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List of works by Mamoru Watanabe

5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis

scientific article published on 07 November 2020

A case of gastric syphilis with the initial manifestation of hematemesis

scientific article published in January 2017

A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression

scientific article published on 01 September 2002

A novel apoptosis-inducing monoclonal antibody (anti-LHK) against a cell surface antigen on colon cancer cells

scientific article published in October 2005

A prospective analysis of the incidence of and risk factors for opportunistic infections in patients with inflammatory bowel disease ⬇️

scientific article published on October 5, 2012

A randomized clinical trial of mesalazine suppository: the usefulness and problems of central review of evaluations of colonic mucosal findings

scientific article

A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers.

scientific article

Adalimumab Monotherapy and a Combination with Azathioprine for Crohn's Disease: A Prospective, Randomized Trial

scientific article published on 26 August 2016

Adalimumab for the induction and maintenance of clinical remission in Japanese patients with Crohn's disease ⬇️

scientific article published on August 26, 2011

Advances in balloon endoscopes

scientific article published on 23 April 2014

Advancing magnetic resonance imaging in Crohn's disease

scientific article

Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis

scientific article published on 01 February 2003

Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis

scientific article published on 01 July 2006

Amino acid substitutions in PKR-eIF2 phosphorylation homology domain (PePHD) of hepatitis C virus E2 protein in genotype 2a/2b and 1b in Japan and interferon efficacy

scientific article published in August 2003

An additional role of FTY720 in chronic colitis

scientific article published in February 2009

Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91

scientific article

Analysis of the mechanism underlying liver diseases using human induced pluripotent stem cells

scientific article published on 01 June 2019

Anti-MAdCAM-1 antibody (PF-00547659) for active refractory Crohn's disease in Japanese and Korean patients: the OPERA study

scientific article published on 30 January 2020

Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology Practice Recommendations for Medical Management and Monitoring of Inflammatory Bowel Disease in Asia

scientific article published on 16 July 2020

Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 1: risk assessment

scientific article published on 18 January 2018

Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 2: Management

scientific article published on 10 October 2017

Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 2: management

scientific article published on 18 January 2018

Asian Organization for Crohn's and Colitis and Asian Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 1: Risk assessment

scientific article published on 10 October 2017

Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents

scientific article published on 07 February 2019

Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line

scientific article

Autoimmune pancreatitis complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis

article by Shigeyuki Kawa et al published July 2015 in Journal of Gastroenterology

Autoimmune pancreatitis complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis

B cell activation in the cecal patches during the development of an experimental colitis model

scientific article published on 9 January 2018

Biologics treatment for ulcerative colitis

scientific article published in November 2013

Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation ⬇️

scientific article published on October 15, 2003

Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis

scientific article published on 25 October 2006

Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

scientific article

Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells

scientific article published on 27 September 2016

C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn's disease

scientific article published on 20 April 2013

CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice

scientific article published on 23 November 2017

CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells

scientific article published on 01 September 2004

CD8αα+ T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo

scientific article published on 19 December 2019

CEACAM1 specifically suppresses B cell receptor signaling-mediated activation

scientific article published on 19 December 2020

Capsule endoscopy findings for the diagnosis of Crohn's disease: a nationwide case-control study

scientific article published on 15 September 2018

Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid

scientific article published on 01 January 2007

Caudal type homeobox 2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis

scientific article published on 11 November 2016

Cellular and molecular mechanisms of the epithelial repair in IBD.

scientific article

Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease

scientific article published on 01 July 2002

Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy

scientific article published on October 2016

Chronic Inflammatory Demyelinating Polyradiculoneuropathy in a Patient with Crohn's Disease ⬇️

scientific article published on 01 January 2013

Chronic hepatitis B with flare due to co-infection of hepatitis delta virus during lamivudine therapy.

scientific article published in July 2003

Chronic hepatitis delta virus infection with genotype IIb variant is correlated with progressive liver disease

scientific article published in December 2003

Circulating Interleukin 6 and Albumin, and Infliximab Levels Are Good Predictors of Recovering Efficacy After Dose Escalation Infliximab Therapy in Patients with Loss of Response to Treatment for Crohn's Disease: A Prospective Clinical Trial

scientific article published on 01 September 2015

Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn's Disease

scientific article

Clinical application of human CD4+ CD25+ regulatory T cells for the treatment of inflammatory bowel diseases

scientific article

Clinical development of new drugs for inflammatory bowel disease

scientific article published on 01 March 2017

Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis

scientific article

Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes

scientific article

Colitis and colony-stimulating factors (CSFs): is stimulation of innate immunity through CSFs really effective for the treatment of chronic colitis?

