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List of works by Douglas E. Williams

A novel mast cell growth factor (MCGF-3) produced by marrow-adherent cells that synergizes with interleukin 3 and interleukin 4.

scientific article published on August 1990

Administration of IL-7 to mice with cyclophosphamide-induced lymphopenia accelerates lymphocyte repopulation

scientific article published on 01 March 1991

Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24 ⬇️

scientific article published on August 1, 1991

Biological activities and potential therapeutic uses of steel factor. A new growth factor active on multiple hematopoietic lineages

scientific article published on January 1, 1992

Biology and potential clinical applications of flt3 ligand ⬇️

scientific article published on May 1, 1995

CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligan

scientific article

Characterization of hematopoietic stem and progenitor cells

scientific article published on January 1987

Characterization of the gene-product of the Steel locus ⬇️

scientific article published on January 1, 1991

Clonal growth of murine pre-B colony-forming cells and their targeted infection by a retroviral vector: dependence on interleukin-7.

scientific article published on March 1990

Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony-stimulating factor-1, and recombinant murine granulocyte-macrophage colony-stimulating factor on myelopoiesis in mice

scientific article

Correlation between CSF-1 responsiveness and expression of (CSF-1 receptor) c-fms in purified murine granulocyte-macrophage progenitor cells (CFU-GM)

scientific article published on 01 March 1988

Correlation between CSF-1 responsiveness and expression of (CSF-1 receptor) c-fms in purified murine granulocyte-macrophage progenitor cells (CFU-GM).

scientific article published in January 1988

Cytokine regulation of hematopoietic stem cells

scientific article published on November 1, 1991

Derivation of mixed phenotype cell lines with ras-myc- and raf-myc-containing retroviral vectors after infection of murine long-term bone marrow cultures

scientific article published on 01 August 1991

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail

scientific article published on October 1, 1992

Diamond-Blackfan anemia: heterogenous response of hematopoietic progenitor cells in vitro to the protein product of the steel locus ⬇️

scientific article published on November 1, 1991

Effect in vivo of multiple injections of purified murine and recombinant human macrophage colony-stimulating factor to mice

scientific article published on 01 July 1989

Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells ⬇️

scientific article published on 01 November 1995

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells ⬇️

scientific article published on May 15, 1991

Effects of flt3 ligand on acute myeloid and lymphocytic leukemic blast cells from children

scientific article published on 01 February 1996

Effects of hematopoietic suppressor molecules on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells

scientific article published on 01 March 1988

Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development

scientific article published in September 1991

Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein ⬇️

scientific article published on July 1, 1991

Ex vivo expansion of peripheral blood progenitor cells with recombinant cytokines

scientific article published on 01 June 1992

Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice ⬇️

scientific article published on 01 November 1997

Growth characteristics of marrow hematopoietic progenitor/precursor cells from patients on a phase I clinical trial with purified recombinant human granulocyte-macrophage colony-stimulating factor

scientific article published on August 1988

Hematologic effects of flt3 ligand in vivo in mice

scientific article published on 01 September 1996

Hybrid cytokines as hematopoietic growth factors

scientific article published on November 1991

Identification of human juvenile chronic myelogenous leukemia stem cells capable of initiating the disease in primary and secondary SCID mice

scientific article published on 01 October 1996

In vivo biologic effects of PIXY321, a synthetic hybrid protein of recombinant human granulocyte-macrophage colony-stimulating factor and interleukin-3 in cancer patients with normal hematopoiesis: a phase I study ⬇️

scientific article published on September 15, 1995

Inducible production of human macrophage growth factor, CSF-1

scientific article published on 01 September 1986

Influence of IL-1 alpha and -1 beta on the survival of human bone marrow cells responding to hematopoietic colony-stimulating factors

scientific article published on 01 June 1989

Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells

scientific article published on February 1, 1991

Influence of purified recombinant human macrophage colony stimulating factor in mice

scientific article published on 01 January 1989

Influence of recombinant human interleukin (IL)-7 on disease progression in mice infected with Friend virus complex

scientific article published on September 9, 1992

Influence of steel factor on hemoglobin synthesis in sickle cell disease

scientific article published on 01 April 1992

Interactions between purified murine colony-stimulating factors (natural CSF-1, recombinant GM-CSF, and recombinant IL-3) on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells

scientific article published on 01 November 1987

Interleukin 4 alone or in combination with interleukin 1 stimulates 3T3 fibroblasts to produce colony-stimulating factors

scientific article published on May 1, 1991

Interleukin-1 alpha enhances the in vitro survival of purified murine granulocyte-macrophage progenitor cells in the absence of colony-stimulating factors

scientific article published on 01 November 1988

Macrophage inflammatory protein (MIP)-1 beta abrogates the capacity of MIP-1 alpha to suppress myeloid progenitor cell growth

scientific article

Mast cell growth factor (c-kit ligand) supports the growth of human multipotential progenitor cells with a high replating potential ⬇️

scientific article published on 01 November 1991

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles ⬇️

scientific article published on October 5, 1990

Mast cell growth factor, a ligand for the receptor encoded by c-kit, affects the growth in culture of the blast cells of acute myeloblastic leukemia

scientific article published on 01 June 1991

Molecular and cellular biology of mast cell growth factor: the gene product of the murine steel locus

scientific article published on December 1, 1991

Molecular cloning and biological characterization of a novel murine lymphoid growth factor

scientific journal article

OCI/AML-4 an acute myeloblastic leukemia cell line: regulation and response to cytosine arabinoside

scientific article published on August 1, 1991

Pharmacokinetic parameters of recombinant mast cell growth factor (rMGF)

scientific article published on 01 October 1992

Pluripotential hematopoietic stem cells in post-5-fluorouracil murine bone marrow express the Thy-1 antigen

scientific article published on 01 August 1985

Preclinical and clinical effects of the hematopoietic colony stimulating factors.

