List of works - Artur Mucha

2-Aminoethylphosphonate utilization by the cold-adapted Geomyces pannorum P11 strain

scientific article published on 27 October 2013

A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

scientific article published on 9 April 2016

A synthetic method for diversification of the P1' substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1' binding pockets of leucine aminopeptidases

scientific article published on 22 February 2007

Addition of H-phosphonates to quinine-derived carbonyl compounds. An unexpected C9 phosphonate-phosphate rearrangement and tandem intramolecular piperidine elimination

scientific article

Aminophosphinates against Helicobacter pylori ureolysis-Biochemical and whole-cell inhibition characteristics.

scientific article

An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.

scientific article

Analysis of pD-dependent complexation of N-benzyloxycarbonylaminophosphonic acids by alpha-cyclodextrin. Enantiodifferentiation of phosphonic acid pKa values.

scientific article

Bis(aminomethyl)phosphinic Acid, a Highly Promising Scaffold for the Development of Bacterial Urease Inhibitors.

scientific article

Bisphosphonic acids and related compounds as inhibitors of nucleotide- and polyphosphate-processing enzymes: A PPK1 and PPK2 case study.

scientific article

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development

scientific article (publication date: 19 January 2007)

Chiral discrimination of ethyl and phenyl N-benzyloxycarbonylaminophosphonates by cyclodextrins

Cinchona alkaloids as privileged chiral solvating agents for the enantiodiscrimination of N-protected aminoalkanephosphonates—a comparative NMR study

Covalent Inhibition of Bacterial Urease by Bifunctional Catechol-Based Phosphonates and Phosphinates

scientific article published on 28 December 2020

Crystal structures of active LytM

scientific journal article

Cyclodextrins as NMR probes in the study of the enantiomeric compositions of N-benzyloxycarbonylamino-phosphonic and phosphinic acids

article

Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues

scientific article

Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis

scientific article published on 09 November 2006

Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity

scientific article published in March 2006

Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study.

scientific article published on 20 September 2016

Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

scientific article published on 26 October 2007

Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase.

scientific article published on 2 February 2008

Metallo-aminopeptidase inhibitors

scientific article published on 10 May 2010

N-Benzyl Residues as the P1' Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases

scientific article published on 22 September 2020

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs.

scientific article

Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles.

scientific article

P1' Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases

scientific article published on 24 April 2020

Peptide and Pseudopeptide Bond Synthesis in Phosphorus Dipeptide Analogs

scientific article published on 01 January 2020

Phosphorylation as a method of tuning the enantiodiscrimination potency of quinine-An NMR study

scientific article published on 17 February 2012

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

scientific article published on 30 September 2009

Recent Developments in Peptidyl Diaryl Phoshonates as Inhibitors and Activity-Based Probes for Serine Proteases

scientific article published on 10 June 2019

Recent developments in the synthesis and applications of phosphinic peptide analogs

scientific article published on 28 February 2019

Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry

scientific article published on 05 August 2011

Stereoselective separations of chiral phosphinic acid pseudodipeptides by CEC using silica monoliths modified with an anion-exchange-type chiral selector

scientific article published on 01 November 2006

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

scientific article

Structural exploration of cinnamate-based phosphonic acids as inhibitors of bacterial ureases

scientific article published on 02 October 2018

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

scientific article

Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.

scientific article

Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin C.

scientific article

Synthesis and modifications of phosphinic dipeptide analogues.

scientific article

The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

scientific article published on 20 August 2007

The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity

scientific article

Unusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine

scientific article published on 28 June 2010

Whole-cell Proteus mirabilis urease inhibition by aminophosphinates for the control of struvite formation.

scientific article

Zwitterionic Phosphorylated Quinines as Chiral Solvating Agents for NMR Spectroscopy

scientific article published on 25 August 2015

List of works by Artur Mucha

2-Aminoethylphosphonate utilization by the cold-adapted Geomyces pannorum P11 strain

A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

A synthetic method for diversification of the P1' substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1' binding pockets of leucine aminopeptidases

Addition of H-phosphonates to quinine-derived carbonyl compounds. An unexpected C9 phosphonate-phosphate rearrangement and tandem intramolecular piperidine elimination

Aminophosphinates against Helicobacter pylori ureolysis-Biochemical and whole-cell inhibition characteristics.

An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.

Analysis of pD-dependent complexation of N-benzyloxycarbonylaminophosphonic acids by alpha-cyclodextrin. Enantiodifferentiation of phosphonic acid pKa values.

Bis(aminomethyl)phosphinic Acid, a Highly Promising Scaffold for the Development of Bacterial Urease Inhibitors.

Bisphosphonic acids and related compounds as inhibitors of nucleotide- and polyphosphate-processing enzymes: A PPK1 and PPK2 case study.

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development

Chiral discrimination of ethyl and phenyl N-benzyloxycarbonylaminophosphonates by cyclodextrins

Cinchona alkaloids as privileged chiral solvating agents for the enantiodiscrimination of N-protected aminoalkanephosphonates—a comparative NMR study

Covalent Inhibition of Bacterial Urease by Bifunctional Catechol-Based Phosphonates and Phosphinates

Crystal structures of active LytM

Cyclodextrins as NMR probes in the study of the enantiomeric compositions of N-benzyloxycarbonylamino-phosphonic and phosphinic acids

Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues

Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis

Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity

Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study.

Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase.

Metallo-aminopeptidase inhibitors

N-Benzyl Residues as the P1' Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs.

Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles.

P1' Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases

Peptide and Pseudopeptide Bond Synthesis in Phosphorus Dipeptide Analogs

Phosphorylation as a method of tuning the enantiodiscrimination potency of quinine-An NMR study

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

Recent Developments in Peptidyl Diaryl Phoshonates as Inhibitors and Activity-Based Probes for Serine Proteases

Recent developments in the synthesis and applications of phosphinic peptide analogs

Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry

Stereoselective separations of chiral phosphinic acid pseudodipeptides by CEC using silica monoliths modified with an anion-exchange-type chiral selector

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

Structural exploration of cinnamate-based phosphonic acids as inhibitors of bacterial ureases

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.

Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin C.

Synthesis and modifications of phosphinic dipeptide analogues.

The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity

Unusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine

Whole-cell Proteus mirabilis urease inhibition by aminophosphinates for the control of struvite formation.

Zwitterionic Phosphorylated Quinines as Chiral Solvating Agents for NMR Spectroscopy