Search filters

List of works by Hajime Ohigashi

(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells

scientific article

1'-Acetoxychavicol acetate induces apoptosis of myeloma cells via induction of TRAIL.

scientific article published on 2 November 2005

1'-Acetoxychavicol acetate-induced cytotoxicity is accompanied by a rapid and drastic modulation of glutathione metabolism

scientific article published on 12 February 2008

1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo

scientific article

1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa

scientific article published on 07 November 2011

1′-Acetoxychavicol Acetate as a Potent Inhibitor of Tumor Promoter-induced Epstein-Barr Virus Activation fromLanguas gaianga, a Traditional Thai Condiment

scientific article published on 14 September 2009

A phase II detoxification enzyme inducer from lemongrass: identification of citral and involvement of electrophilic reaction in the enzyme induction

scientific article published on March 2003

Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36

scientific article published on 01 April 2007

Auraptene decreases the activity of matrix metalloproteinases in dextran sulfate sodium-induced ulcerative colitis in ICR mice.

scientific article published on 7 December 2006

Cancer prevention with food factors: alone and in combination

scientific article

Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells

scientific article

Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin

scientific article published in January 2002

Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism ⬇️

scientific article published on 11 September 2006

Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats

scientific article

Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation

scientific article

Combinatorial effects of nonsteroidal anti-inflammatory drugs and food constituents on production of prostaglandin E2 and tumor necrosis factor-alpha in RAW264.7 murine macrophages

scientific article published in May 2003

Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis

scientific article published on 11 December 2012

Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages

scientific article published on 13 June 2007

Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice

scientific article published on 13 November 2009

Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression

scientific article published on 15 December 2004

Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis

scientific article

Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages

scientific article published on May 2003

Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages

scientific article

FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid

scientific article published on June 2002

Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells

scientific article published on 17 September 2002

Growth inhibitory activities of crude extracts obtained from herbal plants in the Ryukyu Islands on several human colon carcinoma cell lines.

scientific article published on July 2005

In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia

scientific article

Induction of apoptosis in human myeloid leukemic cells by 1'-acetoxychavicol acetate through a mitochondrial- and Fas-mediated dual mechanism

scientific article published on March 2004

Inhibition by (-)-Persenone A-related Compounds of Nitric Oxide and Superoxide Generation from Inflammatory Leukocytes

scientific article published on 01 December 2010

Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis.

scientific article published on 26 September 2005

Involvement of protein tyrosine phosphorylation and reduction of cellular sulfhydryl groups in cell death induced by 1' -acetoxychavicol acetate in Ehrlich ascites tumor cells

scientific article published in February 2002

Isolation and Identification of Acetylenic Spiroketal Enol Ethers fromArtemisia lactifloraas Inhibitors of Superoxide Generation Induced by a Tumor Promoter in Differentiated HL-60 Cells

scientific article published on 26 July 2002

Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.

scientific article published on 4 May 2009

Metabolism and absorption of auraptene (7-geranyloxylcoumarin) in male SD rats: comparison with 7-ethoxycoumarin

scientific article published in May 2008

Modifying effects of 1'-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats

scientific article

Modifying effects of dietary factors on (-)-epigallocatechin-3-gallate-induced pro-matrix metalloproteinase-7 production in HT-29 human colorectal cancer cells

scientific article published on 7 October 2007

Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells

scientific article

Mutagenicity of reactive oxygen and nitrogen species as detected by co-culture of activated inflammatory leukocytes and AS52 cells

scientific article published on February 2003

New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages

scientific article published on November 2005

Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells

scientific article

Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.

scientific article

Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells

scientific article

Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages

scientific article

Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, ofBoesenbergia pandurata

scientific article published on 14 September 2009

Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats.

scientific article

Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS52 cells

scientific article published on February 2002

Search for Naturally-occurring Antioxidative Chemopreventors on the Basis of the Involvement of Leukocyte-derived Reactive Oxygen Species in Carcinogenesis

scientific article published on 01 January 2000

Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages

scientific article

Superoxide Scavenging Activity of Rosmarinic Acid fromPerilla frutescensBritton Var.acutaf.viridis

scientific article published on 26 July 2002

Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination.

scientific article published in October 2003

Suppressive Effects of Edible Thai Plants on Superoxide and Nitric Oxide Generation

scientific article published on January 1, 2002

Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.

scientific article published in October 2005

Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells

scientific article published on January 2007

Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages

scientific article published on November 2005

Suppressive effects of natural and synthetic agents on dextran sulfate sodium-induced interleukin-1beta release from murine peritoneal macrophages

scientific article published in February 2004

Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice

scientific article

Suppressive effects of selected antioxidants on the activated leukocytes-induced mutagenesis in the co-culture assay systems

scientific article published in January 2004

Suppressive properties of extracts from Japanese edible plants regarding nitric oxide generation.

scientific article

Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors

scientific article published on February 2003

Synthesis of feruloyl-myo-insitol derivatives and their inhibitory effects on phorbol ester-induced superoxide generation and Esptein-Barr virus activation

scientific article published on June 2002

Synthesis of novel polyphenols consisted of ferulic and gallic acids, and their inhibitory effects on phorbol ester-induced Epstein-Barr virus activation and superoxide generation

scientific article published on April 2002

Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals

scientific article

The modifying effects of green tea polyphenols on acute colitis and inflammation-associated colon carcinogenesis in male ICR mice

scientific article published in January 2010

Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin

scientific article published on 01 April 2006

Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages

scientific article published on 26 September 2005

Ursolic acid: an anti- and pro-inflammatory triterpenoid

scientific article published on January 2008

Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2.

scientific article published on 2 March 2011

Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.

scientific article published on 7 April 2007

Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.

scientific article

Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway

scientific article published on January 2007

Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice

scientific article

Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes

scientific article published on August 2004

Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines.

scientific article

Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action

scientific article published on 01 December 2005

Paulina is supported by:

About Paulina

Help