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List of works by Amato J. Giaccia

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death.

scientific article

A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.

scientific article published on 9 February 2018

A central role for hypoxic signaling in cartilage, bone, and hematopoiesis

scientific article

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

scientific article published on 15 September 2013

A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: the Atkins diet suppresses tumor growth

scientific article

A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy

scientific article

A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia

scientific article published on July 2005

A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth

scientific article published on 28 June 2013

ATM activation and signaling under hypoxic conditions.

scientific article

ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation

scientific article published on 7 January 2003

AXL Expression and Risk of Relapse in Non-Small Cell Lung Cancer

AXL is an essential factor and therapeutic target for metastatic ovarian cancer

scientific article

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

scientific article

Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia

scientific article published on 26 November 2007

An Activatable NIR Fluorescent Rosol for Selectively Imaging Nitroreductase Activity

scientific article published on 30 November 2019

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

scientific article

An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers.

scientific article published in March 2006

Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function

scientific article

Angiogenesis is required for successful bone induction during distraction osteogenesis

scientific article

Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment

scientific article published in April 2005

Antiangiogenic therapy and p53.

scientific article published in July 2002

BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer

scientific article

Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours

scientific article

Blood and bones: osteoblastic HIF signaling regulates erythropoiesis

scientific article published on 15 June 2012

Bringing H2AX into the angiogenesis family

scientific article published on June 2009

Checking in on hypoxia/reoxygenation

scientific article

Comment on: osteopontin as toxic marker.

scientific article

Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest

scientific article

Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis

scientific article published on 01 June 2006

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

scientific article

Corrigendum: Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin

scientific article published on June 2015

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

scientific article

DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response

scientific article

Dead cells don't form tumors: HIF-dependent cytotoxins

scientific article published on February 2004

Developmental response to hypoxia

scientific article

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.

scientific article

Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5

scientific article

Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells

scientific article

Effects of perillyl alcohol on melanoma in the TPras mouse model

scientific article published in June 2002

Emerging Treatment Paradigms in Radiation Oncology

scientific article

Energy regulation: HIF MXIes it up with the C-MYC powerhouse

scientific article published on June 2007

Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury.

scientific article

Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

scientific article published on 01 October 2016

Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas

scientific article published on September 2007

Fibrosis and hypoxia-inducible factor-1α-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors

scientific article published on 5 September 2015

Functional analysis of p53 binding under differential stresses

scientific article published on October 2006

Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response.

scientific article

Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance

scientific article published on 01 December 2019

Galectin-1: a link between tumor hypoxia and tumor immune privilege

scientific article published on 11 October 2005

Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy

scientific article

Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers

scientific article

Genome-wide analysis of p53 under hypoxic conditions

scientific article published on May 2006

HIF gene expression in cancer therapy

scientific article published on January 2007

HIF-alpha, a gender independent transcription factor

scientific article published on 01 July 2003

HIF1alpha delays premature senescence through the activation of MIF.

scientific article

HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors

scientific article published on 15 July 2019

Hypoxia and Bone Metastatic Disease

scientific article

Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression ⬇️

scientific article published on 08 March 2011

Hypoxia in models of lung cancer: implications for targeted therapeutics

scientific article published on 21 September 2010

Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells.

scientific article published in June 2007

Hypoxia links ATR and p53 through replication arrest

scientific article

Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer.

scientific article published on September 2005

Hypoxia, gene expression, and metastasis

scientific article published on June 2007

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

scientific article

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

scientific article

Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual

scientific article published on 21 February 2019

Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers?

scientific article published on September 2006

Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion

scientific article

Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.

scientific article

Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy

scientific article

Hypoxia: Signaling the Metastatic Cascade

scientific article published on 2 June 2016

Hypoxic control of metastasis

scientific article

Hypoxic gene expression and metastasis

scientific article published on August 2004

Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells

scientific article

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

scientific article published on 16 September 2016

Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling.

scientific article

Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas

scientific article published on January 2003

Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents

scientific article published on 20 December 2013

In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis

scientific article published on December 2007

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

scientific article published on 19 September 2016

Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation

scientific article published on September 2004

Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells

scientific article published on December 2009

Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies

scientific article

Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis

scientific article published on 21 September 2020

Investigating hypoxic tumor physiology through gene expression patterns

scientific article

Irradiation or temozolomide chemotherapy enhances anti-CD47 treatment of glioblastoma

scientific article published on 23 September 2019

Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions

scientific article published on January 2016

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

scientific article published in September 2004

KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage ⬇️

scientific article

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

scientific article published on January 2011

Long-range hypoxia signaling in NAFLD.

