List of works by Else Marie Agger

A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

A comparative study of cationic liposome and niosome-based adjuvant systems for protein subunit vaccines: characterisation, environmental scanning electron microscopy and immunisation studies in mice

scientific article published on 01 June 2006

A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells

scientific article

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

scientific article published on 30 October 2014

A novel liposome-based adjuvant CAF01 for induction of CD8(+) cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice

scientific article

A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity

scientific article

Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection

scholarly article by Else Marie Agger et al published June 2008 in Immunology

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

scientific article published on 11 February 2009

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation

scientific article

Adjuvants induce distinct immunological phenotypes in a bovine tuberculosis vaccine model

scientific article published on 29 July 2009

Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant

scientific article

Aluminium hydroxide potentiates a protective Th1 biased immune response against polio virus that allows for dose sparing in mice and rats

scientific article published on 17 February 2015

An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines

scientific article

Broadening CD4+ and CD8+ T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

scientific article published on 26 April 2017

Broadening of the T-cell repertoire to HIV-1 Gag p24 by vaccination of HLA-A2/DR transgenic mice with overlapping peptides in the CAF05 adjuvant

scientific article

CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations

scientific article published on 29 October 2009

CAF01 potentiates immune responses and efficacy of an inactivated influenza vaccine in ferrets

scientific article (publication date: 2011)

CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice

Cationic liposomes as vaccine adjuvants

scientific article published on October 2007

Cationic liposomes as vaccine adjuvants

scientific article published on April 2011

Cationic liposomes containing mycobacterial lipids: a new powerful Th1 adjuvant system

scientific article

Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements

scientific article

Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses

scientific article published on 14 November 2005

Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants

scientific article published on 13 December 2016

Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3β-[N-(N′,N′-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome

Comparison of vesicle based antigen delivery systems for delivery of hepatitis B surface antigen

scientific article published on 27 January 2007

Control of chronic mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells

scientific article published on 15 May 2013

Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate

scientific article

Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice

scientific article published on 05 August 2019

Determining Adjuvant Activity on T-Cell Function In Vivo: Th Cells

article published in 2009

Developing solid particulate vaccine adjuvants: surface bound antigen favours a humoural response, whereas entrapped antigen shows a tendency for cell mediated immunity

scientific article published in June 2013

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

scientific article published on 21 January 2016

ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination

scientific article

Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes

scientific article

HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

scientific article published on 01 October 2019

High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis

scientific article published in January 2017

High-frequency vaccine-induced CD8⁺ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection

scientific article

Host immunity to Mycobacterium tuberculosis and risk of tuberculosis: A longitudinal study among Greenlanders.

scientific article published on 27 October 2016

Human B cells produce chemokine CXCL10 in the presence of Mycobacterium tuberculosis specific T cells

scientific article published on 22 October 2014

Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis

scientific article published on December 2003

Immunity by formulation design: induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method

scientific article

Immunization with Mycobacterium tuberculosis-Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette-Guérin Vaccination and Improves Protection in Mice

scientific article published on 04 September 2020

Immunological memory transferred with CD4 T cells specific for tuberculosis antigens Ag85B-TB10.4: persisting antigen enhances protection

scientific article

Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo

scientific article

Incorporation of the TLR4 Agonist Monophosphoryl Lipid A Into the Bilayer of DDA/TDB Liposomes: Physico-Chemical Characterization and Induction of CD8+ T-Cell Responses In Vivo

article

Inducing dose sparing with inactivated polio virus formulated in adjuvant CAF01.

scientific article

Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6.

scientific article published on 07 April 2017

License to kill: Formulation requirements for optimal priming of CD8(+) CTL responses with particulate vaccine delivery systems

scientific article published on 25 August 2011

Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response

article

Liposome delivery of Chlamydia muridarum major outer membrane protein primes a Th1 response that protects against genital chlamydial infection in a mouse model

scientific article published on September 2008

Liposome-based cationic adjuvant formulations (CAF): past, present, and future

scientific article published on January 2009

Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres

scientific article published in August 2008

Low Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy.

scientific article

Mucosal boosting of H56:CAF01 immunization promotes lung-localized T cells and an accelerated pulmonary response to Mycobacterium tuberculosis infection without enhancing vaccine protection

scientific article published on 13 February 2019

NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01.

scientific article published on 23 July 2008

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

scientific article published on 20 July 2009

PLGA microspheres for the delivery of a novel subunit TB vaccine

scientific article published on 01 May 2008

PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family

scientific article

Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6

scientific article published on 01 April 2005

Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation

scientific article published on 26 February 2014

Protective anti-mycobacterial T cell responses through exquisitein vivo activation of vaccine-targeted dendritic cells

article

Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31.

scientific article published on 17 April 2006

Protein energy malnutrition during vaccination has limited influence on vaccine efficacy but abolishes immunity if administered during Mycobacterium tuberculosis infection

scientific article

Re-formulation of selected DNA vaccine candidates and their evaluation as protein vaccines using a guinea pig aerosol infection model of tuberculosis

scientific article published on 07 March 2006

Subunit Vaccines: Distearoylphosphatidylcholine-Based Liposomes Entrapping Antigen Offer a Neutral Alternative to Dimethyldioctadecylammonium-Based Cationic Liposomes as an Adjuvant Delivery System

scientific article published on 10 December 2010

Synchronization of dendritic cell activation and antigen exposure is required for the induction of Th1/Th17 responses

scientific article

Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis

scientific article

T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties

scientific article published on 7 December 2017

T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection

scientific article

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis

scientific article

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling

scientific article

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

scientific article published on 29 February 2016

The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes

scientific article

The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis

scientific article published on 30 October 2006

The dynamics of immune responses to Mycobacterium tuberculosis during different stages of natural infection: A longitudinal study among Greenlanders.

scientific article

The physical stability of the recombinant tuberculosis fusion antigens h1 and h56.

scientific article published on 19 July 2013

The supramolecular structure is decisive for the immunostimulatory properties of synthetic analogues of a mycobacterial lipid in vitro

Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying

scientific article published on 13 May 2007

Tuberculosis

Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells

scientific article published in June 2009

Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics

scientific article published on 06 January 2014

Vaccine-induced th17 cells are maintained long-term postvaccination as a distinct and phenotypically stable memory subset

scientific article

alpha,alpha'-trehalose 6,6'-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying

scientific article published on 26 January 2008

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