scientific article published on 01 August 2005

Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice

scientific article published in December 2008

Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells

scientific article

Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study

scientific article published on 4 August 2017

Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features

scientific article

Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma

scientific article published on 09 August 2019

Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan ⬇️

scientific article published on March 11, 2011

Concerns and Side Effects of Azathioprine During Adalimumab Induction and Maintenance Therapy for Japanese Patients With Crohn's Disease: A Subanalysis of a Prospective Randomised Clinical Trial [DIAMOND Study]

scientific article published in September 2019

Continuous generation of colitogenic CD4(+) T cells in persistent colitis

scientific article published in May 2008

Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium

scientific article published in December 2017

Correction to: Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study.

scientific article published on 13 October 2017

Correction: Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind, placebo-controlled study

Corrigendum: Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies

scientific article published on 27 July 2018

Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision.

scientific article published on 25 September 2007

Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis

scientific article published on 18 January 2008

Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract

scientific article published on 26 August 2002

Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine

scientific article

Definition and epidemiology of inflammatory bowel disease

scientific article published on 01 March 2017

Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells

scientific article

Development and Validation of a Deep Neural Network for Accurate Evaluation of Endoscopic Images From Patients with Ulcerative Colitis

scientific article published on 11 February 2020

Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity

scientific article published on 22 October 2007

Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

article

Diagnosis and treatment for small intestinal lesions in patients with Crohn's disease

scientific article

Diagnosis and treatment of microscopic colitis

scientific article

Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine

scientific article

Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection

scientific article published on 17 August 2017

Do fatty acids influence functions of intestinal dendritic cells?

scientific article published on 01 March 2006

Ectopic CD40 ligand expression on B cells triggers intestinal inflammation

scientific article published in May 2004

Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial

scientific article published on 27 July 2018

Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C.

scientific article

Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents

scientific article published on 05 October 2016

Effects of vedolizumab in Japanese patients with Crohn's disease: a prospective, multicenter, randomized, placebo-controlled Phase 3 trial with exploratory analyses

scientific article published on 13 December 2019

Efficacy and Safety of Dose Escalation to Adalimumab 80 mg Every Other Week in Japanese Patients with Crohn's Disease Who Lost Response to Maintenance Therapy

scientific article published on 15 May 2018

Efficacy and safety of a new vedolizumab subcutaneous formulation in Japanese patients with moderately to severely active ulcerative colitis

scientific article published on 18 August 2020

Efficacy and safety of adalimumab in Japanese patients with moderately to severely active ulcerative colitis

scientific article published on 24 December 2013

Efficacy of Endocuff-assisted colonoscopy in the detection of colorectal polyps

scientific article published on 29 March 2018

Efficacy of Endoscopic Balloon Dilation for Small Bowel Strictures in Patients With Crohn's Disease: A Nationwide, Multi-centre, Open-label, Prospective Cohort Study

scientific article published on 01 March 2018

Efficacy of Indigo naturalis in a Multicenter Randomized Controlled Trial of Patients with Ulcerative Colitis

scientific article published on 22 November 2017

Efficacy of additional radiofrequency ablation after transcatheter arterial chemoembolization for intermediate hepatocellular carcinoma

scientific article published on 15 September 2015

Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis

scientific article published on 20 January 2014

Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes

scientific article published on July 2002

Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis

scientific article published in May 2017

Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report

scientific article published on 28 September 2012

Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis

scientific article

Erratum to: Four-year maintenance treatment with adalimumab in Japanese patients with moderately to severely active ulcerative colitis.

scientific article

Erratum: Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis

scientific article published on 01 December 2019

Establishment of a Novel Scoring System for Colon Capsule Endoscopy to Assess the Severity of Ulcerative Colitis-Capsule Scoring of Ulcerative Colitis

scientific article published on 01 November 2018

Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids

scientific article published on 01 January 2019

Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System

scientific article published on 15 March 2016

Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome

scientific article published on 23 June 2015

Evaluation of diagnostic criteria for Crohn’s disease in Japan ⬇️

scientific article published on April 3, 2013

Evaluation of performance of the Omni mode for detecting video capsule endoscopy images: A multicenter randomized controlled trial

scientific article published on 8 August 2016

Evidence-based clinical practice guidelines for Crohn’s disease, integrated with formal consensus of experts in Japan ⬇️

scientific article published on October 23, 2012

Evidence-based clinical practice guidelines for cholelithiasis 2016.

scientific article

Evidence-based clinical practice guidelines for chronic pancreatitis 2015.

scientific article published on 4 January 2016

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015.

scientific article

Evidence-based clinical practice guidelines for inflammatory bowel disease.

scientific article published on 10 February 2018

Evidence-based clinical practice guidelines for liver cirrhosis 2015.

scientific article published on 31 May 2016

Evidence-based clinical practice guidelines for management of colorectal polyps

scientific article published on 7 January 2015

Extracorporeal elimination of TNF-alpha-producing CD14(dull)CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis

scientific article published on 01 March 2007

Extranodal NK/T cell lymphoma, nasal type, of the small intestine diagnosed by double-balloon endoscopy

scientific article published on 20 November 2009

FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow

scientific article

Factors associated with exacerbation of newly diagnosed mild ulcerative colitis based on a nationwide registry in Japan

scientific article

Fas-ligand and perforin expression in infiltrating cytotoxic T lymphocytes in the liver of chronic hepatitis C

scientific article published on 01 July 2002

First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis-results from a multicenter prospective randomized controlled trial and its post hoc analysis

scientific article published on 11 July 2015

Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells

scientific article

Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt

scientific article published on 29 October 2014

Four-year maintenance treatment with adalimumab in Japanese patients with moderately to severely active ulcerative colitis

scientific article

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell

scientific article published on 11 March 2012

Functional relevance of intestinal epithelial cells in inflammatory bowel disease

scientific article

Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.

scientific article

Genetic and environmental factors drive personalized medicine for Crohn's disease

scientific article published on 15 October 2018

Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C.

scientific article published on 17 July 2013

Gut Microbiota and Internal Diseases: Update Information. Topics: V. Gut Microbiota: Topics in Various Medical Fields; 4. Interactions between the host immune system and microbes

scientific article published in January 2015

HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells

scientific article published on 30 January 2017

Hematologic malignancies in the Japanese patients with inflammatory bowel disease ⬇️

scientific article published on August 19, 2013

Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients

scientific article

Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease

scientific article published on 13 February 2009

Hepatitis C virus infection in human liver tissue engrafted in mice with an infectious molecular clone

scientific article published on June 2004

Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.

scientific article published on 14 December 2013

High b-value computed diffusion-weighted imaging for differentiating bowel inflammation in Crohn's disease

scientific article published on 21 October 2020

High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage

scientific article published on 03 December 2019

Histological diagnosis of follicular lymphoma by biopsy of small intestinal normal mucosa ⬇️

scientific article published on October 22, 2012

Histologically Confirmed IgG4-Related Small Intestinal Lesions Diagnosed via Double Balloon Enteroscopy ⬇️

scientific article published on June 14, 2012

Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease.

scientific article published on July 2009

Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus

scientific article published on 08 July 2016

Human umbilical cord blood as a source of transplantable hepatic progenitor cells

scientific article published on 01 January 2003

Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease.

scientific article published in March 2004

Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis

scientific article published on 01 February 2004

ICOS costimulation in inflammatory bowel disease.

scientific article

IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis

scientific article published in September 2010

IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.

scientific article published on 25 August 2010

IL-7 Is essential for the development and the persistence of chronic colitis

scientific article published on 01 April 2007

IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice

scientific article published on 18 November 2004

IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis

scientific article published in October 2009

IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice.

scientific article published on 23 September 2013

IP10 released by colonic subepithelial myofibroblasts: by which stimuli and for which tissue?

scientific article published on 01 May 2005

IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.

scientific article

ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin.

scientific article published on 27 January 2017

Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death

scientific journal article

Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis

scientific article published on 01 May 2008

Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients

article published in 2019

Incidence and Risk Factor Analysis of Thromboembolic Events in East Asian Patients With Inflammatory Bowel Disease, a Multinational Collaborative Study

scientific article published on 01 July 2018

Increase of Bone Marrow–Derived Secretory Lineage Epithelial Cells During Regeneration in the Human Intestine

scientific article published on 01 June 2005

Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.

