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List of works by Hyong Joo Lee

20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol suppresses UV-Induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway

scientific article published on October 2014

20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice

scientific article published on 21 November 2013

20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx.

scientific article published on 11 January 2013

3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation

scientific article published on 26 October 2013

3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity.

scientific article published on 6 June 2017

5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer.

scientific article published on 16 March 2010

6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.

scientific article

7,3',4'-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice

scientific article published on 13 November 2013

7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase

scientific article

7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4.

scientific article

A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K.

scientific article published on 4 June 2013

Abies nephrolepis leaf phenolics prevent the inhibition of gap junction intercellular communication by hydrogen peroxide in rat liver epithelial cells

scientific article published in January 2004

Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin

scientific article

Anthocyanidins, novel FAK inhibitors, attenuate PDGF-BB-induced aortic smooth muscle cell migration and neointima formation

scientific article

Anti-inflammatory effects of recombinant arginine deiminase originating from Lactococcus lactis ssp. lactis ATCC 7962.

scientific article published in September 2007

Antioxidant activity of black tea vs. green tea

scientific article published on 01 April 2002

Antiproliferative effects of dietary phenolic substances and hydrogen peroxide

scientific article

Arginine deiminase originating from Lactococcus lactis ssp. lactis American Type Culture Collection (ATCC) 7962 induces G1-phase cell-cycle arrest and apoptosis in SNU-1 stomach adenocarcinoma cells

scientific article

Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase

scientific article

Ascorbic acid 6-palmitate suppresses gap-junctional intercellular communication through phosphorylation of connexin 43 via activation of the MEK-ERK pathway

scientific article

Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals

scientific article published on 5 November 2008

Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth

scientific article

CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth

scientific article published on 22 May 2013

Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B

scientific article published on February 2008

Caffeic acid phenethyl ester, a major component of propolis, suppresses high fat diet-induced obesity through inhibiting adipogenesis at the mitotic clonal expansion stage.

scientific article published on 5 May 2014

Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression

scientific article published on 10 December 2008

Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H₂O₂-induced apoptosis in primary cortical neurons

scientific article published on 15 February 2012

Cancer chemopreventive effects of lactic acid bacteria

scientific article published on August 2007

Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.

scientific article published on 26 July 2010

Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine

scientific article

Cocoa phytochemicals: recent advances in molecular mechanisms on health

scientific article published on January 2014

Cocoa polyphenols attenuate hydrogen peroxide-induced inhibition of gap-junction intercellular communication by blocking phosphorylation of connexin 43 via the MEK/ERK signaling pathway

scientific article

Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kappaB and MAPKs in mouse skin in vivo

scientific article

Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells

scientific article published on 16 June 2010

Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity

scientific article published on 25 February 2009

Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities

scientific article

Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK.

scientific article

Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase

scientific article published on 2 June 2008

Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK

scientific article

Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells.

scientific article published on November 2005

Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1.

scientific article

Cyanidin-3-glucoside suppresses B[a]PDE-induced cyclooxygenase-2 expression by directly inhibiting Fyn kinase activity

scientific article published on 9 April 2011

Cytoplasmic fraction of Lactococcus lactis ssp. lactis induces apoptosis in SNU-1 stomach adenocarcinoma cells.

scientific article

Decaffeinated coffee prevents scopolamine-induced memory impairment in rats

scientific article published on 14 February 2013

Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.

scientific article

Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling

scientific article

Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase

scientific article published on 23 September 2009

Differential regulation of the hydrogen-peroxide-induced inhibition of gap-junction intercellular communication by resveratrol and butylated hydroxyanisole

scientific article

Effects of phenolics in Empire apples on hydrogen peroxide-induced inhibition of gap-junctional intercellular communication

scientific article

Enhanced oxidative stability of a hydrophilic arginine-conjugated linoleic acid complex

scientific article published in January 2004

Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway

scientific article published on 27 August 2007

Eupatilin, a major flavonoid of Artemisia, attenuates aortic smooth muscle cell proliferation and migration by inhibiting PI3K, MKK3/6, and MKK4 activities

scientific article published on 22 July 2013

Extraction and chromatographic separation of anticarcinogenic fractions from cacao bean husk

scientific article published in January 2005

Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha

scientific article published on 7 January 2009

Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2.

scientific article published in August 2009

Gallic acid, a metabolite of the antioxidant propyl gallate, inhibits gap junctional intercellular communication via phosphorylation of connexin 43 and extracellular-signal-regulated kinase1/2 in rat liver epithelial cells

scientific article published on 22 October 2007

H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cells

scientific article published on October 2006

Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation

scientific article published on 11 September 2014

Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target

scientific article published on 19 December 2005

Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways

scientific article

Improved assay for determining the total radical-scavenging capacity of antioxidants and foods

scientific article published on 10 June 2008

Induction of apoptosis in a human lymphoma cell line by hydrophobic peptide fraction separated from anchovy sauce.

scientific article

Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester

scientific article

Inhibition of gap junctional intercellular communication by the green tea polyphenol (-)-epigallocatechin gallate in normal rat liver epithelial cells

scientific article published on 2 October 2008

Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus

scientific article published on 14 August 2011

Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma

scientific article published on 08 October 2013

Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K.

