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List of works by Hanne Merritt

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

scientific article published on 30 May 2017

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

scientific article published on 16 May 2019

Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model

scientific article

Expression, purification and characterization of inactive and active forms of ERK2 from insect expression system

scientific article published on 25 March 2015

Identification and structure–activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors ⬇️

scientific article published on October 13, 2010

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer

scientific article published on 26 August 2011

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.

scientific article

RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation ⬇️

scientific article published on May 13, 2013

Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K

scientific article

Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis

scientific article published on 17 February 2020

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