List of works - Homme Hellinga

A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity

scientific article

An empirical model for electrostatic interactions in proteins incorporating multiple geometry‐dependent dielectric constants ⬇️

scientific article published on May 15, 2003

Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor

scientific article

Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins

scientific article published on 5 July 2006

Computational design of a biologically active enzyme

scientific article

Computational design of receptor and sensor proteins with novel functions ⬇️

scientific article published on May 8, 2003

Computational design of receptors for an organophosphate surrogate of the nerve agent soman

scientific article

Construction of a fluorescent biosensor family

scientific article published on November 2002

Construction of new ligand binding sites in proteins of known structure

scientific article (publication date: December 1991)

Control of a biomolecular motor-powered nanodevice with an engineered chemical switch

scientific article published in November 2002

Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design

scientific article

Crystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design

scientific article

Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium

scientific article published on 12 January 2020

Design of a calcium-binding protein with desired structure in a cell adhesion molecule

scientific article published in February 2005

Engineering key components in a synthetic eukaryotic signal transduction pathway

scientific article published on 19 May 2009

Harnessing environmental Ca2+ for extracellular protein thermostabilization

scientific article published on 11 September 2020

Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates

scientific article published on 2 June 2006

In the wake of two retractions, a request for investigation

scientific article published on 01 July 2008

In this issue

Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein-protein interactions directly from DNA.

scientific article

Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.

scientific article published on 22 May 2017

Ligand-induced conformational changes in a thermophilic ribose-binding protein

scientific article

Local encoding of computationally designed enzyme activity

scientific article published on 5 December 2006

Multifactorial Determinants of Protein Expression in Prokaryotic Open Reading Frames ⬇️

scientific article published on August 18, 2010

Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms

scientific article published on 2 December 2004

Periplasmic binding proteins: a versatile superfamily for protein engineering

scientific article published in August 2004

Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity

scientific article

Programmable ligand detection system in plants through a synthetic signal transduction pathway

scientific article

Protein fabrication automation

scientific article

Quantitation of protein-protein interactions by thermal stability shift analysis

scientific article

Rational design of a calcium-binding protein

scientific article published in May 2003

Retraction

scientific article published on 01 February 2008

Structural Analysis of Semi-specific Oligosaccharide Recognition by a Cellulose-binding Protein of Thermotoga maritima Reveals Adaptations for Functional Diversification of the Oligopeptide Periplasmic Binding Protein Fold

scientific article

Structural Analysis of a Periplasmic Binding Protein in the Tripartite ATP-independent Transporter Family Reveals a Tetrameric Assembly That May Have a Role in Ligand Transport

scientific article

Structural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and Ribonucleotides

scientific article

Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins

scientific article

Structural analysis, identification, and design of calcium-binding sites in proteins

scientific article

Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

scientific article

Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle

scientific article published on 22 October 2008

Structure-based design of robust glucose biosensors using aThermotoga maritimaperiplasmic glucose-binding protein

scientific article

Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

scientific article

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

scientific article

The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog

scientific article

The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites

scientific article published on 10 August 2006

Thermodynamic Analysis of Ligand-Induced Changes in Protein Thermal Unfolding Applied to High-Throughput Determination of Ligand Affinities with Extrinsic Fluorescent Dyes ⬇️

scientific article published on December 3, 2010

Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation

scientific article

List of works by Homme Hellinga

A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity

An empirical model for electrostatic interactions in proteins incorporating multiple geometry‐dependent dielectric constants ⬇️

Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor

Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins

Computational design of a biologically active enzyme

Computational design of receptor and sensor proteins with novel functions ⬇️

Computational design of receptors for an organophosphate surrogate of the nerve agent soman

Construction of a fluorescent biosensor family

Construction of new ligand binding sites in proteins of known structure

Control of a biomolecular motor-powered nanodevice with an engineered chemical switch

Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design

Crystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design

Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium

Design of a calcium-binding protein with desired structure in a cell adhesion molecule

Engineering key components in a synthetic eukaryotic signal transduction pathway

Harnessing environmental Ca2+ for extracellular protein thermostabilization

Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates

In the wake of two retractions, a request for investigation

In this issue

Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein-protein interactions directly from DNA.

Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.

Ligand-induced conformational changes in a thermophilic ribose-binding protein

Local encoding of computationally designed enzyme activity

Multifactorial Determinants of Protein Expression in Prokaryotic Open Reading Frames ⬇️

Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms

Periplasmic binding proteins: a versatile superfamily for protein engineering

Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity

Programmable ligand detection system in plants through a synthetic signal transduction pathway

Protein fabrication automation

Quantitation of protein-protein interactions by thermal stability shift analysis

Rational design of a calcium-binding protein

Retraction

Structural Analysis of Semi-specific Oligosaccharide Recognition by a Cellulose-binding Protein of Thermotoga maritima Reveals Adaptations for Functional Diversification of the Oligopeptide Periplasmic Binding Protein Fold

Structural Analysis of a Periplasmic Binding Protein in the Tripartite ATP-independent Transporter Family Reveals a Tetrameric Assembly That May Have a Role in Ligand Transport

Structural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and Ribonucleotides

Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins

Structural analysis, identification, and design of calcium-binding sites in proteins

Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle

Structure-based design of robust glucose biosensors using aThermotoga maritimaperiplasmic glucose-binding protein

Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog

The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites

Thermodynamic Analysis of Ligand-Induced Changes in Protein Thermal Unfolding Applied to High-Throughput Determination of Ligand Affinities with Extrinsic Fluorescent Dyes ⬇️

Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation