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List of works by Sarah Crunkhorn

ACC inhibitors block platelet production

scientific article published on 29 September 2020

ASO rescues Pelizaeus-Merzbacher disease

scientific article published on 06 July 2020

AbbVie invests in pioneering celiac disease therapy ⬇️

scientific article published on 01 July 2013

Ageing: Improving muscle function

scientific article published on 01 August 2016

Ageing: Reversing muscle degeneration

scientific article published on 21 September 2018

Aging: Promoting NAD+ production

scientific article published on 01 November 2018

Alcon invests in first non-surgical therapy for common eye disorder ⬇️

scientific article published on April 30, 2012

Alzheimer disease: Antimicrobial role of amyloid-β

scientific article published on 01 June 2016

Alzheimer disease: Antisense oligonucleotide reverses tau pathology

scientific article published on 01 March 2017

Alzheimer disease: BACE1 inhibitor reduces β-amyloid production in humans

scientific article

Alzheimer disease: Identification of blood-based biomarkers

scientific article published in February 2018

Alzheimer disease: Identification of novel Aβ inhibitors

scientific article published in February 2017

Antibacterial agents: Gallium fights infection in phase I trial

scientific article published on 19 October 2018

Antibacterial agents: Microbiome-derived antibiotic identified

scientific article

Antibacterial agents: New routes to tuberculosis treatment

scientific article published on 11 August 2017

Antibacterial drugs: New antibiotics on the horizon?

scientific article published in February 2013

Antibacterials: Curing infection with antibacterial drones

scientific article published on 01 October 2018

Antibacterials: Microcins limit intestinal infection

scientific article

Antibacterials: Synthetic peptides eradicate resistant infections.

scientific article

Antibody intervention rescues mice from sepsis

scientific article published on 22 April 2020

Anticancer agents: ACC inhibition suppresses lung cancer

scientific article published on November 2016

Anticancer agents: Allosteric histone methyltransferase modulators block tumour growth.

scientific article

Anticancer agents: An alternative route to targeting telomere elongation

scientific article published on 01 March 2015

Anticancer agents: Engineered platelets deliver immunotherapy

scientific article published on 01 March 2017

Anticancer agents: Osteoporosis drug shows potential for breast cancer prevention

scientific article published on 22 July 2016

Anticancer drugs: Chasing elusive targets

scientific article published on 17 October 2014

Anticancer drugs: Curbing self-renewal of cancer-initiating cells.

scientific article published in February 2014

Anticancer drugs: Selectively targeting proteins for degradation

scientific article published on 19 June 2015

Anticancer drugs: Stapled peptide reactivates p53.

scientific article published on 20 September 2013

Anticancer drugs: Tumour-specific angiogenesis inhibition

scientific article published on 01 May 2016

Anticancer drugs: a Notch closer

scientific article published on 01 June 2010

Anticancer drugs: stapled peptide rescues p53

scientific article published on 01 January 2011

Antifungal agent fights cystic fibrosis

scientific article published on 05 April 2019

Antigen-specific therapy for multiple sclerosis

scientific article published on 01 December 2020

Antimalarials: Novel proteasome inhibitor combats malaria

scientific article published in April 2016

Antimicrobials: Novel antibodies defeat dengue virus

scientific article published on August 2015

Antiparasitic drugs: Proteasome inhibition combats kinetoplastid infections

scientific article published on September 2016

Antiviral drugs: Novel antibodies defeat dengue virus

scientific article published on 14 August 2015

Antivirals: Identifying adenoviral receptors

scientific article published on 01 February 2011

Antivirals: Topical therapy for ocular herpes

scientific article published on 01 March 2018

Applying the human metabolome

scientific article published on 01 September 2019

Asthma: Alternative route to airway relaxation

scientific article published on 16 March 2018

Atherosclerosis: Haematopoietic mutation promotes atherogenesis

scientific article published on 01 March 2017

Autoimmune disease: Aryl hydrocarbon receptor suppresses inflammation

scientific article published on 01 June 2018

Autoimmune disease: Blocking the drivers

scientific article published on 20 May 2011

Autoimmune disease: CK2 blockade ameliorates EAE.

