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List of works by Kishor M. Wasan

A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

scientific article

A review of the application of lipid-based systems in systemic, dermal/ transdermal, and ocular drug delivery.

scientific article published on January 2008

A simple and sensitive method for determination of vitamins D3 and K1 in rat plasma: application for an in vivo pharmacokinetic study.

scientific article published on 4 February 2013

Acute P-407 administration to mice causes hypercholesterolemia by inducing cholesterolgenesis and down-regulating low-density lipoprotein receptor expression.

scientific article

Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model

scientific article published in March 2010

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

scientific article published on 20 November 2017

Assessing lipid lowering and plasma cholesteryl ester transfer protein activity of simvastatin following administration to rabbits fed a high fat/cholesterol diet.

scientific article published in June 2006

Assessing the antifungal activity of a new oral lipid-based amphotericin B formulation following administration to rats infected with Aspergillus fumigatus

scientific article published in July 2007

Assessing the antifungal activity, pharmacokinetics, and tissue distribution of amphotericin B following the administration of Abelcet and AmBisome in combination with caspofungin to rats infected with Aspergillus fumigatus

scientific article published on 01 July 2007

Assessing the safety, tolerability, pharmacokinetics and biodistribution of novel oral formulations of amphotericin B following single and multiple dose administration to Beagle dogs

scientific article published on 17 August 2020

Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model

scientific article published on 20 September 2011

Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model.

scientific article published on 18 February 2012

Association of the endotoxin antagonist E5564 with high-density lipoproteins in vitro: dependence on low-density and triglyceride-rich lipoprotein concentrations

scientific article published on September 2003

Barriers to treatment for visceral leishmaniasis in hyperendemic areas: India, Bangladesh, Nepal, Brazil and Sudan

scientific article

Biodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009).

scientific article published on 22 September 2010

Cholesterol as a Potential Target for Castration-Resistant Prostate Cancer ⬇️

scientific article published on 04 August 2010

Competitive displacement of clozapine from plasma proteins in normolipidemic and hyperlipidemic plasma samples: clinical implications

scientific article published in May 2005

Cyclosporine A and Rapamycin induce in vitro cholesteryl ester transfer protein activity, and suppress lipoprotein lipase activity in human plasma

scientific article published on 27 March 2008

Deactivation of the lipopolysaccharide antagonist eritoran (E5564) by high-density lipoprotein-associated apolipoproteins ⬇️

scientific article published on March 7, 2011

Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography

scientific article published in October 2007

Development and characterization of liposomal disodium ascorbyl phytostanyl phosphates (FM-VP4).

scientific article published in August 2004

Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans

scientific article published on 17 January 2009

Development and in vitro characterization of chitosan-coated polymeric nanoparticles for oral delivery and sustained release of the immunosuppressant drug mycophenolate mofetil

scientific article published on 25 September 2018

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines

scientific article published on 15 August 2016

Dietary supplementation with phytosterol and ascorbic acid reduces body mass accumulation and alters food transit time in a diet-induced obesity mouse model ⬇️

scientific article published on June 28, 2011

Differences in human phospholipid transfer protein activity following incubation of Fungizone compared to lipid-based Amphotericin-B formulations in normolipidemic and hyperlipidemic plasma

scientific article published in September 2009

Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds

scientific article published on 13 December 2005

Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases

scientific article published on 21 May 2008

Disodium Ascorbyl Phytostanyl Phosphates (FM-VP4) reduces plasma cholesterol concentration, body weight and abdominal fat gain within a dietary-induced obese mouse model

scientific article published on 24 August 2005

Disodium ascorbyl phytostanyl phosphate reduces plasma cholesterol concentrations and atherosclerotic lesion formation in apolipoprotein E-deficient mice ⬇️

scientific article published on April 1, 2003

Does P-glycoprotein contribute to amphotericin B epithelial transport in Caco-2 cells?

