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List of works by Brian M. Wolpin

A Transcriptome-Wide Association Study (TWAS) Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer

scientific article published on 09 January 2020

A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis

scientific article

A cohort study of p27 localization in colon cancer, body mass index, and patient survival

scientific article published on June 2009

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

scientific article

A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma ⬇️

scientific article published on January 7, 2011

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

scientific article published on 01 February 2021

A phase 1 clinical trial of ASG-5ME, a novel drug-antibody conjugate targeting SLC44A4, in patients with advanced pancreatic and gastric cancers

scientific article

A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer

scientific article published on 02 January 2020

A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer

scientific article published on 29 July 2011

A phase I and pharmacokinetic study of ganetespib (STA-9090) in advanced hepatocellular carcinoma

scientific article published on 24 September 2014

A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts

scientific article published on 14 December 2012

A resequence analysis of genomic loci on chromosomes 1q32.1, 5p15.33, and 13q22.1 associated with pancreatic cancer risk

scientific article published on March 2013

A step forward in the treatment of advanced biliary tract cancer

scientific article published in April 2010

ABO Blood Group and Risk of Colorectal Cancer ⬇️

scientific article published on March 17, 2011

ABO blood group and breast cancer incidence and survival ⬇️

scientific article published on February 10, 2012

ABO blood group and incidence of epithelial ovarian cancer

scientific article

ABO blood group and risk of coronary heart disease in two prospective cohort studies

scientific article

ABO blood group and the risk of pancreatic cancer

scientific article published on 10 March 2009

Acid-suppressive medications and risk of colorectal cancer: results from three large prospective cohort studies

scientific article published on 16 June 2020

Adjuvant treatment of colorectal cancer

scientific article published on 01 May 2007

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

scientific article published on 12 December 2018

Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)

scientific article

Alliance for clinical trials in oncology (ALLIANCE) trial A021501: preoperative extended chemotherapy vs. chemotherapy plus hypofractionated radiation therapy for borderline resectable adenocarcinoma of the head of the pancreas

scientific article

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

scientific article published on 02 June 2020

Altered exocrine function can drive adipose wasting in early pancreatic cancer

scientific article published in Nature

An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population

scientific article published on 13 September 2013

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

journal article published in 2015

Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).

scientific article

Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells

scientific article published on 18 September 2017

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

scientific article published on 03 July 2020

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study ⬇️

scientific article published on 23 February 2017

Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma

scientific article

Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study

scientific article published on 16 May 2016

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

scientific article published on 24 October 2019

BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

scientific article published on 25 May 2020

Bead-Based Extracellular Vesicle Analysis Using Flow Cytometry

scientific article published on 25 October 2020

Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies ⬇️

scientific article

Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues

scientific article published on 20 June 2017

Characterization of large structural genetic mosaicism in human autosome

journal article published in 2015

Cigarette Smoking and Pancreatic Cancer Survival

scientific article published on 30 March 2017

Circulating Exosomes in Pancreatic Cancer: Will They Succeed on the Long, Littered Road to Early Detection Marker?

scientific article published on 31 December 2015

Circulating Metabolites and Survival Among Patients With Pancreatic Cancer

scientific article published on 11 January 2016

Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts

scientific article (publication date: 2 July 2007)

Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer

scientific article published in August 2007

Clinical problem-solving. The writing on the wall

scientific article published in October 2009

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

scientific article published on 22 June 2015

Comparison of autologous stem cell transplantation versus consolidation chemotherapy for patients with cytogenetically normal acute myeloid leukemia (CN‐AML) and FLT3ITD ⬇️

scientific article published on July 1, 2011

Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer

scientific article published on 01 December 2020

Correlation of CT patterns of primary intrahepatic cholangiocarcinoma at the time of presentation with the metastatic spread and clinical outcomes: retrospective study of 92 patients

scientific article published on December 2014

Covariate selection for association screening in multiphenotype genetic studies

scientific article published on 16 October 2017

CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma

scientific article published on 20 March 2007

Critical role for arginase 2 in obesity-associated pancreatic cancer

scientific article published on 14 August 2017

Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes

scientific article published on 13 July 2016

Defining determinants of pancreatic cancer risk: are we making progress?