scientific article published in November 2016

Autoimmune disease: Parkinson's drug promotes myelin repair

scientific article

Autoimmune disease: Re-establishing immune tolerance

scientific article published on 01 July 2016

Autoimmune disease: Reversing systemic lupus erythematosus

scientific article published on 01 June 2016

Autoimmune disease: Reversing vitiligo

scientific article published on 01 August 2018

Autoimmune disease: Targeting glucose transport in psoriasis

scientific article published on 01 May 2018

Autoimmune diseases: New route to targeting TNF

scientific article published on 01 May 2011

Bicyclic azetidines treat cryptosporidiosis

scientific article published on 02 November 2020

Biogen acquires Stromedix to pursue novel fibrosis therapy ⬇️

scientific article published on March 30, 2012

Blocking GDF15 signalling reverses cachexia

scientific article published on 23 July 2020

Blocking PCSK9 enhances immune checkpoint therapy

scientific article published on 01 December 2020

Blocking hyaluronan synthesis

scientific article published on 01 July 2019

Body-on-a-chip for anticancer drug testing

scientific article published on 01 July 2019

Boost for base editing to treat inherited blood disorders

scientific article published on 31 March 2020

Breast cancer: FASN inhibitor increases survival

scientific article published on 01 July 2016

Breast cancer: Inhibiting fatty acid oxidation blocks tumour growth

scientific article published on 01 May 2016

CAR T cells combat cardiac fibrosis

scientific article published on 01 November 2019

CAR T cells combat cardiac fibrosis

scientific article published on 01 December 2019

CAR-T cells combat cardiac fibrosis

scientific article published on 01 October 2019

CNS injury: Microtubule stabilizer repairs spinal cord injury

scientific article published on 24 April 2015

CNS injury: Promoting neural repair

scientific article published on 22 September 2017

CRISPR-engineered fat cells prevent obesity

scientific article published on 01 September 2020

Cachexia: Inhibiting FAO rescues muscle-wasting

scientific article published on 01 June 2016

Cancer immunotherapy: Targeting regulatory T cells

scientific article published on 01 October 2017

Cancer: Anticancer effects of alcohol abuse drug

scientific article published in February 2018

Cancer: BMI1 inhibition reverses lung cancer

scientific article published in September 2016

Cancer: Bacterium-based immunotherapy

scientific article published on 01 March 2017

Cancer: Blocking metastasis

scientific article published on 18 November 2016

Cancer: Combating resistance to EGFR inhibitors

scientific article published on 01 December 2018

Cancer: Combination therapy for lung cancer.

scientific article

Cancer: Disrupting energy metabolism

scientific article published on 01 October 2018

Cancer: Inhibiting DNA damage signalling

scientific article published in December 2017

Cancer: Minimizing metastasis

scientific article published on 01 June 2018

Cancer: New path to improving immunotherapy

scientific article published on 16 February 2018

Cancer: Overcoming resistance to checkpoint blockade

scientific article published on 01 August 2018

Cancer: Peptibodies rescue mice from lymphoma

scientific article published in June 2016

Cancer: Preventing metastatic relapse

scientific article published on 01 May 2018

Cancer: RNA-based approaches target KRAS.

scientific article published in July 2017

Cancer: Redirecting T cell activity in solid tumours

scientific article published on 01 November 2018

Cancer: Reducing melanoma in redheads

scientific article published on 01 October 2017

Cancer: Releasing tumour suppressors

scientific article published on 20 July 2018

Cancer: Repurposing SGLT2 inhibitors

scientific article published on 01 December 2018

Cancer: Restoring p53 activity

scientific article published on 01 May 2018

Cancer: Targeting minimal residual disease

scientific article published on 01 August 2018

Cancer: Targeting telomeres

scientific article published in December 2017

Cancer: Targeting the ubiquitin pathway

scientific article published on 01 February 2018

Cancer: mRNA-encoded bispecific antibodies eliminate tumours

scientific article published on 01 July 2017

Cancer: mTOR inhibition curbs colorectal cancer

scientific article published in January 2015

Cardiovascular disease: CRHR2 blockade prevents heart failure.

scientific article

Cardiovascular disease: Dietary supplement protects the heart.

