Search filters

List of works by David R. Jones

A Phase I Trial of High-Dose Clofarabine, Etoposide, and Cyclophosphamide and Autologous Peripheral Blood Stem Cell Transplantation in Patients with Primary Refractory and Relapsed and Refractory Non-Hodgkin Lymphoma ⬇️

scientific article published on October 20, 2010

A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157.

scientific article published on 8 December 2016

A phase I and pharmacokinetic trial of erlotinib in combination with weekly docetaxel in patients with taxane-naive malignancies.

scientific article published in February 2008

A phase I dose escalation and pharmacokinetic study of vatalanib (PTK787/ZK 222584) in combination with paclitaxel in patients with advanced solid tumors

scientific article published on 29 November 2009

A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic ⬇️

scientific article published on June 7, 2011

ATPS-75TARGETING THE Mdm2-Akt SIGNALING NETWORK IN COMBINATION WITH TEMOZOLOMIDE IMPROVES EFFICACY IN ECTOPIC AND ORTHOTOPIC PATIENT-DERIVED GLIOBLASTOMA XENOGRAFT MODELS.

scientific article

Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity

scientific article published on 01 March 2007

CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer

scientific article published on 8 November 2017

Chemopreventative celecoxib fails to prevent schwannoma formation or sensorineural hearing loss in genetically engineered murine model of neurofibromatosis type 2.

scientific article published on 24 October 2017

Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers

scientific article published on 2 June 2016

Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

scientific article

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

scientific article

Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

scientific article published on 4 September 2017

Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5).

scientific article published on 30 May 2007

Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz.

scientific article

Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance

scientific article published on 8 April 2005

Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil

scientific article published on 2 February 2005

Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes

scientific article published in November 2002

Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer

scientific article

EXTH-13. REDUCTION OF TUMOR BURDEN AND HEARING LOSS WITH A MULTIPLE RECEPTOR TYROSINE KINASE INHIBITOR BRIGATINIB IN A GENETICALLY ENGINEERED MOUSE MODEL OF NEUROFIBROMATOSIS TYPE 2

Efavirenz primary and secondary metabolism in vitro and in vivo: identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation

scientific article

Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes

scientific article published on 01 February 2007

Humanized Bone Marrow Mouse Model as a Preclinical Tool to Assess Therapy-Mediated Hematotoxicity ⬇️

scientific article published on April 12, 2011

Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

scientific article

In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs

scientific article published in PLoS ONE

In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies

scientific article published on 15 February 2013

In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

scientific article

Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats

scientific article published in January 2010

Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1-Deficient Mice

scientific article published on 16 September 2019

Mechanism-based inactivation of CYP3A by HIV protease inhibitors

scientific article published on 2 November 2004

Pharmacokinetic and Pharmacodynamic Alterations in the Roux-en-Y Gastric Bypass Recipients ⬇️

scientific article published on August 1, 2013

Pharmacokinetics of Cefepime in Patients with Cancer and Febrile Neutropenia in the Setting of Hematologic Malignancies or Hematopoeitic Cell Transplantation.

scientific article published on 6 August 2016

Phase I, pharmacogenomic, drug-interaction study of sorafenib and bevacizumab in combination with paclitaxel in patients with advanced refractory solid tumors

scientific article published on 26 August 2020

Population pharmacokinetics of cefepime in febrile neutropenia: implications for dose-dependent susceptibility and contemporary dosing regimens.

scientific article

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.

scientific article

Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites

scientific article published in February 2004

Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition

scientific article

Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial

scientific article

Quantification of vincristine and its major metabolite in human plasma by high-performance liquid chromatography/tandem mass spectrometry

scientific article published in June 2008

Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples

scientific article published on 01 February 2007

Relationship between differential hepatic microRNA expression and decreased hepatic cytochrome P450 3A activity in cirrhosis

scientific article

Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.

scientific article published on 6 May 2009

Small-molecule inhibition of the uPAR·uPA interaction: Synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis ⬇️

scientific article published on January 9, 2013

Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome

scientific article published on 12 February 2020

Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo

scientific article published on 22 January 2016

Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS

scientific article published on 18 February 2016

Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity

scientific article published on 25 May 2016

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

scientific article published on 3 April 2003

The quantification of erlotinib (OSI-774) and OSI-420 in human plasma by liquid chromatography-tandem mass spectrometry

scientific article published on 13 November 2006

Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer

scientific article

Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis

scientific article published on 4 October 2011

Paulina is supported by:

About Paulina

Help