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Authors whose works are in public domain in at least one jurisdiction

List of works by Stewart D. Lyman

A new cytokine receptor superfamily

scientific article published on July 1990

Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha

scientific article published on 01 June 1996

Accelerated cell-cycling of hematopoietic progenitors by the flt3 ligand that is modulated by transforming growth factor-beta

scientific article published on 01 March 1996

Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model ⬇️

scientific article published on August 15, 1997

Bidirectional effect of interleukin-10 on early murine B-cell development: stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB c

scientific article published in December 1997

Biologic effects and potential clinical applications of Flt3 ligand ⬇️

scientific article published on May 1, 1998

Biological activities and potential therapeutic uses of steel factor. A new growth factor active on multiple hematopoietic lineages

scientific article published on January 1, 1992

Biology and potential clinical applications of flt3 ligand ⬇️

scientific article published on May 1, 1995

Biology of flt3 ligand and receptor

scientific article published on August 1995

Characterization of the gene-product of the Steel locus ⬇️

scientific article published on January 1, 1991

Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene

scientific article published on 01 April 1993

Chronic overexpression of membrane-bound flt3 ligand by T lymphocytes in severe aplastic anaemia

scientific article published on 01 April 2000

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells

scientific article

Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells.

scientific article published in August 1996

Comparative effects of retroviral-mediated gene transfer into primary human stromal cells of Flt3-ligand, interleukin 3 and GM-CSF on production of cord blood progenitor cells in long-term culture

scientific article published on 01 January 1998

Cytokine regulation of hematopoietic stem cells

scientific article published on November 1, 1991

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail

scientific article published on October 1, 1992

Diamond-Blackfan anemia: heterogenous response of hematopoietic progenitor cells in vitro to the protein product of the steel locus ⬇️

scientific article published on November 1, 1991

Dramatic Numerical Increase of Functionally Mature Dendritic Cells in FLT3 Ligand-Treated Mice ⬇️

scientific article published on January 1, 1997

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified

scientific article

Effect of flt3 ligand on in vitro growth and expansion of colony-forming bone marrow cells from patients with aplastic anemia

scientific article published on 01 July 1997

Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells ⬇️

scientific article published on 01 November 1995

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells ⬇️

scientific article published on May 15, 1991

Effects of Flt3 ligand and interleukin-7 on in vitro growth of acute lymphoblastic leukemia cells

scientific article published on 01 February 1996

Effects of flt3 ligand on acute myeloid and lymphocytic leukemic blast cells from children

scientific article published on 01 February 1996

Efficient Retrovirus-Mediated Gene Transfer of Dendritic Cells Generated from CD34+Cord Blood Cells under Serum-Free Conditions ⬇️

scientific article published on September 20, 1997

Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development

scientific article published in September 1991

Endogenous FLT-3 ligand serum levels are associated with disease stage in patients with myelodysplastic syndromes

scientific article published on 01 April 1999

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture ⬇️

scientific article published on June 1, 1992

Expression of the flt3 receptor and its ligand on hematopoietic cells

scientific article published on July 1, 1995

FLT-3 ligand provides hematopoietic protection from total body irradiation in rabbits ⬇️

scientific article published on August 1, 1998

FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells

scientific article published on November 1996

Flt3 ligand enhances the yield of primitive cells after Ex vivo cultivation of CD34+ CD38dim cells and CD34+ CD38dim CD33dim HLA-DR+ cells ⬇️

scientific article published on November 15, 1997

Flt3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia

scientific article published on 01 December 1996

Flt3 ligand prolongs survival of CD34++ + human umbilical cord blood myeloid progenitors in serum-depleted culture medium

scientific article published on 01 March 1996

Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells

scientific article published on 01 September 1995

Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7

article

Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice ⬇️

scientific article published on 01 November 1997

Flt3-ligand production by human bone marrow stromal cells

scientific article published on 01 June 1996

Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk.