scientific article

Cardiovascular disease: Improving cardiomyocyte contractility

scientific article published on 20 July 2018

Cardiovascular disease: Inhalation therapy for heart failure

scientific article published on 01 February 2018

Cardiovascular disease: Insulin sensitizer protects the heart

scientific article published on 01 February 2015

Cardiovascular disease: Patching up the heart

scientific article published on 16 October 2015

Cardiovascular disease: Thioredoxin lowers hypertension

scientific article published in March 2017

Cardiovascular disorders: microRNA modulation elevates HDL

scientific article published on 18 November 2011

Cardiovascular drugs: Engineered apyrase averts clot formation

scientific article published on 19 September 2014

Combination therapy combats aggressive breast cancer

scientific article published on 06 April 2020

Combination treatment stimulates β-cell proliferation

scientific article published on 01 April 2020

Computational chemistry: Novel virtual screening approach

scientific article

Controlling CRISPR-Cas9 activity

scientific article published on 01 July 2019

Converting cancer cells to fat

scientific article published on 01 March 2019

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

scientific article

Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress

Deal watch: Genentech dives deeper into the next wave of cancer immunotherapies

scientific article published on 01 December 2014

Deal watch: Shire increases focus on regenerative medicine

scientific article published on 01 June 2012

Decoy receptor targets lung cancer

scientific article published on 01 January 2020

Deep learning identifies DDR1 kinase inhibitors

scientific article published on 01 October 2019

Degrading sialoglycans delays tumour growth

scientific article published on 01 September 2020

Delivering CARs with oncolytic viruses

scientific article published on 29 September 2020

Depression: Understanding ketamine action

scientific article published in June 2016

Designing cytokine mimics can optimize cancer therapy potential

scientific article published on 01 March 2019

Developing closed-loop neuromodulatory devices

scientific article published on 01 February 2019

Diabetes: Human iPSC-derived β-like cells rescue diabetic mice

scientific article published on 20 May 2016

Diabetes: Safer PPARγ-targeted drugs on the horizon?

scientific article published on 14 October 2011

Diabetes: Selective FOXO1 modulation

scientific article published in November 2017

Driving CARs to clear senescent cells

scientific article published on 24 June 2020

Driving CARs to clear senescent cells

scientific article published on 07 July 2020

Drug delivery: Star-shaped pill sustains drug release.

scientific article published in December 2016

Drug design: Cannabinoid receptor structure revealed

scientific article published on 18 November 2016

Drug discovery: Targeting transcription factors

scientific article published on 01 December 2018

Drug repurposing: Heart failure drug effective in medulloblastoma

scientific article published on 01 November 2018

Drug toxicity: Cardiac safety index for TKIs

scientific article published in March 2017

Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes

scientific article

Dual-acting combination meets heart failure end point ⬇️

scientific article published on 01 October 2012

Dual-acting peptide tackles triglycerides

scientific article published on 01 March 2020

DuoCAR-T cells eliminate HIV

scientific article published on 01 September 2019

Eliminating disseminated tumour cells

scientific article published on 01 March 2019

Eliminating vaccine cross-reactivity

scientific article published on 01 October 2019

Endocrinology: Reducing fat and building bone.