scientific article published on 25 June 2014

Dose-dependent targeted suppression of P-glycoprotein expression and function in Caco-2 cells

scientific article

Dual physiologically based pharmacokinetic model of liposomal and nonliposomal amphotericin B disposition

scientific article published on 21 June 2013

Effect of cyclosporine A on the binding affinity and internalization of low-density lipoproteins in human skin fibroblasts

scientific article published on 01 December 2002

Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism.

scientific article published on 11 June 2008

Effect of heat-treated amphotericin B on renal and fungal cytotoxicity

scientific article published on January 2004

Effect of heat-treatment and the role of phospholipases on Fungizone-induced cytotoxicity within human kidney proximal tubular (HK-2) cells and Aspergillus fumigatus

scientific article published on July 2005

Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to rats

scientific article published on 16 February 2010

Effect of variations in treatment regimen and liver cirrhosis on exposure to benzodiazepines during treatment of alcohol withdrawal syndrome.

scientific article published on 7 August 2015

Effects of Lipid-Based Oral Formulations on Plasma and Tissue Amphotericin B Concentrations and Renal Toxicity in Male Rats

scientific article published in November 2008

Effects of lipid-based oral formulations on plasma and tissue amphotericin B concentrations and renal toxicity in male rats

scientific article

Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers

scientific article

Effects of three and eight weeks oral administration of bis(maltolato)oxovanadium(IV) on plasma homocysteine and cysteine levels in streptozotocin-induced diabetic rats.

scientific article published on January 2004

Efficacy and toxicity of a tropically stable lipid-based formulation of amphotericin B (iCo-010) in a rat model of invasive candidiasis

scientific article published on 06 July 2012

Efficacy of an oral and tropically stable lipid-based formulation of Amphotericin B (iCo-010) in an experimental mouse model of systemic candidiasis

scientific article published on 29 October 2013

Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections

scientific article

Evaluation of the contribution of the ATP binding cassette transporter, P-glycoprotein, to in vivo cholesterol homeostasis.

scientific article published on 24 June 2013

Evaluation of the effect of plant sterols on the intestinal processing of cholesterol using an in vitro lipolysis model.

scientific article published on 28 July 2012

Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia ⬇️

scientific article published on October 17, 2003

Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma

scientific article published on 23 July 2009

Heat-treated Fungizone retains amphotericin B antifungal activity without renal toxicity in rats infected with Aspergillus fumigatus

scientific article published in September 2004

Highly effective oral amphotericin B formulation against murine visceral leishmaniasis

scientific article

Impact of co-administration of protonated nanostructured aluminum silicate (cholesterol absorption inhibitor) on the absorption of lipid soluble vitamins D3 and K1: an assessment of pharmacokinetic and in vitro intraluminal processing

scientific article published on 27 February 2013

Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery

scientific article

In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines

scientific article

Influence of phytostanol phosphoryl ascorbate (FM-VP4) on insulin resistance, hyperglycemia, plasma lipid levels, and gastrointestinal absorption of exogenous cholesterol in Zucker (fa/fa) fatty and lean rats

scientific article published in February 2003

Influence of phytostanol phosphoryl ascorbate, FM-VP4, on pancreatic lipase activity and cholesterol accumulation within Caco-2 cells.

scientific article published in January 2002

Influence of plasma cholesterol and triglyceride concentrations and eritoran (E5564) micelle size on its plasma pharmacokinetics and ex vivo activity following single intravenous bolus dose into healthy female rabbits.

scientific article published on 12 September 2007

Inhibition of cholesterol absorption: targeting the intestine.