scientific article published in November 1994

Haematopoietic action of flt3 ligand on cord blood‐derived CD34‐positive cells expressing different levels of flt3 or c‐kit tyrosine kinase receptor: comparison with stem cell factor ⬇️

scientific article published on May 1, 1998

Hematologic effects of flt3 ligand in vivo in mice

scientific article published on 01 September 1996

Human FLT3 ligand acts on myeloid as well as multipotential progenitors derived from purified CD34+ blood progenitors expressing different levels of c-kit protein

scientific article published on 01 April 1997

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily

scientific article

Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs

scientific article

In vitro expansion of hematopoietic progenitors and maintenance of stem cells: comparison between FLT3/FLK-2 ligand and KIT ligand

scientific article published on 01 March 1997

In vivo effects of Flt3/Flk2 ligand on mobilization of hematopoietic progenitors in primates and potent synergistic enhancement with granulocyte colony-stimulating factor ⬇️

scientific article published on July 15, 1997

Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells

scientific article published on February 1, 1991

Influence of steel factor on hemoglobin synthesis in sickle cell disease

scientific article published on 01 April 1992

Isolation and characterization of primitive hematopoietic progenitors of murine fetal liver

scientific article published on 01 February 1996

Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases

scientific article

KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells

scientific article published on 01 August 1993

Leukemic predisposition of mice transplanted with gene-modified hematopoietic precursors expressing flt3 ligand ⬇️

scientific article published on September 15, 1998

Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins

scientific article

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles ⬇️

scientific article published on October 5, 1990

Mast cell growth factor, a ligand for the receptor encoded by c-kit, affects the growth in culture of the blast cells of acute myeloblastic leukemia

scientific article published on 01 June 1991

Mechanism of flt3 ligand expression in bone marrow failure: translocation from intracellular stores to the surface of T lymphocytes after chemotherapy-induced suppression of hematopoiesis

scientific article published on 01 April 1999

Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells

scientific article

Modulation of haematopoietic progenitor development by FLT-3 ligand

scientific article published on 01 September 1999

Molecular and cellular biology of mast cell growth factor: the gene product of the murine steel locus

scientific article published on December 1, 1991

Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells

scientific article

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms ⬇️

scientific article published on October 5, 1990

Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors

scientific article published on 01 September 1995

OCI/AML-4 an acute myeloblastic leukemia cell line: regulation and response to cytosine arabinoside

scientific article published on August 1, 1991

Plasma/serum levels of flt3 ligand are low in normal individuals and highly elevated in patients with Fanconi anemia and acquired aplastic anemia

scientific article published on 01 December 1995

Recombinant murine steel factor stimulates in vitro production of granulocyte–macrophage progenitor cells ⬇️

scientific article published on 01 November 1992

Requirement for mast cell growth factor for primordial germ cell survival in culture ⬇️

scientific article published on August 29, 1991

Retroviral mediated gene transfer of Flt3 ligand enhances proliferation and MAP kinase activity of AML5 cells

scientific article published on January 1997

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase ⬇️

scientific article published on September 1, 1991

Soluble thrombopoietin receptor (Mpl) and granulocyte colony-stimulating factor receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel factor or the ligand for Flt3/Flk2

scientific article published on 01 December 1996

Steel factor is required for maintenance, but not differentiation, of melanocyte precursors in the neural crest

scientific article published on 01 October 1992

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains ⬇️

scientific article published on June 1, 1991

Stem cell factor, but not flt3 ligand, induces differentiation and activation of human mast cells

scientific article published on May 1996

Structural analysis of human and murine flt3 ligand genomic loci

scientific article

Structure-Function Analysis of FLT3 Ligand-FLT3 Receptor Interactions Using a Rapid Functional Screen ⬇️

scientific article published on July 10, 1998

Synergistic action of Flt3 and gp130 signalings in human hematopoiesis ⬇️

scientific article published on December 1, 1997

Synergy of growth factors during mobilization of peripheral blood precursor cells with recombinant human Flt3-ligand and granulocyte colony-stimulating factor in rabbits

scientific article published on 01 January 1999

The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro

scientific article published on 01 February 1996

The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors

scientific article published on April 1995

The Steel factor

scientific article published on June 1, 1992

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

scientific article published on June 1991

The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta.

scientific article

The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors

scientific article published on 01 April 1995

The flt3 ligand: a hematopoietic stem cell factor whose activities are distinct from steel factor.

scientific article published on January 1994

The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3

scientific article

The interleukin-4 receptor: structure, function, and signal transduction

scientific article

The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow

scientific article published on May 1, 1998

Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand

scientific article published on 01 April 1997

Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3

Thrombopoietin, steel factor and the ligand for flt3/flk2 interact to stimulate the proliferation of human hematopoietic progenitors in culture

scientific article published on 01 December 1997

c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas ⬇️

scientific article published on February 1, 1992

c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities

scientific article published on February 1998

flt3 ligand in cooperation with transforming growth factor-beta1 potentiates in vitro development of Langerhans-type dendritic cells and allows single-cell dendritic cell cluster formation under serum-free conditions ⬇️

scientific article published on August 15, 1997

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