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List of works by Niels Borregaard

A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa.

scientific article

Alpha-1-antitrypsin is produced by human neutrophil granulocytes and their precursors and liberated during granule exocytosis.

scientific article published in June 2011

An ELISA for SGP28/CRISP-3, a cysteine-rich secretory protein in human neutrophils, plasma, and exocrine secretions

scientific article

Antimicrobial peptides in innate immune responses.

scientific article published on January 2008

Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils.

scientific article

Azurophil granule proteins constitute the major mycobactericidal proteins in human neutrophils and enhance the killing of mycobacteria in macrophages.

scientific article

Candida albicans escapes from mouse neutrophils

scientific article

Cathelicidins--nature's attempt at combinatorial chemistry.

scientific article

Changes in Gene Expression during G-CSF-Induced Emergency Granulopoiesis in Humans.

scientific article published on August 2016

Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tract

scientific article

Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients.

scientific article

Compound exocytosis of granules in human neutrophils.

scientific article published in June 2002

Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma

scientific article published in October 2004

Defensin-rich granules of human neutrophils: characterization of secretory properties.

scientific article published in August 2002

Derangement of transcription factor profiles during in vitro differentiation of HL60 and NB4 cells

scientific article published on 30 August 2006

End-stage differentiation of neutrophil granulocytes in vivo is accompanied by up-regulation of p27kip1 and down-regulation of CDK2, CDK4, and CDK6

scientific article published on 23 December 2003

Expression of neutrophil gelatinase-associated lipocalin in skin epidermis

scientific article published on 01 February 2006

Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP.

scientific article published on 9 September 2009

Granulopoiesis and granules of human neutrophils.

scientific article

Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.

scientific article published on 16 March 2006

Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils

scientific article published on 7 June 2005

Human CRISP-3 binds serum alpha(1)B-glycoprotein across species

scientific article published on 28 January 2010

Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

scientific article published on 01 July 2018

Human α-defensin expression is not dependent on CCAAT/enhancer binding protein-ε in a murine model

scientific article

IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta

scientific article

Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils

scientific article

Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules

scientific article published in January 2002

Impact of microRNA-130a on the neutrophil proteome

scientific article (publication date: 25 November 2015)

Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta.

scientific article published on 10 March 2010

Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis.

scientific article

Lipocalin 2 is protective against E. coli pneumonia

scientific article

Lipocalin-2 Functions as Inhibitor of Innate Resistance to

Lipocalin-2 from both myeloid cells and the epithelium combats Klebsiella pneumoniae lung infection in mice

scientific article published on 10 April 2017

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3.

scientific article

Localization of serglycin in human neutrophil granulocytes and their precursors

scientific article

MicroRNA profiling in human neutrophils during bone marrow granulopoiesis and in vivo exudation.

scientific article

MicroRNA-130a-mediated down-regulation of Smad4 contributes to reduced sensitivity to TGF-β1 stimulation in granulocytic precursors

scientific article

MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis

scientific article

Microarray-based classification of diffuse large B-cell lymphoma

scientific article

Molecular biology diagnostics: malignant lymphoid tumors in adults

scientific article published in February 2003

NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity

scientific article published on July 31, 2013

Neutrophil elastase depends on serglycin proteoglycan for localization in granules

scientific article published on 01 February 2007

Neutrophil extracellular traps - the dark side of neutrophils

scientific article published on 2 May 2016

Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori

scientific article published in September 2009

Neutrophil gelatinase-associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin

scientific article published on December 2002

Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha.

scientific article published on December 2003

Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein.

scientific article

Neutrophil granules: a library of innate immunity proteins

scientific article

No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer

scientific article

Olfactomedin 4 defines a subset of human neutrophils

scientific article published on 20 December 2011

On mouse and man: neutrophil gelatinase associated lipocalin is not involved in apoptosis or acute response

scientific article

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses

scientific article

Pharmacogenetics and tailored drug therapy

scientific article published in March 2009

Plasma levels of OLFM4 in normals and patients with gastrointestinal cancer

scientific article

ProHNPs are the principal α-defensins of human plasma

scientific article

Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo

scientific article published on 6 May 2015

Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina

scientific article

Prodefensins are matrix proteins of specific granules in human neutrophils

scientific article

Prognostic significance of metallothionein in B-cell lymphomas

scientific article published on 25 July 2006

Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus

scientific article

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors.

scientific article published on 6 May 2013

Research update for articles published in EJCI in 2013.

scientific article published on October 2015

Serglycin participates in retention of α-defensin in granules during myelopoiesis

scientific article (publication date: 20 October 2011)

Serglycin proteoglycan is not implicated in localizing exocrine pancreas enzymes to zymogen granules.

scientific article published on 14 May 2009

Systems biology of neutrophil differentiation and immune response.

scientific article

Technical advance: immunophenotypical characterization of human neutrophil differentiation.

scientific article published on 7 June 2011

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain

scientific article

The Ficolins

scientific article published on 30 October 2009

The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

scientific article published on December 2003

The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium

scientific article published on 01 March 2003

The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake

scientific journal article

The genetics of ficolins

scientific article published on 24 September 2009

The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow

scientific article published on 30 January 2003

The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma

scientific article

The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils

scientific article

The transcriptional activation program of human neutrophils in skin lesions supports their important role in wound healing.

scientific article published in June 2004

The transcriptional program of terminal granulocytic differentiation

scientific article

Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils

scientific article

Vitamin d-directed rheostatic regulation of monocyte antibacterial responses

scientific article published on April 2009

Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors

scientific article

beta-Microseminoprotein binds CRISP-3 in human seminal plasma

scientific article

miRNA-130a regulates C/EBP-ε expression during granulopoiesis.

scientific article published on 7 January 2014