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List of works by Magdeleine Hung

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

scientific article published on 09 September 2019

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly

scientific article

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

scientific article published on 28 September 2009

Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir

scientific article

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.

scientific article published on 24 February 2017

Clinical targeting of HIV capsid protein with a long-acting small molecule

scientific article published on 01 July 2020

Development and application of a fast, reproducible assay to measure HCV NS3 protease activity using Escherichia coli lysate

scientific article published on 18 September 2015

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).

scientific article published on 20 October 2017

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation

scientific article published on 21 February 2011

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly

scientific article published on 24 March 2015

GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein

scientific article published on 31 August 2015

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

scientific article published on 14 February 2007

Large-Scale Functional Purification of Recombinant HIV-1 Capsid ⬇️

scientific article published on March 5, 2013

Lipid-Sensing High-Throughput ApoA-I Assays ⬇️

scientific article published on July 17, 2012

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

scientific article published on May 2013

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action ⬇️

scientific article published on April 25, 2012

PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy

scientific article published on 22 October 2019

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH

scientific article published on 18 April 2006

Preparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery

scientific article

Screening and Identification of a Novel Class of TGF-β Type 1 Receptor Kinase Inhibitor ⬇️

scientific article published on April 26, 2011

Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes

scientific article published on 30 July 2019

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors

scientific article published on 9 January 2014

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor

scientific article published on 15 November 2018

The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function

scientific article

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

scientific article published in January 2007

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties

scientific article published on 06 May 2010

Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

scientific article published on 04 April 2020

Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex

scientific article

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