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List of works by Anita Niedziela-Majka

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

scientific article published on 09 September 2019

A nonuniform stepping mechanism for E. coli UvrD monomer translocation along single-stranded DNA

scientific article published on May 2007

A novel bacteriophage-encoded RNA polymerase binding protein inhibits transcription initiation and abolishes transcription termination by host RNA polymerase

scientific article published on June 2002

A role for interaction of the RNA polymerase flap domain with the sigma subunit in promoter recognition.

scientific article

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly

scientific article

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

scientific article

Autoinhibition of Escherichia coli Rep monomer helicase activity by its 2B subdomain

scientific article

Bacillus stearothermophilus PcrA monomer is a single-stranded DNA translocase but not a processive helicase in vitro.

scientific article published on 12 July 2007

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.

scientific article published on 15 August 2017

Characterization of the interactions between the bacteriophage T4 AsiA protein and RNA polymerase.

scientific article

Clinical targeting of HIV capsid protein with a long-acting small molecule

scientific article published on 01 July 2020

Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent

scientific article published on 9 April 2015

Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation

scientific article published on 19 November 2019

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation

scientific article published on 21 February 2011

Escherichia coli RNA polymerase contacts outside the -10 promoter element are not essential for promoter melting

scientific article

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly

scientific article published on 24 March 2015

GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein

scientific article published on 31 August 2015

Hepatitis B Virus X Protein Function Requires Zinc Binding

scientific article published on 30 July 2019

High-throughput screening of formulations to optimize the thermal stability of a therapeutic monoclonal antibody

scientific article published on 10 November 2014

Highly potent HCV NS4B inhibitors with activity against multiple genotypes

scientific article published on 18 February 2014

Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness

scientific article published on 25 March 2013

Interaction of T4 AsiA with its target sites in the RNA polymerase sigma70 subunit leads to distinct and opposite effects on transcription

scientific article published on 01 February 2003

Large-scale functional purification of recombinant HIV-1 capsid

scientific article

Lipid-sensing high-throughput ApoA-I assays

scientific article published on 17 July 2012

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

scientific article

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells

scientific article (publication date: 2013)

PcrA helicase dismantles RecA filaments by reeling in DNA in uniform steps

scientific article

Purification of Drosophila melanogaster ultraspiracle protein and analysis of its A/B region-dependent dimerization behavior in vitro

scientific article

Regulation of UvrD Helicase Activity by MutL

article

Rotations of the 2B Sub-domain of E. coli UvrD Helicase/Translocase Coupled to Nucleotide and DNA Binding

scientific article

Self-assembly of Escherichia coli MutL and its complexes with DNA

scientific article

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors

scientific article published on 9 January 2014

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor

scientific article published on 15 November 2018

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM

scientific article published on 10 February 2019

The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint

scientific article

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties

scientific article published on 06 May 2010

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