scientific article published on 7 December 2016

Indolent T cell lymphoproliferative disorder with villous atrophy in small intestine diagnosed by single-balloon enteroscopy

scientific article published on 09 April 2019

Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation

scientific article

Infliximab biosimilar CT-P13 is interchangeable with its originator for patients with inflammatory bowel disease in real world practice

scientific article published on 23 August 2019

Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase

scientific article

Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs

scientific article

Inhibitory effect of a triterpenoid compound, with or without alpha interferon, on hepatitis C virus infection

scientific article

Innate and acquired immunity in inflammatory bowel disease

scientific article published on February 1, 2012

Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.

scientific article

Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice

scientific article published on 01 August 2003

Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation

scientific article published on 01 April 2007

Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm

scientific article published on 04 December 2020

Intestinal stem cell transplantation

scientific article published on 25 November 2016

Investigating cell therapy for inflammatory bowel disease

scientific article published on 26 April 2016

JSGE Clinical Practice Guidelines 2014: standards, methods, and process of developing the guidelines

scientific article

LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells

scientific article published in Scientific Reports

Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis.

scientific article published on 27 July 2016

Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells

scientific article

Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis

scientific article published on 28 September 2009

Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids.

scientific article published in May 2017

Long-term safety and effectiveness of adalimumab in Japanese patients with Crohn's disease: 3-year results from a real-world study

scientific article published on 20 November 2020

Long-term safety and efficacy of adalimumab in Japanese patients with moderate to severe Crohn's disease

scientific article published on 27 May 2014

Loss of fibrocystin promotes interleukin-8-dependent proliferation and CTGF production of biliary epithelium

scientific article published on 19 March 2019

Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation

scientific article published on 26 August 2011

MKL1 expressed in macrophages contributes to the development of murine colitis

scientific article

Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs

scientific article published on 08 August 2020

Macrophage-Derived IL-18 Targeting for the Treatment of Crohns Disease ⬇️

scientific article (publication date: June 2003)

Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease

scientific article published on 25 October 2010

Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease

scientific article

Management of Primary Nonresponders and Partial Responders to Tumor Necrosis Factor-α Inhibitor Induction Therapy among Patients with Crohn's Disease

scientific article published on 06 March 2020

Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells.

scientific article published on 24 December 2015

Mechanism of mucosal regeneration in inflammatory bowel disease

scientific article published on 01 February 2012

Modified single-operator method for double-balloon endoscopy

scientific article published on 01 November 2012

Molecular and clinical basis for the regeneration of human gastrointestinal epithelia.

scientific article published on January 2004

Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase

scientific journal article

Mucosal T cells as a target for treatment of IBD

scientific article published on March 1, 2003

Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis

scientific article published on 01 August 2003

Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells

scientific article

Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection

scientific article published on 30 January 2010

MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis

scientific article published on 01 January 2005

MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis

scientific article published in April 2008

Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis

scientific article

Need for appropriate programs for prevention of hepatitis B infection: Lessons from the latest nationwide survey in Japan

scientific article published in January 2016

Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis

scientific article published in November 2008

Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R.

scientific article published on 7 November 2016

Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62.

scientific article published on 22 November 2017

Organoid-based regenerative medicine for inflammatory bowel disease

scientific article published on 13 January 2020

PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells

scientific article

Pathology and pathophysiology of inflammatory bowel diseases. Development of inflammatory bowel disease due to disruption of the intestinal immuno-regulatory mechanism

scientific article published in January 2009

Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable

scientific article published on June 2009

Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases

scientific article published on 30 July 2015

Polymorphism Near the Interleukin-28B Gene and Anti-Hepatitis C Viral Response

scientific article published on 15 September 2013

Poor Recall of Prior Exposure to Varicella Zoster, Rubella, Measles, or Mumps in Patients with IBD ⬇️

scientific article published on February 1, 2013

Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study

scientific article published on 24 September 2019

Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan

scientific article

Predicting outcomes to optimize disease management in inflammatory bowel disease in Japan: their differences and similarities to Western countries.

scientific article published on 30 April 2018

Prediction of disease activity of Crohn's disease through fecal calprotectin evaluated by balloon-assisted endoscopy

scientific article published on 27 June 2018

Predictors of mucosal healing during induction therapy in patients with acute moderate-to-severe ulcerative colitis

scientific article published on 04 January 2019

Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan

scientific article published on 27 April 2016

Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population

scientific article published on 23 April 2010

Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule

scientific article published on 13 August 2014

Prospects for stem cell-based mucosal regeneration therapy in inflammatory bowel disease

scientific article published on 01 March 2017

Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer

scientific article published on 12 February 2008

Quantitation of the level of hepatitis delta virus RNA in serum, by real-time polymerase chain reaction--and its possible correlation with the clinical stage of liver disease

scientific article published on 12 March 2004

RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis

scientific article published in May 2009

RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.