scientific article

Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells

scientific article published on January 2007

Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase

scientific article

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

scientific article

Lactococcus lactis ssp. lactis inhibits the proliferation of SNU-1 human stomach cancer cells through induction of G0/G1 cell cycle arrest and apoptosis via p53 and p21 expression

scientific article

Licorice-derived dehydroglyasperin C increases MKP-1 expression and suppresses inflammation-mediated neurodegeneration

scientific article published on 29 September 2013

Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer

scientific article published on 9 March 2010

Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/threonine kinase, inhibits tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells.

scientific article

MKK4 is a novel target for the inhibition of tumor necrosis factor-alpha-induced vascular endothelial growth factor expression by myricetin

scientific article

MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo

scientific article

Major Phenolics in Apple and Their Contribution to the Total Antioxidant Capacity ⬇️

scientific article published on October 22, 2003

Myricetin down-regulates phorbol ester-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking activation of nuclear factor kappa B.

scientific article

Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo

scientific article

Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.

scientific article

Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis.

scientific article

Myricetin suppresses UVB-induced skin cancer by targeting Fyn.

scientific article published in July 2008

Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.

scientific article

NADPH oxidase is a novel target of delphinidin for the inhibition of UVB-induced MMP-1 expression in human dermal fibroblasts

scientific article

Naturally occurring phytochemicals for the prevention of Alzheimer's disease

scientific article published on 26 December 2009

Optimal recovery of high-purity rutin crystals from the whole plant of Fagopyrum esculentum Moench (buckwheat) by extraction, fractionation, and recrystallization

scientific article published on 25 February 2005

Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase

scientific article published on 28 February 2014

Peonidin inhibits phorbol-ester-induced COX-2 expression and transformation in JB6 P+ cells by blocking phosphorylation of ERK-1 and -2.

scientific article

Peptides from anchovy sauce induce apoptosis in a human lymphoma cell (U937) through the increase of caspase-3 and -8 activities

scientific article

Persimmon peel extract attenuates PDGF-BB-induced human aortic smooth muscle cell migration and invasion through inhibition of c-Src activity

scientific article published on 18 June 2013

Phenolic phytochemicals derived from red pine (Pinus densiflora) inhibit the invasion and migration of SK-Hep-1 human hepatocellular carcinoma cells

scientific article published on January 2007

Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signaling

scientific article

Phosphatidylinositol 3-kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation

scientific article

Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells

scientific article published on 3 November 2009

Piceatannol attenuates 4-hydroxynonenal-induced apoptosis of PC12 cells by blocking activation of c-Jun N-terminal kinase

scientific article published in August 2009

Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK

scientific journal article

Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission

scientific article published on 05 July 2013

Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression

scientific article published on 18 July 2013

Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis.

scientific article published on 26 February 2011

Preventive effects of vitamin C on carcinogenesis

scientific article published in January 2002

Production of nitric oxide, tumor necrosis factor-alpha and interleukin-6 by RAW264.7 macrophage cells treated with lactic acid bacteria isolated from kimchi.

scientific article

Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells

scientific article published in May 2010

Protective effects of piceatannol against beta-amyloid-induced neuronal cell death

scientific article published on 01 January 2007

Protective effects of red wine flavonols on 4-hydroxynonenal-induced apoptosis in PC12 cells

scientific article published in August 2009

Quercetin suppresses intracellular ROS formation, MMP activation, and cell motility in human fibrosarcoma cells

scientific article published on 31 July 2013

Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase

scientific article published on 8 July 2013

Quercetin, the active phenolic component in kiwifruit, prevents hydrogen peroxide-induced inhibition of gap-junction intercellular communication

scientific article published on 22 March 2010

Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine

scientific article published on February 2008

Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin

scientific article published on 21 November 2012

Recovery effect of onion peel extract against H2 O2 -induced inhibition of gap-junctional intercellular communication is mediated through quercetin

scientific article

Resveratrol counteracts gallic acid-induced down-regulation of gap-junction intercellular communication

scientific article published on 25 March 2008

Rg3-enriched ginseng extract ameliorates scopolamine-induced learning deficits in mice

scientific article published on 18 February 2016

Src kinase is a direct target of apigenin against UVB-induced skin inflammation

scientific article

Structural and functional analysis of the natural JNK1 inhibitor quercetagetin

scientific article

The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer

scientific article published on 02 August 2013

The atopic dermatitis-like symptoms induced by MC903 were alleviated in JNK1 knockout mice

scientific article published on 17 September 2013

The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK

scientific article published on December 2008

The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1

scientific article published on 13 October 2015

The roles of polyphenols in cancer chemoprevention

scientific article published on January 2006

Total antioxidant capacity of arginine-conjugated linoleic acid (CLA) complex

scientific article published on 01 February 2004

Tpl2 is a key mediator of arsenite-induced signal transduction

scientific article

Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance

scientific article published on 17 April 2015

USP8 is a novel target for overcoming gefitinib resistance in lung cancer

scientific article published on 07 June 2013

Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars

scientific article published in September 2004

Vitamin C and cancer chemoprevention: reappraisal

scientific article published on December 2003

Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals.

scientific article

Vitamins, phytochemicals, diets, and their implementation in cancer chemoprevention

p38 is a key signaling molecule for H-ras-induced inhibition of gap junction intercellular communication in rat liver epithelial cells.

scientific article published on December 2004

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