scientific article published on January 1988

Protective effects of recombinant human interleukin-1 alpha in doxorubicin-treated normal and tumor-bearing mice

scientific article published on 01 April 1993

Purification of murine bone-marrow-derived granulocyte-macrophage colony-forming cells

scientific article published on 01 March 1987

Purified murine granulocyte/macrophage progenitor cells express a high-affinity receptor for recombinant murine granulocyte/macrophage colony-stimulating factor

scientific article published on January 1988

Qualitative functional deficiency of affinity-purified lactoferrin from neutrophils of patients with chronic myelogenous leukemia, and lactoferrin/H-ferritin-cell interactions in a patient with lactoferrin-deficiency with normal numbers of circulati

scientific article published on 01 January 1991

Recombinant human granulocyte-colony stimulating factor and recombinant human macrophage-colony stimulating factor synergize in vivo to enhance proliferation of granulocyte-macrophage, erythroid, and multipotential progenitor cells in mice

scientific article published on 01 October 1988

Recombinant murine steel factor stimulates in vitro production of granulocyte–macrophage progenitor cells ⬇️

scientific article published on 01 November 1992

Requirement for mast cell growth factor for primordial germ cell survival in culture ⬇️

scientific article published on August 29, 1991

Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: effects of mast cell growth factor (MGF) combined with other cytokines

scientific article published in October 1992

Role for cyclic AMP in the postreceptor control of cytokine-stimulated stromal cell growth factor production

scientific article published on July 1990

Role of stromal populations in hemopoietic stem cell proliferation. I. Physically distinct subpopulations of hemopoietic stem cells and stromal progenitors determine long-term culture hemopoiesis

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase ⬇️

scientific article published on September 1, 1991

Steel factor (c-kit ligand) stimulates the in vitro growth of immature CD3-/CD4-/CD8- thymocytes: synergy with IL-7.

scientific article published on August 1994

Steel factor is required for maintenance, but not differentiation, of melanocyte precursors in the neural crest

scientific article published on 01 October 1992

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains ⬇️

scientific article published on June 1, 1991

Suppressive effects in vivo of purified recombinant human H-subunit (acidic) ferritin on murine myelopoiesis

scientific article published on January 1989

Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. Multiple actions

scientific article published on 01 December 1988

Synergistic interaction of hematopoietic colony stimulating and growth factors in the regulation of myelopoiesis

scientific article published on 01 August 1988

Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3, and recombinant murine granulocyte/macrophage colony-stimulating factor

scientific article

T-cell growth factor P40 promotes the proliferation of myeloid cell lines and enhances erythroid burst formation by normal murine bone marrow cells in vitro

scientific article published on September 1990

Temporal adaptation of neutrophil oxidative responsiveness to n-formyl-methionyl-leucyl-phenylalanine. Acceleration by granulocyte-macrophage colony stimulating factor.

scientific article published in October 1988

The Steel factor

scientific article published on June 1, 1992

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

scientific article published on June 1991

The effects in vivo of purified preparations of murine macrophage colony stimulating factor-1, recombinant murine granulocyte-macrophage colony stimulating factor and natural and recombinant murine interleukin 3 without and with pretreatment of mice

scientific article published on 01 September 1986

The effects of interleukin 7 (IL-7) on human bone marrow in vitro

scientific article published on September 1, 1991

The effects of purified recombinant murine interleukin-3 and/or purified natural murine CSF-1 in vivo on the proliferation of murine high- and low-proliferative potential colony-forming cells: demonstration of in vivo synergism

scientific article published on 01 August 1987

The flt3 ligand: a hematopoietic stem cell factor whose activities are distinct from steel factor.

scientific article published on January 1994

The influence in vivo of murine colony-stimulating factor-1 on myeloid progenitor cells in mice recovering from sublethal dosages of cyclophosphamide

scientific article published on 01 March 1987

The influence in vivo of natural murine interleukin-3 on the proliferation of myeloid progenitor cells in mice recovering from sublethal dosages of cyclophosphamide

scientific article published on 01 January 1987

The influence of purified recombinant human heavy-subunit and light-subunit ferritins on colony formation in vitro by granulocyte-macrophage and erythroid progenitor cells

scientific article published on 01 December 1986

The opposing actions in vivo on murine myelopoiesis of purified preparations of lactoferrin and the colony stimulating factors

scientific article published on 01 January 1987

The production of myeloid blood cells and their regulation during health and disease

scientific article published on January 1988

The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma

scientific article published on 01 June 1986

c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas ⬇️

scientific article published on February 1, 1992

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