List of works by Michael D. Edstein

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

scientific article published on 05 March 2019

A sensitive bioassay for serum cycloguanil using Plasmodium falciparum in vitro

scientific article

A statistical analysis of the antimalarial activity of proguanil and cycloguanil in human volunteers

scientific article published in December 1994

Absence of an interaction between artesunate and atovaquone--proguanil

scientific article published in August 1999

Activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum in an in vivo-in vitro model

scientific article published in September 1996

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity

scientific article

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity.

scientific article published on 22 September 2014

An improved high-performance liquid chromatographic method for the simultaneous measurement of halofantrine and desbutylhalofantrine in human serum

scientific article published in January 1991

Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases

scientific article published on 27 July 2015

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp. ⬇️

scientific article

Antimalarial activity of the triple combination of proguanil, atovaquone and dapsone ⬇️

scientific article published on September 30, 1997

Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate--JPC2056--in cynomolgus monkeys using an in vivo in vitro model

scientific article published on 23 July 2007

Artemisone--a highly active antimalarial drug of the artemisinin class

scientific article published in March 2006

Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro

scientific article published on 6 October 2014

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents

scientific article

Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis

scientific article

Causal prophylactic and radical curative activity of WR182393 (a guanylhydrazone) against Plasmodium cynomolgi in Macaca mulatta

scientific article published in October 1993

Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

scientific article published on 8 January 2018

Chloroquine bioassay of plasma specimens obtained from soldiers on chloroquine plus doxycycline for malaria prophylaxis

scientific article published on November 1996

Chloroquine or sulfadoxine-pyrimethamine for the treatment of uncomplicated, Plasmodium falciparum malaria during an epidemic in Central Java, Indonesia

scientific article

Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine after Lapudrine administration

scientific article published in January 1987

Ciprofloxacin treatment of drug-resistant falciparum malaria

scientific article published on September 1991

Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography

scientific article published on December 1994

Comparison of tafenoquine (WR238605) and primaquine in the post-exposure (terminal) prophylaxis of vivax malaria in Australian Defence Force personnel

scientific article published in November 2002

Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.

scientific article published on 7 May 2018

Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor

article

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.

scientific article published on 21 November 2017

Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration

scientific article published on 01 October 2019

Disposition of proguanil in Thai patients with uncomplicated falciparum malaria

scientific article published in May 1997

Does gender, food or grapefruit juice alter the pharmacokinetics of primaquine in healthy subjects?

scientific article published in June 2006

Doxycycline for malaria prophylaxis in Australian soldiers deployed to United Nations missions in Somalia and Cambodia

scientific article published on September 1995

Effectiveness of doxycycline combined with primaquine for malaria prophylaxis

scientific article published in March 1995

Efficacy of Artesunate-mefloquine for Chloroquine-resistant Plasmodium vivax Malaria in Malaysia: An Open-label, Randomized, Controlled Trial

scientific article published on 22 April 2016

Efficacy of chloroquine in the treatment of uncomplicated Plasmodium falciparum infection in East Timor, 2000.

scientific article

Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malaria

scientific article published on 20 September 2004

Efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in East Timor

scientific article published on March 2006

Evaluation of WR250417 (a proguanil analog) for causal prophylactic activity in the Plasmodium cynomolgi-Macaca mulatta model

scientific article published in February 1994

Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum

scientific article published on 08 June 2009

Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum

scientific article published on 14 December 2015

Evaluation of the safety and tolerability of a short higher-dose primaquine regimen for presumptive anti-relapse therapy in healthy subjects.

scientific article

Evolution from double to triple-antimalarial drug combinations

scientific article published on 30 December 2014

Ex vivo antimalarial activity of proguanil combined with dapsone against cycloguanil-resistant Plasmodium falciparum isolates ⬇️

scientific article published on September 10, 1997

Excretion of chloroquine, dapsone and pyrimethamine in human milk

scientific article

Excretion of mefloquine in human breast milk

scientific article published in January 1988

Failure of dapsone/pyrimethamine plus chloroquine against falciparum malaria in Papua New Guinea

scientific article published in January 1988

Fatty food does not alter blood mefloquine concentrations in the treatment of falciparum malaria

scientific article published on 6 September 2005

First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone

scientific article published on 16 June 2008

Gender differences in gastrointestinal disturbances and plasma concentrations of tafenoquine in healthy volunteers after tafenoquine administration for post-exposure vivax malaria prophylaxis

scientific article published on 30 June 2006

Halofantrine for the treatment of mefloquine chemoprophylaxis failures in Plasmodium falciparum infections

scientific article published in October 1991

Halofantrine given with food for falciparum malaria

scientific article published on May 1, 1992

Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria

scientific article published on April 1993

High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria.

