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List of works by Wolfgang Müller-Klieser

A bioluminescence technique for quantitative and structure-associated imaging of pyruvate

scientific article published on 27 November 2006

A new photometric method for oxygen consumption measurements in cell suspensions

scientific article published on 01 August 1986

A pressure chamber for removing cryobiopsies from small laboratory animals

scientific article published on 01 July 1984

ATP concentrations in multicellular tumor spheroids assessed by single photon imaging and quantitative bioluminescence

scientific article published on 01 August 1990

Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry

scientific article published on March 1990

Bioactivity of well-defined green tea extracts in multicellular tumor spheroids.

scientific article published in December 2002

Biological response of multicellular EMT6 spheroids to exogenous lactate

scientific article published on 01 March 1991

Blood flow, tissue oxygenation, and pH-distribution in malignant tumors upon localized hyperthermia. Basic pathophysiological aspects and the role of various thermal doses

scientific article published on 01 February 1983

Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids

scientific article published on 01 May 1995

Carbon ions and X‑rays induce pro‑inflammatory effects in 3D oral mucosa models with and without PBMCs

scientific article published on 22 August 2014

Cell line and growth site as relevant parameters governing tumor tissue oxygenation

scientific article

Cellular growth and metabolic adaptations to nutrient stress environments in tumor microregions

scientific article published on 01 April 1986

Changes in O2 consumption of multicellular spheroids during development of necrosis.

scientific article published in January 1985

Circulatory and metabolic responses of malignant tumors during localized hyperthermia

scientific article published in January 1980

Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.

scientific article

Comparative imaging of structure and metabolites in tumours

scientific article published in July 1991

Comparative metabolic analysis in head and neck cancer and the normal gingiva

scientific article published on 22 July 2017

Comparative pO2 measurements in cell spheroids cultured with different techniques

scientific article

Correlation between regional ATP and blood flow in tumors and surrounding normal tissue

scientific article published on 01 January 1994

Correlation of high lactate levels in head and neck tumors with incidence of metastasis

scientific article published on February 1997

Correlation of high lactate levels in human cervical cancer with incidence of metastasis ⬇️

scientific article published on 01 November 1995

Cytostatic activity of aeroplysinin-1 against lymphoma and epithelioma cells

scientific article published in July 1989

Differential Superiority of Heavy Charged-Particle Irradiation to X-Rays: Studies on Biological Effectiveness and Side Effect Mechanisms in Multicellular Tumor and Normal Tissue Models

scientific article

Differential changes in purine nucleotides after Doxorubicin treatment of human cancer cells in vitro

scientific article

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

scientific article

Distributions of oxygen, nutrient, and metabolic waste concentrations in multicellular spheroids and their dependence on spheroid parameters

scientific article published on January 1991

Effect of CO2 and lactic acid on intracellular pH of ascites tumor cells

scientific article published in September 1981

Effect of hyperthermia on tumor blood flow

scientific article published on 01 January 1984

Effect of microencapsulation on oxygen distribution in islets organs

scientific article published on 01 May 1994

Effectiveness of respiratory hyperoxia, of normobaric and of hyperbaric oxygen atmospheres in improving tumor oxygenation.

scientific article

Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo

scientific article

Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action

scientific article published on 21 July 2010

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

scientific article

Endothelial capillaries chemotactically attract tumour cells.

scientific article published in March 2001

Evidence for a major role of glucose in controlling development of necrosis in EMT6/Ro multicell tumor spheroids

scientific article published on 01 January 1983

Experimental evidence for a hyperthermia-induced breakdown of tumor blood flow during normoglycemia

scientific article published on 01 January 1983

Feasibility of induced metabolic bioluminescence imaging in advanced ovarian cancer patients: first results of a pilot study

scientific article published on 24 June 2016

Frequency distribution histograms of oxygen tensions in multicell spheroids

scientific article published on 01 January 1983

Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging ⬇️

scientific article published on June 1, 1993

Glucose Diffusion Coefficients Determined from Concentration Profiles in Emt6 Tumor Spheroids Incubated in Radioactively Labeled L-Glucose ⬇️

scientific article published on January 1, 1994

Glucose levels and succinate and lactate dehydrogenase activity in EMT6/Ro tumor spheroids

scientific article published on 01 March 1995

Glucose levels in microregions of multicellular EMT6/Ro tumor spheroids

scientific article published in January 1991

Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats

scientific article published on 01 December 1988

Glutathione content of V79 cells in two- or three-dimensional culture

scientific article published on May 1997

Glycolysis-related gene induction and ATP reduction during fractionated irradiation. Markers for radiation responsiveness of human tumor xenografts

scientific article published on 6 July 2013

Glycolytic metabolism and tumour response to fractionated irradiation.

scientific article

Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization

scientific article published on 5 May 2011

Growth rates or radiobiological hypoxia are not correlated with local metabolite content in human melanoma xenografts with similar vascular network

scientific article

Growth-related changes of oxygen consumption rates of tumor cells grown in vitro and in vivo

scientific article published on 01 January 1989

Hemodilution in isolated tumor perfusion.

