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List of works by Qi Shi

(Ctm)PrP and ER stress: a neurotoxic mechanism of some special PrP mutants

scientific article published on July 2011

A Chinese Creutzfeldt-Jakob disease patient with E196K mutation inPRNP ⬇️

scientific article published on April 1, 2011

A Chinese patient of P102L Gerstmann-Sträussler-Scheinker disease contains three other disease-associated mutations in SYNE1.

scientific article published on 6 March 2018

A novel PrP partner HS-1 associated protein X-1 (HAX-1) protected the cultured cells against the challenge of H₂O₂.

scientific article

A patient with Creutzfeldt-Jakob disease with an insertion of 7 octa-repeats in the PRNP gene: molecular characteristics and clinical features

scientific article published in December 2008

A point mutation in the DNA-binding domain of HPV-2 E2 protein increases its DNA-binding capacity and reverses its transcriptional regulatory activity on the viral early promoter

scientific article

A redox process of ethanethiol group increases formation of beta-sheet structure and amyloid fibrils of wild type human prion protein

scientific article published on 01 June 2012

Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents

scientific article published on 6 December 2016

Aberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection

scientific article published on 2 October 2017

Abnormal Activation of Microglia Accompanied with Disrupted CX3CR1/CX3CL1 Pathway in the Brains of the Hamsters Infected with Scrapie Agent 263K ⬇️

scientific article published on March 24, 2013

Abnormally Upregulated αB-crystallin Was Highly Coincidental with the Astrogliosis in the Brains of Scrapie-Infected Hamsters and Human Patients with Prion Diseases ⬇️

scientific article published on July 6, 2013

Abortive Cell Cycle Events in the Brains of Scrapie-Infected Hamsters with Remarkable Decreases of PLK3/Cdc25C and Increases of PLK1/Cyclin B1 ⬇️

scientific article published on April 27, 2013

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

scientific article

Alternative complement pathway is activated in the brains of scrapie-infected rodents

scientific article published on 12 November 2019

Analyses of the Survival Time and the Influencing Factors of Chinese Patients with Prion Diseases Based on the Surveillance Data from 2008–2011 ⬇️

scientific article published on May 6, 2013

Analyses of the expressions of GFAP in the brain tissues of hamsters infected with various amounts of scrapie strain 263K at terminal stage

scientific article published in August 2008

Analyses of the mitochondrial mutations in the Chinese patients with sporadic Creutzfeldt-Jakob disease

scientific article

Analysis of the advantage features of Beijing surveillance network for Creutzfeldt-Jakob disease

scientific article

Analysis of the compliance and the related influence factors in the follow-up process of surveillance for Creutzfeldt-Jakob disease in China

scientific article

Apparent reduction of ADAM10 in scrapie-infected cultured cells and in the brains of scrapie-infected rodents

scientific article published on 26 April 2014

Associations of TP53 mutations, codon 72 polymorphism and human papillomavirus in head and neck squamous cell carcinoma patients

scientific article published on 20 September 2013

Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD ⬇️

scientific article published on July 1, 2013

Clinical and Laboratory Features of Three Rare Chinese V210I gCJD Patients

scientific article published on 28 September 2020

Clinical and familial characteristics of eight Chinese patients with T188K genetic Creutzfeldt–Jakob disease ⬇️

scientific article published on December 20, 2012

Clinical and laboratory features of 14 young Chinese probable sCJD patients

scientific article published on 9 March 2017

Clinical, histopathological and genetic studies in a family with fatal familial insomnia

scientific article published on 22 January 2010

Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China

scientific article published on 01 December 2020

Co-expressions of Casein Kinase 2 (CK2) Subunits Restore the Down-Regulation of Tubulin Levels and Disruption of Microtubule Structures Caused by PrP Mutants ⬇️

scientific article published on July 1, 2012

Comparative analysis of gene expression profiles between cortex and thalamus in Chinese fatal familial insomnia patients