scientific article published on 24 November 2014

Real life results in using 5-ASA for maintaining mild to moderate UC patients in Japan, a multi-center study, OPTIMUM Study.

scientific article

Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro

scientific article published on 7 February 2012

Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells

scientific article published on 29 January 2020

Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.

scientific article

Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease

scientific article

Regeneration of the intestinal epithelia: regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells.

scientific article published on May 2006

Regulation of hepatitis C virus replication by interferon regulatory factor 1

scientific article

Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

scientific article published on 6 July 2016

Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells

scientific article published on 01 June 2005

Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells

scientific article published in July 2003

Regulatory interaction of HNF1-alpha to microRNA-194 gene during intestinal epithelial cell differentiation

scientific article published on January 2007

Relation of Geriatric Nutritional Risk Index with Clinical Risks in Elderly-Onset Ulcerative Colitis

scientific article published on 24 June 2020

Reply to GASTRO-D- 20-00591

scientific article published on 12 August 2020

Requirement of Notch activation during regeneration of the intestinal epithelia

scientific article published on 20 November 2008

Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism

scientific article

Retrieval of serum infliximab level by shortening the maintenance infusion interval is correlated with clinical efficacy in Crohn's disease

scientific article published on 10 October 2011

Revision of the training curriculum of Japan Society of Gastroenterology

scientific article published on May 1, 2013

Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease

scientific article published on 03 July 2015

Role of the innate immune system in the development of chronic colitis.

scientific article

Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients With Active Ulcerative Colitis

scientific article published on 29 August 2015

Safety and usefulness of balloon endoscopy in Crohn's disease patients with postoperative ileal lesions

Safety of Adalimumab and Predictors of Adverse Events in 1693 Japanese Patients with Crohn's Disease

scientific article published on 09 March 2016

Sargramostim in patients with Crohn's disease: results of a phase 1-2 study

scientific article published on 8 April 2009

Sequence elements correlating with circulating viral load in genotype 1b hepatitis C virus infection

scientific article published on July 2003

Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy

scientific article published on 19 July 2016

Sialadenitis in patients with chronic hepatitis C is not directly related to hepatitis C virus

scientific article published in September 2003

Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis

scientific article

Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties

scientific article

Single-operator double-balloon endoscopy (DBE) is as effective as dual-operator DBE.

scientific article

Small intestinal obstruction due to the metastasis of intrahepatic cholangiocarcinoma: A case report

scientific article published in March 2018

Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon

scientific article published on August 2014

Stem cell-based therapy for inflammatory bowel disease

scientific article published on 25 July 2019

Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture

scientific article published on 30 January 2011

Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis

scientific article published on 6 January 2011

Surveillance for dysplasia in patients with ulcerative colitis: Discrepancy between guidelines and practice

scientific article published on 15 March 2017

Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis

scientific article published on 01 January 2008

Systemically circulating colitogenic memory CD4+T cells may be an ideal target for the treatment of inflammatory bowel diseases

scientific article published on December 2009

T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice

scientific article published on 28 July 2012

TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells

scientific article published on 01 February 2020

TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice

scientific article published on 01 February 2006

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy

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TP53 Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer

scientific article published on 15 April 2019

Tacrolimus for the Treatment of Ulcerative Colitis

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Tenofovir alafenamide for hepatitis B virus infection including switching therapy from tenofovir disoproxil fumarate

scientific article published on 21 May 2019

Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement

scientific article published on 01 December 2002

Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota.

scientific article

The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein.

scientific article published on 16 January 2013

The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis

scientific article published on 13 February 2012

The history and definition of inflammatory bowel diseases

scientific article published on 01 February 2012

The logics of leukocytapheresis as a natural biological therapy for inflammatory bowel disease

scientific article

The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development

scientific article published on 10 November 2016

The use of traditional and newer calcineurin inhibitors in inflammatory bowel disease ⬇️

scientific article published on 04 December 2010

Therapeutic Approaches to Chronic Intestinal Inflammation by Specific Targeting of Mucosal IL-7 / IL-7R Signal Pathway ⬇️

scientific article published on June 1, 2003

Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient

scientific article published on 05 February 2020

Tofacitinib as Induction and Maintenance Therapy in Japanese Patients with Active Ulcerative Colitis

scientific article published on 08 August 2019

Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies.