scientific article

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

scientific article published on 01 February 2000

High-energy shock waves enhance hyperthermic response of tumors: effects on blood flow, energy metabolism, and tumor growth

scientific article published on 01 February 1994

Hyperlactacidaemia in isolated hyperthermic perfusion of tumour bearing rat limbs: a study of feasibility using a novel infusion solution

scientific article published on 01 March 1999

Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death

scientific article published on 4 September 2008

Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy

scientific article published on January 2016

Impact of carbon ion irradiation on epidermal growth factor receptor signaling and glioma cell migration in comparison to conventional photon irradiation ⬇️

scientific article published on February 21, 2013

Impact of exogenous lactate on survival and radioresponse of carcinoma cells in vitro

scientific article

Impact of hypoxia and the metabolic microenvironment on radiotherapy of solid tumors. Introduction of a multi-institutional research project

scientific article published in October 2004

Impact of various thermal doses on the oxygenation and blood flow in malignant tumors upon localized hyperthermia

scientific article published on 01 January 1984

Improvement of tumor spheroid oxygenation by tetrachlorodecaoxide

scientific article published on 01 January 1987

In regard to Tarnawski et al., IJROBP 2002;52:1271-1276.

scientific article published in December 2002

Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids

scientific article

Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1

scientific article published on 01 January 1990

Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment.

scientific article published on 23 June 2011

International conference on cell interactions in malignancy, development and differentiation. Heidelberg, Germany, April 1995.

scientific article

Interrelationship among morphology, metabolism, and proliferation of tumor cells in monolayer and spheroid culture

scientific article published on 01 January 1989

Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia ⬇️

scientific article published on March 1, 1979

Intracapillary oxyhaemoglobin saturation in malignant tumours with central or peripheral blood supply and drainage [proceedings]

scientific article published in November 1978

Intracapillary oxyhemoglobin saturation in malignant tumours with central or peripheral blood supply

scientific article published on 01 February 1980

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

scientific article published on 01 October 1981

Ischemia and loss of ATP in tumours following treatment with focused high energy shock waves

scientific article

LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

scientific article

Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-beta1

scientific article published on 18 May 2007

Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years

scientific article published on 4 January 2016

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

scientific article published on 25 May 2011

Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology

scientific article published in August 2004

Lactate-An Integrative Mirror of Cancer Metabolism

scientific article

Lactate-induced inhibition of tumor cell proliferation ⬇️

scientific article published on 01 May 1988

Lactate: a metabolic key player in cancer

scientific article

Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration

scientific article published on 22 November 2015

Low light level in vitro monitoring of cellular and antigen-antibody reactions using a photon detection camera system--new perspectives for clinical diagnosis and research

scientific article published on January 1990

MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts

scientific article

Manipulation of tumor metabolism for therapeutic approaches: ovarian cancer-derived cell lines as a model system

scientific article published on 19 August 2015

Mapping and quantification of biomolecules in tumor biopsies using bioluminescence

scientific article published in May 1996

Metabolic Imaging in Microregions of Tumors and Normal Tissues With Bioluminescence and Photon Counting ⬇️

scientific article published on 01 August 1988

Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue

scientific article published on 11 April 2010

Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?

scientific article

Metabolic imaging in human tumor xenografts in rnu/rnu-rats using bioluminescence

scientific article published on 01 July 1989

Metabolic imaging in multicellular spheroids of oncogene-transfected fibroblasts

scientific article

Metabolic mapping with bioluminescence: basic and clinical relevance

scientific article

Metabolic micromilieu in tumours

scientific article published on January 2010

Metabolit-induced bioluminescence for tumor prediction: detection of metabolites in tumors of the head and neck region

scientific article published in January 2010

Method for the determination of oxygen consumption rates and diffusion coefficients in multicellular spheroids

scientific article

Microelectrode measurement of oxygen tension distributions in multicellular spheroids cultured in spinner flasks

scientific article published on 01 January 1984

Multicellular spheroids. A review on cellular aggregates in cancer research

scientific article

Multicellular tumor spheroids: an underestimated tool is catching up again.

scientific article published on 25 January 2010

On the Cross-Section Structure of the Mitochondrial Cristae-Membrane as Revealed by X-Ray Diffraction ⬇️

scientific article published on September 1, 1976

On the relation between size of necrosis and diameter of tumor spheroids

scientific article published in January 1996

Oncogene-associated growth behavior and oxygenation of multicellular spheroids from rat embryo fibroblasts.

scientific article published on January 1994

Oxygen consuming regions in EMT60/Ro multicellular tumour spheroids determined by nonlinear regression analysis of experimental PO2 profiles

scientific article published on 01 January 1987

Oxygen consumption rate of tumour cells as a function of their proliferative status

scientific article published on 01 January 1987

Oxygen profile of microencapsulated islets: effect of immobilised hemoglobin in the alginate matrix

scientific article published in November 2001

Oxygenation and differentiation in multicellular spheroids of human colon carcinoma

scientific article published on 01 October 1986

Oxygenation status of rhabdomyosarcoma spheroids with different stages of differentiation

scientific article published on 01 January 1994

Pathophysiological approaches to identifying tumor hypoxia in patients

scientific article published in January 1991

Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies.