scientific article published on 21 February 2013

Comparative peptidome analyses of the profiles of the peptides ranging from 1–10 KD in CSF samples pooled from probable sporadic CJD and non-CJD patients ⬇️

scientific article published on January 1, 2012

Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages

scientific article published on 19 December 2016

Comparison of the pathologic and pathogenic features in six different regions of postmortem brains of three patients with fatal familial insomnia ⬇️

scientific article published on November 22, 2012

Cytosolic PrP Induces Apoptosis of Cell by Disrupting Microtubule Assembly ⬇️

scientific article published on September 14, 2010

Cytosolic prion protein induces apoptosis in human neuronal cell SH-SY5Y via mitochondrial disruption pathway

scientific article published in July 2009

Decrease of RyR2 in the prion infected cell line and in the brains of the scrapie infected mice models and the patients of human prion diseases

scientific article published on 20 April 2018

Development of a multiplex PCR method for detecting and typing human papillomaviruses in verrucae vulgaris

scientific article published on 14 September 2007

Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies

scientific article published on 11 April 2008

Different post-mortem brain regions from three Chinese FFI patients induce different reactive profiles both in the first and second generation RT-QuIC assays

scientific article published on 01 December 2020

Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells

scientific article published on 4 January 2014

Down-regulation of brain-derived neurotrophic factor and its signaling components in the brain tissues of scrapie experimental animals

scientific article published on 30 August 2016

Elevated Levels of Tau Protein in Cerebrospinal Fluid of Patients With Probable Creutzfeldt-Jakob Disease ⬇️

scientific article published on 01 October 2010

Establishment of a protein misfolding cyclic amplification for PrPSc

scientific article

Establishment of a sandwich ELISA method for detection of vascular endothelial growth factor in serum samples of hepatocellular carcinoma patients.

scientific article

Establishment of a stable PrP(Sc) panel from brain tissues of experimental hamsters with scrapie strain 263K.

scientific article

Evaluation of the effect of various main elements on the PrPSc detection by real-time quaking-induced conversion assay

Expression of prion protein is closely associated with pathological and clinical progression and abnormalities of p53 in head and neck squamous cell carcinomas

scientific article published on 16 November 2015

Expressions of Nucleoside Diphosphate Kinase (nm23) in Tumor Tissues are Related with Metastasis and Length of Survival of Patients with Hepatocellular Carcinoma ⬇️

scientific article published on August 1, 2010

FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection

scientific article

Familial CJD Associated PrP Mutants within Transmembrane Region Induced Ctm-PrP Retention in ER and Triggered Apoptosis by ER Stress in SH-SY5Y Cells ⬇️

scientific article published on January 27, 2011

Flotillin-1 Mediates PrPC Endocytosis in the Cultured Cells During Cu2+ Stimulation Through Molecular Interaction ⬇️

scientific article published on April 27, 2013

Generation and characterization of two strains of transgene mice expressing chimeric MiniSOG-MusPrP

scientific article published on 13 May 2020

Global protein differential expression profiling of cerebrospinal fluid samples pooled from Chinese sporadic CJD and non-CJD patients

scientific article published on 4 August 2013

Global transcriptional profiling of the postmortem brain of a patient with G114V genetic Creutzfeldt-Jakob disease ⬇️

scientific article published on January 10, 2013

Heat shock protein 104 inhibited the fibrillization of prion peptide 106–126 and disassembled prion peptide 106–126 fibrils in vitro ⬇️

scientific article published on February 3, 2011

Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction ⬇️

scientific article published on December 6, 2012

Human Prion disease with a T188K mutation in Chinese: a case report

scientific article published on 29 May 2009

Human prion disease with a G114V mutation and epidemiological studies in a Chinese family: a case series

scientific article published on 17 October 2008

Human prion protein mutants with deleted and inserted octarepeats undergo different pathways to trigger cell apoptosis

scientific article

Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases

scientific article published on 23 May 2016

Infection of prions and treatment of PrP106-126 alter the endogenous status of protein 14-3-3 and trigger the mitochondrial apoptosis possibly via activating Bax pathway

scientific article published on 18 October 2013

Interaction between 14-3-3β and PrP influences the dimerization of 14-3-3 and fibrillization of PrP106-126.