scientific article

Delaying chemoradiation until after completion of adjuvant chemotherapy for pancreatic cancer may not impact local control

scientific article published on 09 August 2013

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

scientific article

Detectable clonal mosaicism and its relationship to aging and cancer

journal article published in 2012

Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium

scientific article

Diabetes, Weight Change, and Pancreatic Cancer Risk

scientific article published on 13 August 2020

Dietary Insulin Load and Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803 (Alliance)

scientific article published on 01 February 2019

Dietary insulin load, dietary insulin index, and risk of pancreatic cancer

scientific article

Discovery of a selective inhibitor of doublecortin like kinase 1

scientific article published on 06 April 2020

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial

scientific article published on 20 November 2020

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial

scientific article published on 01 April 2019

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

scientific article

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

scientific article published on 16 April 2020

Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).

scientific article

Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk

scientific article published on 14 March 2019

Feasibility of Computer-Based Self-Administered Cancer-Specific Geriatric Assessment in Older Patients With Gastrointestinal Malignancy ⬇️

scientific article published on January 3, 2013

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

journal article published in 2016

Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression

scientific article published on November 2016

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 ⬇️

scientific article

Genetic and Circulating Biomarker Data Improve Risk Prediction for Pancreatic Cancer in the General Population

scientific article published on 22 April 2020

Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk

scientific article published on 08 July 2020

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

scientific article

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

scientific article

Genome-wide association study of survival in patients with pancreatic adenocarcinoma

scientific journal article

Genome-wide gene-diabetes and gene-obesity interaction scan in 8,255 cases and 11,900 controls from the PanScan and PanC4 Consortia

scientific article published on 16 June 2020

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

scientific article published on 8 February 2018

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

article

Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer.

scientific article published on 28 February 2013

Hyperglycemia, insulin resistance, impaired pancreatic β-cell function, and risk of pancreatic cancer.

scientific article published on 11 July 2013

Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.

scientific article

Identifying the metabolomic fingerprint of high and low flavonoid consumers.

scientific article published on 14 July 2017

Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma Exhibit Differential Growth and Metabolic Patterns in the Pre-Diagnostic Period: Implications for Early Detection

scientific article published on 02 December 2020

Impact of Pre-analytic Blood Sample Collection Factors on Metabolomics

scientific article published on 03 March 2016

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

journal article published in 2014

Inflammatory plasma markers and pancreatic cancer risk: a prospective study of five U.S. cohorts

scientific article published on 5 March 2013

Influence of dietary insulin scores on survival in colorectal cancer patients

scientific article

Influence of genetic variation in the vitamin D pathway on plasma 25-hydroxyvitamin D levels and survival among patients with metastatic colorectal cancer

scientific article published on 18 May 2019

Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer

scientific article published on 08 December 2008

Insulin-like growth factor-1 receptor expression and disease recurrence and survival in patients with resected pancreatic ductal adenocarcinoma

scientific article published on 28 May 2020

Interaction of molecular markers and physical activity on mortality in patients with colon cancer

scientific article published on September 2009

Interactive medical case. The writing on the wall

scientific article published in September 2009

Lead-time trajectory of CA19-9 as an anchor marker for pancreatic cancer early detection

scientific article published on 10 December 2020

Learning to cope: how far is too close?

scientific article

Leucocyte telomere length, genetic variants at the TERT gene region and risk of pancreatic cancer

scientific article

Long-Term Risk of Pancreatic Malignancy in Patients with Branch Duct Intraductal Papillary Mucinous Neoplasm in A Referral Center

scientific article

Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival.

scientific article

Managing advanced colorectal cancer: have we reached the PEAK with current therapies?

scientific article published on 16 June 2014

Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk

scientific article published on 23 September 2020

Metabolic Alterations as a Signpost to Early Pancreatic Cancer

scientific article published on 26 March 2019

Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions

scientific article published on 07 January 2021

Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease

scientific article

Multi-drug inhibition of the HER pathway in metastatic colorectal cancer: Results of a phase I study of pertuzumab plus cetuximab in cetuximab-refractory patients ⬇️

scientific article published on 09 April 2013

Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer

scientific article

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

scientific article published on 27 August 2020

Neoadjuvant Therapy is Associated with Improved Survival in Borderline-Resectable Pancreatic Cancer

scientific article published on 04 December 2019

Nurses' Health Study Contributions on the Epidemiology of Less Common Cancers: Endometrial, Ovarian, Pancreatic, and Hematologic

scientific article published on 26 July 2016

Nut consumption and risk of pancreatic cancer in women

scientific article published on 22 October 2013

Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer

scientific article

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

article

Pancreatic Adenocarcinoma, Version 1.2019

scientific article published on 01 March 2019

Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

scientific article published on 01 August 2017

Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines.