scientific article

Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus.

scientific article

Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development

scientific article published on 24 June 2014

Lysyl oxidase mediates hypoxic control of metastasis

scientific article

Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients

scientific article published on 07 June 2018

Matrix crosslinking forces tumor progression by enhancing integrin signaling

scientific article

Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells

scientific article published on January 2016

Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1.

scientific article published on 15 February 2016

MiR-210--micromanager of the hypoxia pathway

scientific article

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

scientific article published on 19 October 2020

Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase

scientific article published on 13 March 2017

Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice

scientific article

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

scientific article published on 13 November 2006

Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer

scientific article published on 01 December 2018

Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions

scientific article published on February 2006

Neurotrophic factor GDNF promotes survival of salivary stem cells

scientific article

Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer

scientific article published on 03 November 2020

Osteoblasts: a novel source of erythropoietin

scientific article published on December 2014

Oxygen sensing and the DNA-damage response

scientific article

Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia.

scientific article published on July 2007

Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin

scientific article

PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2.

scientific article

PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing

scientific article published in January 2018

PHD2 in tumour angiogenesis

scientific article published on 11 May 2010

Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism

article published in the Proceedings of the National Academy of Sciences of the United States of America

Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location

scientific article

Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104

scientific article

Plasma osteopontin is an independent prognostic marker for head and neck cancers

scientific article published on 01 November 2006

Pre-metastatic niches: organ-specific homes for metastases.

scientific article published on 17 March 2017

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

RETRACTED: scientific article (publication date: 27 April 2006)

Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma

scientific article published on 01 January 2020

Recruitment of circulating breast cancer cells is stimulated by radiotherapy

scientific article

Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis

scientific article

Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis

scientific article published on 10 July 2013

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

scientific article

Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth

scientific article

Reprogramming the immunological microenvironment through radiation and targeting Axl.

scientific article published on 23 December 2016

Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis

scientific article published on 01 March 2020

Role of carcinoma-associated fibroblasts and hypoxia in tumor progression

scientific article published on January 2010

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

scientific article published on 16 August 2002

SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells

scientific article published on 24 April 2011

Selection of external beam radiotherapy approaches for precise and accurate cancer treatment

scientific article published on 24 January 2018

Stem cell differentiation

scientific article published in July 2004

Stress-responsive HILPDA is necessary for thermoregulation during fasting

scientific article published on 24 July 2017

Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate

scientific article published on 16 May 2019

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

scientific article published on 25 June 2015

Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death

scientific article published on 13 October 2008

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality ⬇️

scientific article published on August 3, 2011

Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics

scientific article published on 12 October 2008

Targeting cancer cells through autophagy for anticancer therapy

scientific article published on 06 January 2010

Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells

scientific article published on 14 July 2017

Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO-AACR Research Workshop

scientific article published on 05 February 2019

Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells.

scientific article

The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

scientific article

The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways

scientific article

The Receptor Tyrosine Kinase AXL in Cancer Progression

scientific article

The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells

scientific article published on 16 December 2013

The end of the hypoxic EPOch

scientific article published in April 2015

The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels

scientific article published on February 2006

The hypoxic tumor microenvironment and gene expression

scientific article published in July 2004

The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation

scientific article

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

scientific article published on 16 January 2005

The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation

scientific article published in August 2004

The role of p53 in hypoxia-induced apoptosis

scientific article

The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth

scientific article published on February 2009

The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation

scientific article

The tumour microenvironment links complement system dysregulation and hypoxic signalling.

scientific article published on 15 March 2018

Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer.

scientific article published on October 2003

Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice

scientific article

Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling

scientific article

Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts

scientific article

Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis

scientific article

Tumor immunologic heterogeneity influences response to radiation and combination immunotherapy.

scientific article published on 4 November 2015

Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface

scientific article published in January 2014

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment

scientific article

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival.

scientific article

VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration

scientific article

Validated limited gene predictor for cervical cancer lymph node metastases

scientific article published on 16 June 2020

Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.

scientific article published on 10 August 2009

Wounds Inhibit Tumor Growth In Vivo

scientific article published on 27 February 2019

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

scientific article published on September 2004

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