scientific article published on 16 June 2017

Enhancing CAR-T cell activity

scientific article published on 01 September 2019

Enzyme replacement success in Phase III trial for rare metabolic disorder ⬇️

scientific article published on January 1, 2013

Epigenetic mechanism of systemic sclerosis

scientific article published on 01 July 2019

Epigenetic route to recovery for spinal cord injury

scientific article published on 01 June 2019

Epigenetic therapy prevents AML

scientific article published on 01 March 2020

Epilepsy: Gene therapy safely reduces seizures in rats

scientific article published on 01 August 2018

Epilepsy: HSP90 inhibition suppresses seizures

scientific article published in February 2017

Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle

scientific article

Exon skipping combats Batten disease

scientific article published on 04 August 2020

Expanding the RNA-editing toolbox

scientific article published on 01 September 2019

Expanding the gene editing landscape

scientific article published on 01 November 2019

Exploiting proteome instability to enhance immunotherapy

scientific article published on 01 April 2020

Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis

scientific article

Fast-fail approach identifies promising anhedonia therapy

scientific article published on 06 April 2020

Fighting glioblastoma with vitamin B3

scientific article published on 06 April 2020

First-in-human trial of bispecific CAR-T cells

scientific article published on 02 November 2020

Fixing the leak

scientific article

Fungal infection: Protecting from Candida albicans

scientific article published on August 2016

G protein-coupled receptors: Illuminating orphan GPCRs

scientific article published on 01 January 2016

GPCR agonist targets obesity and diabetes

scientific article published on 01 March 2020

GPCRs: Crystal structure of D4 dopamine receptor

scientific article published in November 2017

GPCRs: Glucagon receptor antagonist binding site identified

scientific article published in June 2016

GPR146 inhibition protects against atherosclerosis

scientific article published on 01 January 2020

Gasdermin D inhibitor protects against sepsis

scientific article published on 08 May 2020

Gene therapy: Reprogramming α-cells reverses diabetes

scientific article published in February 2018

Genetic disorders: PI3K inhibitor reverses overgrowth syndrome

scientific article published on 20 July 2018

Genetic disorders: Steps towards epigenetic therapy for PWS

scientific article published on 01 February 2017

HIV integrase inhibitor-based regimen beats market leader ⬇️

scientific article published on September 1, 2012

HIV: Achieving sustained remission.

scientific article

HIV: CRISPR screen identifies novel therapeutic targets

scientific article published on February 2017

HIV: Trispecific antibodies block infection.

scientific article published in October 2017

Hepatokine improves glucose control

scientific article published on 29 September 2020

Huntington disease: Boosting PPARδ blocks neurodegeneration

scientific article published on 29 January 2016

Hydrogel fights infection and inflammation

scientific article published on 01 February 2020

Hypertension: Purinergic receptor inhibition lowers blood pressure

scientific article published in November 2016

Identifying antimalarial drug targets

scientific article published on 01 February 2019

Immune disorders: Blocking the alternative complement pathway

scientific article published on 18 November 2016

Immunotherapy: Blocking T cell sequestration

scientific article published on 01 October 2018

Immunotherapy: Oncolytic virotherapy enables checkpoint blockade

scientific article published in February 2018

Immunotherapy: Vaccine patch to treat melanoma

scientific article published in December 2017

Immunotherapy: iPSC-based cancer vaccine

scientific article published on 01 March 2018

Improving immunotherapy

scientific article published on 01 February 2020

Improving safety and efficacy of immunotherapeutics

scientific article published on 01 June 2019

Infectious disease: 3D structure of Zika virus protease

scientific article published on August 2016

Infectious disease: Alphavirus receptor identified

scientific article published on 01 June 2018

Infectious disease: Blocking malaria parasite invasion and egress

scientific article published on 15 December 2017

Infectious disease: Blocking malaria transmission

scientific article published on 22 September 2017

Infectious disease: Combination therapy combats MRSA.

scientific article published on 22 April 2016

Infectious disease: Curbing cholera

scientific article published on 20 July 2018

Infectious disease: Fighting influenza B.

scientific article published in November 2017

Infectious disease: Glutamine analogue reverses cerebral malaria

scientific article

Infectious disease: Peroxin inhibitor treats Trypanosoma infection

scientific article published on May 2017

Infectious disease: Virus-based tuberculosis vaccine.

scientific article published in March 2018

Infectious diseases: Novel agents fight flu infection

scientific article published on 19 April 2013

Infectious diseases: Targeting T cells to treat Chikungunya virus infections

scientific article published on March 2017

Infectious diseases: new leads for tackling malaria

scientific article published in April 2011

Inflammation: Microbiome manipulation ameliorates colitis

scientific article published in February 2018

Inflammatory disease: T cell-targeted antibody reverses fibrosis

scientific article published on 22 July 2016

Inflammatory disorders: Blocking proinflammatory gene transcription

scientific article published on 01 December 2018

Inflammatory disorders: targeting TRAFs tames inflammation

scientific article published on 17 May 2013

Inhibiting Wolbachia to treat parasitic diseases

scientific article published on 05 April 2019

Inhibiting enolase eradicates tumours

scientific article published on 01 December 2020

Inhibiting hypoxia in muscular dystrophy

scientific article published on 06 April 2020

Inhibiting insulin degradation

scientific article published on 01 July 2019

Inhibiting peptidoglycan remodelling

scientific article published on 01 April 2020

Inhibiting sebum production to treat acne

scientific article published on 01 July 2019

Inhibiting the HIV capsid protein

scientific article published on 06 July 2020

Ischaemic disorders: Nanotherapeutic delivers clot-busting drug

scientific article published on 20 August 2012

Ischaemic disorders: Safe path to thrombosis prevention

scientific article published on 01 March 2017

Links between thyroid hormone action, oxidative metabolism, and diabetes risk?