scientific article published on 22 November 2013

Knockdown of prion protein (PrP) by RNA interference weakens the protective activity of wild-type PrP against copper ion and antagonizes the cytotoxicity of fCJD-associated PrP mutants in cultured cells ⬇️

scientific article published on May 2, 2011

Low activity of complement in the cerebrospinal fluid of the patients with various prion diseases

scientific article published on 3 May 2016

Manganese-induced changes of the biochemical characteristics of the recombinant wild-type and mutant PrPs

scientific article published on 25 July 2009

MiRNA expression profiles in the brains of mice infected with scrapie agents 139A, ME7 and S15.

scientific article

Molecular Interaction of TPPP with PrP Antagonized the CytoPrP-Induced Disruption of Microtubule Structures and Cytotoxicity ⬇️

scientific article published on August 12, 2011

Molecular epidemiological study on prevalence of human papillomaviruses in patients with common warts in Beijing area

scientific article published on 01 February 2009

Mouse-adapted scrapie strains 139A and ME7 overcome species barrier to induce experimental scrapie in hamsters and changed their pathogenic features ⬇️

scientific article published on March 9, 2012

Mutations in various functional domains of HPV2 E2 protein inhibit the transcriptional depression activities

scientific article published on 01 June 2011

Optimization of the isolation and enrichment of S-nitrosylated proteins from brain tissues of rodents and humans with various prion diseases for iTRAQ-based proteomics

scientific article published on 22 October 2014

Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy

scientific journal article

Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.

scientific article published on 17 November 2013

Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction

scientific article

PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn ⬇️

scientific article published on January 3, 2013

PrP protein can bind to protein kinase CK2 both in native and recombinant forms in vitro

scientific article published in September 2008

PrP(Sc) of scrapie 263K propagates efficiently in spleen and muscle tissues with protein misfolding cyclic amplification

scientific article published on 20 January 2009

Preparation of human tau exon-2- and -10-specific monoclonal antibodies for the recognition of brain tau proteins in various mammals

scientific article published on 3 June 2015

Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion Diseases

scientific article published on 04 September 2019

Protein Disulfide Isomerase Regulates Endoplasmic Reticulum Stress and the Apoptotic Process during Prion Infection and PrP Mutant-Induced Cytotoxicity ⬇️

scientific article published on June 7, 2012

Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions

scientific article published on 4 June 2016

Proteomic Analyses for the Global S-Nitrosylated Proteins in the Brain Tissues of Different Human Prion Diseases

scientific article published on 21 September 2015

Proteomics analyses for the global proteins in the brain tissues of different human prion diseases

scientific article

Quality evaluation for the surveillance system of human prion diseases in China based on the data from 2010 to 2016.

scientific article

Rare E196A mutation in PRNP gene of 3 Chinese patients with Creutzfeldt-Jacob disease

scientific article published on 16 June 2016

Rare V180I mutation in PRNP gene of a Chinese patient with Creutzfeldt-Jakob disease

scientific article

Rare V203I mutation in thePRNPgene of a Chinese patient with Creutzfeldt–Jakob disease ⬇️

scientific article published on May 1, 2013

Rare genetic Creutzfeldt-Jakob disease with T188K mutation: analysis of clinical, genetic and laboratory features of30 Chinese patients

scientific article

Re-infection of the prion from the scrapie‑infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c

scientific article published on 25 January 2016

Recombinant neural protein PrP can bind with both recombinant and native apolipoprotein E in vitro

scientific article published on September 2006

Redox induces diverse effects on recombinant human wild-type PrP and mutated PrP with inserted or deleted octarepeats

scientific article published on 30 January 2018

Reduction of NF-κB (p65) in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents

scientific article published on 07 August 2017

Remarkable Activation of the Complement System and Aberrant Neuronal Localization of the Membrane Attack Complex in the Brain Tissues of Scrapie-Infected Rodents

scientific article published on 14 October 2014

Remarkable Reduction of MAP2 in the Brains of Scrapie-Infected Rodents and Human Prion Disease Possibly Correlated with the Increase of Calpain ⬇️

scientific article published on January 17, 2012

Remarkable impairment of Wnt/β-catenin signaling in the brains of the mice infected with scrapie agents

scientific article published on 3 November 2015

Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection

scientific article published on 28 September 2017

Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss

scientific article published on 29 May 2014

SARS-CoV-2 Lambda Variant: Spatiotemporal Distribution and Potential Public Health Impact

scientific article

Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of Sirt1.

scientific article

Significant enhanced expressions of aquaporin-1, -4 and -9 in the brains of various prion diseases

scientific article published on 01 January 2019

Significant reduction of the GLUT3 level, but not GLUT1 level, was observed in the brain tissues of several scrapie experimental animals and scrapie-infected cell lines

scientific article published on 16 November 2013

Stilbene compounds inhibit the replications of various strains of prions in the levels of cell culture, PMCA and RT-QuIC possibly via molecular binding

scientific article published on 08 June 2020

Study on the characteristics of patients with Creutzfeldt-Jakob disease under 2008 surveillance data in China

scientific article

Successive passaging of the scrapie strains, ME7-ha and 139A-ha, generated by the interspecies transmission of mouse-adapted strains into hamsters markedly shortens the incubation times, but maintains their molecular and pathological properties

scientific article published on 13 February 2015

Surveillance for Creutzfeldt-Jakob disease in China from 2006 to 2007.

scientific article

The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models

scientific article

The Features of Genetic Prion Diseases Based on Chinese Surveillance Program

scientific article published on 21 October 2015

The Levels of Tau Isoforms Containing Exon-2 and Exon-10 Segments Increased in the Cerebrospinal Fluids of the Patients with Sporadic Creutzfeldt-Jakob Disease

scientific article published on 19 July 2015

The analysis of human papillomavirus infection in lip squamous cell carcinoma patients

scientific article published on October 1, 2012

The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI.

scientific article published on 8 December 2017

The distribution of human papillomavirus in tissues from patients with head and neck squamous cell carcinoma

scientific article published on 24 August 2012

The diversities of PrPSc distributions and pathologic changes in various brain regions from a Chinese patient with G114V genetic CJD ⬇️

scientific article published on July 7, 2011

The epidemiological, clinical, and laboratory features of sporadic Creutzfeldt-Jakob disease patients in China: surveillance data from 2006 to 2010

scientific article

The first Chinese case of Creutzfeldt-Jakob disease patient with R208H mutation inPRNP ⬇️

scientific article published on July 1, 2011

The first Chinese case of Creutzfeldt-Jakob disease with mutation of E200K in PRNP.

scientific article published in April 2010

The genetic Creutzfeldt-Jakob disease with E200K mutation: analysis of clinical, genetic and laboratory features of 30 Chinese patients

scientific article published in Scientific Reports

The low levels of nerve growth factor and its upstream regulatory kinases in prion infection is reversed by resveratrol

scientific article published on 28 December 2019

The prepared tau exon-specific antibodies revealed distinct profiles of tau in CSF of the patients with Creutzfeldt-Jakob disease ⬇️

scientific article published on July 29, 2010

Treatment of SMB-S15 Cells with Resveratrol Efficiently Removes the PrP(Sc) Accumulation In Vitro and Prion Infectivity In Vivo

scientific article published on 6 October 2015

[Studies on heredity rule of the first genealogy regarding fatal familial insomnia in Henan province].

scientific article published in January 2009

[Study on the characteristic of Surveillance Creutzfeldt-Jakob disease patients from January to August in 2006 in China]

scientific article published on 01 September 2007

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