Phosphatidylinositol linkage of a truncated form of the platelet-derived growth factor receptor.

scientific article published in October 1988

Phospholipase C gamma activation, phosphotidylinositol hydrolysis, and calcium mobilization are not required for FGF receptor-mediated chemotaxis.

scientific article published on January 1994

Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines

scientific article published on February 1990

Platelet-derived growth factor receptor inducibility is acquired immediately after translation and does not require glycosylation.

scientific article published on June 1989

Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types

scientific journal article

Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation

scientific article published in January 1988

Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor

scientific article

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

scientific article published on August 20, 1992

Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies

scientific article published on June 1987

Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos

scientific article published on July 1993

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

scientific article published on April 1995

Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways

scientific article published on 01 September 1995

Reduction of food intake and weight gain by the ob protein requires a specific secondary structure and is reversible.

scientific article

Regulated expression of the platelet-derived growth factor A chain gene in microvascular endothelial cells

scientific article published in October 1987

Regulation of adenylate cyclase coupled beta-adrenergic receptors

scientific article published on January 1976

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

scientific article published on February 1994

Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells

scientific article published on October 2000

Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone ⬇️

scientific article published on October 1, 1977

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK ⬇️

scientific article published on January 1, 1998

Role of phosphatidylinositol kinase in PDGF receptor signal transduction

scientific journal article

Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor

scientific article

SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase

scientific article published on May 1997

Signal transduction by the platelet-derived growth factor receptor

scientific article published on January 1988

Signaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association.

scientific article

Signalling by receptor tyrosine kinases ⬇️

scientific article published on January 1, 1993

Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor ⬇️

scientific article published on October 25, 1977

Specific binding of the calcium antagonist [3H]nitrendipine to subcellular fractions isolated from canine myocardium. Evidence for high affinity binding to ryanodine-sensitive sarcoplasmic reticulum vesicles

scientific article published on 01 May 1983

Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes ⬇️

scientific article published on March 1, 1977

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor ⬇️

scientific article published on April 1, 1992

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

scientific article published on February 21, 1992

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

scientific article published on April 1994

The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor

scientific article published on January 1987

Thrombin stimulates c-sis gene expression in microvascular endothelial cells

scientific article

Thyroid hormone regulation of beta-adrenergic receptor number ⬇️

scientific article published on April 25, 1977

Thyroxine and Propylthiouracil Effects on Alpha- and Beta-Adrenergic Receptor Number, ATPase Activities, and Sialic Acid Content of Rat Cardiac Membrane Vesicles ⬇️

scientific article published on November 1, 1979

Tyrosine 508 of the 85-kilodalton subunit of phosphatidylinositol 3-kinase is phosphorylated by the platelet-derived growth factor receptor

scientific article published on September 1994

Viability of transgenic mice expressing a platelet derived growth factor (PDGF) antagonist in plasma

scientific article published on 01 April 1996

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor ⬇️

scientific article published on April 5, 1991

Paulina is supported by:

About Paulina

Help