scientific article published on December 1992

In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model

scientific article published on 21 February 2020

In Vivo Efficacy and Tolerability of Artesunate-Azithromycin for the Treatment of Falciparum Malaria in Vietnam

scientific article published on 23 May 2016

In vitro activities of the biguanide PS-15 and its metabolite, WR99210, against cycloguanil-resistant Plasmodium falciparum isolates from Thailand.

scientific article published on October 1997

JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium

scientific article

Lack of effect of proguanil on the pharmacokinetics of dapsone in healthy volunteers

scientific article published in July 1993

Lack of sex effect on the pharmacokinetics of primaquine.

scientific article published in June 2006

Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

scientific article published on 8 February 2016

Lengthy antimalarial activity of atovaquone in human plasma following atovaquone-proguanil administration

scientific article published on October 2005

Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border

scientific article published in June 1992

Malaria prophylaxis/radical cure: recent experiences of the Australian Defence Force

scientific article

Malaria vectors of Timor-Leste

scientific article

Measurement of ciprofloxacin in human plasma, whole blood, and erythrocytes by high-performance liquid chromatography

scientific article published in May 1991

Measurement of tafenoquine (WR 238605) in human plasma and venous and capillary blood by high-pressure liquid chromatography

scientific article published in April 2000

Mefloquine and doxycycline malaria prophylaxis in Australian soldiers in East Timor.

scientific article

Mefloquine-resistant falciparum malaria on the Thai-Burmese border

scientific article published on May 1991

Modern malaria chemoprophylaxis

scientific article

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

scientific article published on 13 December 2019

Multiple-dose kinetics in healthy volunteers and in vitro antimalarial activity of proguanil plus dapsone

scientific article published on January 1990

Multiple-dose pharmacokinetics and in vitro antimalarial activity of dapsone plus pyrimethamine (Maloprim) in man.

scientific article published on August 1990

New quinoline di-Mannich base compounds with greater antimalarial activity than chloroquine, amodiaquine, or pyronaridine.

scientific article published on June 1997

Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam

scientific article published on 19 March 2009

Oxidative activation of proguanil and dapsone acetylation in Thai soldiers

scientific article published on January 1994

Persistence and immunogenicity of chemically attenuated blood stage Plasmodium falciparum in Aotus monkeys

scientific article published on 26 May 2016

Pharmacokinetic study of mefloquine in Thai children aged 5-12 years suffering from uncomplicated falciparum malaria treated with MSP or MSP plus primaquine

scientific article published on January 1994

Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers

scientific article published on 21 February 2020

Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects

scientific article published on December 2008

Pharmacokinetics and ex vivo antimalarial activity of artesunate-azithromycin in healthy volunteers

scientific article

Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisinin-piperaquine in patients with uncomplicated falciparum malaria in Vietnam

scientific article published on 15 June 2009

Pharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine ⬇️

scientific article published on January 1, 1991

Pharmacokinetics of proguanil in malaria patients treated with proguanil plus atovaquone

scientific article published on June 1, 1996

Pharmacokinetics of the antimalarial drug piperaquine in healthy Vietnamese subjects.

scientific article published in October 2008

Phenolic glycosides with antimalarial activity from Grevillea "Poorinda Queen".

scientific article

Plasma chloroquine concentrations in young and older malaria patients treated with chloroquine

scientific article published on September 1997

Plasma concentrations of tafenoquine, a new long-acting antimalarial agent, in thai soldiers receiving monthly prophylaxis

scientific article published on 20 November 2003

Plasmodium vivax trophozoites insensitive to chloroquine

scientific article

Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis.