scientific article

Treatment of inflammatory immunologic disease 1. Leukocytapheresis for inflammatory immunologic disease (tentative)

scientific article published on 15 August 2007

Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication

scientific article published on 20 July 2008

Ubiquitin D is up-regulated by synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients

scientific article published on 01 March 2019

Ulcerative colitis -recent advance in clinical practice and basic research

scientific article published on 01 March 2016

Ulcerative colitis outcomes research in Japan: protocol for an observational prospective cohort study of YOURS (YOu and Ulcerative colitis: Registry and Social network)

scientific article published on 08 September 2019

Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis

scientific article published on 7 January 2011

Use of capsule endoscopy in patients with Crohn's disease in Japan: a multicenter survey

scientific article published on 01 January 2014

Usefulness of immunomodulators for long-term prognosis of Crohn's disease

scientific article published on 01 March 2011

Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts

scientific article published on 24 December 2019

Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind, placebo-controlled study

scientific article published on 26 February 2019

Withdrawal of thiopurines in Crohn's disease treated with scheduled adalimumab maintenance: a prospective randomised clinical trial (DIAMOND2)

scientific article published on 30 April 2019

[A case of acute portal and mesenteric venous thrombosis treated with urokinase via superior mesenteric artery].

scientific article published in February 2005

[A case of amebic liver abscess with anaphylactoid purpura]

scientific article published on 01 November 2002

[A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia]

scientific article published in August 2014

[A case of gastric neuroendocrine carcinoma with liver metastasis and portal vein invasion successfully treated by S-1 and cisplatin chemotherapy]

scientific article published on 01 January 2013

[A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient]

scientific article published on 01 September 2006

[A long-term survival case of colon cancer with multiple liver metastases treated with multidisciplinary therapy]

scientific article published on 01 February 2010

[Advances of magnetic resonance imaging in Crohn's disease]

scientific article published on 01 July 2015

[An abdominal follicular dendritic cell tumor in Castleman's disease]

scientific article published on 01 September 2004

[Clinical relevance of tacrolimus trough levels in outpatients with active ulcerative colitis]

scholarly article by Makoto Naganuma et al published 1 February 2014 in Nihon Shokakibyo Gakkai zasshi

[Current trend in the management of inflammatory bowel disease: a discussion]

scientific article published on 01 January 2009

[Endoscopic and imaging diagnosis and assessment of inflammatory bowel disease]

scientific article published on 01 January 2018

[Genetic and immunological basis for ulcerative colitis]

scientific article published on 01 May 2005

[Immune responses in intestinal mucosa]

scientific article published on 01 April 2005

[Inflammatory bowel diseases]

scientific article published on 01 November 2012

[Leukocytapheresis for inflammatory immune diseases]

scientific article published on 01 September 2006

[Management and treatment of ulcerative colitis. 1. Treatment of ulcerative colitis in the field of internal medicine]

scientific article published on 01 January 2009

[Manipulating the differentiation and regeneration of the gastrointestinal epithelia--prospects for clinical application]

scientific article published on 01 December 2003

[New concept of cell therapy using regulatory T cells for the treatment of inflammatory bowel disease]

scientific article published on 01 September 2005

[Regulation of epithelial cell differentiation and regeneration in IBD]

scientific article published on 01 August 2007

[Regulatory T cells and inflammatory bowel diseases]

scientific article published on 01 October 2004

[Review: treatment of irritable bowel syndrome based upon a Japanese guideline]

scientific article published on 01 August 2006

[Stem Cell System. The intestinal stem cell system.]

scientific article published on 01 January 2017

[The cutting-edge of medicine; Towards adult stem cell-based therapy for intestinal diseases]

scientific article published on 01 December 2012

[Treatment strategy for refractory inflammatory bowel disease to improve endoscopic lesions and long-term prognosis]

scientific article published on 01 January 2012

[Treatment strategy for severe and refractory inflammatory bowel disease]

scientific article published on 01 February 2012

α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C ⬇️

scientific article published on August 19, 2013

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