scientific article published on 25 August 2012

Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds

scientific article

Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells

scientific article published on 01 January 2007

Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: in vitro/in vivo case studies

scientific article published on February 2007

Lipid-based systems for the enhanced delivery of poorly water soluble drugs

Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols

scientific article

Long circulating lipid nanocapsules for drug detoxification

scientific article published on 01 February 2007

Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols

scientific article published on 21 October 2011

Modifications in lipoprotein surface charge alter cyclosporine A association with low-density lipoproteins

scientific article published on 01 January 2003

Modifications in low-density lipoprotein receptor expression affects Cyclosporin A cellular uptake and cytotoxicity

scientific article published on June 2008

Neglected Populations: Safeguarding the Health of Street‐Involved Children in Ghana ⬇️

scientific article published on July 6, 2012

Novel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature.

scientific article published on 29 August 2014

Pharmacokinetics and biodistribution of N-isopropylacrylamide copolymers for the design of pH-sensitive liposomes

scientific article published on 26 January 2009

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.

scientific article published on 27 April 2009

Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats

scientific article published on 18 September 2012

Physiologically based pharmacokinetic model of amphotericin B disposition in rats following administration of deoxycholate formulation (Fungizone®): pooled analysis of published data.

scientific article

Plasma protein binding, lipoprotein distribution and uptake of free and lipid-associated BCL-2 antisense oligodeoxynucleotides (G3139) in human melanoma cells.

scientific article

Potential mechanisms by which Peceol increases the gastrointestinal absorption of amphotericin B.

scientific article published in August 2004

Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake

scientific article published on May 2004

Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet

scientific article published on 28 July 2009

Review and analysis of FDA approved drugs using lipid-based formulations.

scientific article published on 4 July 2017

Review of the quality of pediatric medications in developing countries

scientific article published on 28 February 2013

Role of phospholipid transfer protein on the plasma distribution of amphotericin B following the incubation of different amphotericin B formulations

scientific article published on 10 May 2006

Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men.

scientific article published on 29 March 2012

Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers

scientific article

Safety, tolerability, and pharmacokinetics of a novel oral amphotericin B formulation (iCo-019) following single-dose administration to healthy human subjects: An alternative approach to parenteral amphotericin B administration

scientific article published on 20 July 2020

Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats.

scientific article published in January 2011

Suitability of LLC-PK1 pig kidney cells for the study of drug action on renal cell cholesterol uptake: identification and characterization of low-density lipoprotein receptors.

scientific article

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

scientific article published in 2011

Tacrolimus-induced elevation in plasma triglyceride concentrations after administration to renal transplant patients is partially due to a decrease in lipoprotein lipase activity and plasma concentrations.

scientific article published in July 2009

The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS).

scientific article published on 20 October 2015

The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine

scientific article published in July 2009

The effect of two novel cholesterol-lowering agents, disodium ascorbyl phytostanol phosphate (DAPP) and nanostructured aluminosilicate (NSAS) on the expression and activity of P-glycoprotein within Caco-2 cells

scientific article

The effects of competitive displacement on haloperidol's plasma distribution in normolipidemic and hyperlipidemic plasma

scientific article published in October 2005

The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world

scientific article published on 01 March 2009

The influence of dyslipidemia on the plasma protein and lipoprotein distribution of haloperidol

scientific article published in January 2003

The influence of hyperlipoproteinemia on in vitro distribution of amiodarone and desethylamiodarone in human and rat plasma

scientific article published on 15 February 2007

The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins

scientific article

The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis

scientific article published on March 2009

The use of the United States FDA programs as a strategy to advance the development of drug products for neglected tropical diseases

scientific article published on 11 February 2014

Treatment with a cholesterol absorption inhibitor (FM-VP4) reduces body mass and adipose accumulation in developing and pre-obese mice

scientific article

Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

scientific article

Unidirectional inhibition of lipid transfer protein I-mediated transfer of cholesteryl esters between high-density and low-density lipoproteins by amphotericin B lipid complex

scientific article published in December 2004

Upregulation of Scavenger Receptor B1 Is Required for Steroidogenic and Nonsteroidogenic Cholesterol Metabolism in Prostate Cancer

scientific article published on 07 May 2019

Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice

scientific article published on 21 December 2009

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