scientific article published on 7 September 2006

Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours ⬇️

scientific article published on December 1, 1992

Potential of Induced Metabolic Bioluminescence Imaging to Uncover Metabolic Effects of Antiangiogenic Therapy in Tumors

scientific article

Proliferation-associated oxygen consumption and morphology of tumor cells in monolayer and spheroid culture

scientific article published on October 1, 1992

Proliferative activity and tumorigenic conversion: impact on cellular metabolism in 3-D culture

scientific article

Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts.

scientific article published on 6 February 2012

Quantification of apoptosis induction by doxorubicin in three types of human mammary carcinoma spheroids

scientific article published on 01 July 1999

Quantitative Imaging of D-2-Hydroxyglutarate in Selected Histological Tissue Areas by a Novel Bioluminescence Technique

scientific article published on 7 March 2016

Radiobiological characterization of human tumor cell multilayers after conventional and particle irradiation.

scientific article published on June 2007

Recommendations for using the standardized terminology of respiratory physiology in radiation research.

scientific article published on November 1983

Relation between autoradiographically measured blood flow and ATP concentrations obtained from imaging bioluminescence in tumors following hyperthermia

scientific article published on March 1993

Relation between secretory function and oxygen supply in isolated islet organs

scientific article published on 01 April 1994

Respiratory gas exchange in the rat spleen in situ and intrasplenic oxyhemoglobin saturation

scientific article published on February 14, 1979

Response of Chinese hamster v79 multicellular spheroids exposed to high-energy carbon ions

scientific article published on February 2004

Rhabdomyosarcoma spheroids with central proliferation and differentiation ⬇️

scientific article published on January 15, 1992

Semiautomatic Growth Analysis of Multicellular Tumor Spheroids ⬇️

scientific article published on September 9, 2011

Semiquantitative bioluminescent assay of glutathione

scientific article published on 01 September 1998

Simultaneous high-resolution measurement of adenosine triphosphate levels and blood flow in the hamster amelanotic melanoma A-Mel-3

scientific article published on November 4, 1992

Size-dependent oxygenation and energy status in multicellular tumor spheroids

scientific article published on 01 January 1990

Spatial analysis of plant metabolism: sucrose imaging within Vicia faba cotyledons reveals specific developmental patterns

scientific article published in February 2002

Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions

scientific article published on December 1993

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

scientific article published in Scientific Reports

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

scientific article published on 14 August 2013

Terminally differentiated postmitotic tumor cells in a rat rhabdomyosarcoma cell line

scientific article published on 01 January 1988

Test system for trifunctional antibodies in 3D MCTS culture

scientific article published on 12 August 2009

Tetrachlorodecaoxide improves the oxygenation status of multicellular tumor spheroids

scientific article published on 01 January 1986

The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assessment by DCE-MRI.

scientific article published on October 2013

The anti-oxidant capacity of tumour glycolysis

scientific article

The establishment of two rat colonic carcinomas in tissue culture. A basic prerequisite for standardized experiments on the biology of colonic carcinomas in vivo

scientific article published on 01 January 1987

The impact of conventional and heavy ion irradiation on tumor cell migration in vitro.

scientific article published on November 2007

The role of oxygen supply in islet transplantation

scientific article published on December 1, 1992

Three-dimensional cell culture induces novel proliferative and metabolic alterations associated with oncogenic transformation

scientific article published on May 1996

Three-dimensional cell cultures: from molecular mechanisms to clinical applications ⬇️

scientific article published on October 1, 1997

Three-dimensional invasion of human glioblastoma cells remains unchanged by X-ray and carbon ion irradiation in vitro

scientific article published on 15 August 2012

Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model ⬇️

scientific article published on November 1, 2001

Tumor biology and experimental therapeutics

scientific article

Tumor blood flow and O2 availability during hemodilution

scientific article published on 01 January 1984

Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions.

scientific article published on 10 June 2010

Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.

scientific article published on 14 September 2006

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

scientific article published on 8 November 2005

Tumour oxygenation under normobaric and hyperbaric conditions

scientific article

Tumour-growth inhibition by induced hyperglycaemia/hyperlactacidaemia and localized hyperthermia

scientific article published on July 1996

Uncovering Metabolic Effects of Anti-angiogenic Therapy in Tumors by Induced Metabolic Bioluminescence Imaging

scientific article published on 01 January 2016

VEGF-targeted therapy stably modulates the glycolytic phenotype of tumor cells

scientific article

Verapamil inhibits the respiration rate of cancer cells

scientific article published on 01 January 1986

[Lactate and redox status in malignant tumors]

scientific article published on 01 May 2007

[Tumor micromilieu. Experimental and theoretical studies of multicellular tumor spheroids]

[Tumor pathophysiology]

scientific article published on 01 November 2012

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