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List of works by Roman Sakowicz

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly

scientific article

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

scientific article

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

scientific article published on 28 September 2009

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.

scientific article published on 24 February 2017

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.

scientific article published on 15 August 2017

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs

scientific article published on 11 October 2017

Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition

scientific article published on 15 January 2020

Clinical targeting of HIV capsid protein with a long-acting small molecule

scientific article published on 01 July 2020

Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2.

scientific article published on 16 February 2007

Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent

scientific article published on 9 April 2015

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation

scientific article published on 21 February 2011

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly

scientific article published on 24 March 2015

GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein

scientific article published on 31 August 2015

High-throughput screening of formulations to optimize the thermal stability of a therapeutic monoclonal antibody

scientific article published on 10 November 2014

Kinetic analysis of Mad2-Cdc20 formation: conformational changes in Mad2 are catalyzed by a C-Mad2-ligand complex

scientific article published on October 2009

Large-scale functional purification of recombinant HIV-1 capsid

scientific article

Lipid-sensing high-throughput ApoA-I assays

scientific article published on 17 July 2012

Mechanism of inhibition of human KSP by ispinesib

scientific article published on 22 February 2008

Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition

scientific article published in December 2004

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

scientific article

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells

scientific article (publication date: 2013)

Novel ATP-competitive kinesin spindle protein inhibitors

scientific article published on 29 August 2007

Off-target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

scientific article published on 23 November 2020

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.

scientific article

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors

scientific article published on 9 January 2014

The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function

scientific article

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM

scientific article published on 10 February 2019

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties

scientific article published on 06 May 2010

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