scientific article

Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

scientific article published on 9 July 2012

Population pharmacokinetics of mefloquine in military personnel for prophylaxis against malaria infection during field deployment.

scientific article published on 11 January 2007

Population pharmacokinetics of tafenoquine during malaria prophylaxis in healthy subjects

scientific article published on 21 May 2007

Population pharmacokinetics of the new antimalarial agent tafenoquine in Thai soldiers

scientific article

Postexposure administration of halofantrine for the prevention of malaria

scientific article published on October 1993

Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro

scientific article published in January 1997

Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil

scientific article published on 30 August 2003

Proguanil combined with dapsone chemoprophylaxis for malaria ⬇️

scientific article published on June 15, 1992

Proguanil plus sulfamethoxazole is not causally prophylactic in the Macaca mulatta--Plasmodium cynomolgi model

scientific article published in May 1994

Proguanil polymorphism does not affect the antimalarial activity of proguanil combined with atovaquone in vitro

scientific article published in July 1996

Protection of Military Personnel Against Vector-Borne Diseases: A Review of Collaborative Work of the Australian and US Military Over the Last 30 Years

scientific article published in October 2016

Quantification of antimalarial drugs. I. Simultaneous measurement of sulphadoxine, N4-acetylsulphadoxine and pyrimethamine in human plasma

scientific article published on 01 February 1984

Quantification of antimalarial drugs. II. Simultaneous measurement of dapsone, monoacetyldapsone and pyrimethamine in human plasma

scientific article published on 01 May 1984

Quantification of quinine in human serum by high-performance liquid chromatography

scientific article published on 01 December 1983

Quantitation of Fansimef components (mefloquine + sulfadoxine + pyrimethamine) in human plasma by two high-performance liquid chromatographic methods

scientific article published in March 1991

Race-linked differences in serum concentrations of dapsone, monoacetyldapsone and pyrimethamine during malaria prophylaxis

scientific article published in January 1986

Randomized, double-blind study of the safety, tolerability, and efficacy of tafenoquine versus mefloquine for malaria prophylaxis in nonimmune subjects

scientific article

Sex affects the steady-state pharmacokinetics of primaquine but not doxycycline in healthy subjects

scientific article published in November 2009

Short report: Molecular evaluation of the efficacy of chloroquine treatment of uncomplicated Plasmodium falciparum malaria in East Timor.

scientific article

Simultaneous measurement of proguanil and cycloguanil in human plasma by high-performance liquid chromatography

scientific article published on 01 July 1986

Simultaneous measurement of quinine and quinidine in human plasma, whole blood, and erythrocytes by high-performance liquid chromatography with fluorescence detection

scientific article published on 01 September 1990

Steady-state kinetics of proguanil and its active metabolite, cycloguanil, in man.

scientific article published in January 1988

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.

scientific article published on 4 September 2019

Survey of personal protection measures against mosquitoes among Australian defense force personnel deployed to East Timor.

scientific article

Susceptibility of Plasmodium falciparum to artemisinins and Plasmodium vivax to chloroquine in Phuoc Chien Commune, Ninh Thuan Province, south-central Vietnam

scientific article published on 17 January 2019

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.

scientific article published on 16 August 2017

Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases

scientific article

Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

scientific article

Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs

scientific article published on 24 May 2017

Tafenoquine for the treatment of recurrent Plasmodium vivax malaria.

scientific article published on March 2007

The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

scientific article

The Spiroindolone KAE609 Does Not Induce Dormant Ring Stages in Plasmodium falciparum Parasites

scientific article

The efficacy and tolerability of artemisinin-piperaquine (Artequick®) versus artesunate-amodiaquine (Coarsucam™) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam

scientific article

The efficacy and tolerability of three different regimens of tafenoquine versus primaquine for post-exposure prophylaxis of Plasmodium vivax malaria in the Southwest Pacific

scientific article

The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria

scientific article published on 30 August 2003

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network

scientific article published on 19 November 2020

Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia

scientific article

Total synthesis of thiaplakortone a: derivatives as metabolically stable leads for the treatment of malaria

scientific article

Vivax malaria: preliminary observations following a shorter course of treatment with artesunate plus primaquine.

scientific article published on 21 March 2007

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