scientific article published on February 2008

Liver disease: Reducing cancer risk

scientific article published on 01 May 2018

Lowering mutant huntingtin protein

scientific article published on 01 January 2020

Lysosomal storage diseases: HSP70 reverses lysosomal pathology

scientific article published in November 2016

Malaria: Clues to vaccine design

scholarly article by Sarah Crunkhorn published 27 April 2018 in Nature Reviews Drug Discovery

Malaria: Novel antimalarial target identified

scientific article published in November 2016

Merck invests in pioneering cytomegalovirus programme ⬇️

scientific article published on 01 December 2012

Metabolic Disease: Protein tyrosine phosphatase inhibitor reverses diabetes

scientific article published on 21 April 2017

Metabolic disease: Beige cells secrete thermogenic factor

scientific article published on 01 May 2016

Metabolic disease: Birch bark compound combats metabolic syndrome

scientific article published on 01 March 2011

Metabolic disease: Ectopic olfactory receptor activation reverses obesity

scientific article published on 17 November 2017

Metabolic disease: Exercise hormone fights metabolic disease

scientific article published on 17 February 2012

Metabolic disease: FGF1 stops diabetes in its tracks

scientific article published on 17 June 2016

Metabolic disease: Leptin sensitizer reverses obesity

scientific article published on 19 August 2016

Metabolic disease: Liver enzyme inflames fat

scientific article published on 20 April 2018

Metabolic disease: Mitochondrial uncoupler reverses diabetes

scientific article published on 14 November 2014

Metabolic disease: New role for HDACs in glucose homeostasis

scientific article published on 01 July 2011

Metabolic disease: Novel fat-secreted hormone regulates glucose homeostasis

scientific article published on 13 May 2016

Metabolic disease: Preventing fat uptake

scientific article published on 01 October 2018

Metabolic disease: Safely mimicking cold exposure to reverse obesity

scientific article published on 01 November 2018

Metabolic disease: Turning 'bad' fat into 'good'

scientific article published on 31 August 2011

Metabolic disease: potassium channel blocker prevents obesity.

scientific article

Metabolic disorders: Betatrophin boosts β-cells

scientific article published on 21 June 2013

Metabolic disorders: Breaking the links between inflammation and diabetes

scientific article published on 15 March 2013

Metabolic disorders: Browning fat

scientific article published on 01 December 2012

Metabolic disorders: FGF21 analogue shows promise in the clinic.

scientific article

Metabolic disorders: Heart microRNA provides new route to metabolic control

scientific article published on 22 June 2012

Metabolic disorders: Hormone conjugate combats metabolic syndrome

scientific article published on 18 November 2016

Metabolic disorders: New avenue to AMPK activation

scientific article published on 12 October 2012

Metabolic disorders: New target for appetite control

scientific article published on 01 August 2012

Metabolic disorders: Safe cannabinoid receptor modulators in sight?

scientific article published on 24 September 2012

Mitochondrial circular RNA mitigates NASH

scientific article published on 29 September 2020

Mitochondrial disease: Eliminating mutant mitochondrial DNA

scientific article published on 01 October 2018

Molecular chaperone treats encephalopathy

scientific article published on 12 March 2019

Multi-antigen-specific T cell therapy for multiple myeloma

scientific article published on 04 August 2020

Muscle disorders: Preventing diaphragm dysfunction

scientific article published on 01 September 2016

Muscular dystrophy: New exon-skipping strategy rescues dystrophin

scientific article published in April 2015

Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue

scientific article published on March 2006

Neoantigen vaccine proven safe and immunogenic

scientific article published on 02 November 2020

Neurodegeneration: HIF-PHD inhibition ameliorates damage after brain haemorrhage

scientific article published on 22 April 2016

Neurodegeneration: New strategy for SBMA therapy

scientific article published in April 2018

Neurodegenerative disease: Immunotherapy opportunity emerges for Alzheimer disease

scientific article

Neurodegenerative disease: Novel ALS therapy shows promise in Phase II

scientific article published on 16 December 2011

Neurodegenerative disease: Phosphatase inhibitor prevents protein-misfolding diseases

scientific article published on 15 May 2015

Neurodegenerative disease: Pituitary adenylate cyclase activator ameliorates SBMA.

