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List of works by Bryan Laffitte

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

scientific article published on 02 July 2020

A laparoscopic knot-tying device for minimally invasive cardiac surgery.

scientific article

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

scientific article

Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies

scientific article published on 21 December 2018

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure

scientific article published on August 2005

GPR68 Senses Flow and Is Essential for Vascular Physiology.

scientific article published in April 2018

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

scientific article published on 16 March 2020

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.

scientific article published on 26 October 2015

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis

scientific article published on 05 February 2020

Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules

scientific article published on 20 April 2016

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

scientific article published on December 2013

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers

scientific article published on 10 December 2019

Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency

scientific article

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133

scientific article published on 20 February 2020

Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents

scientific article published on 17 May 2019

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