scientific article published on June 2012

Pancreatic Cancer

scientific article published on 01 August 2015

Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report

scientific article published on September 2016

Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms

scientific article published on 25 October 2016

Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines

scientific article published in August 2014

Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium

scientific article

Panitumumab in Patients with KRAS Wild-Type Colorectal Cancer after Progression on Cetuximab ⬇️

scientific article published on December 30, 2011

Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer

scientific article

Patterns of Chemotherapy Use in a U.S.-Based Cohort of Patients with Metastatic Pancreatic Cancer

scientific article published on 5 May 2017

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma

scientific article published on 12 July 2019

Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer

scientific article (publication date: 2012)

Phase I study of gefitinib plus FOLFIRI in previously untreated patients with metastatic colorectal cancer

scientific article published on 01 September 2006

Phase I study of pasireotide (SOM 230) and everolimus (RAD001) in advanced neuroendocrine tumors ⬇️

scientific article published on September 14, 2012

Phase II and pharmacodynamic study of autophagy inhibition using hydroxychloroquine in patients with metastatic pancreatic adenocarcinoma

scientific article

Plasma 25-hydroxyvitamin D and risk of pancreatic cancer

scientific article published on 15 November 2011

Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts

scientific article

Plasma inflammatory cytokines and survival of pancreatic cancer patients

scientific article published on 25 April 2018

Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741.

scientific article

Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4.

scientific article

Population-Scale CT-based Body Composition Analysis of a Large Outpatient Population Using Deep Learning to Derive Age-, Sex-, and Race-specific Reference Curves

scientific article published on 24 November 2020

Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer

scientific article published on 18 September 2019

Prediagnosis Use of Statins Associates With Increased Survival Times of Patients With Pancreatic Cancer.

scientific article published on 20 February 2018

Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival

scientific article published on 19 August 2019

Prediagnostic Plasma 25-Hydroxyvitamin D and Pancreatic Cancer Survival

scientific article published on 20 June 2016

Prediagnostic body mass index and pancreatic cancer survival

scientific article

Prediagnostic circulating concentrations of vitamin D binding protein and survival among colorectal cancer patients

scientific article published on 11 September 2020

Prediagnostic plasma C-peptide and pancreatic cancer risk in men and women

scientific article published on 28 September 2007

Prediagnostic plasma folate and the risk of death in patients with colorectal cancer

scientific article published on July 2008

Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies

scientific article

Prospective study of ABO blood type and the risk of pulmonary embolism in two large cohort studies

scientific article published on 30 September 2010

Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer

scientific article published on 18 August 2009

Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer.

scientific article published on 16 March 2010

Publisher correction: Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

scientific article published on 05 March 2018

Quantifying the Genetic Correlation between Multiple Cancer Types

scientific article published on 21 June 2017

Rapid progression of combined hepatocellular carcinoma and cholangiocarcinoma

scientific article

Re: Regular use of aspirin or non-aspirin nonsteroidal anti-inflammatory drugs is not associated with risk of incident pancreatic cancer in two large cohort studies

scientific article published on 09 August 2018

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

scientific article published on 14 June 2018

Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies.

scientific article published on 8 December 2017

Reply to A. Braillon

scientific article published on 17 January 2017

Reply to Y. Mao et al

scientific article published on 04 May 2015

Reproducibility of metabolomic profiles among men and women in 2 large cohort studies

scientific article published on 29 July 2013

Response to the letter by Lai et al. regarding our manuscript "Statin use and pancreatic cancer risk in two prospective cohort studies"

scientific article published on 14 February 2020

Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus

scientific article

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

scientific article published on 01 December 2020

Systemic treatment of colorectal cancer

scientific article published on 01 May 2008

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility

scientific article

Testing for Verification Bias in Reported Malignancy Risks for Side-Branch Intraductal Papillary Mucinous Neoplasms: A Simulation Modeling Approach

scientific article published on 08 January 2019

The Mediterranean diet, plasma metabolome, and cardiovascular disease risk

scientific article published on 14 May 2020

Therapeutic Approaches for Metastatic Pancreatic Adenocarcinoma

scientific article published on 09 June 2015

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

scientific article (publication date: August 2016)

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

scientific article

Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium

scientific article

Variants associated with susceptibility to pancreatic cancer and melanoma do not reciprocally affect risk

scientific article

When, What, and Why of Perioperative Treatment of Potentially Curable Pancreatic Adenocarcinoma

scientific article published on 28 December 2016

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

scientific article (publication date: December 2016)

Winners curse correction and variable thresholding improve performance of polygenic risk modeling based on summary-level data from genome-wide association studies

scientific article published on 10 January 2016

iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer

scientific article published on 10 August 2018

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