scientific article published in February 2017

Neurodegenerative disease: RXR agonist reverses Alzheimer's disease

scientific article published on 30 March 2012

Neurodegenerative disease: Taming the RAGE of Alzheimer's disease

scientific article published on 01 May 2012

Neurodegenerative disorders: Ataxin 2 reduction rescues motor defects

scientific article published on 19 May 2017

Neurodegenerative disorders: Linking apolipoprotein E to LOAD.

scientific article

Neurodegenerative disorders: Rescuing mitochondrial motility

scientific article published on 18 May 2018

Neurodegenerative disorders: SRC-ABL inhibitors protect motor neurons

scientific article published on 01 July 2017

Neurodegenerative disorders: restoring the balance

scientific article published on 01 August 2011

Neurological disorders: Nanoparticle opens door to cerebral palsy treatment

scientific article published on 18 May 2012

Neurological disorders: Reversing Rett syndrome

scientific article published on 22 September 2017

Neurological disorders: targeting translation in autism

scientific article

New clues for flu vaccine design ⬇️

scientific article published on September 30, 2011

New route to sepsis therapy

scientific article published on 04 March 2019

Novel incretin receptor antibodies combat weight gain

scientific article published on 01 February 2019

Obesity: Blocking ceramide formation

scientific article published on 01 October 2018

Obesity: Neurotensin inhibition prevents weight gain

scientific article

Obesity: Role of BAT in satiation

scientific article published on 01 December 2018

Ocular disorders: Collagen IV-derived peptide prevents angiogenesis

scientific article published on 01 March 2017

Ocular disorders: Vitamin B3 blocks glaucoma

scientific article published in March 2017

Orphan GPCR exhibits anti-opioid activity

scientific article published on 01 September 2019

Osteoporosis: Serotonin biosynthesis block builds bone

scientific article published in April 2010

Ovarian cancer: Cyclic peptide inhibits metastases

scientific article published on 01 May 2016

Overcoming adaptive resistance in AML

scientific article published on 01 October 2019

Overcoming chemoresistance

scientific article published on 01 July 2019

Pain: Blocking pain in inherited erythromelalgia.

scientific article

Pain: Silencing chronic pain with botulinum toxin

scientific article published on 17 August 2018

Patent-evading drug synthesis

scientific article published on 01 March 2019

Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation

scientific article published on 06 April 2007

Phage therapy for Mycobacterium abscessus

scientific article published on 01 July 2019

Phages fight alcoholic hepatitis

scientific article published on 01 January 2020

Pioneering RNAi therapy shows antitumour activity in humans ⬇️

scientific article published on 01 March 2013

Polypharmacology: Repurposing ceritinib

scientific article published in November 2017

Predicting novel antibacterial agents

scientific article published on 01 April 2020

Prion diseases: Polythiophenes delay prion-induced neurodegeneration

scientific article published on 21 September 2015

Profiling the malaria transcriptome

scientific article published on 01 September 2019

Programming bacteria to fight cancer

scientific article published on 01 September 2019

Prospecting for new antibiotics

scientific article published on 01 July 2019

Protecting β-cells in type 1 diabetes

scientific article published on 04 August 2020

Protein conformational diseases: Rescuing protein homeostasis

RNA interference: clinical gene-silencing success

scientific article published on 01 May 2010

RNA-based therapeutics: Increasing efficacy

scientific article published on 22 September 2017

Rare diseases: Bacterial peptide reverses Wilson disease

scientific article published on 01 July 2016

Rare diseases: Repurposing ciclopirox

scientific article published on 01 October 2018

Rebalancing protein synthesis in fragile X syndrome

scientific article published on 01 July 2020

Redesigning kinase inhibitors

scholarly article by Sarah Crunkhorn published February 2008 in Nature Reviews Drug Discovery

Reducing AAV vector associated neurotoxicity

scientific article published on 01 December 2020

Reducing α-synuclein accumulation

scientific article published on 01 March 2020

Regenerative disorders: notching up hearing

scientific article published on 15 February 2012

Regenerative medicine: Inhibiting Hippo repairs tissue

scientific article published in September 2016

Regenerative medicine: Inhibiting prostaglandin breakdown triggers tissue regeneration

scientific article published on 24 July 2015

Regulatory watch: enhanced chance of success for protein replacement therapies

scientific article

Reprogrammed α-cells reverse diabetes

scientific article published on 12 March 2019

Respiratory diseases: Gq protein inhibition induces airway relaxation

scientific article published in October 2017

Response to Brosch et al

scientific article published on March 2012

Restoring FGF21 reverses pancreatitis

scientific article published on 01 February 2020

Restoring vision loss with base editing

scientific article published on 26 October 2020

Reversing Rett syndrome

scientific article published on 01 September 2019

Reversing cerebrovascular dysfunction

scientific article published on 08 June 2020

Reversing inflammaging

scientific article published on 01 March 2020

Reversing obesity and diabetes

scientific article published on 01 June 2019

Reversing resistance to MRSA

scientific article published on 01 January 2020

Role of the Protein Data Bank

scientific article published on 01 February 2019

Role of the gut microbiota in PCOS

scientific article published on 01 September 2019

Selectively targeting antibiotic-resistant bacteria

scientific article published on 01 June 2019

Selectively targeting pathogenic TH17 cells

scientific article published on 06 July 2020

Selectively triggering mitotic failure

scientific article published on 17 September 2020

Sepsis: Gut bacteria induce protective IgA

scientific article published on 01 March 2018

Shortening jet-lag recovery

scientific article published on 08 May 2020

Sleep protects against atherosclerosis

scientific article published on 12 March 2019

Small molecule targets toxic RNA repeats

scientific article published on 10 November 2020

Small-molecule inhibitors of human mitochondrial DNA transcription

scientific article published on 04 January 2021

Sorafenib analogue combats MRSA

scientific article published on 01 February 2020

Statin therapy improves endothelial dysfunction

scientific article published on 04 August 2020

Strengthening the sting of immunotherapy

scientific article published on 25 August 2020

Strengthening the sting of immunotherapy

scientific article published on 08 September 2020

Stroke: Opening the therapeutic window

scientific article published on 15 June 2018

Stroke: Promoting neuronal recovery

scientific article published in September 2016

TRAIL blockade improves heart function

scientific article published on 08 May 2020

Targeted therapy for chordoma

scientific article published on 01 March 2019

Targeting CAR T cells to glioblastoma

scientific article published on 01 April 2020

Targeting CD70 in acute myeloid leukaemia

scientific article published on 06 July 2020

Targeting CDK12 to treat DM1

scientific article published on 08 May 2020

Targeting EBV-associated malignancies

scientific article published on 05 April 2019

Targeting NETs to treat gallstones

scientific article published on 01 September 2019

Targeting TGFβ signalling in T helper cells

scientific article published on 02 November 2020

Targeting TREM2 to enhance immunotherapy

scientific article published on 01 September 2020

Targeting cancer cell metabolism in glioblastoma

scientific article published on 27 March 2019

Targeting cancer cell metabolism in glioblastoma

scientific article published on 01 May 2019

Targeting macrophages enhances chemotherapy

scientific article published on 05 April 2019

Targeting polyamines in neuroblastoma

scientific article published on 12 March 2019

Targeting the epitranscriptome in AML

scientific article published on 01 June 2019

Technology: New method for endogenous protein degradation

scientific article

Towards a vaccine for equine encephalitis viruses

scientific article published on 01 July 2019

Towards long-acting HIV inhibitors

scientific article published on 01 October 2019

Transplantation: Combining OX40L and mTOR blockade

scientific article published on 01 October 2017

Treating Dravet syndrome with TANGO

scientific article published on 01 September 2020

Trial watch: Novel antimicrobial fights TB resistance

scientific article published on 20 July 2012

Trial watch: PCSK9 antibody reduces LDL cholesterol

Trial watch: Success in amyloidosis trials supports potential of systemic RNAi.

scientific article published in November 2013

Trial watch: integrin antagonist shows promise in MS

scientific article published on 01 March 2012

Type 2 diabetes: Broccoli extract lowers glucose levels.

scientific article published in July 2017

Type 2 diabetes: Microbial metabolite impairs insulin signaling

scientific article published on 01 November 2018

Type 2 diabetes: Targeting glutamine metabolism

scientific article published on 01 April 2018

Using loss-of-function human mutations to evaluate drug targets

scientific article published on 08 June 2020

Viral diseases: Zeroing in on RSV vaccine design

scientific article published on 13 December 2013

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